BRPI0408892A - uso de timosina alfa 1 para tratar as infecções por arpergillus - Google Patents
uso de timosina alfa 1 para tratar as infecções por arpergillusInfo
- Publication number
- BRPI0408892A BRPI0408892A BRPI0408892-1A BRPI0408892A BRPI0408892A BR PI0408892 A BRPI0408892 A BR PI0408892A BR PI0408892 A BRPI0408892 A BR PI0408892A BR PI0408892 A BRPI0408892 A BR PI0408892A
- Authority
- BR
- Brazil
- Prior art keywords
- arpergillus
- infections
- treat
- thymosin alfa
- immuno
- Prior art date
Links
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 102000007501 Thymosin Human genes 0.000 title 1
- 108010046075 Thymosin Proteins 0.000 title 1
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 title 1
- 241000228212 Aspergillus Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 108010078233 Thymalfasin Proteins 0.000 abstract 1
- 102400000800 Thymosin alpha-1 Human genes 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 238000010322 bone marrow transplantation Methods 0.000 abstract 1
- 210000004443 dendritic cell Anatomy 0.000 abstract 1
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 abstract 1
- 229960004231 thymalfasin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2292—Thymosin; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"USO DA TIMOSINA ALFA 1 PARA TRATAR AS INFECçõES POR ASPERGILLUS". Um método para tratar um ser humano infectado com o Aspergillus pelo uso da timosina alfa 1 como um immuno estimulante na ativação de células dendríticas. O uso é particularmente útil em prevenir uma infecção por Aspergillus em um hospedeiro immuno-comprometido que está sendo tratado com transplante de medula óssea.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45791103P | 2003-03-28 | 2003-03-28 | |
| PCT/US2004/009550 WO2004087067A2 (en) | 2003-03-28 | 2004-03-29 | Treatment of aspergillus infections with thymosin alpha 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0408892A true BRPI0408892A (pt) | 2006-04-11 |
Family
ID=42828702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0408892-1A BRPI0408892A (pt) | 2003-03-28 | 2004-03-29 | uso de timosina alfa 1 para tratar as infecções por arpergillus |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8207294B2 (pt) |
| EP (1) | EP1613340B1 (pt) |
| JP (1) | JP4629033B2 (pt) |
| KR (1) | KR101089145B1 (pt) |
| AT (1) | ATE467422T1 (pt) |
| AU (1) | AU2004226403B2 (pt) |
| BR (1) | BRPI0408892A (pt) |
| CA (1) | CA2520400C (pt) |
| DK (1) | DK1613340T3 (pt) |
| EA (1) | EA008037B1 (pt) |
| IL (1) | IL171118A (pt) |
| MX (1) | MXPA05010391A (pt) |
| NO (1) | NO329997B1 (pt) |
| NZ (1) | NZ542900A (pt) |
| PL (1) | PL1613340T3 (pt) |
| UA (1) | UA80870C2 (pt) |
| WO (1) | WO2004087067A2 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA008037B1 (ru) | 2003-03-28 | 2007-02-27 | Сциклон Фармасьютикалс, Инк. | ЛЕЧЕНИЕ ИНФЕКЦИЙ, ВЫЗЫВАЕМЫХ ГРИБАМИ p. ASPERGILLUS, С ПОМОЩЬЮ ТИМОЗИНА АЛЬФА 1 |
| EP1835931A4 (en) * | 2004-12-06 | 2008-12-17 | Sciclone Pharmaceuticals Inc | ALPHA THYMOSINE PEPTIDES AS CANCER VACCINE ADJUVANTIES |
| EP2018180B1 (en) * | 2006-05-19 | 2015-08-26 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Thymosin alpha 1 for use in the treatment of graft versus host disease |
| ITRM20060583A1 (it) * | 2006-10-27 | 2008-04-28 | Francesco Bistoni | Uso della timosina alfa 1 per la preparazione di un medicamento per la prevenzione e la cura delle allergie |
| WO2012109106A1 (en) * | 2011-02-09 | 2012-08-16 | Sciclone Pharmaceuticals, Inc. | Thymosin alpha peptide for preventing, reducing the severity of, and treating infection |
| ITUB20153714A1 (it) * | 2015-09-18 | 2017-03-18 | Luigina Romani | Timosina alfa 1 per l?uso nel trattamento della fibrosi cistica. |
| CA2976062C (en) * | 2015-02-09 | 2025-05-13 | Sciclone Pharmaceuticals International (Sg) Pte. Ltd. | THYMOSINE ALPHA 1 INTENDED FOR USE IN THE TREATMENT OF CYSTIC FIBROSIS |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4002740A (en) * | 1975-08-21 | 1977-01-11 | Gideon Goldstein | Tridecapeptide compositions and methods |
| US4079127A (en) * | 1976-10-28 | 1978-03-14 | Board Of Regents Of The University Of Texas | Thymosin alpha 1 |
| US4116951A (en) * | 1977-04-22 | 1978-09-26 | Hoffmann-La Roche Inc. | [Asn2 ]-thymosin α1 and analogs thereof |
| DE2919592A1 (de) * | 1979-05-15 | 1981-01-15 | Max Planck Gesellschaft | Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon |
| US4612365A (en) * | 1980-03-25 | 1986-09-16 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften | Medicaments containing alpha 1-thymosin and having an immuno regulatory action and alpha 1-thymosin fragments |
| US4374197A (en) * | 1980-10-30 | 1983-02-15 | Hoffmann-La Rocche Inc. | Process for thymosin α1 |
| TW224053B (pt) | 1991-09-13 | 1994-05-21 | Paul B Chretien | |
| CN1058500C (zh) * | 1993-02-03 | 2000-11-15 | 施塞克龙药品公司 | 胸腺素α－1衍生物 |
| CN1072961C (zh) | 1993-03-05 | 2001-10-17 | 施塞克龙药品公司 | 治疗对干扰素治疗无反应者的丙型肝炎的方法 |
| TW252045B (pt) * | 1993-10-07 | 1995-07-21 | Allan L Goldstein | |
| RU2107692C1 (ru) * | 1995-06-07 | 1998-03-27 | Дейгин Владислав Исакович | Пептид и способ его получения |
| US5888980A (en) * | 1994-06-30 | 1999-03-30 | Bio-Logic Research And Development Corporation | Compositions for enhancing immune function |
| US5632983A (en) | 1994-11-17 | 1997-05-27 | University Of South Florida | Method for treating secondary immunodeficiency |
| AU6164898A (en) * | 1997-02-18 | 1998-09-08 | Sciclone Pharmaceuticals, Inc. | Use of thymosin alpha 1 for the manufacture of a medicament for promoting stem cell development |
| UA80957C2 (en) * | 2001-11-01 | 2007-11-26 | Sciclone Pharmaceuticals Inc | Method of administering a thymosin alpha 1 peptide |
| EA008037B1 (ru) | 2003-03-28 | 2007-02-27 | Сциклон Фармасьютикалс, Инк. | ЛЕЧЕНИЕ ИНФЕКЦИЙ, ВЫЗЫВАЕМЫХ ГРИБАМИ p. ASPERGILLUS, С ПОМОЩЬЮ ТИМОЗИНА АЛЬФА 1 |
-
2004
- 2004-03-29 EA EA200501414A patent/EA008037B1/ru not_active IP Right Cessation
- 2004-03-29 EP EP04749495A patent/EP1613340B1/en not_active Expired - Lifetime
- 2004-03-29 AT AT04749495T patent/ATE467422T1/de active
- 2004-03-29 UA UAA200509921A patent/UA80870C2/xx unknown
- 2004-03-29 KR KR1020057018335A patent/KR101089145B1/ko not_active Expired - Fee Related
- 2004-03-29 DK DK04749495.0T patent/DK1613340T3/da active
- 2004-03-29 MX MXPA05010391A patent/MXPA05010391A/es active IP Right Grant
- 2004-03-29 CA CA2520400A patent/CA2520400C/en not_active Expired - Lifetime
- 2004-03-29 JP JP2006509423A patent/JP4629033B2/ja not_active Expired - Lifetime
- 2004-03-29 PL PL04749495T patent/PL1613340T3/pl unknown
- 2004-03-29 BR BRPI0408892-1A patent/BRPI0408892A/pt not_active IP Right Cessation
- 2004-03-29 NZ NZ542900A patent/NZ542900A/en not_active IP Right Cessation
- 2004-03-29 US US10/551,341 patent/US8207294B2/en active Active
- 2004-03-29 WO PCT/US2004/009550 patent/WO2004087067A2/en not_active Ceased
- 2004-03-29 AU AU2004226403A patent/AU2004226403B2/en not_active Ceased
-
2005
- 2005-09-27 IL IL171118A patent/IL171118A/en not_active IP Right Cessation
- 2005-10-24 NO NO20054912A patent/NO329997B1/no not_active IP Right Cessation
-
2012
- 2012-05-29 US US13/482,978 patent/US8389680B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO329997B1 (no) | 2011-02-07 |
| NO20054912L (no) | 2005-12-20 |
| NO20054912D0 (no) | 2005-10-24 |
| KR20050114264A (ko) | 2005-12-05 |
| WO2004087067A2 (en) | 2004-10-14 |
| AU2004226403B2 (en) | 2008-12-04 |
| EA200501414A1 (ru) | 2006-04-28 |
| NZ542900A (en) | 2007-06-29 |
| ATE467422T1 (de) | 2010-05-15 |
| EP1613340B1 (en) | 2010-05-12 |
| US20070129292A1 (en) | 2007-06-07 |
| JP4629033B2 (ja) | 2011-02-09 |
| DK1613340T3 (da) | 2010-08-30 |
| WO2004087067A3 (en) | 2004-12-29 |
| AU2004226403A1 (en) | 2004-10-14 |
| KR101089145B1 (ko) | 2011-12-02 |
| US8207294B2 (en) | 2012-06-26 |
| MXPA05010391A (es) | 2005-11-04 |
| US8389680B2 (en) | 2013-03-05 |
| JP2006521406A (ja) | 2006-09-21 |
| IL171118A (en) | 2011-10-31 |
| UA80870C2 (en) | 2007-11-12 |
| EA008037B1 (ru) | 2007-02-27 |
| US20120295840A1 (en) | 2012-11-22 |
| CA2520400C (en) | 2013-02-19 |
| EP1613340A2 (en) | 2006-01-11 |
| CA2520400A1 (en) | 2004-10-14 |
| EP1613340A4 (en) | 2009-07-01 |
| PL1613340T3 (pl) | 2010-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |