DK0922102T3 - Receptor-agonister af hepatocyt-vækstfaktor og anvendelser deraf - Google Patents
Receptor-agonister af hepatocyt-vækstfaktor og anvendelser derafInfo
- Publication number
- DK0922102T3 DK0922102T3 DK97931275.8T DK97931275T DK0922102T3 DK 0922102 T3 DK0922102 T3 DK 0922102T3 DK 97931275 T DK97931275 T DK 97931275T DK 0922102 T3 DK0922102 T3 DK 0922102T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptor agonists
- growth factor
- hepatocyte growth
- applications
- factor receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2121596P | 1996-07-03 | 1996-07-03 | |
| PCT/US1997/010688 WO1998000543A1 (en) | 1996-07-03 | 1997-06-20 | Hepatocyte growth factor receptor agonists and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0922102T3 true DK0922102T3 (da) | 2010-08-16 |
Family
ID=21803007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97931275.8T DK0922102T3 (da) | 1996-07-03 | 1997-06-20 | Receptor-agonister af hepatocyt-vækstfaktor og anvendelser deraf |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6099841A (da) |
| EP (1) | EP0922102B1 (da) |
| JP (1) | JP2000515735A (da) |
| AT (1) | ATE465257T1 (da) |
| AU (1) | AU729029B2 (da) |
| CA (1) | CA2258153C (da) |
| DE (1) | DE69739856D1 (da) |
| DK (1) | DK0922102T3 (da) |
| IL (1) | IL127558A0 (da) |
| WO (1) | WO1998000543A1 (da) |
| ZA (1) | ZA975851B (da) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| PT1053256E (pt) * | 1998-01-26 | 2011-09-28 | Genentech Inc | Anticorpos para o receptor de morte 4 (dr4) e utilizações destes |
| US6660905B1 (en) | 1999-07-14 | 2003-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Mice comprising engrafted functional human hepatocytes |
| ATE409494T1 (de) * | 1999-10-29 | 2008-10-15 | Anges Mg Inc | Gentherapie für diabetische ischämie |
| US20080241835A1 (en) * | 1999-11-01 | 2008-10-02 | Genentech, Inc. | Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same |
| AU7785401A (en) * | 2000-06-29 | 2002-01-14 | Long Island Jewish Res Inst | Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof |
| EP1516185A4 (en) * | 2001-12-27 | 2007-06-20 | Van Andel Res Inst | Monoclonal antibody imaging and therapy of tumors that express met and bind hepatocyte growth factor |
| US20050069549A1 (en) | 2002-01-14 | 2005-03-31 | William Herman | Targeted ligands |
| US9701754B1 (en) | 2002-10-23 | 2017-07-11 | City Of Hope | Covalent disulfide-linked diabodies and uses thereof |
| EP1592713A2 (en) * | 2003-02-13 | 2005-11-09 | Pharmacia Corporation | Antibodies to c-met for the treatment of cancers |
| US7407660B2 (en) * | 2003-04-16 | 2008-08-05 | Genentech, Inc. | Methods and compositions for selective modulation of vascularization |
| US20040208876A1 (en) * | 2003-04-18 | 2004-10-21 | Kim Kyung Jin | Monoclonal antibodies to hepatocyte growth factor |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| ITMI20031127A1 (it) * | 2003-06-05 | 2004-12-06 | Uni Degli Studi Del Piemont E Orientale Am | Anticorpi anti-hgf-r e loro uso |
| HN2004000285A (es) | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| EP2385069A3 (en) | 2003-11-12 | 2012-05-30 | Biogen Idec MA Inc. | Neonatal Fc rReceptor (FcRn)- binding polypeptide variants, dimeric Fc binding proteins and methods related thereto |
| WO2005108424A1 (en) * | 2004-05-06 | 2005-11-17 | Genentech, Inc. | Crystal structure of the complex of hepatocyte growth factor bata chain with met receptor and methods of use |
| WO2006001911A2 (en) * | 2004-05-06 | 2006-01-05 | Genentech, Inc. | Crystal structure of the hepatocyte growth factor beta chain and methods of use |
| JP2008516629A (ja) * | 2004-10-20 | 2008-05-22 | ペアス インスティテュート アーベー | 肝細胞増殖因子(hgf)の生物活性に関する評価 |
| AU2006203889A1 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | CRIPTO binding molecules |
| WO2006077675A1 (ja) * | 2005-01-24 | 2006-07-27 | Kringle Pharma Inc. | 移植臓器の線維化抑制剤 |
