ATE469963T1 - Identifizierung der virulenz-assoziierten regionen rd1 und rd5, die die entwicklung von verbesserten impfstoffen mit m. bovis bcg und m. microti ermöglicht - Google Patents

Identifizierung der virulenz-assoziierten regionen rd1 und rd5, die die entwicklung von verbesserten impfstoffen mit m. bovis bcg und m. microti ermöglicht

Info

Publication number
ATE469963T1
ATE469963T1 AT02290864T AT02290864T ATE469963T1 AT E469963 T1 ATE469963 T1 AT E469963T1 AT 02290864 T AT02290864 T AT 02290864T AT 02290864 T AT02290864 T AT 02290864T AT E469963 T1 ATE469963 T1 AT E469963T1
Authority
AT
Austria
Prior art keywords
microti
bovis bcg
strains
virulence
identification
Prior art date
Application number
AT02290864T
Other languages
English (en)
Inventor
Stewart Cole
Alexander S Pym
Roland Brosch
Priscille Brodin
Laleh Majlessi
Claude Leclerc
Original Assignee
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut filed Critical Pasteur Institut
Application granted granted Critical
Publication of ATE469963T1 publication Critical patent/ATE469963T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
AT02290864T 2002-04-05 2002-04-05 Identifizierung der virulenz-assoziierten regionen rd1 und rd5, die die entwicklung von verbesserten impfstoffen mit m. bovis bcg und m. microti ermöglicht ATE469963T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02290864A EP1350839B1 (de) 2002-04-05 2002-04-05 Identifizierung der Virulenz-assoziierten Regionen RD1 und RD5, die die Entwicklung von verbesserten Impfstoffen mit M. bovis BCG und M. microti ermöglicht

Publications (1)

Publication Number Publication Date
ATE469963T1 true ATE469963T1 (de) 2010-06-15

Family

ID=27838170

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02290864T ATE469963T1 (de) 2002-04-05 2002-04-05 Identifizierung der virulenz-assoziierten regionen rd1 und rd5, die die entwicklung von verbesserten impfstoffen mit m. bovis bcg und m. microti ermöglicht
AT07122295T ATE535600T1 (de) 2002-04-05 2002-04-05 Identifizierung der virulenz-assoziierten region rd1, die die entwicklung von verbesserten impstoffen mit m. microti ermöglicht

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT07122295T ATE535600T1 (de) 2002-04-05 2002-04-05 Identifizierung der virulenz-assoziierten region rd1, die die entwicklung von verbesserten impstoffen mit m. microti ermöglicht

Country Status (11)

