ATE469223T1 - Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden - Google Patents

Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden

Info

Publication number
ATE469223T1
ATE469223T1 AT01915099T AT01915099T ATE469223T1 AT E469223 T1 ATE469223 T1 AT E469223T1 AT 01915099 T AT01915099 T AT 01915099T AT 01915099 T AT01915099 T AT 01915099T AT E469223 T1 ATE469223 T1 AT E469223T1
Authority
AT
Austria
Prior art keywords
polypeptides
mushroom
processes
transcription activator
nucleic acid
Prior art date
Application number
AT01915099T
Other languages
English (en)
Inventor
Carsten Hjort
C Hondel
P Punt
F Schuren
Tove Christensen
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE469223T1 publication Critical patent/ATE469223T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/385—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Penicillium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT01915099T 2000-03-14 2001-03-14 Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden ATE469223T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000406 2000-03-14
PCT/DK2001/000169 WO2001068864A1 (en) 2000-03-14 2001-03-14 Fungal transcriptional activator useful in methods for producing polypeptides

Publications (1)

Publication Number Publication Date
ATE469223T1 true ATE469223T1 (de) 2010-06-15

Family

ID=8159325

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01915099T ATE469223T1 (de) 2000-03-14 2001-03-14 Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden

Country Status (8)

Country Link
EP (1) EP1266011B1 (de)
JP (1) JP2003526374A (de)
CN (2) CN102174535B (de)
AT (1) ATE469223T1 (de)
AU (1) AU2001242299A1 (de)
DE (1) DE60142226D1 (de)
DK (1) DK1266011T3 (de)
WO (1) WO2001068864A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4638418B2 (ja) 2003-03-31 2011-02-23 ノボザイムス，インコーポレイティド アスペルギラス・ニガーの酵素−欠失変異体における生物学的物質の生成方法
CN101094919B (zh) 2004-10-12 2014-09-03 帝斯曼知识产权资产管理有限公司 在生产多肽的方法中有用的真菌转录活化因子
US7888489B2 (en) 2005-01-24 2011-02-15 Dsm Ip Assets B.V. Method for producing a compound of interest in a filamentous fungal cell
EP1861421B1 (de) 2005-03-16 2011-10-19 Novozymes Adenium Biotech A/S Rekombinante expression von insekten defensinen in aspergillus
EP1941025B1 (de) 2005-10-17 2011-06-29 Novozymes A/S Verwendung von pilzmutanten zur expression von antikörpern
EP1954812B1 (de) 2005-11-29 2012-11-21 DSM IP Assets B.V. Dna-bindungsstelle eines transkriptionsaktivators mit eignung bei der genexpression
WO2008000632A1 (en) 2006-06-29 2008-01-03 Dsm Ip Assets B.V. A method for achieving improved polypeptide expression
JP5497632B2 (ja) 2007-05-09 2014-05-21 ノボザイムス アクティーゼルスカブ 関心対象のポリペプチドを産生するライブラリークローンの選択に適した発現クローニング法
CN101182352B (zh) * 2007-11-21 2010-06-09 中国科学院微生物研究所 一种转录激活因子及其编码基因与应用
EP3293264A1 (de) 2009-07-22 2018-03-14 DSM IP Assets B.V. Verbesserte wirtszelle für die herstellung von relevanten produkten
CN101906393B (zh) * 2010-06-28 2012-07-25 江南大学 一种谷氨酰胺转胺酶编码基因阻断吸水链霉菌及其应用
WO2012098246A1 (en) 2011-01-20 2012-07-26 Novozymes A/S Expression of plant peroxidases in filamentous fungi
EP2527432A1 (de) 2011-05-23 2012-11-28 Novozymes A/S Bidirektionaler Cytosin-Deaminase-codierender Selektionsmarker
EP2527448A1 (de) 2011-05-23 2012-11-28 Novozymes A/S Gleichzeitige standortspezifische Integrationen von mehreren Genkopien in faserige Pilze
RU2645252C2 (ru) 2012-01-05 2018-02-19 Глюкос Финланд Ой Клетка нитчатых грибов с дефицитом протеаз и способы ее применения
EP2852610B1 (de) 2012-05-23 2018-07-11 Glykos Finland Oy Herstellung von fucosylierten glykoproteinen
JP6468561B2 (ja) 2012-07-19 2019-02-13 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． ＡｇｓＥ欠損株
SG11201600115SA (en) 2013-07-10 2016-02-26 Novartis Ag Multiple proteases deficient filamentous fungal cells and methods of use thereof
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
WO2016110453A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a filamentous fungal host cell
JP6473339B2 (ja) * 2015-02-05 2019-02-20 本田技研工業株式会社 麹菌変異株及び形質転換体
CN108138213A (zh) * 2015-02-20 2018-06-08 罗尔公司 控制蛋白酶产生的方法
US20200063166A1 (en) 2017-03-13 2020-02-27 Dsm Ip Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
WO2018167153A1 (en) 2017-03-17 2018-09-20 Novozymes A/S Improved filamentous fungal host cell
BR112020025589A2 (pt) 2018-06-19 2021-03-23 Dsm Ip Assets B.V. variantes de enzima lipolítica
US20230212634A1 (en) 2020-01-14 2023-07-06 The Protein Brewery B.V. Expression of Ovalbumin and its Natural Variants
US20250304938A1 (en) 2022-05-16 2025-10-02 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2023242273A1 (en) 2022-06-14 2023-12-21 Newmilkbuzz B.V. Expression of milk caseins in filamentous fungi
EP4623075A1 (de) 2022-11-22 2025-10-01 NewMilkBuzz B.V Verbesserte caseinsekretion durch nichtsäugerwirtszellen
WO2024133849A1 (en) 2022-12-22 2024-06-27 The Protein Brewery B.V. Ovalbumin fermentation

