ATE465408T1 - Verfahren zur diagnose und überwachung von neurologischen erkrankungen durch nachweis eines encephalotoxins - Google Patents

Verfahren zur diagnose und überwachung von neurologischen erkrankungen durch nachweis eines encephalotoxins

Info

Publication number
ATE465408T1
ATE465408T1 AT04705647T AT04705647T ATE465408T1 AT E465408 T1 ATE465408 T1 AT E465408T1 AT 04705647 T AT04705647 T AT 04705647T AT 04705647 T AT04705647 T AT 04705647T AT E465408 T1 ATE465408 T1 AT E465408T1
Authority
AT
Austria
Prior art keywords
encephalotoxin
diagnosing
detecting
neurological diseases
disclosed
Prior art date
Application number
AT04705647T
Other languages
English (en)
Inventor
Dana Giulian
Original Assignee
Jacobus Pharmaceutical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jacobus Pharmaceutical Company filed Critical Jacobus Pharmaceutical Company
Application granted granted Critical
Publication of ATE465408T1 publication Critical patent/ATE465408T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058Neurological cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/15Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
AT04705647T 2003-01-27 2004-01-27 Verfahren zur diagnose und überwachung von neurologischen erkrankungen durch nachweis eines encephalotoxins ATE465408T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44321903P 2003-01-27 2003-01-27
PCT/US2004/002236 WO2004066943A2 (en) 2003-01-27 2004-01-27 Methods for diagnosis anf monitoring of neurological disease by detection of an encephalotoxin

Publications (1)

Publication Number Publication Date
ATE465408T1 true ATE465408T1 (de) 2010-05-15

Family

ID=32825308

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04705647T ATE465408T1 (de) 2003-01-27 2004-01-27 Verfahren zur diagnose und überwachung von neurologischen erkrankungen durch nachweis eines encephalotoxins

Country Status (12)

Country Link
US (2) US20060035929A1 (de)
EP (2) EP1592388B1 (de)
JP (2) JP4571619B2 (de)
KR (2) KR20050119104A (de)
CN (2) CN100502847C (de)
AT (1) ATE465408T1 (de)
AU (3) AU2004207551B2 (de)
CA (2) CA2514396A1 (de)
DE (1) DE602004026683D1 (de)
IL (1) IL169889A (de)
WO (2) WO2004066943A2 (de)
ZA (2) ZA200506033B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344853B2 (en) 2003-01-27 2008-03-18 Baylor College Of Medicine Methods for diagnosis and monitoring of neurological disease by detection of an encephalotoxin
US20050059656A1 (en) * 2003-04-07 2005-03-17 Cornell Research Foundation, Inc. Compositions and methods for protecting against mitochondria component-mediated pathology
WO2007056580A2 (en) * 2005-11-08 2007-05-18 Pharmadyn, Inc. Methods and compositions for treating diseases associated with pathogenic proteins
EP1976495A2 (de) * 2006-01-06 2008-10-08 Aarhus Universitet Auf den serotonin-transporter wirkende verbindungen
CN101466380A (zh) 2006-02-16 2009-06-24 麦克莱恩医院 治疗帕金森病的方法和组合物
JP5665089B2 (ja) * 2009-05-14 2015-02-04 国立大学法人岐阜大学 プリオンタンパク質構造変換抑制剤及びその利用
GB2568291A (en) * 2017-11-13 2019-05-15 Crisby Milita New use
CN108143734A (zh) * 2018-02-09 2018-06-12 南京中医药大学 阿莫地喹及其药学上可接受的盐在制备用于治疗阿尔茨海默病的药物中的应用
EP3764102A4 (de) * 2018-03-09 2021-12-15 National University Corporation Tokyo Medical and Dental University Nachweis von alzheimerkrankheit, frontotemporaler lobarer degeneration, amyotropher lateraler sklerose, parkinson-krankheit und demenz mit lewy-körpern, angezeigt durch marcks-phosphorylierung
WO2021257273A1 (en) * 2020-06-15 2021-12-23 Merck Patent Gmbh Tlr7/8 antagonists and uses thereof
WO2023059867A1 (en) * 2021-10-08 2023-04-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds for treating or preventing alzheimer's disease