Country Link
US (2) US7883712B2 (de)
EP (4) EP1914299B9 (de)
AT (2) ATE469963T1 (de)
AU (1) AU2003223039A1 (de)
CA (1) CA2481318C (de)
CY (1) CY1110764T1 (de)
DE (1) DE60236573D1 (de)
DK (1) DK1350839T3 (de)
ES (1) ES2346043T3 (de)
PT (1) PT1350839E (de)
WO (1) WO2003085098A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20040091A1 (it) 2004-02-19 2004-05-19 Istituto Naz Per Le Malattie Test immunologico rapido per la diagnosi ed il monitoraggio dell'infezione tubercolare.
GB0406271D0 (en) 2004-03-19 2004-04-21 Isis Innovation Diagnostic test
WO2006117538A2 (en) * 2005-04-29 2006-11-09 Fusion Antibodies Limited Assays for diagnosis of tuberculosis and uses thereof
US8398991B2 (en) * 2005-06-22 2013-03-19 Institut Pasteur Modified ESAT-6 molecules and improved vaccine strains of Mycobacterium bovis BCG
GB0618127D0 (en) * 2006-09-14 2006-10-25 Isis Innovation Biomarker
WO2008140598A2 (en) * 2006-12-04 2008-11-20 Bacilligen, Inc. Novel immunotherapeutic mycobacteria, pharmaceutic formulations and uses thereof
EP2421557B1 (de) * 2009-04-24 2018-12-05 Statens Serum Institut Tuberkulose-tb-impstoff zur reaktivierungsverhinderung
US8367055B2 (en) 2009-05-14 2013-02-05 Wisconsin Alumni Research Foundation Immunogenic compositions against tuberculosis
TR201101874A2 (tr) * 2011-02-25 2011-08-22 Leyla A�An Nac�Ye Yüzeyel mesane tümorü tedavisinde kullanılabilecek mycobacterıum(mikobakteri) brumae hücre duvarı ekstreleri.
GR20120100415A (el) * 2012-08-08 2014-03-17 Νικολαος Χρηστου Πουλακης Μεθοδος αμεσης ανιχνευσης του μυκοβακτηριδιου της φυματιωσης
EP2912056B1 (de) * 2012-10-23 2020-02-12 Statens Serum Institut M.- tuberkulose-impfstoffe
US10010597B2 (en) 2014-06-03 2018-07-03 Institut Pasteur Recombinant Mycobacterium bovis BCG expressing antigens of the Mycobacterium marinum ESX-1 secretion system
CN104628834B (zh) * 2015-01-23 2016-03-23 中国疾病预防控制中心传染病预防控制所 一种结核感染t细胞免疫检测抗原及其应用
CN104678097B (zh) * 2015-03-10 2017-04-05 中国人民解放军军事医学科学院基础医学研究所 一种用于肺结核诊断的结核分枝杆菌组合抗原
CN109406776B (zh) * 2017-08-18 2022-02-11 中国科学院生物物理研究所 用于特异性检测结核分枝杆菌感染的蛋白Rv2818c
CN109406777B (zh) * 2017-08-18 2022-02-18 中国科学院生物物理研究所 用于特异性检测结核分枝杆菌感染的蛋白Rv2824c
EP3643399B1 (de) 2018-10-25 2022-04-27 Heraeus Medical GmbH Vorrichtung und verfahren zum bereitstellen von knochenzement
DE102018131266B4 (de) 2018-12-07 2021-12-23 Heraeus Medical Gmbh Vorrichtung zum Mischen eines Knochenzements mit Hohlraum zum Monomertransfer und Verfahren zur Herstellung eines Knochenzementteigs
DE102018131268B4 (de) 2018-12-07 2021-11-25 Heraeus Medical Gmbh Vorrichtung zum Mischen eines Knochenzements mit Hohlraum zum Monomertransfer
CN110763843B (zh) * 2019-11-06 2020-09-15 华中农业大学 一种牛支原体双抗夹心elisa检测试剂盒及其应用
CN116173213A (zh) * 2023-01-16 2023-05-30 武汉大学 Rv1977在制备抗结核分枝杆菌感染药物中的应用
CN120966730B (zh) * 2025-10-21 2026-04-03 华南理工大学 一种基因改造牛分枝杆菌减毒菌株及其构建方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096879A (en) 1978-12-18 2000-08-01 Institut Pasteur Nucleotide sequence comprising the genome of hepatitis B virus, nucleotide sequence coding the surface antigen of the hepatitis B virus, vectors containing the nucleotide sequences, process for the preparation thereof, and antigen obtained thereby
EP0038765B1 (de) 1980-04-22 1987-09-02 Institut Pasteur Impfstoff gegen Hepatitis B Virus, Verfahren und transformierte eukaryotische Zellen zur Herstellung dieses Impfstoffes
EP0387915B1 (de) 1984-10-18 1993-03-10 Institut Pasteur F Antigene vom menschlichen Immunodefizienz-Virus und deren Verwendungen
FR2682122B1 (fr) 1991-10-03 1995-06-09 Pasteur Institut Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.
FR2735478B1 (fr) 1995-06-13 1997-08-22 Pasteur Institut Molecules polypeptidiques de stade pre-erythrocytaire du paludisme
FR2744724B1 (fr) 1996-02-14 2002-08-02 Pasteur Institut Proteine recombinante contenant un fragment c-terminal de la proteine msp-1 d'un plasmodium infectieux pour l'homme pour la production de vaccins anti-paludiques
WO1999004005A1 (en) * 1997-07-16 1999-01-28 Institut Pasteur A polynucleotide functionally coding for the lhp protein from mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same
AU749672B2 (en) * 1998-03-06 2002-07-04 Statens Serum Institut Production of mycobacterial polypeptides by lactic acid bacteria
US6294328B1 (en) * 1998-06-24 2001-09-25 The Institute For Genomic Research DNA sequences for strain analysis in Mycobacterium tuberculosis
WO2000066157A1 (en) * 1999-05-04 2000-11-09 The Public Health Research Institute Of The City Of New York, Inc. Proteins expressed by mycobacterium tuberculosis and not by bcg and their use as diagnostic reagents and vaccines
ES2286212T3 (es) 2002-02-25 2007-12-01 Pasteur Institut Secuencias suprimidas especificamente del genoma de mycobacterium tuberculosis, y su uso en el diagnostico y como vacunas.

Also Published As

Publication number Publication date
WO2003085098A2 (en) 2003-10-16
EP1914299B9 (de) 2012-05-02
AU2003223039A1 (en) 2003-10-20
US20050220811A1 (en) 2005-10-06
AU2003223039A8 (en) 2003-10-20
EP1914299A2 (de) 2008-04-23
DK1350839T3 (da) 2010-07-12
CA2481318A1 (en) 2003-10-16
ES2346043T3 (es) 2010-10-08
HK1059803A1 (en) 2004-07-16
PT1350839E (pt) 2010-08-12
US8747866B2 (en) 2014-06-10
EP1492867A2 (de) 2005-01-05
US7883712B2 (en) 2011-02-08
CY1110764T1 (el) 2015-06-10
EP2302033A3 (de) 2012-03-07
CA2481318C (en) 2014-06-10
EP1914299A3 (de) 2008-05-21
EP1350839A1 (de) 2003-10-08
EP1914299B1 (de) 2011-11-30
EP2302033A2 (de) 2011-03-30
US20120189662A1 (en) 2012-07-26
DE60236573D1 (de) 2010-07-15
WO2003085098A3 (en) 2004-01-29
ATE535600T1 (de) 2011-12-15
EP1350839B1 (de) 2010-06-02

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