ATE465633T1 - Verfahren zur preservierung von zellen, gewebe und organen - Google Patents

Verfahren zur preservierung von zellen, gewebe und organen

Info

Publication number: ATE465633T1
Authority: AT; Austria
Prior art keywords: organs; tissues; polyglycerol; lactose; cells
Prior art date: 2002-02-01

Application number

AT03737581T

Other languages

English (en)

Inventor

Greg Fahy

Jun Wu

Original Assignee

21St Century Medicine Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-01

Filing date

2003-01-31

Publication date

2010-05-15

2003-01-31 Application filed by 21St Century Medicine Inc filed Critical 21St Century Medicine Inc

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE465633T1 publication Critical patent/ATE465633T1/de

Links

210000000056 organ Anatomy 0.000 title abstract 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 4
239000008101 lactose Substances 0.000 abstract 4
229920000223 polyglycerol Polymers 0.000 abstract 4
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 2
230000002631 hypothermal effect Effects 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 abstract 1
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
229930024421 Adenine Natural products 0.000 abstract 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
229920001287 Chondroitin sulfate Polymers 0.000 abstract 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
108010024636 Glutathione Proteins 0.000 abstract 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
229960000643 adenine Drugs 0.000 abstract 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
229960005069 calcium Drugs 0.000 abstract 1
ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 abstract 1
229960001076 chlorpromazine Drugs 0.000 abstract 1
229940059329 chondroitin sulfate Drugs 0.000 abstract 1
229940001468 citrate Drugs 0.000 abstract 1
230000006735 deficit Effects 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
229960001031 glucose Drugs 0.000 abstract 1
229960003180 glutathione Drugs 0.000 abstract 1
230000000302 ischemic effect Effects 0.000 abstract 1
229910052749 magnesium Inorganic materials 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1
229940091250 magnesium supplement Drugs 0.000 abstract 1
230000002503 metabolic effect Effects 0.000 abstract 1
239000006174 pH buffer Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K3/00—Materials not provided for elsewhere
- C09K3/18—Materials not provided for elsewhere for application to surfaces to minimize adherence of ice, mist or water thereto; Thawing or antifreeze materials for application to surfaces
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K5/00—Heat-transfer, heat-exchange or heat-storage materials, e.g. refrigerants; Materials for the production of heat or cold by chemical reactions other than by combustion
- C09K5/20—Antifreeze additives therefor, e.g. for radiator liquids

Landscapes

Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Materials Engineering (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Dentistry (AREA)
Combustion & Propulsion (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
Thermal Sciences (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT03737581T 2002-02-01 2003-01-31 Verfahren zur preservierung von zellen, gewebe und organen ATE465633T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10/066,285 US6949335B2 (en)	1999-11-30	2002-02-01	Polyglycerol and lactose compositions for the protection of living systems from states of reduced metabolism
PCT/US2003/002939 WO2003065801A2 (en)	2002-02-01	2003-01-31	Polyglycerol and lactose compositions for the protection of living systems from states of reduced metabolism

Publications (1)

Publication Number	Publication Date
ATE465633T1 true ATE465633T1 (de)	2010-05-15

Family

ID=27732208

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03737581T ATE465633T1 (de)	2002-02-01	2003-01-31	Verfahren zur preservierung von zellen, gewebe und organen

Country Status (6)

