ATE470668T1 - Pyrazolopyrimidine als inhibitoren von cyclinabhängiger kinase zur behandlung von krebs - Google Patents

Pyrazolopyrimidine als inhibitoren von cyclinabhängiger kinase zur behandlung von krebs

Info

Publication number: ATE470668T1
Authority: AT; Austria
Prior art keywords: compounds; treatment; cyclin; pyrazolopyrimidines; cancer
Prior art date: 2005-10-06

Application number

AT06816244T

Other languages

English (en)

Inventor

Timothy Guzi

Kamil Paruch

Michael Dwyer

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-06

Filing date

2006-10-04

Publication date

2010-06-15

2006-10-04 Application filed by Schering Corp filed Critical Schering Corp

2010-06-15 Application granted granted Critical

2010-06-15 Publication of ATE470668T1 publication Critical patent/ATE470668T1/de

Links

206010028980 Neoplasm Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
239000002875 cyclin dependent kinase inhibitor Substances 0.000 title 1
229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
238000000034 method Methods 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 3
108091007914 CDKs Proteins 0.000 abstract 2
102000003903 Cyclin-dependent kinases Human genes 0.000 abstract 1
108090000266 Cyclin-dependent kinases Proteins 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT06816244T 2005-10-06 2006-10-04 Pyrazolopyrimidine als inhibitoren von cyclinabhängiger kinase zur behandlung von krebs ATE470668T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11/244,772 US7205308B2 (en)	2002-09-04	2005-10-06	Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
PCT/US2006/038838 WO2007044420A1 (en)	2005-10-06	2006-10-04	Pyrazolopyrimidines as cyclin dependent kinase inhibitors for the treatment of cancer

Publications (1)

Publication Number	Publication Date
ATE470668T1 true ATE470668T1 (de)	2010-06-15

Family

ID=37708298

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06816244T ATE470668T1 (de)	2005-10-06	2006-10-04	Pyrazolopyrimidine als inhibitoren von cyclinabhängiger kinase zur behandlung von krebs

Country Status (9)

Country	Link
US (1)	US7205308B2 (de)
EP (1)	EP1934224B1 (de)
JP (1)	JP2009511483A (de)
CN (1)	CN101321757A (de)
AT (1)	ATE470668T1 (de)
CA (1)	CA2624822A1 (de)
DE (1)	DE602006014848D1 (de)
ES (1)	ES2345631T3 (de)
WO (1)	WO2007044420A1 (de)

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EP2970288A1 (de)	2013-03-15	2016-01-20	Vertex Pharmaceuticals Incorporated	Als atr-kinaseinhibitoren nützliche verbindungen
WO2014143240A1 (en)	2013-03-15	2014-09-18	Vertex Pharmaceuticals Incorporated	Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
US8957078B2 (en)	2013-03-15	2015-02-17	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of ATR kinase
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EP3057956B1 (de)	2013-10-18	2021-05-05	Dana-Farber Cancer Institute, Inc.	Polycyclische inhibitoren der cyclin-dependent-kinase 7 (cdk7)
PT3077397T (pt)	2013-12-06	2020-01-22	Vertex Pharma	Composto de 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-carboxamida útil como inibidor da atr quinase, a sua preparação, diferentes formas sólidas e derivados radiomarcados do mesmo
MX373102B (es)	2014-06-05	2020-04-17	Vertex Pharma	Derivados radiomarcados de un compuesto de 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útil como inhibidor de ataxia telangiectasia mutada y rad3 relacionado (atr) cinasa, preparación de tal compuesto y diferentes formas sólidas del mismo.
SG11201610500WA (en)	2014-06-17	2017-01-27	Vertex Pharma	Method for treating cancer using a combination of chk1 and atr inhibitors
JP6854762B2 (ja)	2014-12-23	2021-04-07	ダナ−ファーバーキャンサーインスティテュート，インコーポレイテッド	サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤
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SI3658557T1 (sl) *	2017-07-28	2024-10-30	Takeda Pharmaceutical Company Limited	Zaviralci TYK2 in njihova uporaba
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WO2019222509A1 (en) *	2018-05-16	2019-11-21	The University Of North Carolina At Chapel Hill	Pyrazolopyrimidines as mertk inhibitors and their application in cancer treatment
EP3810132A4 (de)	2018-06-25	2022-06-22	Dana-Farber Cancer Institute, Inc.	Kinaseinhibitoren der taire und ihre verwendungen
CN113271940A (zh) *	2018-10-15	2021-08-17	林伯士拉克许米公司	Tyk2抑制剂和其用途
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CN113677341B (zh) *	2019-02-01	2024-07-05	南卡罗莱纳大学	双环吡啶组合物及其用于癌症治疗的方法
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2005
- 2005-10-06 US US11/244,772 patent/US7205308B2/en not_active Expired - Lifetime
2006
- 2006-10-04 DE DE602006014848T patent/DE602006014848D1/de active Active
- 2006-10-04 CA CA002624822A patent/CA2624822A1/en not_active Abandoned
- 2006-10-04 JP JP2008534663A patent/JP2009511483A/ja not_active Ceased
- 2006-10-04 AT AT06816244T patent/ATE470668T1/de not_active IP Right Cessation
- 2006-10-04 EP EP06816244A patent/EP1934224B1/de active Active
- 2006-10-04 ES ES06816244T patent/ES2345631T3/es active Active
- 2006-10-04 WO PCT/US2006/038838 patent/WO2007044420A1/en not_active Ceased
- 2006-10-04 CN CNA2006800454027A patent/CN101321757A/zh active Pending

