ATE465257T1 - Agonisten für den rezeptor des hepatozyten- wachstumsfaktors und deren anwendungen - Google Patents
Agonisten für den rezeptor des hepatozyten- wachstumsfaktors und deren anwendungenInfo
- Publication number
- ATE465257T1 ATE465257T1 AT97931275T AT97931275T ATE465257T1 AT E465257 T1 ATE465257 T1 AT E465257T1 AT 97931275 T AT97931275 T AT 97931275T AT 97931275 T AT97931275 T AT 97931275T AT E465257 T1 ATE465257 T1 AT E465257T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor agonists
- growth factor
- hepatocyte growth
- applications
- factor receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2121596P | 1996-07-03 | 1996-07-03 | |
| PCT/US1997/010688 WO1998000543A1 (en) | 1996-07-03 | 1997-06-20 | Hepatocyte growth factor receptor agonists and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE465257T1 true ATE465257T1 (de) | 2010-05-15 |
Family
ID=21803007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97931275T ATE465257T1 (de) | 1996-07-03 | 1997-06-20 | Agonisten für den rezeptor des hepatozyten- wachstumsfaktors und deren anwendungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6099841A (de) |
| EP (1) | EP0922102B1 (de) |
| JP (1) | JP2000515735A (de) |
| AT (1) | ATE465257T1 (de) |
| AU (1) | AU729029B2 (de) |
| CA (1) | CA2258153C (de) |
| DE (1) | DE69739856D1 (de) |
| DK (1) | DK0922102T3 (de) |
| IL (1) | IL127558A0 (de) |
| WO (1) | WO1998000543A1 (de) |
| ZA (1) | ZA975851B (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| WO1999037684A1 (en) * | 1998-01-26 | 1999-07-29 | Genentech, Inc. | Antibodies to death receptor 4 (dr4) and uses thereof |
| AU6092900A (en) * | 1999-07-14 | 2001-02-05 | Board Of Trustees Of The Leland Stanford Junior University | Animals comprising human hepatocellular tissue |
| JP3877148B2 (ja) * | 1999-10-29 | 2007-02-07 | アンジェスMg株式会社 | 糖尿病性虚血性疾患遺伝子治療 |
| US20080241835A1 (en) * | 1999-11-01 | 2008-10-02 | Genentech, Inc. | Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same |
| AU2001277854B2 (en) * | 2000-06-29 | 2007-03-01 | North Shore-Long Island Jewish Health System | Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof |
| AU2002357388A1 (en) * | 2001-12-27 | 2003-07-24 | The United States Of America, As Represented By The Department Of Veterans Affairs | Monoclonal antibody imaging and therapy of tumors that express met and bind hepatocyte growth factor |
| EP2075256A2 (de) | 2002-01-14 | 2009-07-01 | William Herman | Gezielte Liganden |
| US9701754B1 (en) | 2002-10-23 | 2017-07-11 | City Of Hope | Covalent disulfide-linked diabodies and uses thereof |
| WO2004072117A2 (en) * | 2003-02-13 | 2004-08-26 | Pharmacia Corporation | Antibodies to c-met for the treatment of cancers |
| WO2004093892A2 (en) * | 2003-04-16 | 2004-11-04 | Genentech, Inc. | Stanniocalcin-1, variant or antagonists thereof for selective modulation of vascularization |
| US20040208876A1 (en) * | 2003-04-18 | 2004-10-21 | Kim Kyung Jin | Monoclonal antibodies to hepatocyte growth factor |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| ITMI20031127A1 (it) * | 2003-06-05 | 2004-12-06 | Uni Degli Studi Del Piemont E Orientale Am | Anticorpi anti-hgf-r e loro uso |
| HN2004000285A (es) | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| CA2545603A1 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto |
| WO2005108424A1 (en) * | 2004-05-06 | 2005-11-17 | Genentech, Inc. | Crystal structure of the complex of hepatocyte growth factor bata chain with met receptor and methods of use |
| US20060003931A1 (en) * | 2004-05-06 | 2006-01-05 | Genentech, Inc. | Crystal structure of the hepatocyte growth factor and methods of use |
| JP2008516629A (ja) * | 2004-10-20 | 2008-05-22 | ペアス インスティテュート アーベー | 肝細胞増殖因子(hgf)の生物活性に関する評価 |
| EP2311880A3 (de) | 2005-01-05 | 2011-07-27 | Biogen Idec MA Inc. | Cripto-bindende Moleküle |
| US7696170B2 (en) * | 2005-01-24 | 2010-04-13 | Kringle Pharma Inc. | Fibrosis inhibitor for implanted organ |
| EP1867339A4 (de) * | 2005-03-02 | 2010-05-26 | Mitsubishi Tanabe Pharma Corp | Antivirales mittel |
