ATE469882T1 - Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen - Google Patents

Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen

Info

Publication number: ATE469882T1
Authority: AT; Austria
Prior art keywords: treatment; ppar; compounds; new compounds; mediated diseases
Prior art date: 2002-10-28

Application number

AT03757742T

Other languages

English (en)

Inventor

Lone Jeppesen

Ingrid Pettersson

Per Sauerberg

Pavel Pihera

Miroslav Havranek

Original Assignee

High Point Pharmaceuticals Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-28

Filing date

2003-10-27

Publication date

2010-06-15

2003-10-27 Application filed by High Point Pharmaceuticals Llc filed Critical High Point Pharmaceuticals Llc

2010-06-15 Application granted granted Critical

2010-06-15 Publication of ATE469882T1 publication Critical patent/ATE469882T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 6
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 2
102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
108010015181 PPAR delta Proteins 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
- C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C409/00—Peroxy compounds
- C07C409/02—Peroxy compounds the —O—O— group being bound between a carbon atom, not further substituted by oxygen atoms, and hydrogen, i.e. hydroperoxides
- C07C409/04—Peroxy compounds the —O—O— group being bound between a carbon atom, not further substituted by oxygen atoms, and hydrogen, i.e. hydroperoxides the carbon atom being acyclic
- C07C409/08—Compounds containing six-membered aromatic rings
- C07C409/10—Cumene hydroperoxide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Reproductive Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03757742T 2002-10-28 2003-10-27 Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen ATE469882T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200201629		2002-10-28
PCT/DK2003/000723 WO2004037775A1 (en)	2002-10-28	2003-10-27	Novel compounds useful in treating ppar mediated diseases

Publications (1)

Publication Number	Publication Date
ATE469882T1 true ATE469882T1 (de)	2010-06-15

Family

ID=32116197

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03757742T ATE469882T1 (de)	2002-10-28	2003-10-27	Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen

Country Status (14)

Country	Link
EP (1)	EP1558571B1 (de)
JP (1)	JP4584714B2 (de)
KR (1)	KR20050055790A (de)
CN (1)	CN1708479A (de)
AT (1)	ATE469882T1 (de)
AU (1)	AU2003273784A1 (de)
BR (1)	BR0315667A (de)
CA (1)	CA2503276A1 (de)
DE (1)	DE60332860D1 (de)
ES (1)	ES2344106T3 (de)
MX (1)	MXPA05004405A (de)
PL (1)	PL376704A1 (de)
RU (1)	RU2005116256A (de)
WO (1)	WO2004037775A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1667964T1 (sl)	2003-09-19	2009-12-31	Janssen Pharmaceutica Nv	4-((fenoksialkil)tio)-fenoksiocetne kisline in analogi
AU2004283147A1 (en) *	2003-10-28	2005-05-06	Dr. Reddy's Laboratories Ltd.	Novel compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
GB0403148D0 (en) *	2004-02-12	2004-03-17	Smithkline Beecham Corp	Chemical compounds
EP1745014B1 (de) *	2004-05-05	2011-07-06	High Point Pharmaceuticals, LLC	Neue verbindungen, deren herstellung und verwendung
JO3006B1 (ar)	2005-09-14	2016-09-05	Janssen Pharmaceutica Nv	املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك
NZ568488A (en) *	2005-12-22	2011-07-29	High Point Pharmaceuticals Llc	Phenoxy acetic acids as PPAR delta activators
PE20080188A1 (es)	2006-04-18	2008-03-10	Janssen Pharmaceutica Nv	Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol
BRPI0911197A2 (pt) *	2008-04-15	2015-10-13	Nippon Chemiphar Co	composto, ativador de receptor ativado pelo proliferador de peroxissoma, e, medicamento para o tratamento e /ou profilaxia de uma doença.
JP2023534835A (ja)	2020-07-22	2023-08-14	レネオファーマシューティカルズ，インク．	結晶性ｐｐａｒデルタアゴニスト
WO2023147309A1 (en)	2022-01-25	2023-08-03	Reneo Pharmaceuticals, Inc.	Use of ppar-delta agonists in the treatment of disease

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2331336A1 (fr) *	1975-11-14	1977-06-10	Rolland Sa A	Acides oxy-4,4' bis(phenoxy-2 alcanocarboxyliques), leurs derives et leur application comme medicament
CA2244831A1 (en)	1996-02-02	1997-08-07	John T. Olson	Method of treating diabetes and related disease states
ATE236137T1 (de)	1996-02-02	2003-04-15	Merck & Co Inc	Heterocyclische verbindungen als antidiabetische mittel und für die behandlung von fettleibigkeit
WO1997028149A1 (en)	1996-02-02	1997-08-07	Merck & Co., Inc.	Method for raising hdl cholesterol levels
JP2002503202A (ja)	1996-02-02	2002-01-29	メルクエンドカンパニーインコーポレーテッド	抗糖尿病薬
CA2245524A1 (en)	1996-02-02	1997-08-07	Wei Han	Antidiabetic agents
US5773469A (en)	1996-06-18	1998-06-30	Ortho Pharmaceutical Corporation	Diaryl antimicrobial agents
AU719663B2 (en)	1996-12-23	2000-05-11	Merck & Co., Inc.	Antidiabetic agents
ES2320181T3 (es)	1997-07-24	2009-05-19	Astellas Pharma Inc.	Composiciones farmaceuticas que tienen un efecto reductor del colesterol.
US6506757B1 (en) *	1998-03-10	2003-01-14	Ono Pharmaceutical Co., Ltd.	Carboxylic acid derivatives and drugs containing the same as the active ingredient
CA2370742A1 (en) *	1999-04-19	2000-10-26	Coelacanth Corporation	Ppar-(gamma) agonists as agents for the treatment of type ii diabetes
CN1348439A (zh) *	1999-04-20	2002-05-08	诺沃挪第克公司	新化合物及其制备和用途
EP1177187B1 (de) *	1999-04-28	2007-07-25	Sanofi-Aventis Deutschland GmbH	Di-aryl-säurederivate als ppar rezeptor liganden
GB9914977D0 (en)	1999-06-25	1999-08-25	Glaxo Group Ltd	Chemical compounds
TWI262185B (en)	1999-10-01	2006-09-21	Eisai Co Ltd	Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
KR20020070508A (ko)	2000-01-28	2002-09-09	노보 노르디스크 에이/에스	프로피온산 유도체 및 당뇨병 및 비만의 치료에 그것의 사용
JP2001354671A (ja)	2000-04-14	2001-12-25	Nippon Chemiphar Co Ltd	ペルオキシソーム増殖剤応答性受容体δの活性化剤
EP1310494B1 (de)	2000-08-11	2012-01-25	Nippon Chemiphar Co., Ltd.	Ppar-delta aktivatoren
GB0031103D0 (en)	2000-12-20	2001-01-31	Glaxo Group Ltd	Chemical compounds
BR0211414A (pt) *	2001-07-30	2004-08-17	Novo Nordisk As	Composto, uso do mesmo, composição farmacêutica, e, métodos para o tratamento e/ou prevenção de condições mediadas pelos receptores nucleares e de diabetes tipo i, diabetes tipo ii, tolerância à glicose, resistência à insulina ou obesidade prejudicadas
HUP0401837A2 (hu) *	2001-10-17	2004-12-28	Novo Nordisk A/S	Dikarbonsavszármazékok, előállításuk és gyógyászati alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények

2003
- 2003-10-27 PL PL376704A patent/PL376704A1/pl not_active Application Discontinuation
- 2003-10-27 ES ES03757742T patent/ES2344106T3/es not_active Expired - Lifetime
- 2003-10-27 EP EP03757742A patent/EP1558571B1/de not_active Expired - Lifetime
- 2003-10-27 RU RU2005116256/04A patent/RU2005116256A/ru not_active Application Discontinuation
- 2003-10-27 AU AU2003273784A patent/AU2003273784A1/en not_active Abandoned
- 2003-10-27 BR BR0315667-2A patent/BR0315667A/pt not_active Application Discontinuation
- 2003-10-27 CA CA002503276A patent/CA2503276A1/en not_active Abandoned
- 2003-10-27 JP JP2004545734A patent/JP4584714B2/ja not_active Expired - Fee Related
- 2003-10-27 KR KR1020057007294A patent/KR20050055790A/ko not_active Withdrawn
- 2003-10-27 DE DE60332860T patent/DE60332860D1/de not_active Expired - Lifetime
- 2003-10-27 MX MXPA05004405A patent/MXPA05004405A/es not_active Application Discontinuation
- 2003-10-27 AT AT03757742T patent/ATE469882T1/de not_active IP Right Cessation
- 2003-10-27 WO PCT/DK2003/000723 patent/WO2004037775A1/en not_active Ceased
- 2003-10-27 CN CNA2003801022262A patent/CN1708479A/zh active Pending

