ATE469891T1 - Sauerstoffhaltige heterocyclen als glycintransporterinhibierende verbindungen - Google Patents

Sauerstoffhaltige heterocyclen als glycintransporterinhibierende verbindungen

Info

Publication number
ATE469891T1
ATE469891T1 AT05820756T AT05820756T ATE469891T1 AT E469891 T1 ATE469891 T1 AT E469891T1 AT 05820756 T AT05820756 T AT 05820756T AT 05820756 T AT05820756 T AT 05820756T AT E469891 T1 ATE469891 T1 AT E469891T1
Authority
AT
Austria
Prior art keywords
oxygen
inhibiting compounds
containing heterocycles
glycine transporter
compounds
Prior art date
Application number
AT05820756T
Other languages
English (en)
Inventor
Andrea Bozzoli
Clive Leslie Branch
Jacqueline Anne Macritchie
Howard Robert Marshall
Roderick Alan Porter
Simone Spada
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE469891T1 publication Critical patent/ATE469891T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
AT05820756T 2004-12-23 2005-12-21 Sauerstoffhaltige heterocyclen als glycintransporterinhibierende verbindungen ATE469891T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0428232.3A GB0428232D0 (en) 2004-12-23 2004-12-23 Compounds
PCT/GB2005/004969 WO2006067437A1 (en) 2004-12-23 2005-12-21 Oxygen containing heterocycles as glycine transporter inhibiting compounds

Publications (1)

Publication Number Publication Date
ATE469891T1 true ATE469891T1 (de) 2010-06-15

Family

ID=34113167

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05820756T ATE469891T1 (de) 2004-12-23 2005-12-21 Sauerstoffhaltige heterocyclen als glycintransporterinhibierende verbindungen

Country Status (7)

Country Link
US (1) US20100137428A1 (de)
EP (1) EP1833811B1 (de)
JP (1) JP2008525403A (de)
AT (1) ATE469891T1 (de)
DE (1) DE602005021698D1 (de)
GB (1) GB0428232D0 (de)
WO (1) WO2006067437A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0428233D0 (en) * 2004-12-23 2005-01-26 Glaxo Group Ltd Compounds
PE20061330A1 (es) * 2004-12-23 2006-12-27 Glaxo Group Ltd Compuestos derivados de benzamida como inhibidores del transportador de glicina
JP2008525398A (ja) * 2004-12-23 2008-07-17 グラクソ グループ リミテッド グリシン輸送阻害剤
GB0600427D0 (en) * 2006-01-10 2006-02-15 Glaxo Group Ltd Compounds
WO2010020548A1 (en) * 2008-08-20 2010-02-25 F. Hoffmann-La Roche Ag Glyt1 receptor antagonists
WO2011153359A1 (en) 2010-06-04 2011-12-08 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
WO2014097140A1 (en) * 2012-12-18 2014-06-26 Actelion Pharmaceuticals Ltd Indole carboxamide derivatives as p2x7 receptor antagonists
US12492178B2 (en) 2021-09-01 2025-12-09 Empathbio, Inc. Stable polymorph of R-MDMA HCl
WO2023034510A1 (en) 2021-09-01 2023-03-09 ATAI Life Sciences AG Synthesis of mdma or its optically active ( r)- or ( s)-mdma isomers
US11845736B2 (en) 2021-10-01 2023-12-19 Empathbio, Inc. Prodrugs of MDMA, MDA, and derivatives thereof
US11912680B2 (en) 2021-12-28 2024-02-27 Empathbio, Inc. Nitric oxide releasing prodrugs of MDA and MDMA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2746959A (en) * 1953-06-02 1956-05-22 American Home Prod Diphenylethylenediamine-penicillin salt
US6121261A (en) * 1997-11-19 2000-09-19 Merck & Co., Inc. Method for treating attention deficit disorder
GB0130696D0 (en) * 2001-12-21 2002-02-06 Smithkline Beecham Plc Chemical Compounds

Also Published As

Publication number Publication date
DE602005021698D1 (de) 2010-07-15
WO2006067437A1 (en) 2006-06-29
EP1833811B1 (de) 2010-06-02
EP1833811A1 (de) 2007-09-19
US20100137428A1 (en) 2010-06-03
GB0428232D0 (en) 2005-01-26
JP2008525403A (ja) 2008-07-17

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Legal Events

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