| US20060263808A1 (en) * | 2005-03-25 | 2006-11-23 | Genentech, Inc. | C-met mutations in lung cancer |
| SG159547A1 (en) * | 2005-03-25 | 2010-03-30 | Genentech Inc | Methods and compositions for modulating hyperstabilized c-met |
| CN101189023B (zh) | 2005-03-31 | 2013-01-30 | 通用医疗公司 | 监测和调制hgf/hgfr活性 |
| MX2007015056A (es) * | 2005-06-02 | 2008-03-11 | Galaxy Biotech Llc | Metodos para el tratamiento de tumores de cerebro con anticuerpos. |
| US8133867B2 (en) | 2006-03-20 | 2012-03-13 | Seikagaku Corporation | Method for treating rheumatoid arthritis with an antibody that binds to a hepatocyte growth factor receptor |
| JP2009531324A (ja) | 2006-03-20 | 2009-09-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 癌標的化のための操作された抗前立腺幹細胞抗原(psca)抗体 |
| AR059922A1 (es) * | 2006-04-01 | 2008-05-07 | Galaxy Biotech Llc | Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos |
| US20100150863A1 (en) | 2006-12-20 | 2010-06-17 | Bayer Pharmaceuticals Corporation | Hydroxy methyl phenyl pyrazolyl urea compound useful in treatment of cancer |
| WO2009032949A2 (en) | 2007-09-04 | 2009-03-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
| US20110092452A1 (en) * | 2008-03-05 | 2011-04-21 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
| WO2010096486A1 (en) | 2009-02-17 | 2010-08-26 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| JP2013511969A (ja) | 2009-11-25 | 2013-04-11 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 確定的内胚葉細胞の肝分化のための方法 |
| EP2506876B1 (de) | 2009-12-02 | 2016-10-12 | Imaginab, Inc. | J591-minikörper und cys-diakörper zur adressierung des prostataspezifischen membranantigens (psma) und verfahren zu deren verwendung |
| EP2588107A1 (de) | 2010-07-01 | 2013-05-08 | Takeda Pharmaceutical Company Limited | Kombination aus einem cmet-hemmer und einem antikörper gegen hgf und/oder cmet |
| ES2739503T3 (es) | 2010-07-09 | 2020-01-31 | Bioverativ Therapeutics Inc | Moléculas de cadena simple procesables y polipéptidos producidos usándolas |
| BR122014027420A2 (pt) | 2010-11-03 | 2019-08-20 | Argenx Bvba | Anticorpos anti c-met |
| US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
| US9926364B2 (en) | 2011-11-03 | 2018-03-27 | Argen-X N.V. | Chimeric human-llama antigens and methods of use |
| LT2802606T (lt) | 2012-01-10 | 2018-10-10 | Biogen Ma Inc. | Terapinių molekulių transporto per kraujo-smegenų barjerą padidinimas |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| EA037906B1 (ru) | 2013-03-15 | 2021-06-04 | Биовератив Терапьютикс Инк. | Препараты полипептида фактора ix |
| JP6426103B2 (ja) * | 2013-10-15 | 2018-11-21 | 国立大学法人 東京大学 | c−Metタンパク質アゴニスト |
| BR112016021383A2 (pt) | 2014-03-24 | 2017-10-03 | Genentech Inc | Método para identificar um paciente com câncer que é susceptível ou menos susceptível a responder ao tratamento com um antagonista de cmet, método para identificar um paciente apresentando câncer previamente tratado, método para determinar a expressão do biomarcador hgf, antagonista anti-c-met e seu uso, kit de diagnóstico e seu método de preparo |
| CN107001471B (zh) | 2014-09-16 | 2022-01-18 | 西福根有限公司 | 抗met抗体和组合物 |
| US11761951B2 (en) | 2015-02-04 | 2023-09-19 | Bristol-Myers Squibb Company | Methods of selecting therapeutic molecules |
| UY36550A (es) | 2015-02-04 | 2016-08-31 | Roche Innovation Ct Copenhagen As | Oligómeros antisentido de tau y sus usos |
| WO2017027325A1 (en) | 2015-08-07 | 2017-02-16 | Imaginab, Inc. | Antigen binding constructs to target molecules |
| WO2018014111A1 (en) | 2016-06-22 | 2018-01-25 | Harless William Warren | Cancer treatment and metastasis inhibition using an anti-cancer stem cell agent in combination with a neul sialidase inhibitor or a cytokine inhibitor after primary cancer treatment |
| GB201611123D0 (en) * | 2016-06-27 | 2016-08-10 | Euremab Srl | Anti met antibodiesand uses thereof |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法 |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| IT201800000535A1 (it) | 2018-01-03 | 2019-07-03 | Procedimenti per la cura del cancro. | |