| EP1867339A4 (en) * | 2005-03-02 | 2010-05-26 | Mitsubishi Tanabe Pharma Corp | ANTIVIRAL AGENT |
| CN101184506B (zh) * | 2005-03-25 | 2013-07-17 | 健泰科生物技术公司 | 用于调节超稳定化的c-met的方法和组合物 |
| MX2007011650A (es) * | 2005-03-25 | 2008-01-16 | Genentech Inc | Mutaciones de la c-met en el cancer del pulmon. |
| ES2440953T3 (es) | 2005-03-31 | 2014-01-31 | The General Hospital Corporation | Modulación de la actividad de HGF/HGFR para tratar un linfedema |
| KR20080026562A (ko) * | 2005-06-02 | 2008-03-25 | 갤럭시 바이오테크, 엘엘씨 | 항체를 이용한 뇌종양 치료 방법 |
| EP1996716B1 (en) | 2006-03-20 | 2011-05-11 | The Regents of the University of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| ES2369739T3 (es) * | 2006-03-20 | 2011-12-05 | Seikagaku Corporation | Agente terapéutico para la artritis reumatoide. |
| AR059922A1 (es) * | 2006-04-01 | 2008-05-07 | Galaxy Biotech Llc | Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos |
| CA2672951A1 (en) | 2006-12-20 | 2008-07-03 | Bayer Healthcare Llc | Hydroxy methyl phenyl pyrazolyl urea compound useful in the treatment of cancer |
| US8940298B2 (en) | 2007-09-04 | 2015-01-27 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection |
| US20110092452A1 (en) * | 2008-03-05 | 2011-04-21 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
| EP3495000A1 (en) | 2009-02-17 | 2019-06-12 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| JP2013511969A (ja) | 2009-11-25 | 2013-04-11 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 確定的内胚葉細胞の肝分化のための方法 |
| MX337600B (es) | 2009-12-02 | 2016-03-11 | Imaginab Inc | Minicuerpos j591 y diacuerpos-cys para apuntar con especificidad de objetivo a un antigeno de membrana especifico para prostata de humano (psma) y metodos para su uso. |
| JP2013532627A (ja) | 2010-07-01 | 2013-08-19 | 武田薬品工業株式会社 | cMET阻害剤とHGFおよび/またはcMETに対する抗体との組み合わせ |
| HRP20191305T1 (hr) | 2010-07-09 | 2019-10-18 | Bioverativ Therapeutics Inc. | Preradive jednolančane molekule i polipeptidi izrađeni koristeći iste |
| BR122014027420A2 (pt) | 2010-11-03 | 2019-08-20 | Argenx Bvba | Anticorpos anti c-met |
| US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
| WO2013064700A2 (en) | 2011-11-03 | 2013-05-10 | Argen-X B.V. | Chimeric polypeptides and methods of use |
| HUE039033T2 (hu) | 2012-01-10 | 2018-12-28 | Biogen Ma Inc | Terápiás molekulák transzportjának fokozása a vér-agy gáton keresztül |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| TWI828269B (zh) | 2013-03-15 | 2024-01-01 | 美商百歐維拉提夫治療公司 | 因子ix多肽調配物 |
| JP6426103B2 (ja) * | 2013-10-15 | 2018-11-21 | 国立大学法人 東京大学 | c−Metタンパク質アゴニスト |
| MX2016012285A (es) | 2014-03-24 | 2017-01-23 | Genentech Inc | Tratamiento de cáncer con antagonista de c-met y correlación de estos con la expresión de hgf. |
| ES2748295T3 (es) | 2014-09-16 | 2020-03-16 | Symphogen As | Anticuerpos anti-MET y composiciones |
| EP3254104B1 (en) | 2015-02-04 | 2021-08-25 | Bristol-Myers Squibb Company | Methods of selecting therapeutic molecules |
| SG11201706293XA (en) | 2015-02-04 | 2017-09-28 | Hoffmann La Roche | Tau antisense oligomers and uses thereof |
| KR20250008141A (ko) | 2015-08-07 | 2025-01-14 | 이미지냅 인코포레이티드 | 분자를 표적화하기 위한 항원 결합 구조체 |
| EP3474859B1 (en) | 2016-06-22 | 2025-12-24 | Harless, William Warren | Cancer treatment using an anti-cancer stem cell agent in combination with a neul sialidase inhibitor after primary cancer treatment |
| GB201611123D0 (en) * | 2016-06-27 | 2016-08-10 | Euremab Srl | Anti met antibodiesand uses thereof |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法 |
| WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
| IT201800000535A1 (it) | 2018-01-03 | 2019-07-03 | Procedimenti per la cura del cancro. | |
| MX2021010114A (es) | 2019-02-21 | 2021-12-10 | Regeneron Pharma | Métodos para tratar el cáncer ocular mediante el uso de anticuerpos anti-met y moléculas de unión a antígeno bispecíficas que se unen a met. |
