IL164817A0 - Keratinocytes expressing exogenous angiogenic growth factors - Google Patents

Keratinocytes expressing exogenous angiogenic growth factors

Info

Publication number
IL164817A0
IL164817A0 IL16481703A IL16481703A IL164817A0 IL 164817 A0 IL164817 A0 IL 164817A0 IL 16481703 A IL16481703 A IL 16481703A IL 16481703 A IL16481703 A IL 16481703A IL 164817 A0 IL164817 A0 IL 164817A0
Authority
IL
Israel
Prior art keywords
growth factors
angiogenic growth
expressing exogenous
keratinocytes
skin tissue
Prior art date
Application number
IL16481703A
Other languages
English (en)
Original Assignee
Stratatech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stratatech Corp filed Critical Stratatech Corp
Publication of IL164817A0 publication Critical patent/IL164817A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/17—Angiopoietin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Prostheses (AREA)
IL16481703A 2002-04-30 2003-04-29 Keratinocytes expressing exogenous angiogenic growth factors IL164817A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37648802P 2002-04-30 2002-04-30
PCT/US2003/013327 WO2003093418A2 (en) 2002-04-30 2003-04-29 Keratinocytes expressing exogenous angiogenic growth factors
US10/425,784 US7498167B2 (en) 2002-04-30 2003-04-29 Keratinocytes expressing exogenous angiogenic growth factors

Publications (1)

Publication Number Publication Date
IL164817A0 true IL164817A0 (en) 2005-12-18

Family

ID=29406758

Family Applications (3)

Application Number Title Priority Date Filing Date
IL16481703A IL164817A0 (en) 2002-04-30 2003-04-29 Keratinocytes expressing exogenous angiogenic growth factors
IL164817A IL164817A (en) 2002-04-30 2004-10-25 Composition comprising near diploid immortalized keratinocytes cells
IL195518A IL195518A (en) 2002-04-30 2008-11-25 Skin graft preparation containing near-immortalized immortalized keratinocytic cells (NIKS) and its uses

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL164817A IL164817A (en) 2002-04-30 2004-10-25 Composition comprising near diploid immortalized keratinocytes cells
IL195518A IL195518A (en) 2002-04-30 2008-11-25 Skin graft preparation containing near-immortalized immortalized keratinocytic cells (NIKS) and its uses

Country Status (9)

Country Link
US (5) US7498167B2 (de)
EP (1) EP1549738B1 (de)
JP (1) JP4753577B2 (de)
AT (1) ATE465242T1 (de)
CA (1) CA2483547C (de)
DE (1) DE60332256D1 (de)
IL (3) IL164817A0 (de)
NZ (1) NZ536205A (de)
WO (1) WO2003093418A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093418A2 (en) * 2002-04-30 2003-11-13 Stratech Corporation Keratinocytes expressing exogenous angiogenic growth factors
US9163076B2 (en) 2005-03-01 2015-10-20 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
WO2009065005A1 (en) 2007-11-14 2009-05-22 Stratatech Corporation Cold storage of organotypically cultured skin equivalents for clinical applications
AU2009313656B2 (en) 2008-11-04 2014-02-20 Stratatech Corporation Dried and irradiated skin equivalents for ready use
US20100330046A1 (en) * 2009-05-21 2010-12-30 Stratatech Corporation Human skin substitutes expressing il-12
TWI488966B (zh) * 2010-07-09 2015-06-21 優普生物科技股份有限公司 Ｄｎａ疫苗
US9597111B2 (en) 2010-08-06 2017-03-21 Kci Licensing, Inc. Methods for applying a skin graft
US8978234B2 (en) 2011-12-07 2015-03-17 MoMelan Technologies, Inc. Methods of manufacturing devices for generating skin grafts
JP2012205516A (ja) * 2011-03-29 2012-10-25 Osaka Univ 人工皮膚モデルの製造方法、及び人工皮膚モデル
US9663564B2 (en) 2013-03-15 2017-05-30 The Regents Of The University Of California Vectors and methods to treat ischemia
US20140065110A1 (en) * 2012-08-31 2014-03-06 The Regents Of The University Of California Genetically modified msc and therapeutic methods
JP6410237B2 (ja) 2012-11-09 2018-10-24 マルコ アーケッティ 拡散性因子および癌細胞
ES2705043T3 (es) 2013-03-13 2019-03-21 Stratatech Corp Criopreservación de sustitutos de piel humana viables
EP2967627B1 (de) 2013-03-14 2017-08-30 KCI Licensing, Inc. Saugfähige substrate zur entnahme von hauttransplantaten
EP3089681B1 (de) 2013-12-31 2021-09-08 3M Innovative Properties Company Flüssigkeitsunterstützte entnahme eines hautimplantats
WO2015103043A1 (en) 2013-12-31 2015-07-09 Kci Licensing, Inc. Sensor systems for skin graft harvesting
WO2016067306A1 (en) * 2014-10-30 2016-05-06 Indian Council Of Medical Research A method for processing of feeder cells suitable for adult stem cell proliferation
WO2016164890A1 (en) 2015-04-09 2016-10-13 Kci Licensing, Inc. Soft-tack, porous substrates for harvesting skin grafts
US11006974B2 (en) 2015-11-03 2021-05-18 Kci Licensing, Inc. Devices for creating an epidermal graft sheet
US20180344448A1 (en) * 2016-02-19 2018-12-06 Kci Licensing, Inc. Transfected epidermal grafts and methods of making the same
EP3551746A1 (de) * 2016-12-09 2019-10-16 The University of Chicago Gewebeorganoide
JP2022549688A (ja) * 2019-09-27 2022-11-28 ストラタテック コーポレーション 急性創傷を治療し、転帰を改善するための方法
JP2023525231A (ja) * 2020-05-13 2023-06-15 ストラタテック コーポレーション 生存能力のある生物工学によって作られた皮膚構築物
US20240207487A1 (en) * 2021-06-08 2024-06-27 Stratatech Corporation Viable bioengineered allogeneic cellularized skin constructs that secrete soluble factors associated with regenerative wound healing
US20240366681A1 (en) * 2021-08-13 2024-11-07 Triovance Holding Llc A skin substitute composition and methods of producing and using the same

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US448096A (en) * 1891-03-10 Hydrant
US4485096A (en) 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
IL95429A (en) 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5292655A (en) * 1990-01-29 1994-03-08 Wille Jr John J Method for the formation of a histologically-complete skin substitute
RU2135191C1 (ru) 1990-04-24 1999-08-27 Ортек Интернэшнл, Инк. Композиционный эквивалент живой кожи, способ его получения, тест-набор
US5292566A (en) * 1990-05-22 1994-03-08 National Label Company Battery label with non-shrinkable top layer
IT1248934B (it) 1990-06-01 1995-02-11 Fidia Spa Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle
US5693332C1 (en) 1995-08-11 2001-01-09 Univ California Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure
US5968546A (en) 1997-05-16 1999-10-19 Baur; Marcus Keratinocyte culture from precursor cells
US20010048917A1 (en) * 1998-03-09 2001-12-06 Warren Hoeffler Skin equivalent and methods of forming and using same
US5989837A (en) 1998-07-13 1999-11-23 Wisconsin Alumni Research Foundation Immortalized human keratinocyte cell line
US20030152562A1 (en) * 2001-10-23 2003-08-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Vitro micro-organs, and uses related thereto
US6458382B1 (en) * 1999-11-12 2002-10-01 Mirus Corporation Nucleic acid transfer complexes
JP2004527462A (ja) * 2000-11-01 2004-09-09 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ 血管新生活性のｉｎｖｉｖｏ刺激
NZ549526A (en) * 2001-03-02 2009-06-26 Stratatech Corp Human skin equivalents comprising near diploid immortalized keratinocyte cells (NIKS)
US6849718B2 (en) 2001-03-20 2005-02-01 Dana Farber Cancer Institute, Inc. Muteins of hypoxia inducible factor alpha and methods of use thereof
WO2003018621A2 (en) * 2001-08-23 2003-03-06 Oxford Biomedica (Uk) Limited Genes
US6838430B2 (en) 2001-09-28 2005-01-04 The Regents Of The University Of California Use of HIF-1a variants to accelerate wound healing
US20040190793A1 (en) 2002-03-01 2004-09-30 Rorvig Mark E. Method for retrieving images by content measure metadata encoding
WO2003093418A2 (en) 2002-04-30 2003-11-13 Stratech Corporation Keratinocytes expressing exogenous angiogenic growth factors
WO2004013606A2 (en) 2002-08-02 2004-02-12 Stratatech Corporation Species specific dna detection
AU2004247072B2 (en) 2003-05-30 2007-09-13 Stratatech Corporation Room temperature storage of organs
WO2005012492A2 (en) 2003-08-01 2005-02-10 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides

Also Published As

Publication number Publication date
US7915042B2 (en) 2011-03-29
WO2003093418A2 (en) 2003-11-13
US20090169528A1 (en) 2009-07-02
IL195518A (en) 2012-08-30
CA2483547A1 (en) 2003-11-13
CA2483547C (en) 2012-03-20
US20040009591A1 (en) 2004-01-15
US20050013807A1 (en) 2005-01-20
US20110059057A1 (en) 2011-03-10
JP2006509529A (ja) 2006-03-23
AU2003228755A1 (en) 2003-11-17
DE60332256D1 (de) 2010-06-02
IL164817A (en) 2010-12-30
NZ536205A (en) 2008-04-30
US8808685B2 (en) 2014-08-19
US7498167B2 (en) 2009-03-03
US7988959B2 (en) 2011-08-02
JP4753577B2 (ja) 2011-08-24
US20110286985A1 (en) 2011-11-24
US7807148B2 (en) 2010-10-05
ATE465242T1 (de) 2010-05-15
EP1549738A4 (de) 2006-11-02
EP1549738A2 (de) 2005-07-06
EP1549738B1 (de) 2010-04-21
WO2003093418A3 (en) 2005-04-21

Similar Documents

Publication Publication Date Title
EP1549738A4 (de) Exogene angiogene wachstumsfaktoren exprimierende keratinozyten
MX2007005200A (es) Plaquetas a partir de celulas germinales.
ECSP105739A (es) Anticuerpos de neutralización contra gdf-8
WO2020186207A3 (en) Non-viral dna vectors and uses thereof for expressing fviii therapeutics
WO2005012492A8 (en) Human skin equivalents expressing exogenous polypeptides
NZ587809A (en) Use of mesenchymal stem cells expressing cd73 and/or cd105 for treating genetic diseases and disorders
AU7707801A (en) Adult human dental pulp stem cells in vitro and in vivo
BR0306665A (pt) Uso de zeìna nativa para aperfeiçoamento do estado do cabelo e agentes
WO2004048545A3 (en) DELIVERY OF siRNAs______________________________________________
WO2004007695A3 (en) Lactobacilli expressing biologically active polypeptides and uses thereof
IL187676A (en) Stable gene transfer to a cell free from serum and production of recombinant human proteins in human cell lines
AU2001277539A1 (en) Pre-adipose cell lines
AU8524901A (en) Membrane penetrating peptides and uses thereof
MXPA03001673A (es) Bacteria de acido lactico capaz de reducir una tendencia individual a desarrollar reacciones alergicas.
GB9925964D0 (en) Hair transplantation
MX2022011805A (es) Vectores de adn no virales y usos de estos para expresar agentes terapéuticos con factor ix.
WO2001068828A3 (en) Compositions and methods for regulated protein expression in gut
TW200635603A (en) Therapeutic formulations of keratinocyte growth factor
GB2434105A (en) Fibronectin-modified ECM tissue graft constructs and methods for preparation and use thereof
WO2002050111A3 (en) Isolated laminin 10
TW200738752A (en) Modulation of MDL-1 activity for treatment of inflammatory disease
AU2000240061A1 (en) Tissue compositions using cultured fibroblasts and keratinocytes and methods of use thereof
AU4037299A (en) Genetically-modified fibroblasts and the use thereof
TW200621293A (en) Cosmetic compositions containing fluorescent colorants for natural skin appearance
WO2005007803A3 (en) Selection free growth of host cells containing multiple integrating vectors