ATE472604T1 - Verfahren zur herstellung von proteinen - Google Patents
Verfahren zur herstellung von proteinenInfo
- Publication number
- ATE472604T1 ATE472604T1 AT03750495T AT03750495T ATE472604T1 AT E472604 T1 ATE472604 T1 AT E472604T1 AT 03750495 T AT03750495 T AT 03750495T AT 03750495 T AT03750495 T AT 03750495T AT E472604 T1 ATE472604 T1 AT E472604T1
- Authority
- AT
- Austria
- Prior art keywords
- producing proteins
- proteins
- producing
- transient expression
- secreted protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000001938 protoplast Anatomy 0.000 abstract 1
- 230000010474 transient expression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020020382 EP1398383A1 (de) | 2002-09-12 | 2002-09-12 | Verfahren zur Herstellung von Proteinen |
| EP03015881 | 2003-07-11 | ||
| PCT/EP2003/009959 WO2004024927A1 (en) | 2002-09-12 | 2003-09-08 | Protein production method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE472604T1 true ATE472604T1 (de) | 2010-07-15 |
Family
ID=31995519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03750495T ATE472604T1 (de) | 2002-09-12 | 2003-09-08 | Verfahren zur herstellung von proteinen |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1539966B1 (de) |
| AT (1) | ATE472604T1 (de) |
| AU (1) | AU2003270152A1 (de) |
| DE (1) | DE60333201D1 (de) |
| DK (1) | DK1539966T3 (de) |
| ES (1) | ES2347325T3 (de) |
| PT (1) | PT1539966E (de) |
| SI (1) | SI1539966T1 (de) |
| WO (1) | WO2004024927A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE038955T2 (hu) | 2003-11-05 | 2018-12-28 | Roche Glycart Ag | Antigén-kötõ molekulák fokozott Fc receptor-kötõ affinitással és effektor funkcióval |
| BRPI0607315B1 (pt) | 2005-02-07 | 2022-05-17 | Roche Glycart Ag | Molécula de ligação ao antígeno anti-egfr humanizada e seus usos, composição farmacêutica, e método para detectar a presença de egfr em uma amostra |
| AU2006290433B2 (en) | 2005-08-26 | 2012-06-07 | Roche Glycart Ag | Modified antigen binding molecules with altered cell signaling activity |
| SE529610C2 (sv) * | 2006-02-13 | 2007-10-02 | Alfa Laval Corp Ab | Centrifugalseparator |
| AR062223A1 (es) | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
| CA2770174A1 (en) | 2009-08-31 | 2011-03-03 | Roche Glycart Ag | Affinity-matured humanized anti cea monoclonal antibodies |
| US20110200595A1 (en) | 2010-02-18 | 2011-08-18 | Roche Glycart | TREATMENT WITH A HUMANIZED IgG CLASS ANTI EGFR ANTIBODY AND AN ANTIBODY AGAINST INSULIN LIKE GROWTH FACTOR 1 RECEPTOR |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| BR112013002444A2 (pt) | 2010-08-13 | 2016-05-24 | Roche Glycart Ag | anticorpo, polinucleotídeo e polipeotídeo isolados, composição, vetor, cécula hospedeira, conjulgado de anticorpo, formulação farmacêutica, uso do anticorpo, métodos para produzir um anticorpo, tratar um indivíduo, induzir a lise celular de uma célula tumorosa e diagnosticar uma doença em um indivíduo |
| PE20171512A1 (es) | 2010-08-13 | 2017-10-20 | Roche Glycart Ag | Anticuerpos anti-fap |
| RU2013139267A (ru) | 2011-02-10 | 2015-03-20 | Рош Гликарт Аг | Улучшенная иммунотерапия |
| US20140088019A1 (en) | 2011-02-11 | 2014-03-27 | Zyngenia, Inc. | Monovalent and Multivalent Multispecific Complexes and Uses Thereof |
| KR101981342B1 (ko) | 2011-03-02 | 2019-05-22 | 로슈 글리카트 아게 | Cea 항체 |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| DK2714738T3 (en) | 2011-05-24 | 2019-01-28 | Zyngenia Inc | MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS |
| JP2014534806A (ja) | 2011-08-23 | 2014-12-25 | ロシュ グリクアート アーゲー | 抗ｍｃｓｐ抗体 |
| KR101721301B1 (ko) | 2011-08-23 | 2017-03-29 | 로슈 글리카트 아게 | 이중특이적 항원 결합 분자 |
| PL3434695T3 (pl) | 2012-08-07 | 2021-05-17 | Roche Glycart Ag | Ulepszona immunoterapia |
| MX2015010789A (es) | 2013-02-26 | 2015-11-26 | Roche Glycart Ag | Anticuerpos anti-pcsm. |
| SG11201708257UA (en) | 2015-04-06 | 2017-11-29 | Subdomain Llc | De novo binding domain containing polypeptides and uses thereof |
| ES2768957T3 (es) | 2015-09-24 | 2020-06-24 | Abvitro Llc | Composiciones de anticuerpos contra el VIH y métodos de uso |
| IL313608A (en) | 2015-12-09 | 2024-08-01 | Hoffmann La Roche | Antibody against CD20 type II to reduce the formation of antibodies against drugs |
| EP3178848A1 (de) | 2015-12-09 | 2017-06-14 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antikörper zur verringerung der bildung von antikörpern gegen medikamente |
| WO2017148880A1 (en) | 2016-03-01 | 2017-09-08 | F. Hoffmann-La Roche Ag | Obinutuzumab variants having altered cell death induction |
| JP7089483B2 (ja) | 2016-05-11 | 2022-06-22 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 修飾された抗テネイシン抗体及び使用方法 |
| EP3252078A1 (de) | 2016-06-02 | 2017-12-06 | F. Hoffmann-La Roche AG | Typ ii anti-cd20 antikörper und anti-cd20/cd3 bispecific antikörper zur behandlung von krebs |
| TWI791519B (zh) | 2017-04-27 | 2023-02-11 | 美商提薩羅有限公司 | 針對淋巴細胞活化基因-3（lag-3）之抗體藥劑及其用途 |
| JP2020521791A (ja) | 2017-06-02 | 2020-07-27 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | がんの治療のためのｉｉ型抗ｃｄ２０抗体及び抗ｃｄ２０／ｃｄ３０二重特異性抗体 |
| AU2018368431B2 (en) | 2017-11-14 | 2024-03-21 | Arcellx, Inc. | Multifunctional immune cell therapies |
| SI3710067T1 (sl) | 2017-11-14 | 2026-01-30 | Arcellx, Inc. | Polipeptidi, ki vsebujejo D-domeno, in njihova uporaba |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| EP3765517A1 (de) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | An calreticulin bindende multifunktionsmoleküle und ihre verwendungen |
| CN112566938B (zh) | 2018-06-03 | 2025-04-01 | 拉姆卡普生物测试有限公司 | 针对ceacam5和cd47的双特异性抗体 |
| WO2020010250A2 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| CN109234284B (zh) * | 2018-09-14 | 2021-04-09 | 昆明理工大学 | 一种三七类甜蛋白基因PnTLP5及应用 |
| CN109295068B (zh) * | 2018-09-14 | 2021-04-09 | 昆明理工大学 | 一种三七类甜蛋白基因PnTLP2及应用 |
| AU2020226893B2 (en) | 2019-02-21 | 2025-02-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| JP7579795B2 (ja) | 2019-02-21 | 2024-11-08 | マレンゴ・セラピューティクス，インコーポレーテッド | ＮＫｐ３０に結合する抗体分子およびその使用 |
| EP3831849A1 (de) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispezifische antikörper gegen ceacam5 und cd47 |
| WO2021138474A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| KR20230112616A (ko) | 2020-10-13 | 2023-07-27 | 아비타이드 엘엘씨 | 3중-나선 번들 단백질들의 친화성 리간드 라이브러리 및 이의 용도 |
| JP2023545375A (ja) | 2020-10-13 | 2023-10-30 | アヴィタイド エルエルシー | Ａａｖ８親和剤 |
| EP4294542A1 (de) | 2021-02-19 | 2023-12-27 | Avitide LLC | Aav2-affinitätswirkstoffe |
| BR112023019689A2 (pt) | 2021-03-26 | 2023-10-31 | Arcellx Inc | Terapias multifuncionais de célula imunológica |
| JP2024514281A (ja) | 2021-04-23 | 2024-04-01 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｎｋ細胞係合剤関連の有害作用の防止または軽減 |
| JP2025500274A (ja) | 2021-12-24 | 2025-01-09 | アヴィタイド エルエルシー | Ｃｈ１ドメイン親和性リガンド及びエージェント |
| EP4562022A1 (de) | 2022-07-29 | 2025-06-04 | Repligen Corporation | Affinitätsagent mit einem ligand zur bindung von vce und mit seq id no: 1 |
| CA3266644A1 (en) | 2022-09-09 | 2024-03-14 | Repligen Corporation | AFFINITY AGENTS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19947290A1 (de) * | 1999-10-01 | 2001-04-19 | Greenovation Pflanzenbiotechno | Verfahren zur Herstellung proteinöser Substanzen |
-
2003
- 2003-09-08 EP EP03750495A patent/EP1539966B1/de not_active Expired - Lifetime
- 2003-09-08 ES ES03750495T patent/ES2347325T3/es not_active Expired - Lifetime
- 2003-09-08 AT AT03750495T patent/ATE472604T1/de active
- 2003-09-08 SI SI200331863T patent/SI1539966T1/sl unknown
- 2003-09-08 DE DE60333201T patent/DE60333201D1/de not_active Expired - Lifetime
- 2003-09-08 AU AU2003270152A patent/AU2003270152A1/en not_active Abandoned
- 2003-09-08 PT PT03750495T patent/PT1539966E/pt unknown
- 2003-09-08 DK DK03750495.8T patent/DK1539966T3/da active
- 2003-09-08 WO PCT/EP2003/009959 patent/WO2004024927A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1539966B1 (de) | 2010-06-30 |
| WO2004024927A1 (en) | 2004-03-25 |
| SI1539966T1 (sl) | 2010-10-29 |
| EP1539966A1 (de) | 2005-06-15 |
| DK1539966T3 (da) | 2010-10-04 |
| DE60333201D1 (de) | 2010-08-12 |
| ES2347325T3 (es) | 2010-10-28 |
| PT1539966E (pt) | 2010-09-14 |
| AU2003270152A1 (en) | 2004-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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