Country	Link
US (2)	US6949335B2 (de)
EP (1)	EP1476014B1 (de)
AT (1)	ATE465633T1 (de)
AU (1)	AU2003210768A1 (de)
DE (1)	DE60332318D1 (de)
WO (1)	WO2003065801A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7592002B2 (en) *	2005-10-31	2009-09-22	Bioderm Research	Sugar esters for depilation (hair removal), demabrasion, and wrinkles reduction
WO2005027633A2 (en)	2003-09-16	2005-03-31	21St Century Medicine, Inc.	Methods and compositions for the cryopreservation of organs
EP1868430B1 (de) *	2005-04-12	2015-07-08	Cleo Cosmetic and Pharmaceutical Co., LLC	Zusammensetzung und verfahren zur in-vitro-konservierung von hornhautgewebe
WO2006130978A1 (en)	2005-06-06	2006-12-14	The University Of British Columbia	Polymer-based serum albumin substitute
EP1937059A2 (de) *	2005-07-27	2008-07-02	University Of North Carolina At Charlotte	Zusammensetzung und verfahren für die instandsetzung und konservierung von transplantationsorganen von dcd-spendern
US7993821B2 (en) *	2005-08-11	2011-08-09	University Of Washington	Methods and apparatus for the isolation and enrichment of circulating tumor cells
EP2211872A4 (de) *	2007-11-02	2012-01-04	Univ British Columbia	Hyperverzweigtes polyglycerol zur verbesserung der herzfunktion
JP2009247276A (ja) *	2008-04-04	2009-10-29	Erii Kk	生体供給用、生体移植用、生体添加用、生体投与用の解凍器官若しくは組織または解凍細胞群とその製造方法及びそれらに用いる過冷却液並びに製造装置
BR112012021991A2 (pt)	2010-03-01	2020-09-01	The University Of British Columbia	policlicerol hiperramificado uso de um poliglicerol hipermanificado, método de adiministração de uma força biologicamente ativa a um tecido biológico, composição farmacêutica e método de síntese de um poliglicerol hiperrramificado.
JP6240665B2 (ja) *	2012-04-24	2017-11-29	ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア	ポリマー系透析物
CA2936650C (en) *	2013-11-21	2022-06-21	The University Of British Columbia	Polymer based transplant preservation solution
CN107668024A (zh) *	2016-08-01	2018-02-09	北京世纪劲得生物技术有限公司	一种骨髓干细胞保护液及其制备方法
US12453805B2 (en)	2020-09-24	2025-10-28	Everest Medical Innovation GmbH	Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery
US12426594B2 (en)	2020-09-24	2025-09-30	Everest Medical Innovation GmbH	Cryoprotective compositions and methods for protection of a surgical site during cryosurgery

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US726857A (en)	1902-02-28	1903-05-05	George A Bulles	Horse-blanket.
AU252524B1 (en) *	1959-11-09	1962-11-08	Union Carbide Corp	Preservation of biological substances
US5145769A (en) *	1987-08-21	1992-09-08	Cryolife Inc.	Method for cryopreserving blood vessels
US5158867A (en) *	1987-08-21	1992-10-27	Cryolife Inc.	Method for cryopreserving blood vessels
US5306711A (en) *	1992-06-24	1994-04-26	Georgetown University	Organ preservative solution
AU725247B2 (en) *	1996-06-14	2000-10-12	Biostore New Zealand Limited	Compositions and methods for the preservation of living tissues
US5782505A (en) *	1996-08-29	1998-07-21	Becton, Dickinson And Company	Catheter adapter assembly
US6194137B1 (en) *	1999-04-13	2001-02-27	Organ Recovery Systems, Inc.	Method of cryopreservation of blood vessels by vitrification
AU4308601A (en) *	1999-11-30	2001-06-18	21St Century Medicine, Inc.	Prevention of ice nucleation by polyglycerol
US6869757B2 (en) *	2000-07-31	2005-03-22	21St Century Medicine, Inc.	Advantageous carrier solution for vitrifiable concentrations of cryoprotectants, and compatible cryoprotectant mixtures
US7250292B2 (en) *	2000-01-26	2007-07-31	21St Century Medicine	Hypertonic reduction of chilling injury
JP4544388B2 (ja) *	2001-02-28	2010-09-15	株式会社富士通ゼネラル	スクロール圧縮機

2002
- 2002-02-01 US US10/066,285 patent/US6949335B2/en not_active Expired - Lifetime
2003
- 2003-01-31 DE DE60332318T patent/DE60332318D1/de not_active Expired - Lifetime
- 2003-01-31 AT AT03737581T patent/ATE465633T1/de not_active IP Right Cessation
- 2003-01-31 EP EP03737581A patent/EP1476014B1/de not_active Expired - Lifetime
- 2003-01-31 WO PCT/US2003/002939 patent/WO2003065801A2/en not_active Ceased
- 2003-01-31 AU AU2003210768A patent/AU2003210768A1/en not_active Abandoned
2005
- 2005-09-23 US US11/234,461 patent/US7550255B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2003065801A2 (en)	2003-08-14
US6949335B2 (en)	2005-09-27
US7550255B2 (en)	2009-06-23
EP1476014B1 (de)	2010-04-28
DE60332318D1 (de)	2010-06-10
AU2003210768A1 (en)	2003-09-02
EP1476014A4 (de)	2006-09-06
US20030027924A1 (en)	2003-02-06
US20060024657A1 (en)	2006-02-02
WO2003065801A3 (en)	2004-02-26
EP1476014A2 (de)	2004-11-17
AU2003210768A8 (en)	2003-09-02

Legal Events

Date	Code	Title	Description
2010-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60332318D1 (de)	2010-06-10	Verfahren zur Preservierung von Zellen, Gewebe und Organen
DE69901877D1 (de)	2002-07-25	Perfusions- und/oder konservierungs- und/oder reperfusionslösung zur organtransplantation
EP2465921A3 (de)	2013-06-05	Herzstammzellen aus der Biopsie
BR0107917A (pt)	2003-02-11	Fonte para tecido de fìgado
AU2003225793A8 (en)	2003-09-29	Methods and compositions for directing cells to target organs
AU2003273276A8 (en)	2004-06-15	Methods and compositions for the preservation of cells, tissues or organs in the vitreous state
BR0210599A (pt)	2004-07-20	Uso de monóxido de carbono, método para manutenção de uma célula animal in vitro, artigo de manufatura, bem como meio celular estéril
WO2006026730A3 (en)	2006-09-08	Cultured three dimensional tissues and uses thereof
EP1425390A4 (de)	2009-03-04	Material und verfahren zur förderung der reparatur von nervengewebe
BRPI0410185A (pt)	2006-05-16	composição para manter a viabilidade de um orgão e célula
WO2004028243A3 (en)	2004-08-05	Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
TR201900937T4 (tr)	2019-02-21	Organların ve dokuların muhafaza edilmesine yönelik yöntem.
WO2006099174A3 (en)	2007-05-31	Organ transplant solutions and method for transplanting organs
DE60036029D1 (de)	2007-09-27	Basismaterialien zur geweberegeneration, transplantatmaterialien und verfahren zur herstellung selbiger
EP1458870A4 (de)	2006-02-15	ZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERWENDUNG VON siRNA, AMPHIPATISCHE VERBINDUNGEN UND POLYKATIONEN
WO2002017921A3 (en)	2002-10-03	Paroxetine compositions and processes for making the same
BR0301159A (pt)	2004-08-17	Solução protetora para prevenção de danos isquêmicos
WO2004027029A3 (en)	2004-08-19	Growth of foreign cells in fetal animals facilitated by conditional and selective destruction of native host cells
DE60001555D1 (de)	2003-04-10	Wässrige lösung zum konservieren von gewebe und organen
ATE327783T1 (de)	2006-06-15	Injizierbare mikrokügelchen für den gewebeaufbau
BR0107544A (pt)	2005-01-11	Composição de promoção de secreção de bile
EA200701017A1 (ru)	2007-10-26	Применение рибозы-цистеина для лечения гипоксии
ATE516040T1 (de)	2011-07-15	Zusammensetzung und verwendung zur vorbeugung oder behandlung von stomatitis
BR0307667A (pt)	2006-04-11	composições e métodos para aumentar a produção de leite em animais
EP1782794A3 (de)	2009-04-08	Wasserfreie Zusammensetzung, ein Säure-Säure-Puffersystem enthaltend