ATE466862T1 - Sigma-2 rezeptoren als biomarkierer der tumorzellenproliferation - Google Patents

Sigma-2 rezeptoren als biomarkierer der tumorzellenproliferation

Info

Publication number
ATE466862T1
ATE466862T1 AT97917552T AT97917552T ATE466862T1 AT E466862 T1 ATE466862 T1 AT E466862T1 AT 97917552 T AT97917552 T AT 97917552T AT 97917552 T AT97917552 T AT 97917552T AT E466862 T1 ATE466862 T1 AT E466862T1
Authority
AT
Austria
Prior art keywords
pct
receptors
sigma
formula
biomarkers
Prior art date
Application number
AT97917552T
Other languages
English (en)
Inventor
Robert Mach
Kenneth Wheeler
Biao Yang
Steven Childers
Original Assignee
Univ Wake Forest Health Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wake Forest Health Sciences filed Critical Univ Wake Forest Health Sciences
Application granted granted Critical
Publication of ATE466862T1 publication Critical patent/ATE466862T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
AT97917552T 1996-03-20 1997-03-19 Sigma-2 rezeptoren als biomarkierer der tumorzellenproliferation ATE466862T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1371796P 1996-03-20 1996-03-20
PCT/US1997/004403 WO1997034892A1 (en) 1996-03-20 1997-03-19 Sigma-2 receptors as biomarkers of tumor cell proliferation

Publications (1)

Publication Number Publication Date
ATE466862T1 true ATE466862T1 (de) 2010-05-15

Family

ID=21761361

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97917552T ATE466862T1 (de) 1996-03-20 1997-03-19 Sigma-2 rezeptoren als biomarkierer der tumorzellenproliferation

Country Status (9)

Country Link
US (1) US6113877A (de)
EP (1) EP0888345B1 (de)
JP (2) JP2000506896A (de)
AT (1) ATE466862T1 (de)
AU (1) AU724780B2 (de)
CA (1) CA2249410C (de)
DE (1) DE69739869D1 (de)
ES (1) ES2342990T3 (de)
WO (1) WO1997034892A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6676925B1 (en) * 1996-03-20 2004-01-13 Wake Forest University Sigma-2 receptors as biomarkers of tumor cell proliferation
US6428784B1 (en) 1997-10-31 2002-08-06 New Horizons Diagnostics Corp Vaginal suppository for treating group B Streptococcus infection
FR2790957B3 (fr) * 1999-03-19 2001-06-01 Sanofi Sa Detection dans un echantillon biologique de la proteine srbp, cette proteine etant associee a un cancer mammaire
WO2001074297A2 (en) 2000-03-31 2001-10-11 Wake Forest University Methods and compositions utilizing an alternative splice variant of the sigma-1 receptor
DE60101570T2 (de) * 2000-04-27 2004-09-30 Wake Forest University Health Sciences Sigma-2 rezeptoren als biomarkierer der tumorzellenproliferation
DE10255040A1 (de) * 2002-11-26 2004-06-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Carbaminsäureester mit anticholinerger Wirksamkeit
US7041674B2 (en) * 2002-11-26 2006-05-09 Boehringer Ingelhiem Pharma Gmbh & Co. Kg Carbamic acid esters with anticholinergic activity
US7659400B2 (en) * 2003-07-31 2010-02-09 Washington University Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging
US7390902B2 (en) * 2003-07-31 2008-06-24 Washington University Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors
WO2005099706A2 (en) * 2004-04-07 2005-10-27 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
US8143222B2 (en) * 2007-10-22 2012-03-27 Washington University Modular platform for targeted therapeutic delivery
JP2023526515A (ja) 2020-05-20 2023-06-21 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ リソソーム蓄積症をヒスタチンペプチドで処置するための方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0235878A3 (de) * 1986-01-16 1989-06-14 Beecham Group Plc Neue Verbindungen
GB8600978D0 (en) * 1986-01-16 1986-02-19 Beecham Group Plc Compounds
GB8618700D0 (en) * 1986-07-31 1986-09-10 Beecham Group Plc Compounds
EP0255297B1 (de) * 1986-07-31 1993-04-21 Beecham Group Plc Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
IE63474B1 (en) * 1987-12-24 1995-04-19 Wyeth John & Brother Ltd Heterocyclic compounds
DK443489D0 (da) * 1989-09-08 1989-09-08 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
US5106543A (en) * 1990-08-17 1992-04-21 Dodds Diego E F Apparatus and method for controlling the discharge or continuous bleed-off of cooling water and evaporative coolers
GB9121835D0 (en) * 1991-10-15 1991-11-27 Smithkline Beecham Plc Pharmaceuticals
GB9217629D0 (en) * 1992-08-19 1992-09-30 Wyeth John & Brother Ltd Aroylureas
EP0747355A4 (de) * 1994-02-10 1997-04-09 Yamanouchi Pharma Co Ltd Neue carbamate und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
CA2249410C (en) 2007-06-12
AU2584297A (en) 1997-10-10
JP2000506896A (ja) 2000-06-06
JP2009167178A (ja) 2009-07-30
US6113877A (en) 2000-09-05
EP0888345A4 (de) 2001-06-27
EP0888345B1 (de) 2010-05-05
ES2342990T3 (es) 2010-07-20
EP0888345A1 (de) 1999-01-07
DE69739869D1 (de) 2010-06-17
WO1997034892A1 (en) 1997-09-25
AU724780B2 (en) 2000-09-28
CA2249410A1 (en) 1997-09-25

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties