ATE466856T1 - Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen - Google Patents

Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen

Info

Publication number
ATE466856T1
ATE466856T1 AT03767343T AT03767343T ATE466856T1 AT E466856 T1 ATE466856 T1 AT E466856T1 AT 03767343 T AT03767343 T AT 03767343T AT 03767343 T AT03767343 T AT 03767343T AT E466856 T1 ATE466856 T1 AT E466856T1
Authority
AT
Austria
Prior art keywords
treating
compounds
methods
flavivirus infections
preventing flavivirus
Prior art date
Application number
AT03767343T
Other languages
English (en)
Inventor
Chun Kong Laval Chan
Sanjoy Das
Nghe Nguyen-Ba
Liliane Halab
Bettina Hamelin
Oswy Pereira
Carl Poisson
Melanie Proulx
Thumkunta Reddy
Ming-Qiang Zhang
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Application granted granted Critical
Publication of ATE466856T1 publication Critical patent/ATE466856T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03767343T 2002-12-10 2003-12-09 Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen ATE466856T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43196402P 2002-12-10 2002-12-10
PCT/CA2003/001912 WO2004052885A1 (en) 2002-12-10 2003-12-09 Compounds and methods for the treatment or prevention of flavivirus infections

Publications (1)

Publication Number Publication Date
ATE466856T1 true ATE466856T1 (de) 2010-05-15

Family

ID=42828817

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03767343T ATE466856T1 (de) 2002-12-10 2003-12-09 Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen

Country Status (10)

Country Link
EP (1) EP1569929B9 (de)
JP (1) JP4926403B2 (de)
AT (1) ATE466856T1 (de)
AU (1) AU2003291885A1 (de)
BR (1) BR0316771A (de)
CA (1) CA2508990C (de)
DK (1) DK1569929T3 (de)
MX (1) MXPA05006196A (de)
NZ (1) NZ540799A (de)
WO (1) WO2004052885A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004061746A1 (de) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Alkinyl-substituierte Thiophene
JP5030947B2 (ja) * 2005-05-13 2012-09-19 ヴァイロケム・ファーマ・インコーポレーテッド フラビウイルス感染の治療及び予防のための化合物及び方法
WO2007071434A1 (en) * 2005-12-22 2007-06-28 Smithkline Beecham Corporation Antiviral 2-carboxy-thiophene compounds
WO2008017688A1 (en) * 2006-08-11 2008-02-14 Smithkline Beecham Corporation 2-carboxy thiophene derivatives as anti-viral agents
WO2008043791A2 (en) * 2006-10-13 2008-04-17 Smithkline Beecham Corporation Thiophene derivatives for treating hepatitis c
SG176488A1 (en) 2006-11-15 2011-12-29 Virochem Pharma Inc Thiophene analogues for the treatment or prevention of flavivirus infections
MX2009011930A (es) 2007-05-04 2009-11-18 Vertex Pharma Terapia de combinacion para el tratamiento de infeccion de virus de hepatitis c.
GB0712393D0 (en) * 2007-06-26 2007-08-01 Smithkline Beecham Corp Compounds
US9162980B2 (en) 2009-01-09 2015-10-20 Board Of Regents Of The University Of Texas System Anti-depression compounds
US9095572B2 (en) 2009-01-09 2015-08-04 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
CA2748813C (en) 2009-01-09 2018-07-10 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US8362277B2 (en) 2009-01-09 2013-01-29 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US9962368B2 (en) 2009-01-09 2018-05-08 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
KR20120051022A (ko) 2009-07-21 2012-05-21 길리애드 사이언시즈, 인코포레이티드 플라비비리데 바이러스의억제제
CA2771124C (en) 2009-09-09 2019-01-15 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
EP2504329A1 (de) * 2009-11-25 2012-10-03 Vertex Pharmaceuticals Incorporated 5-alkynyl-thiophen-2-carbonsäurederivate und ihre verwendung zur behandlung oder prävention von flavivirus-infektionen
EA201290575A1 (ru) 2010-01-15 2013-01-30 Джилид Сайэнс, Инк. Ингибиторы вирусов flaviviridae
TWI491609B (zh) 2010-01-15 2015-07-11 Gilead Sciences Inc 黃熱病毒科（Ｆｌａｖｉｖｉｒｉｄａｅ）病毒之抑制劑類
WO2012006070A1 (en) * 2010-06-28 2012-01-12 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flavivirus infections
CA2808291A1 (en) * 2010-08-17 2012-02-23 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flaviviridae viral infections
US8771665B2 (en) 2010-12-17 2014-07-08 Cocrystal Discovery, Inc. Inhibitors of hepatitis C virus polymerase
US8741946B2 (en) 2011-07-13 2014-06-03 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
WO2013016491A1 (en) 2011-07-26 2013-01-31 Vertex Pharmaceuticals Incorporated Thiophene compounds
WO2014055142A1 (en) 2012-06-20 2014-04-10 Cocrystal Discovery, Inc. Inhibitors of hepatitis c virus polymerase
US8841340B2 (en) 2012-08-17 2014-09-23 Gilead Sciences, Inc. Solid forms of an antiviral compound
US8927741B2 (en) 2012-08-17 2015-01-06 Gilead Sciences, Inc. Synthesis of an antiviral compound
US8759544B2 (en) 2012-08-17 2014-06-24 Gilead Sciences, Inc. Synthesis of an antiviral compound
EP2887803A4 (de) 2012-08-24 2016-08-03 Univ Texas Pro-neurogene verbindungen
WO2015070237A1 (en) 2013-11-11 2015-05-14 Board Of Regents Of The University Of Texas System Neuroprotective chemicals and methods for identifying and using same
EP3068388A4 (de) 2013-11-11 2017-04-12 Board of Regents of the University of Texas System Nervenschützende verbindungen und verwendung davon
TWI731854B (zh) 2015-03-23 2021-07-01 美商共結晶製藥公司 Ｃ型肝炎病毒聚合酶之抑制劑
CN112203652A (zh) 2018-05-09 2021-01-08 共晶制药公司 用于治疗hcv的组合疗法
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005170A1 (en) * 1993-08-13 1995-02-23 Warner-Lambert Company Methods of inhibiting hiv and inhibiting the activation of hiv
US5734081A (en) * 1994-08-05 1998-03-31 Warner-Lambert Company Arylthio compounds
MXPA02001498A (es) * 1999-08-12 2003-07-21 Pharmacia & Italia S P A Derivados de 3(5)-amino-pirazol, procedimiento para la preparacion de los mismos y usos como agentes antitumorales.
MXPA03009647A (es) * 2001-04-19 2004-01-29 Vertex Pharma Heterociclildicarbamidas como inhibidores de caspasa.
EP2363396A1 (de) * 2001-06-11 2011-09-07 Virochem Pharma Inc. Thiophenderivate als antivirale Mittel gegen Flavivirus-Infektion
EP1395571A1 (de) * 2001-06-11 2004-03-10 Shire Biochem Inc. Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen

Also Published As

Publication number Publication date
CA2508990A1 (en) 2004-06-24
CA2508990C (en) 2013-05-28
EP1569929B9 (de) 2011-09-14
EP1569929A1 (de) 2005-09-07
MXPA05006196A (es) 2006-01-27
BR0316771A (pt) 2005-10-25
AU2003291885A1 (en) 2004-06-30
NZ540799A (en) 2008-09-26
JP4926403B2 (ja) 2012-05-09
WO2004052885A1 (en) 2004-06-24
EP1569929B1 (de) 2010-05-05
JP2006510636A (ja) 2006-03-30
DK1569929T3 (da) 2010-08-16

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