ATE467422T1 - Behandlung von aspergillus-infektionen mit thymosin alpha 1 - Google Patents

Behandlung von aspergillus-infektionen mit thymosin alpha 1

Info

Publication number: ATE467422T1
Authority: AT; Austria
Prior art keywords: thymosin alpha; treating; aspergillus infections; treating aspergillus; immuno
Prior art date: 2003-03-28

Application number

AT04749495T

Other languages

English (en)

Inventor

Guido Rasi

Enrico Garaci

Francesco Bistoni

Luigina Romani

Francesco Paolo Di

Original Assignee

Sciclone Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-28

Filing date

2004-03-29

Publication date

2010-05-15

2004-03-29 Application filed by Sciclone Pharmaceuticals Inc filed Critical Sciclone Pharmaceuticals Inc

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE467422T1 publication Critical patent/ATE467422T1/de

Links

108010078233 Thymalfasin Proteins 0.000 title abstract 2
102400000800 Thymosin alpha-1 Human genes 0.000 title abstract 2
NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 title abstract 2
229960004231 thymalfasin Drugs 0.000 title abstract 2
201000002909 Aspergillosis Diseases 0.000 title 1
208000036641 Aspergillus infections Diseases 0.000 title 1
241000228212 Aspergillus Species 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
206010061598 Immunodeficiency Diseases 0.000 abstract 1
230000003213 activating effect Effects 0.000 abstract 1
238000010322 bone marrow transplantation Methods 0.000 abstract 1
210000004443 dendritic cell Anatomy 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2292—Thymosin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT04749495T 2003-03-28 2004-03-29 Behandlung von aspergillus-infektionen mit thymosin alpha 1 ATE467422T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45791103P	2003-03-28	2003-03-28
PCT/US2004/009550 WO2004087067A2 (en)	2003-03-28	2004-03-29	Treatment of aspergillus infections with thymosin alpha 1

Publications (1)

Publication Number	Publication Date
ATE467422T1 true ATE467422T1 (de)	2010-05-15

Family

ID=42828702

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04749495T ATE467422T1 (de)	2003-03-28	2004-03-29	Behandlung von aspergillus-infektionen mit thymosin alpha 1

Country Status (17)

Country	Link
US (2)	US8207294B2 (de)
EP (1)	EP1613340B1 (de)
JP (1)	JP4629033B2 (de)
KR (1)	KR101089145B1 (de)
AT (1)	ATE467422T1 (de)
AU (1)	AU2004226403B2 (de)
BR (1)	BRPI0408892A (de)
CA (1)	CA2520400C (de)
DK (1)	DK1613340T3 (de)
EA (1)	EA008037B1 (de)
IL (1)	IL171118A (de)
MX (1)	MXPA05010391A (de)
NO (1)	NO329997B1 (de)
NZ (1)	NZ542900A (de)
PL (1)	PL1613340T3 (de)
UA (1)	UA80870C2 (de)
WO (1)	WO2004087067A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4629033B2 (ja)	2003-03-28	2011-02-09	サイクローン・ファーマシューティカルズ・インコーポレイテッド	チモシンα１によるアスペルギルス感染の治療
WO2006062917A2 (en) *	2004-12-06	2006-06-15	Sciclone Pharmaceuticals, Inc.	Alpha thymosin peptides as cancer vaccine adjuvants
BRPI0712595A2 (pt) *	2006-05-19	2012-07-03	Sigma Tau Ind Farmaceuti	uso de timosina alfa 1 para o tratamento de doenças imunológicas.
ITRM20060583A1 (it) *	2006-10-27	2008-04-28	Francesco Bistoni	Uso della timosina alfa 1 per la preparazione di un medicamento per la prevenzione e la cura delle allergie
WO2012109106A1 (en) *	2011-02-09	2012-08-16	Sciclone Pharmaceuticals, Inc.	Thymosin alpha peptide for preventing, reducing the severity of, and treating infection
ITUB20153714A1 (it) *	2015-09-18	2017-03-18	Luigina Romani	Timosina alfa 1 per l?uso nel trattamento della fibrosi cistica.
AU2016217473B2 (en) *	2015-02-09	2021-07-29	Sciclone Pharmaceuticals International (Sg) Pte. Ltd.	Thymosin alpha 1 for use in treatment of cystic fibrosis