Also Published As

Publication number	Publication date
JP2006503881A (ja)	2006-02-02
KR20050055790A (ko)	2005-06-13
RU2005116256A (ru)	2006-02-27
AU2003273784A1 (en)	2004-05-13
EP1558571A1 (de)	2005-08-03
ES2344106T3 (es)	2010-08-18
PL376704A1 (pl)	2006-01-09
CN1708479A (zh)	2005-12-14
WO2004037775A1 (en)	2004-05-06
CA2503276A1 (en)	2004-05-06
DE60332860D1 (de)	2010-07-15
BR0315667A (pt)	2005-09-06
MXPA05004405A (es)	2005-07-05
EP1558571B1 (de)	2010-06-02
JP4584714B2 (ja)	2010-11-24

Legal Events

Date	Code	Title	Description
2010-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
MXPA04000891A (es)	2004-05-21	Nuevos derivados de acido vinilcarboxilico y su uso como antidiabeticos.
ATE368031T1 (de)	2007-08-15	Neue gamma secretase inhibitoren
MY138906A (en)	2009-08-28	Phenyl derivatives as ppar agonists
SE0403006D0 (sv)	2004-12-09	New compounds
EA201000643A1 (ru)	2010-08-30	Замещенное производное этилендиамина для лечения микобактериальных заболеваний и фармацевтическая композиция на его основе
CY1111050T1 (el)	2015-06-11	Φωσφονικα, μονοφωσφοναμιδικα, διφωσφοναμιδικα για την αγωγη των ιϊκων παθησεων
ATE443043T1 (de)	2009-10-15	Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
ATE396973T1 (de)	2008-06-15	Benzylether- und benzylamino-beta-sekretase- hemmer zur behandlung von alzheimer-krankheit
EP1615914A4 (de)	2008-03-12	Cgrp-rezeptorantagonisten
PL1716152T3 (pl)	2009-01-30	Skondensowane związki heterocykliczne i ich zastosowanie jako antagonistów receptora metabotropowego do leczenia zaburzeń żołądkowo-jelitowych
EP1689713A4 (de)	2009-02-18	Benzylether und benzylaminoverbindungen als inhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
EA200601239A1 (ru)	2007-02-27	Замещённые хинолиновые соединения
NO20050851L (no)	2005-03-29	Kaspase-inhibitorer og anvendelser derav
IS8485A (is)	2006-05-26	Notkun á setnum 2-amínótetralínum í fyrirbyggjandi meðferð á Parkinsons-veiki
NO20056192L (no)	2005-12-27	Kapaseinhibitorer og anvendelse derav
MX2007011695A (es)	2008-03-11	Derivados de oxindol sustituido, medicamentos que contienen dichos derivados y uso de los mismos.
DE602004002394D1 (de)	2006-10-26	(3-ä3-'(2,4-BIS-TRIFLUORMETHYL-BENZYL)-(5-ETHYL-PYRIMIDIN-2-YL)-AMINOÜ-PROPOXYü-PHENYL)-ESSIGSÄURE UND VERWANDTE VERBINDUNGEN ALS MODULATOREN VON PPARS UND VERFAHREN ZUR BEHANDLUNG VON STOFFWECHSELSTÖRUNGEN
DE60310767D1 (de)	2007-02-08	PYRAZOL-3,4-d-PYRIMIDINDERIVATE UND IHRE VERWENDUNG BEI DER BEHANDLUNG VON H.PYLORI-INFEKTIONEN
ATE469882T1 (de)	2010-06-15	Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen
DE60220385D1 (de)	2007-07-12	Benzimidazole zur behandlung sexueller fehlfunktionen
DE60333211D1 (de)	2010-08-12	Neue verbindungen und deren verwendung als ppar-modulatoren
ATE422201T1 (de)	2009-02-15	4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen
ATE432278T1 (de)	2009-06-15	Verbindungen zur behandlung von krankheiten
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