| SG11202108525VA (en) | 2019-02-21 | 2021-09-29 | Regeneron Pharma | Methods of treating ocular cancer using anti-met antibodies and bispecific antigen binding molecules that bind met |
| EP4003003A4 (de) * | 2019-07-26 | 2023-07-26 | Ambys Medicines, Inc. | Verfahren und zusammensetzungen zur herstellung von hepatozyten |
| CN114340684B (zh) | 2019-09-16 | 2025-09-12 | 瑞泽恩制药公司 | 用于免疫pet成像的放射性标记的met结合蛋白 |
| TW202305012A (zh) * | 2021-03-22 | 2023-02-01 | 日商肽夢想股份有限公司 | c-Met 蛋白質結合肽複合物 |
| IL318630A (en) | 2022-09-01 | 2025-03-01 | Regeneron Pharma | Methods for treating non-small cell lung cancer using mesenchymal-epithelial transition factor (MET) targeting factors |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5648273A (en) * | 1989-12-27 | 1997-07-15 | The United States Of America, As Represented By The Department Of Health And Human Services | Hepatic growth factor receptor is the MET proto-oncogene |
| US5362716A (en) * | 1989-12-27 | 1994-11-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines |
| JP2750372B2 (ja) * | 1990-06-19 | 1998-05-13 | 敏一 中村 | 賢疾患治療剤 |
| US6566098B1 (en) * | 1990-09-14 | 2003-05-20 | The United States Of America As Represented By The Department Of Health And Human Services | DNA encoding truncated hepatocyte growth factor variants |
| DK0584125T3 (da) * | 1991-05-10 | 1997-09-08 | Pharmacia & Upjohn Spa | Afkortede former af hepatocyt vækstfaktor (HGF) receptor |
| US5227158A (en) * | 1991-06-10 | 1993-07-13 | Genentech, Inc. | Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon |
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| DE69333807T2 (de) * | 1992-02-06 | 2006-02-02 | Chiron Corp., Emeryville | Marker für krebs und biosynthetisches bindeprotein dafür |
| US5316921A (en) * | 1992-05-18 | 1994-05-31 | Genentech, Inc. | Single-chain hepatocyte growth factor variants |
| US5328837A (en) * | 1992-05-18 | 1994-07-12 | Genentech, Inc. | Hepatocyte growth factor protease domain variants |
| CA2134773A1 (en) * | 1992-06-04 | 1993-12-09 | Robert J. Debs | Methods and compositions for in vivo gene therapy |
| DE69310525T2 (de) * | 1992-09-16 | 1997-10-02 | Genentech Inc | Schutz gegen leberschäden mit hgf |
| WO1994009969A1 (de) | 1992-10-28 | 1994-05-11 | Max Born Inst Fuer Nichtlinear | Metall/kunststoff-verbundkörper, verfahren zu dessen herstellung und vorrichtung zur ausführung des verfahrens |
| ATE183513T1 (de) | 1993-06-03 | 1999-09-15 | Therapeutic Antibodies Inc | Herstellung von antikörperfragmenten |
| US5464815A (en) * | 1993-09-08 | 1995-11-07 | Genentech, Inc. | Inhibition of heparin-binding |
| US5686292A (en) * | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| US8200624B2 (en) | 2010-07-20 | 2012-06-12 | Sybase, Inc. | Membership tracking and data eviction in mobile middleware scenarios |
-
1997
- 1997-06-20 JP JP10504193A patent/JP2000515735A/ja not_active Ceased
- 1997-06-20 AT AT97931275T patent/ATE465257T1/de not_active IP Right Cessation
- 1997-06-20 DK DK97931275.8T patent/DK0922102T3/da active
- 1997-06-20 DE DE69739856T patent/DE69739856D1/de not_active Expired - Lifetime
- 1997-06-20 WO PCT/US1997/010688 patent/WO1998000543A1/en not_active Ceased
- 1997-06-20 EP EP97931275A patent/EP0922102B1/de not_active Expired - Lifetime
- 1997-06-20 IL IL12755897A patent/IL127558A0/xx unknown
- 1997-06-20 AU AU34949/97A patent/AU729029B2/en not_active Expired
- 1997-06-20 CA CA002258153A patent/CA2258153C/en not_active Expired - Lifetime
- 1997-06-27 US US08/884,669 patent/US6099841A/en not_active Expired - Lifetime
- 1997-07-01 ZA ZA975851A patent/ZA975851B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0922102T3 (da) | 2010-08-16 |
| ZA975851B (en) | 1999-01-04 |
| DE69739856D1 (de) | 2010-06-02 |
| US6099841A (en) | 2000-08-08 |
| WO1998000543A1 (en) | 1998-01-08 |
| EP0922102B1 (de) | 2010-04-21 |
| JP2000515735A (ja) | 2000-11-28 |
| AU729029B2 (en) | 2001-01-25 |
| IL127558A0 (en) | 1999-10-28 |
| CA2258153C (en) | 2004-08-17 |
| CA2258153A1 (en) | 1998-01-08 |
| AU3494997A (en) | 1998-01-21 |
| EP0922102A1 (de) | 1999-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |