ATE466571T1 - Verbindungen zur hemmung der iapp-assoziierten amyloid-ablagerung - Google Patents

Verbindungen zur hemmung der iapp-assoziierten amyloid-ablagerung

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Publication number
ATE466571T1
ATE466571T1 AT00930923T AT00930923T ATE466571T1 AT E466571 T1 ATE466571 T1 AT E466571T1 AT 00930923 T AT00930923 T AT 00930923T AT 00930923 T AT00930923 T AT 00930923T AT E466571 T1 ATE466571 T1 AT E466571T1
Authority
AT
Austria
Prior art keywords
iapp
amyloid deposition
methods
inhibiting
compositions
Prior art date
Application number
AT00930923T
Other languages
English (en)
Inventor
Walter A Szarek
Donald Weaver
Xianqi Kong
Ajay Gupta
David Migneault
Original Assignee
Bellus Health Int Ltd
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Publication date
Application filed by Bellus Health Int Ltd filed Critical Bellus Health Int Ltd
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Publication of ATE466571T1 publication Critical patent/ATE466571T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/415—1,2-Diazoles
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AT00930923T 1999-05-24 2000-05-24 Verbindungen zur hemmung der iapp-assoziierten amyloid-ablagerung ATE466571T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13554599P 1999-05-24 1999-05-24
US14312399P 1999-07-09 1999-07-09
US09/576,677 US6562836B1 (en) 1999-05-24 2000-05-23 Methods and compounds for inhibiting amyloid deposits
PCT/CA2000/000607 WO2000071101A2 (en) 1999-05-24 2000-05-24 Methods and compounds for inhibiting amyloid deposits

Publications (1)

Publication Number Publication Date
ATE466571T1 true ATE466571T1 (de) 2010-05-15

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AT00930923T ATE466571T1 (de) 1999-05-24 2000-05-24 Verbindungen zur hemmung der iapp-assoziierten amyloid-ablagerung

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US (3) US6562836B1 (de)
EP (1) EP1227803B1 (de)
JP (1) JP2003500350A (de)
CN (1) CN100435785C (de)
AT (1) ATE466571T1 (de)
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CA2373093A1 (en) 2000-11-30
IL146681A (en) 2007-12-03
US7786174B2 (en) 2010-08-31
WO2000071101A2 (en) 2000-11-30
AU4905000A (en) 2000-12-12
US7393875B2 (en) 2008-07-01
WO2000071101A3 (en) 2001-12-06
MXPA01011989A (es) 2002-05-06
US6562836B1 (en) 2003-05-13
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CN100435785C (zh) 2008-11-26
NZ552354A (en) 2008-04-30
CA2684016A1 (en) 2000-11-30
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CN1377260A (zh) 2002-10-30
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US20080227767A1 (en) 2008-09-18
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