| CN114206107A (zh) * | 2019-07-26 | 2022-03-18 | 安必思医药公司 | 用于产生肝细胞的方法和组合物 |
| JP7750828B2 (ja) | 2019-09-16 | 2025-10-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 免疫pet撮像のための放射標識されたmet結合タンパク質 |
| TW202509086A (zh) * | 2021-03-22 | 2025-03-01 | 日商肽夢想股份有限公司 | c-Met蛋白質結合肽複合物 |
| KR20250058748A (ko) | 2022-09-01 | 2025-04-30 | 리제너론 파마슈티칼스 인코포레이티드 | 중간엽 상피 전이 인자 (met)-표적 제제를 이용한 비-소 세포성 폐암 치료 방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5362716A (en) * | 1989-12-27 | 1994-11-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines |
| US5648273A (en) * | 1989-12-27 | 1997-07-15 | The United States Of America, As Represented By The Department Of Health And Human Services | Hepatic growth factor receptor is the MET proto-oncogene |
| JP2750372B2 (ja) * | 1990-06-19 | 1998-05-13 | 敏一 中村 | 賢疾患治療剤 |
| US6566098B1 (en) * | 1990-09-14 | 2003-05-20 | The United States Of America As Represented By The Department Of Health And Human Services | DNA encoding truncated hepatocyte growth factor variants |
| ATE155525T1 (de) * | 1991-05-10 | 1997-08-15 | Pharmacia & Upjohn Spa | Verkürzte formen den hepatozyten wachstumsfaktor (hgf) rezeptors |
| US5227158A (en) * | 1991-06-10 | 1993-07-13 | Genentech, Inc. | Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon |
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| WO1993016185A2 (en) * | 1992-02-06 | 1993-08-19 | Creative Biomolecules, Inc. | Biosynthetic binding protein for cancer marker |
| US5328837A (en) * | 1992-05-18 | 1994-07-12 | Genentech, Inc. | Hepatocyte growth factor protease domain variants |
| US5316921A (en) * | 1992-05-18 | 1994-05-31 | Genentech, Inc. | Single-chain hepatocyte growth factor variants |
| WO1993024640A2 (en) * | 1992-06-04 | 1993-12-09 | The Regents Of The University Of California | Methods and compositions for in vivo gene therapy |
| DE69310525T2 (de) * | 1992-09-16 | 1997-10-02 | Genentech Inc | Schutz gegen leberschäden mit hgf |
| WO1994009969A1 (de) | 1992-10-28 | 1994-05-11 | Max Born Inst Fuer Nichtlinear | Metall/kunststoff-verbundkörper, verfahren zu dessen herstellung und vorrichtung zur ausführung des verfahrens |
| DE69420137T2 (de) | 1993-06-03 | 1999-12-23 | Therapeutic Antibodies, Inc. | Herstellung von antikörperfragmenten |
| US5464815A (en) * | 1993-09-08 | 1995-11-07 | Genentech, Inc. | Inhibition of heparin-binding |
| US5686292A (en) * | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| US8200624B2 (en) | 2010-07-20 | 2012-06-12 | Sybase, Inc. | Membership tracking and data eviction in mobile middleware scenarios |
-
1997
- 1997-06-20 JP JP10504193A patent/JP2000515735A/ja not_active Ceased
- 1997-06-20 IL IL12755897A patent/IL127558A0/xx unknown
- 1997-06-20 DK DK97931275.8T patent/DK0922102T3/da active
- 1997-06-20 WO PCT/US1997/010688 patent/WO1998000543A1/en not_active Ceased
- 1997-06-20 DE DE69739856T patent/DE69739856D1/de not_active Expired - Lifetime
- 1997-06-20 CA CA002258153A patent/CA2258153C/en not_active Expired - Lifetime
- 1997-06-20 AT AT97931275T patent/ATE465257T1/de not_active IP Right Cessation
- 1997-06-20 EP EP97931275A patent/EP0922102B1/en not_active Expired - Lifetime
- 1997-06-20 AU AU34949/97A patent/AU729029B2/en not_active Expired
- 1997-06-27 US US08/884,669 patent/US6099841A/en not_active Expired - Lifetime
- 1997-07-01 ZA ZA975851A patent/ZA975851B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA975851B (en) | 1999-01-04 |
| AU729029B2 (en) | 2001-01-25 |
| DE69739856D1 (de) | 2010-06-02 |
| IL127558A0 (en) | 1999-10-28 |
| WO1998000543A1 (en) | 1998-01-08 |
| EP0922102B1 (en) | 2010-04-21 |
| EP0922102A1 (en) | 1999-06-16 |
| CA2258153A1 (en) | 1998-01-08 |
| CA2258153C (en) | 2004-08-17 |
| ATE465257T1 (de) | 2010-05-15 |
| US6099841A (en) | 2000-08-08 |
| JP2000515735A (ja) | 2000-11-28 |
| AU3494997A (en) | 1998-01-21 |
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