ATE543803T1 - 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren - Google Patents

3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren

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Publication number
ATE543803T1
ATE543803T1 AT05825102T AT05825102T ATE543803T1 AT E543803 T1 ATE543803 T1 AT E543803T1 AT 05825102 T AT05825102 T AT 05825102T AT 05825102 T AT05825102 T AT 05825102T AT E543803 T1 ATE543803 T1 AT E543803T1
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AT
Austria
Prior art keywords
azylamino
acetylaminoü
oxo
pyridine
acid derivatives
Prior art date
Application number
AT05825102T
Other languages
English (en)
Inventor
Jean-Damien Charrier
Ronald Knegtel
Michael Mortimore
John Studley
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE543803T1 publication Critical patent/ATE543803T1/de

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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AT05825102T 2004-11-24 2005-11-21 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren ATE543803T1 (de)

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PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
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MX2007014114A (es) 2005-05-10 2008-03-14 Intermune Inc Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
DK2794597T3 (en) 2011-12-21 2018-01-15 Ono Pharmaceutical Co PYRIDINON AND PYRIMIDINON DERIVATIVES AS FACTOR XIA INHIBITORS
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones
EP3814327A1 (de) 2018-06-29 2021-05-05 Histogen, Inc. (s)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorphenoxy)pentansäure-derivate und verwandte verbindungen als caspase-inhibitoren zur behandlung kardiovaskulärer erkrankungen
WO2023215559A1 (en) * 2022-05-05 2023-11-09 Aria Pharmaceuticals, Inc. Compounds, compositions, and methods

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RU2412936C2 (ru) 2011-02-27
EP1833794A1 (de) 2007-09-19
WO2006057961A1 (en) 2006-06-01
NZ555565A (en) 2008-11-28
JP2008521809A (ja) 2008-06-26
KR20070086610A (ko) 2007-08-27
IL183373A0 (en) 2007-09-20
MX2007006258A (es) 2007-07-20
CN101098855A (zh) 2008-01-02
RU2007123615A (ru) 2008-12-27
CN101098855B (zh) 2012-06-06
JP5055129B2 (ja) 2012-10-24
CA2588713A1 (en) 2006-06-01
AU2005309776A1 (en) 2006-06-01
NO20073170L (no) 2007-06-22
AU2005309776B2 (en) 2011-12-22
ES2380632T3 (es) 2012-05-17
US20060160862A1 (en) 2006-07-20
ZA200704913B (en) 2008-09-25
EP1833794B1 (de) 2012-02-01
JP2009108067A (ja) 2009-05-21
US8362043B2 (en) 2013-01-29

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