ATE472099T1 - Multiplex-fluoreszenzdetektionsvorrichtung mit entfernbaren optischen modulen - Google Patents

Multiplex-fluoreszenzdetektionsvorrichtung mit entfernbaren optischen modulen

Info

Publication number
ATE472099T1
ATE472099T1 AT06748651T AT06748651T ATE472099T1 AT E472099 T1 ATE472099 T1 AT E472099T1 AT 06748651 T AT06748651 T AT 06748651T AT 06748651 T AT06748651 T AT 06748651T AT E472099 T1 ATE472099 T1 AT E472099T1
Authority
AT
Austria
Prior art keywords
optical modules
removable optical
species
detection device
fluorescent light
Prior art date
Application number
AT06748651T
Other languages
English (en)
Inventor
William Bedingham
Peter D Ludowise
Barry W Robole
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Application granted granted Critical
Publication of ATE472099T1 publication Critical patent/ATE472099T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/173—Nucleic acid detection characterized by the use of physical, structural and functional properties staining/intercalating agent, e.g. ethidium bromide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/02—Mechanical
    • G01N2201/024—Modular construction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT06748651T 2005-04-01 2006-03-24 Multiplex-fluoreszenzdetektionsvorrichtung mit entfernbaren optischen modulen ATE472099T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66746105P 2005-04-01 2005-04-01
US11/174,754 US7507575B2 (en) 2005-04-01 2005-07-05 Multiplex fluorescence detection device having removable optical modules
PCT/US2006/010787 WO2006107619A1 (en) 2005-04-01 2006-03-24 Multiplex fluorescence detection device having removable optical modules

Publications (1)

Publication Number Publication Date
ATE472099T1 true ATE472099T1 (de) 2010-07-15

Family

ID=36591356

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06748651T ATE472099T1 (de) 2005-04-01 2006-03-24 Multiplex-fluoreszenzdetektionsvorrichtung mit entfernbaren optischen modulen

Country Status (12)