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Publication number Priority date Publication date Assignee Title
US4288627A (en) 1980-02-12 1981-09-08 Phillips Petroleum Company Oxidation of thiols employing cobalt molybdate/triethylamine catalyst
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
CA1333777C (en) 1988-07-01 1995-01-03 Randy M. Berka Aspartic proteinase deficient filamentous fungi
ATE252156T1 (de) 1992-04-15 2003-11-15 Novartis Pharma Gmbh Neue schimmel-protease
DK52293D0 (de) 1993-05-05 1993-05-05 Novo Nordisk As
DK76893D0 (de) 1993-06-28 1993-06-28 Novo Nordisk As
FI964808A0 (fi) 1994-06-03 1996-12-02 Novo Nordisk Biotech Inc Puhdistetut Myceliophthora lakkaasit ja niitä koodaavat nukleiinihapot
ATE256191T1 (de) * 1994-06-17 2003-12-15 Novozymes As Ein pilz, in dem das area-gen verändert ist, und ein area-gen aus aspergillus oryzae
CN101659926A (zh) 1994-06-30 2010-03-03 诺沃奇梅兹有限公司 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子
WO1997012045A1 (en) 1995-09-27 1997-04-03 Chiron Corporation Method of making a protease deficient host
JP4263241B2 (ja) 1996-03-27 2009-05-13 ノボザイムス アクティーゼルスカブ アルカリプロテアーゼを欠失した糸状真菌
CN100432099C (zh) 1996-07-05 2008-11-12 诺沃奇梅兹有限公司 转录因子
EP0956338B1 (de) 1996-09-19 2005-12-21 Novozymes A/S Wirtszellen und methoden für die produktion von proteinen
DK1117798T3 (da) * 1998-10-05 2007-04-10 Novozymes As Fungal transskriptionel aktivator egnet ved fremgangsmåder til produktion af polypeptider

Also Published As

Publication number Publication date
JP2003526374A (ja) 2003-09-09
DK1266011T3 (da) 2010-07-26
EP1266011B1 (de) 2010-05-26
CN1425068B (zh) 2011-05-18
CN102174535A (zh) 2011-09-07
DE60142226D1 (de) 2010-07-08
CN102174535B (zh) 2014-04-09
CN1425068A (zh) 2003-06-18
WO2001068864A1 (en) 2001-09-20
AU2001242299A1 (en) 2001-09-24
EP1266011A1 (de) 2002-12-18

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