ATE465733T1 - Substituierte indeno-ä1,2-cü-isochinolin-derivate und verwendungszwecke dafür - Google Patents

Substituierte indeno-ä1,2-cü-isochinolin-derivate und verwendungszwecke dafür

Info

Publication number: ATE465733T1
Authority: AT; Austria
Prior art keywords: isocinoline; derivatives; substituted indeno; indeno; substituted
Prior art date: 2001-08-31

Application number

AT02766175T

Other languages

English (en)

Inventor

Prakash Jagtap

Erkan Baloglu

Duzer John Van

Csaba Szabo

Andrew Salzman

Original Assignee

Inotek Pharmaceuticals Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-31

Filing date

2002-08-30

Publication date

2010-05-15

2002-08-30 Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE465733T1 publication Critical patent/ATE465733T1/de

Links

CVBPOLXDFLTAGK-UHFFFAOYSA-N 11h-indeno[1,2-c]isoquinoline Chemical class C1=CC=CC2=C3CC4=CC=CC=C4C3=NC=C21 CVBPOLXDFLTAGK-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Health & Medical Sciences (AREA)
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Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Psychology (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pulmonology (AREA)

AT02766175T 2001-08-31 2002-08-30 Substituierte indeno-ä1,2-cü-isochinolin-derivate und verwendungszwecke dafür ATE465733T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/944,524 US20030096833A1 (en)	2001-08-31	2001-08-31	Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
PCT/US2002/027585 WO2003020700A2 (en)	2001-08-31	2002-08-30	SUBSTITUTED INDENO[1,2-c]ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF

Publications (1)

Publication Number	Publication Date
ATE465733T1 true ATE465733T1 (de)	2010-05-15

Family

ID=25481570

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02766175T ATE465733T1 (de)	2001-08-31	2002-08-30	Substituierte indeno-ä1,2-cü-isochinolin-derivate und verwendungszwecke dafür

Country Status (20)

Country	Link
US (3)	US20030096833A1 (de)
EP (2)	EP1420785B1 (de)
JP (1)	JP2005502681A (de)
KR (1)	KR100922825B1 (de)
CN (2)	CN1880306A (de)
AT (1)	ATE465733T1 (de)
AU (1)	AU2002329920B2 (de)
BR (1)	BR0212225A (de)
CA (1)	CA2457534A1 (de)
CO (1)	CO5560543A2 (de)
DE (1)	DE60236170D1 (de)
EC (1)	ECSP044997A (de)
ES (1)	ES2345436T3 (de)
IL (1)	IL160437A0 (de)
MX (1)	MXPA04001887A (de)
NO (1)	NO20040845L (de)
NZ (1)	NZ531218A (de)
RU (1)	RU2300523C2 (de)
WO (1)	WO2003020700A2 (de)
ZA (1)	ZA200401376B (de)

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US10531655B2 (en)	2011-12-02	2020-01-14	The Regents Of The University Of California	Reperfusion protection solution and uses thereof
US8912213B2 (en)	2012-04-13	2014-12-16	Purdue Research Foundation	Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors
US9034870B2 (en)	2012-07-13	2015-05-19	Purdue Research Foundation	Azaindenoisoquinoline topoisomerase I inhibitors
US8686146B2 (en)	2012-07-13	2014-04-01	Purdue Research Foundation	Azaindenoisoquinoline topoisomerase I inhibitors
CN105175333A (zh) *	2014-06-10	2015-12-23	中国人民解放军第二军医大学	5H-茚并[1,2-c]喹啉-6,11-二酮类化合物及其制备方法和用途
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2001
- 2001-08-31 US US09/944,524 patent/US20030096833A1/en not_active Abandoned
2002
- 2002-08-30 CA CA002457534A patent/CA2457534A1/en not_active Abandoned
- 2002-08-30 NZ NZ531218A patent/NZ531218A/en not_active IP Right Cessation
- 2002-08-30 MX MXPA04001887A patent/MXPA04001887A/es active IP Right Grant
- 2002-08-30 CN CNA2006100924325A patent/CN1880306A/zh active Pending
- 2002-08-30 JP JP2003524971A patent/JP2005502681A/ja active Pending
- 2002-08-30 IL IL16043702A patent/IL160437A0/xx unknown
- 2002-08-30 KR KR1020047002771A patent/KR100922825B1/ko not_active Expired - Fee Related
- 2002-08-30 RU RU2004109141/04A patent/RU2300523C2/ru not_active IP Right Cessation
- 2002-08-30 EP EP02766175A patent/EP1420785B1/de not_active Expired - Lifetime
- 2002-08-30 AU AU2002329920A patent/AU2002329920B2/en not_active Ceased
- 2002-08-30 DE DE60236170T patent/DE60236170D1/de not_active Expired - Lifetime
- 2002-08-30 BR BR0212225-1A patent/BR0212225A/pt not_active IP Right Cessation
- 2002-08-30 ES ES02766175T patent/ES2345436T3/es not_active Expired - Lifetime
- 2002-08-30 WO PCT/US2002/027585 patent/WO2003020700A2/en not_active Ceased
- 2002-08-30 AT AT02766175T patent/ATE465733T1/de not_active IP Right Cessation
- 2002-08-30 CN CNB028213254A patent/CN100503574C/zh not_active Expired - Fee Related
- 2002-08-30 US US10/233,198 patent/US6828319B2/en not_active Expired - Fee Related
- 2002-08-30 EP EP10152431A patent/EP2174659A1/de not_active Withdrawn
2004
- 2004-02-19 ZA ZA200401376A patent/ZA200401376B/en unknown
- 2004-02-25 CO CO04016685A patent/CO5560543A2/es not_active Application Discontinuation
- 2004-02-26 NO NO20040845A patent/NO20040845L/no unknown
- 2004-02-27 EC EC2004004997A patent/ECSP044997A/es unknown
2008
- 2008-06-16 US US12/140,120 patent/US20080262016A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO20040845L (no)	2004-04-01
EP1420785B1 (de)	2010-04-28
RU2004109141A (ru)	2005-03-27
WO2003020700A2 (en)	2003-03-13
RU2300523C2 (ru)	2007-06-10
US20080262016A1 (en)	2008-10-23
MXPA04001887A (es)	2005-03-07
ZA200401376B (en)	2004-11-19
CN1880306A (zh)	2006-12-20
EP1420785A2 (de)	2004-05-26
WO2003020700A3 (en)	2004-02-12
US20030171392A1 (en)	2003-09-11
KR20040044486A (ko)	2004-05-28
JP2005502681A (ja)	2005-01-27
ES2345436T3 (es)	2010-09-23
US20030096833A1 (en)	2003-05-22
CO5560543A2 (es)	2005-09-30
KR100922825B1 (ko)	2009-10-21
AU2002329920B2 (en)	2008-07-31
CA2457534A1 (en)	2003-03-13
CN100503574C (zh)	2009-06-24
NZ531218A (en)	2006-02-24
EP2174659A1 (de)	2010-04-14
ECSP044997A (es)	2004-04-28
CN1575172A (zh)	2005-02-02
IL160437A0 (en)	2004-07-25
EP1420785A4 (de)	2005-10-19
BR0212225A (pt)	2005-01-18
DE60236170D1 (de)	2010-06-10
US6828319B2 (en)	2004-12-07

Legal Events

Date	Code	Title	Description
2010-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60236170D1 (de)	2010-06-10	Substituierte indeno-ä1,2-cü-isochinolin-derivate und verwendungszwecke dafür
FR20C1039I2 (fr)	2021-08-13	Derives de l'uk-2a
IL160051A0 (en)	2004-06-20	Ecteinascidin derivatives and pharmaceutical compositions containing the same
CO4910133A1 (es)	2000-04-24	Antagonistas de 5-h[1f]
FI943749A0 (fi)	1994-08-15	Taksaanijohdannaisten fosfono-oksimetyylieetterit
NO20042739L (no)	2004-07-23	Farmasoytiske sammensetninger av 5,6,14-triazatetracyklo(10.3.1.0(2,11).0(4,9))-heksadeca-2(11)3,5,7,9-pentan
PT1224205E (pt)	2006-08-31	Derivados 5-beta-sapogenina e pseudo-sapogenina e sua utilizacao no tratamento de demencia
DE60235083D1 (de)	2010-03-04	Substituierte tetracyclin-verbindungen zur behandlung von malaria
NZ234327A (en)	1992-12-23	Quinazoline derivatives and pharmaceutical compositions
WO2003057145A3 (en)	2003-12-04	SUBSTITUTED 4,9-DIHYDROCYCLOPENTA[imn]PHENANTHRIDINE-5-ONES DERIVATIVES THEREOF AND THEIR USES
BRPI0409376A (pt)	2006-04-25	derivados de indeno como agentes farmacêuticos
HUP0401588A3 (en)	2005-06-28	Indeno[1,2-c]pyrazol-4-one derivatives useful as anti-cancer and anti-proliferative agents and pharmaceutical compositions containing them
CY1106376T1 (el)	2011-10-12	Δικυκλικα παραγωγα των αμινο-πυραζινονων, μεθοδος παρασκευης τους και οι φαρμακευτικες συνθεσεις που τα πepιεχουν
NO20002408D0 (no)	2000-05-09	5-HT1F antagonister
AR028607A1 (es)	2003-05-14	Derivados de 1,4-diazepan-2,5-diona
DK1373232T3 (da)	2006-03-27	Fremgangsmåde til fremstilling af N-substituerede 2,6-dialkylmorpholiner
PT937708E (pt)	2003-04-30	Derivados de sulfonamidas
DE60236623D1 (de)	2010-07-15	Amorphe substanz eines tricyclischen triazolobenzazepinderivats
DE60100045D1 (de)	2002-12-19	1,2-Substituierte 2,3-dihydro-1H-5,9-dioxacyclohepta(f)inden-7-one und 7-substituierte Benzo(b)[1,4]dioxepin-3-one
BR0210749A (pt)	2004-07-20	Composições de fragrância e sabor
FR2807033B1 (fr)	2004-05-14	Compositions de mono- et poly- benzyl-1,2,3,4- tetrahydronaphtalenes
BR0212114A (pt)	2004-07-20	Métodos e composições de fluridona suportada
ITRM20010083A0 (it)	2001-02-20	Procedimento per l'acilazione di 4-amminopiperidina e derivati di 4-amminopiperidina.
HK1052704A (en)	2003-09-26	Novel form of (r)- i n /i- 5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide
UA5201S (uk)	2001-09-17	Набір предметів для дитячого майданчика