Country Link
US (2) US7507575B2 (de)
EP (2) EP2207026A1 (de)
JP (1) JP5021614B2 (de)
KR (1) KR101265362B1 (de)
AT (1) ATE472099T1 (de)
AU (1) AU2006232922A1 (de)
BR (1) BRPI0609544B8 (de)
CA (1) CA2602587A1 (de)
DE (1) DE602006015043D1 (de)
ES (1) ES2347077T3 (de)
MX (1) MX2007012159A (de)
WO (1) WO2006107619A1 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
JP4996248B2 (ja) 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド 粒子含有サンプルの処理
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US7507575B2 (en) * 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7709249B2 (en) * 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
US20070009382A1 (en) * 2005-07-05 2007-01-11 William Bedingham Heating element for a rotating multiplex fluorescence detection device
US7527763B2 (en) * 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2007112114A2 (en) 2006-03-24 2007-10-04 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
CA2722484A1 (en) * 2008-04-24 2009-10-29 Peter D. Ludowise Analysis of nucleic acid amplification curves using wavelet transformation
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
GB0817991D0 (en) * 2008-10-02 2008-11-05 Enigma Diagnostics Ltd Fluorescence based detection methods and apparatus
US10434514B2 (en) * 2008-12-05 2019-10-08 Biocartis S.A. Thermal cycling system comprising transport heater
JP5279481B2 (ja) 2008-12-25 2013-09-04 株式会社日立ハイテクノロジーズ 核酸分析装置
WO2010086622A1 (en) 2009-01-30 2010-08-05 Oxford Nanopore Technologies Limited Adaptors for nucleic acid constructs in transmembrane sequencing
JP2012524242A (ja) * 2009-04-15 2012-10-11 ビオカルティ ソシエテ アノニム Ｐｃｒ反応をリアルタイムで監視するための光検出システム
EP2277624A3 (de) * 2009-07-20 2013-12-18 Samsung Electronics Co., Ltd. Scheibenartige mikrofluidische Vorrichtung und Bluttestgerät, das sie verwendet
EP3375890B1 (de) * 2009-09-10 2020-01-22 DiaSorin S.p.A. Verfahren und vorrichtungen zur bestimmung einer übersprechkorrection bei der nukleinsäureamplifikation
CA2781581C (en) 2009-12-01 2018-03-06 Oxford Nanopore Technologies Limited Biochemical analysis instrument
BR112012021202B1 (pt) * 2010-02-23 2020-06-09 Genturadx Usa Inc aparelho e métodos para preparação, reação e detecção integradas de amostras
US8729502B1 (en) 2010-10-28 2014-05-20 The Research Foundation For The State University Of New York Simultaneous, single-detector fluorescence detection of multiple analytes with frequency-specific lock-in detection
CN102175612B (zh) * 2011-01-18 2012-12-26 河北工业大学 一种多路光电检测装置
US9096892B1 (en) 2011-02-04 2015-08-04 K2 Biomicrosystems, LLC Nucleic acid amplification and monitoring apparatus
CA2827614C (en) 2011-03-08 2019-07-02 Universite Laval Fluidic centripetal device
AU2012242510B2 (en) 2011-04-15 2015-05-14 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
EP3081301B1 (de) 2011-05-04 2019-08-14 Luminex Corporation Vorrichtung und verfahren für integrierte probenzubereitung, - reaktion und -erkennung
KR101992503B1 (ko) 2011-05-18 2019-06-24 디아소린 에스.피.에이. 샘플 처리 장치에서 선택된 부피의 물질의 존재를 검출하기 위한 시스템 및 방법
US9067205B2 (en) 2011-05-18 2015-06-30 3M Innovative Properties Company Systems and methods for valving on a sample processing device
KR20140022399A (ko) 2011-05-18 2014-02-24 쓰리엠 이노베이티브 프로퍼티즈 컴파니 샘플 처리 장치 상의 체적 계량을 위한 시스템 및 방법
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
BR112014001699A2 (pt) 2011-07-25 2017-06-13 Oxford Nanopore Tech Ltd método para sequenciar de um polinucleotídeo alvo de filamento duplo, kit, métodos para preparar um polinucleotídeo alvo de filamento duplo para sequenciamento e para sequenciar um polinucleotídeo alvo de filamento duplo, e, aparelho
JP6117217B2 (ja) 2011-09-30 2017-04-19 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ ユニット化された試薬ストリップ
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
CN104093853B (zh) 2011-09-30 2016-06-01 生命技术公司 用于可视化和评估数据的方法和系统
EP2773892B1 (de) 2011-11-04 2020-10-07 Handylab, Inc. Vorrichtung zur vorbereitung von polynukleotidproben
BR112014019168B1 (pt) 2012-02-03 2021-10-05 California Institute Of Technology Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos
ES2978107T3 (es) 2012-02-03 2024-09-05 Becton Dickinson Co Archivos externos para distribución de pruebas de diagnóstico molecular y determinación de compatibilidad entre pruebas
CN204832037U (zh) 2012-04-03 2015-12-02 伊鲁米那股份有限公司 检测设备
BR112014026197B1 (pt) * 2012-04-23 2020-10-13 Siemens Healthcare Diagnostics Inc. analisador de amostra e método para analisar uma amostra de ensaio
EP2875154B1 (de) 2012-07-19 2017-08-23 Oxford Nanopore Technologies Limited SSB-Verfahren zur Charakterisierung einer Nukleinsäure
CN104662172B (zh) * 2012-08-03 2018-07-06 加州理工学院 Pcr中具有减少的硬件和要求的多重化和定量
US9932632B2 (en) 2012-08-10 2018-04-03 Streck, Inc. Real-time optical system for polymerase chain reaction
CN103364378B (zh) * 2013-03-05 2016-04-20 江苏天瑞仪器股份有限公司 一种用于原子荧光光谱仪的多功能联合进样系统
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
AU2014224432B2 (en) 2013-03-08 2019-10-24 Oxford Nanopore Technologies Limited Enzyme stalling method
US8858886B1 (en) 2013-05-08 2014-10-14 Agilent Technologies, Inc. Scanning system with interchangeable optical cartridges for fluorescence measurements
EP3495803A1 (de) 2013-06-28 2019-06-12 Streck, Inc. Vorrichtungen für echtzeit-polymerasekettenreaktionen
DE102013012609B4 (de) * 2013-07-26 2024-06-27 Carl Zeiss Microscopy Gmbh Optoelektronischer Detektor, insbesondere für hochauflösende Lichtrastermikroskope und Lichtrastermikroskop
KR102043320B1 (ko) * 2013-08-08 2019-11-11 일루미나, 인코포레이티드 플로우 셀로의 시약 전달을 위한 유체 시스템
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
US20180268358A1 (en) * 2015-01-09 2018-09-20 Apex Industrial Technologies Llc Order fulfillment system and method with item sensor
WO2016160996A1 (en) * 2015-03-30 2016-10-06 DeNovix, Inc. Apparatus and method for measuring fluorescence of a sample
US10209242B2 (en) 2015-05-21 2019-02-19 Emit Imaging, Inc. Fluorescence histo-tomography (FHT) systems and methods
KR20180048586A (ko) * 2015-08-31 2018-05-10 인비크로, 엘엘씨 형광 조직-단층촬영(fht) 시스템 및 방법
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
US10272510B2 (en) * 2016-01-14 2019-04-30 United Technologies Corporation Electrical discharge machining apparatus
JP6687834B2 (ja) * 2016-02-03 2020-04-28 株式会社Ｊｖｃケンウッド 分析装置及び分析方法
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
KR101904506B1 (ko) * 2016-05-25 2018-10-05 (주)옵토레인 피씨알모듈
KR101972579B1 (ko) * 2016-05-25 2019-08-23 (주)옵토레인 피씨알모듈 및 이를 이용한 검사방법
CN106198480B (zh) * 2016-08-30 2018-09-14 广州蓝勃生物科技有限公司 一种自动干式荧光检测仪
CN106290286A (zh) * 2016-09-20 2017-01-04 广东顺德工业设计研究院(广东顺德创新设计研究院) 时间分辨荧光分析系统及检测装置
GB201704771D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Modular optical analytic systems and methods
US10431441B2 (en) * 2018-01-31 2019-10-01 Palodex Group Oy Reducing calibration of components in an imaging plate scanner
CN112424377A (zh) 2018-04-17 2021-02-26 克罗玛科德公司 用于多重分析的方法和系统
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method
US12203129B2 (en) 2018-07-03 2025-01-21 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
CN110656046A (zh) * 2019-11-01 2020-01-07 中国人民解放军军事科学院军事医学研究院 一种探测装置及pcr仪
CN112823890B (zh) * 2020-07-30 2024-07-19 北京金诺美科技股份有限公司 一种实时荧光定量pcr仪
CN112798773A (zh) * 2020-12-27 2021-05-14 北京工业大学 一种基于stm32单片机的高分辨率酶标仪电控系统
US12461029B2 (en) * 2021-03-10 2025-11-04 Northeastern University Continuous flow air sampling and rapid pathogen detection system
EP4419893A4 (de) * 2021-10-20 2025-08-06 Bio Rad Laboratories Inc Fluoreszenz-nachweissystem

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2055944A1 (de) 1970-11-13 1972-05-18 Leitz Ernst Gmbh Fluoreszenzauflichtilluminator
US3918793A (en) * 1970-05-02 1975-11-11 Leitz Ernst Gmbh Fluorescence illuminator for incident light microscope
DE2420545C3 (de) 1974-04-27 1979-01-25 H. Maihak Ag, 2000 Hamburg Infrarotstrahleranordnung
JPS55156840A (en) 1979-05-25 1980-12-06 Olympus Optical Co Ltd Specimen detector
JPS6120839A (ja) 1984-07-10 1986-01-29 Fuji Photo Film Co Ltd バクテリアカウンタ
US4726676A (en) * 1986-02-06 1988-02-23 General Signal Corporation Optical signal power measurement method and apparatus
US4927766A (en) 1986-05-27 1990-05-22 The Boc Group, Inc. Gas constituent measurement and recording
US4909990A (en) 1987-09-02 1990-03-20 Myron J. Block Immunoassay apparatus
GB8919700D0 (en) 1989-08-31 1989-10-11 Electricity Council Infra-red radiation emission arrangement
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5296958A (en) * 1992-05-29 1994-03-22 Eastman Kodak Company Multiple wavelength laser beam scanning system
AU668951B2 (en) 1992-07-17 1996-05-23 Becton Dickinson & Company Method and apparatus for detecting bacterial growth by spectrophotometric sampling of a fiber-optic array
JPH0634546A (ja) 1992-07-17 1994-02-08 Tosoh Corp 蛍光検出器
US5414600A (en) 1993-07-30 1995-05-09 Cogent Light Technologies, Inc. Condensing and collecting optical system using an ellipsoidal reflector
EP0706649B1 (de) 1994-04-29 2001-01-03 Perkin-Elmer Corporation Verfahren und vorrichtung zur echtzeiterfassung der produkte von nukleinsäureamplifikation
US5766889A (en) 1994-06-08 1998-06-16 The Perkin-Elmer Corporation Method for determining the characteristics of the concentration growth of target nucleic acid molecules in polymerase chain reaction sample
US6327031B1 (en) 1998-09-18 2001-12-04 Burstein Technologies, Inc. Apparatus and semi-reflective optical system for carrying out analysis of samples
GB9418981D0 (en) 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5639668A (en) 1995-09-14 1997-06-17 Boehringer Mannheim Corporation Optical apparatus for performing an immunoassay
US6342349B1 (en) 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
US5751874A (en) * 1996-09-13 1998-05-12 Nuvisions International, Inc. Coupling device for linking optical fiber connectors
DE19707226A1 (de) * 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Lichtabtastvorrichtung
BR9808653A (pt) 1997-02-28 2001-07-31 Burstein Lab Inc Laboratório em um disco
EP0969452A4 (de) * 1997-03-25 2000-12-27 Sanyo Electric Co Gerät zur informationswiedergabe und -aufzeichnung sowie referenzmarkierungsdetektionsschaltung
WO1999013370A1 (de) * 1997-09-05 1999-03-18 Leica Microsystems Ag Mikroskop, insbesondere fluoreszenzmikroskop, insbesondere stereo-fluoreszenzmikroskop
US6597450B1 (en) 1997-09-15 2003-07-22 Becton, Dickinson And Company Automated Optical Reader for Nucleic Acid Assays
US6561428B2 (en) * 1997-10-17 2003-05-13 Hand Held Products, Inc. Imaging device having indicia-controlled image parsing mode
US5994150A (en) 1997-11-19 1999-11-30 Imation Corp. Optical assaying method and system having rotatable sensor disk with multiple sensing regions
CA2318180A1 (en) * 1998-01-26 1999-07-29 Massachusetts Institute Of Technology Fluorescence imaging endoscope
US6210882B1 (en) 1998-01-29 2001-04-03 Mayo Foundation For Medical Education And Reseach Rapid thermocycling for sample analysis
US6014618A (en) * 1998-08-06 2000-01-11 Dsp Software Engineering, Inc. LPAS speech coder using vector quantized, multi-codebook, multi-tap pitch predictor and optimized ternary source excitation codebook derivation
US6161946A (en) 1998-11-09 2000-12-19 Bishop; Christopher B. Light reflector
WO2000036151A1 (en) * 1998-12-14 2000-06-22 Li-Cor, Inc. A heterogeneous assay for pyrophosphate detection
JP3597729B2 (ja) * 1999-05-11 2004-12-08 日立ソフトウエアエンジニアリング株式会社 蛍光測光方法及び蛍光測光装置
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
EP1190232A1 (de) 1999-06-26 2002-03-27 Packard Instrument Company, Inc. Mikroplattenleser
US7088650B1 (en) * 1999-08-23 2006-08-08 Worthington Mark O Methods and apparatus for optical disc data acquisition using physical synchronization markers
CN1311436A (zh) * 2000-03-01 2001-09-05 上海和泰光电科技有限公司 旋转平台上的生物芯片荧光图象的读取
JP2001281587A (ja) * 2000-03-31 2001-10-10 Fuji Photo Optical Co Ltd 光走査装置用光源部の保持構造
US6795189B2 (en) 2000-06-15 2004-09-21 Packard Instrument Company Universal microplate analyzer
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6734401B2 (en) * 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6563581B1 (en) 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
FR2812306B1 (fr) 2000-07-28 2005-01-14 Gabriel Festoc Systeme d'amplification en chaine par polymerse de sequences nucleiques cibles
US6545758B1 (en) 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US6452879B1 (en) * 2000-09-29 2002-09-17 Fujitsu Limited Optical storage apparatus
AU2001296499A1 (en) 2000-10-04 2002-04-15 Cogent Light Technologies, Inc. Temperature control for arc lamps
SE0004296D0 (sv) 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
US20020172980A1 (en) * 2000-11-27 2002-11-21 Phan Brigitte Chau Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems
AU2002219979A1 (en) 2000-12-01 2002-06-11 Burstein Technologies, Inc. Apparatus and methods for separating components of particulate suspension
US20030077598A1 (en) * 2001-01-04 2003-04-24 Phan Brigitte Chau Dual bead assays including covalent linkages for improved specificity and related optical analysis discs
WO2002073605A2 (en) 2001-03-14 2002-09-19 Burstein Technologies, Inc. Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
US20030054563A1 (en) 2001-09-17 2003-03-20 Gyros Ab Detector arrangement for microfluidic devices
US6597832B2 (en) * 2001-12-07 2003-07-22 Yu-Feng Cheng Optical fiber selector
US6889468B2 (en) * 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
AU2003202951A1 (en) * 2002-01-14 2003-07-30 Burstein Technologies, Inc. Method and apparatus for visualizing data
WO2003065355A2 (en) 2002-01-31 2003-08-07 Burstein Technologies, Inc. Bio-safety features for optical analysis disc and disc system including same
US6767155B2 (en) * 2002-04-05 2004-07-27 Eastman Kodak Company High stability latch mechanism
JP4338529B2 (ja) 2002-04-08 2009-10-07 ユロス・パテント・アクチボラゲット ホーミングプロセス
US6833536B2 (en) 2002-05-22 2004-12-21 Applera Corporation Non-contact radiant heating and temperature sensing device for a chemical reaction chamber
JP2005526253A (ja) 2002-05-17 2005-09-02 アプレラ コーポレイション 励起波長による複数の蛍光シグナルを分化するための装置および方法
AU2003243268A1 (en) 2002-05-17 2003-12-02 Applera Corporation Optical instrument including excitation source
US20030219754A1 (en) 2002-05-23 2003-11-27 Oleksy Jerome E. Fluorescence polarization detection of nucleic acids
AUPS267802A0 (en) 2002-05-30 2002-06-20 Bio-Molecular Holdings Pty Limited Improved dna amplification apparatus and method
JP4193421B2 (ja) 2002-06-06 2008-12-10 ソニー株式会社 バイオアッセイ装置及びその製造方法、並びにバイオアッセイ方法
US7452507B2 (en) * 2002-08-02 2008-11-18 Sandia Corporation Portable apparatus for separating sample and detecting target analytes
CN101158447B (zh) 2002-12-04 2012-12-26 斯宾克斯公司 流体的可程控微量控制用装置和方法
US20050014249A1 (en) 2003-02-21 2005-01-20 Norbert Staimer Chromatographic analysis on optical bio-discs and methods relating thereto
US20050032089A1 (en) 2003-03-05 2005-02-10 Phan Brigitte Chau Sample preparation for colorimetric and fluorescent assays as implemented on optical analysis discs
WO2004087950A2 (en) 2003-04-04 2004-10-14 Roche Diagnostics Gmbh Improved system for multi color real time pcr
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
US7238269B2 (en) 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
US6879032B2 (en) * 2003-07-18 2005-04-12 Agilent Technologies, Inc. Folded flex circuit interconnect having a grid array interface
US7317415B2 (en) 2003-08-08 2008-01-08 Affymetrix, Inc. System, method, and product for scanning of biological materials employing dual analog integrators
US20050074784A1 (en) 2003-10-07 2005-04-07 Tuan Vo-Dinh Integrated biochip with continuous sampling and processing (CSP) system
US7322254B2 (en) 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7295316B2 (en) 2004-01-14 2007-11-13 Applera Corporation Fluorescent detector with automatic changing filters
US7709249B2 (en) * 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7527763B2 (en) 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
US20070009382A1 (en) 2005-07-05 2007-01-11 William Bedingham Heating element for a rotating multiplex fluorescence detection device

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EP1872112A1 (de) 2008-01-02
WO2006107619A1 (en) 2006-10-12
CA2602587A1 (en) 2006-10-12
AU2006232922A1 (en) 2006-10-12
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DE602006015043D1 (de) 2010-08-05
US20060223169A1 (en) 2006-10-05
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US7507575B2 (en) 2009-03-24
BRPI0609544B1 (pt) 2018-02-06
EP2207026A1 (de) 2010-07-14
ES2347077T3 (es) 2010-10-25
BRPI0609544B8 (pt) 2021-07-27
US20090218517A1 (en) 2009-09-03
BRPI0609544A2 (pt) 2011-10-18
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JP5021614B2 (ja) 2012-09-12
EP1872112B1 (de) 2010-06-23

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