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2546658A (en) * 1949-07-23 1951-03-27 Sterling Drug Inc 7-chloro-4-[5-(n-ethyl-n-2-hydroxyethylamino)-2-pentyl] aminoquinoline, its acid addition salts, and method of preparation
BE759163A (fr) * 1969-11-20 1971-05-19 Merck & Co Inc (p-sulfonilyl)phenyluree appliquee au traitement de la maladie de mare
US3775403A (en) * 1970-09-17 1973-11-27 Merck & Co Inc Diphenyl sulfones
US3702362A (en) * 1970-09-17 1972-11-07 Merck & Co Inc Use of ureido diphenyl sulfones in the treatment of marek's disease
US3715375A (en) * 1970-09-17 1973-02-06 Merck & Co Inc New diphenyl sulfones
US3786050A (en) * 1971-07-06 1974-01-15 Merck & Co Inc Diphenyl sulfones
US3775444A (en) * 1971-07-13 1973-11-27 Merck & Co Inc 4-amino,3-or 3'-fluoro-4'-ureido diphenyl sulfones
US4338334A (en) * 1977-12-29 1982-07-06 Merck & Co., Inc. 1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases
US4963565A (en) * 1986-07-30 1990-10-16 National Jewish Center For Immunology And Respiratory Medicine In vivo treatment of mycobacterial infections with 6-cyclo octylamino-5,8-quinoline quinone
US5532219A (en) * 1991-04-23 1996-07-02 The University Of British Columbia Dapsone and promin for the treatment of dementia
US6071493A (en) * 1996-09-20 2000-06-06 Baylor College Of Medicine Method of screening for an agent that inhibits mononuclear phagocyte-plaque component complex formation
US6043283A (en) * 1996-09-20 2000-03-28 Baylor College Of Medicine Tyramine compounds and their neuronal effects
US20020198231A1 (en) * 1999-07-13 2002-12-26 Jodi Nelson Compositions and methods for the treatment of Parkinson's disease
WO2001003649A2 (en) * 1999-07-13 2001-01-18 Alpha Research Group, Llc Compositions and methods for the treatment of parkinson's disease
US20030092635A1 (en) * 1999-12-08 2003-05-15 Aberg A K Gunnar Galenical preparations of dapsone and related sulphones, and method of therapeutic and preventative treatment of disease

Also Published As

Publication number Publication date
AU2004207551B2 (en) 2008-12-11
DE602004026683D1 (de) 2010-06-02
EP1592388A4 (de) 2008-08-06
AU2009200927A1 (en) 2009-04-02
WO2004066943A2 (en) 2004-08-12
KR20050119104A (ko) 2005-12-20
AU2004207551A1 (en) 2004-08-12
CA2514396A1 (en) 2004-08-12
KR20060002752A (ko) 2006-01-09
JP2006516629A (ja) 2006-07-06
EP1592388B1 (de) 2010-04-21
CA2514327A1 (en) 2004-08-12
JP2007524353A (ja) 2007-08-30
CN100502847C (zh) 2009-06-24
AU2004207561B2 (en) 2009-07-30
ZA200506033B (en) 2007-01-31
ZA200506000B (en) 2007-11-28
WO2004066940A3 (en) 2005-01-20
CN101238370A (zh) 2008-08-06
CA2514327C (en) 2013-04-02
JP4571619B2 (ja) 2010-10-27
WO2004066940A2 (en) 2004-08-12
IL169889A0 (en) 2007-07-04
IL169889A (en) 2011-04-28
WO2004066943A3 (en) 2008-03-27
AU2004207561A1 (en) 2004-08-12
EP1594485A4 (de) 2009-01-14
US20070129439A1 (en) 2007-06-07
CN1819822A (zh) 2006-08-16
EP1592388A2 (de) 2005-11-09
EP1594485A2 (de) 2005-11-16
US20060035929A1 (en) 2006-02-16

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