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4002740A (en)	1975-08-21	1977-01-11	Gideon Goldstein	Tridecapeptide compositions and methods
US4079127A (en)	1976-10-28	1978-03-14	Board Of Regents Of The University Of Texas	Thymosin alpha 1
US4116951A (en)	1977-04-22	1978-09-26	Hoffmann-La Roche Inc.	[Asn2 ]-thymosin α1 and analogs thereof
DE2919592A1 (de)	1979-05-15	1981-01-15	Max Planck Gesellschaft	Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon
US4612365A (en)	1980-03-25	1986-09-16	Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften	Medicaments containing alpha 1-thymosin and having an immuno regulatory action and alpha 1-thymosin fragments
US4374197A (en)	1980-10-30	1983-02-15	Hoffmann-La Rocche Inc.	Process for thymosin α1
TW224053B (de)	1991-09-13	1994-05-21	Paul B Chretien
CN1058500C (zh)	1993-02-03	2000-11-15	施塞克龙药品公司	胸腺素α－1衍生物
CN1072961C (zh)	1993-03-05	2001-10-17	施塞克龙药品公司	治疗对干扰素治疗无反应者的丙型肝炎的方法
TW252045B (de) *	1993-10-07	1995-07-21	Allan L Goldstein
RU2107692C1 (ru) *	1995-06-07	1998-03-27	Дейгин Владислав Исакович	Пептид и способ его получения
US5888980A (en)	1994-06-30	1999-03-30	Bio-Logic Research And Development Corporation	Compositions for enhancing immune function
US5632983A (en)	1994-11-17	1997-05-27	University Of South Florida	Method for treating secondary immunodeficiency
AU6164898A (en) *	1997-02-18	1998-09-08	Sciclone Pharmaceuticals, Inc.	Use of thymosin alpha 1 for the manufacture of a medicament for promoting stem cell development
UA80957C2 (en) *	2001-11-01	2007-11-26	Sciclone Pharmaceuticals Inc	Method of administering a thymosin alpha 1 peptide
JP4629033B2 (ja)	2003-03-28	2011-02-09	サイクローン・ファーマシューティカルズ・インコーポレイテッド	チモシンα１によるアスペルギルス感染の治療

2004
- 2004-03-29 JP JP2006509423A patent/JP4629033B2/ja not_active Expired - Lifetime
- 2004-03-29 BR BRPI0408892-1A patent/BRPI0408892A/pt not_active IP Right Cessation
- 2004-03-29 MX MXPA05010391A patent/MXPA05010391A/es active IP Right Grant
- 2004-03-29 KR KR1020057018335A patent/KR101089145B1/ko not_active Expired - Fee Related
- 2004-03-29 AU AU2004226403A patent/AU2004226403B2/en not_active Ceased
- 2004-03-29 AT AT04749495T patent/ATE467422T1/de active
- 2004-03-29 US US10/551,341 patent/US8207294B2/en active Active
- 2004-03-29 EA EA200501414A patent/EA008037B1/ru not_active IP Right Cessation
- 2004-03-29 PL PL04749495T patent/PL1613340T3/pl unknown
- 2004-03-29 WO PCT/US2004/009550 patent/WO2004087067A2/en not_active Ceased
- 2004-03-29 EP EP04749495A patent/EP1613340B1/de not_active Expired - Lifetime
- 2004-03-29 CA CA2520400A patent/CA2520400C/en not_active Expired - Lifetime
- 2004-03-29 DK DK04749495.0T patent/DK1613340T3/da active
- 2004-03-29 NZ NZ542900A patent/NZ542900A/en not_active IP Right Cessation
- 2004-03-29 UA UAA200509921A patent/UA80870C2/xx unknown
2005
- 2005-09-27 IL IL171118A patent/IL171118A/en not_active IP Right Cessation
- 2005-10-24 NO NO20054912A patent/NO329997B1/no not_active IP Right Cessation
2012
- 2012-05-29 US US13/482,978 patent/US8389680B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2520400C (en)	2013-02-19
KR101089145B1 (ko)	2011-12-02
JP4629033B2 (ja)	2011-02-09
EP1613340B1 (de)	2010-05-12
BRPI0408892A (pt)	2006-04-11
US20070129292A1 (en)	2007-06-07
US8389680B2 (en)	2013-03-05
IL171118A (en)	2011-10-31
EA200501414A1 (ru)	2006-04-28
WO2004087067A3 (en)	2004-12-29
US8207294B2 (en)	2012-06-26
KR20050114264A (ko)	2005-12-05
EP1613340A4 (de)	2009-07-01
EA008037B1 (ru)	2007-02-27
PL1613340T3 (pl)	2010-10-29
UA80870C2 (en)	2007-11-12
JP2006521406A (ja)	2006-09-21
WO2004087067A2 (en)	2004-10-14
NO20054912D0 (no)	2005-10-24
CA2520400A1 (en)	2004-10-14
NO20054912L (no)	2005-12-20
MXPA05010391A (es)	2005-11-04
EP1613340A2 (de)	2006-01-11
AU2004226403B2 (en)	2008-12-04
NO329997B1 (no)	2011-02-07
US20120295840A1 (en)	2012-11-22
DK1613340T3 (da)	2010-08-30
AU2004226403A1 (en)	2004-10-14
NZ542900A (en)	2007-06-29

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2010-11-15

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