Also Published As

Publication number	Publication date
US7205308B2 (en)	2007-04-17
HK1112233A1 (en)	2008-08-29
US20060041131A1 (en)	2006-02-23
CN101321757A (zh)	2008-12-10
DE602006014848D1 (de)	2010-07-22
JP2009511483A (ja)	2009-03-19
ES2345631T3 (es)	2010-09-28
EP1934224A1 (de)	2008-06-25
EP1934224B1 (de)	2010-06-09
CA2624822A1 (en)	2007-04-19
WO2007044420A1 (en)	2007-04-19

Legal Events

Date	Code	Title	Description
2010-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE470668T1 (de)	2010-06-15	Pyrazolopyrimidine als inhibitoren von cyclinabhängiger kinase zur behandlung von krebs
BRPI0314001B8 (pt)	2021-05-25	pirazolopirimidinas como inibidores de cinase dependente de ciclina e composição farmacêutica compreendendo as mesmas
MX2009011355A (es)	2009-11-05	Nuevas pirazolopirimidinas como inhibidores de quinasas dependientes de ciclinas.
WO2007044449A3 (en)	2007-05-24	Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
MY149044A (en)	2013-07-15	Pyrazolopyrimidines - derivatives as cyclin dependent kinase inhibitors
MX2009003733A (es)	2009-04-22	Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina.
WO2007044401A3 (en)	2007-06-07	Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
TW200745123A (en)	2007-12-16	Pyrazolopyrimidines as protein kinase inhibitors
MY137843A (en)	2009-03-31	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
MY137888A (en)	2009-03-31	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
TW200745128A (en)	2007-12-16	Pyrazolopyrimidines as protein kinase inhibitors
WO2008045267A3 (en)	2008-07-31	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
MY139336A (en)	2009-09-30	N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
MX2009003734A (es)	2009-06-11	Pirazolopirimidinas como inhibidor de cinasas dependientes de ciclina.
WO2007058873A3 (en)	2007-07-19	Imidazopyrazines as cyclin depentend kinase inhibitors
MY134589A (en)	2007-12-31	Imidazopyrazines as cyclin dependent kinase inhibitors
TW200745127A (en)	2007-12-16	Pyrazolopyrimidines as protein kinase inhibitors
WO2004026310A8 (en)	2005-06-30	Novel imidazopyrazines as cyclin dependent kinase inhibitors
MY133311A (en)	2007-11-30	Novel imidazopyridines as cyclin dependent kinase inhibitors
WO2007032936A3 (en)	2007-05-03	Azafused cyclin dependent kinase inhibitors
MY136840A (en)	2008-11-28	Pyrazolopyridines as cyclin dependent kinase inhibitors
CY1110666T1 (el)	2015-06-11	Πυραζολοπυριμιδινες καταλληλες για θεραπεια καρκινικων νοσων
ECSP066763A (es)	2006-11-16	Pirazolopirimidinas novedosas como inhibidores de quinasa ciclina-dependientes
TH148526B (th)	2016-04-07	ไพราโซโลไพริมิดีนชนิดใหม่ (Novel pyrazolopyrimidines) ล่าสุดในฐานะตัวยับยั้งไซคลินดีเพนเดนท์คิเนส (Cyclin dependent kinase inhibitors)