ATE473240T1 - Modifizierte mitglieder der leukocyten-ig- ähnlichen-rezeptorfamilie (lir's) mit erhöhter affinität für klasse-i-mhc und deren anwendungen bei der modulierung der t-zellen-aktivierung - Google Patents

Modifizierte mitglieder der leukocyten-ig- ähnlichen-rezeptorfamilie (lir's) mit erhöhter affinität für klasse-i-mhc und deren anwendungen bei der modulierung der t-zellen-aktivierung

Info

Publication number
ATE473240T1
ATE473240T1 AT06727147T AT06727147T ATE473240T1 AT E473240 T1 ATE473240 T1 AT E473240T1 AT 06727147 T AT06727147 T AT 06727147T AT 06727147 T AT06727147 T AT 06727147T AT E473240 T1 ATE473240 T1 AT E473240T1
Authority
AT
Austria
Prior art keywords
class
pmhc
lir
mhc
leukocyte
Prior art date
Application number
AT06727147T
Other languages
English (en)
Inventor
Bent Karsten Jakobsen
Yi Li
Ruth Karen Moysey
Original Assignee
Medigene Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medigene Ltd filed Critical Medigene Ltd
Application granted granted Critical
Publication of ATE473240T1 publication Critical patent/ATE473240T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AT06727147T 2005-05-25 2006-05-19 Modifizierte mitglieder der leukocyten-ig- ähnlichen-rezeptorfamilie (lir's) mit erhöhter affinität für klasse-i-mhc und deren anwendungen bei der modulierung der t-zellen-aktivierung ATE473240T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0510627.3A GB0510627D0 (en) 2005-05-25 2005-05-25 Polypeptides
PCT/GB2006/001860 WO2006125963A2 (en) 2005-05-25 2006-05-19 Modified leukocyte ig-like receptor family members (lir' s) with increased affinity for class i mhc and their uses in modulating t cell activation

Publications (1)

Publication Number Publication Date
ATE473240T1 true ATE473240T1 (de) 2010-07-15

Family

ID=34834594

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06727147T ATE473240T1 (de) 2005-05-25 2006-05-19 Modifizierte mitglieder der leukocyten-ig- ähnlichen-rezeptorfamilie (lir's) mit erhöhter affinität für klasse-i-mhc und deren anwendungen bei der modulierung der t-zellen-aktivierung

Country Status (15)

Country Link
US (1) US8092807B2 (de)
EP (1) EP1885752B1 (de)
JP (1) JP2008545404A (de)
CN (1) CN101268100A (de)
AT (1) ATE473240T1 (de)
AU (1) AU2006250976A1 (de)
BR (1) BRPI0611167A2 (de)
CA (1) CA2609447A1 (de)
DE (1) DE602006015306D1 (de)
EA (1) EA200702609A1 (de)
ES (1) ES2348674T3 (de)
GB (1) GB0510627D0 (de)
MX (1) MX2007014585A (de)
WO (1) WO2006125963A2 (de)
ZA (1) ZA200709924B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0623539D0 (en) * 2006-11-24 2007-01-03 Avidex Ltd Polypeptides
AU2006351162A1 (en) 2006-11-24 2008-05-29 Medigene Ag ILT-2 (LIRL ) variants with increased affinity for MHC class I molecules
WO2009060159A1 (en) * 2007-11-08 2009-05-14 Medigene Limited Mutated ilt molecules
CN119569893B (zh) * 2023-09-06 2025-10-31 上海恩凯细胞技术有限公司 特异性靶向肿瘤的嵌合抗原受体细胞及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE456656T1 (de) 1996-12-06 2010-02-15 Schering Corp Isolierte gene aus säuger monozyten und betreffende reagentien
US6384203B1 (en) 1999-05-12 2002-05-07 Immunex Corporation Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR)
US6448035B1 (en) * 1997-04-24 2002-09-10 Immunex Corporation Family of immunoregulators designated leukocyte immunoglobulin-like receptor (LIR)
GB9722779D0 (en) 1997-10-28 1997-12-24 Isis Innovation Human CD8 as an inhibitor of the cellular immune system
WO1999060120A2 (en) 1998-05-19 1999-11-25 Avidex Limited Soluble t cell receptor
JP2004524001A (ja) 2000-01-25 2004-08-12 ハイセック，インコーポレーテッド 白血球免疫グロブリン受容体（ｌｉｒ様）ポリペプチドおよびポリヌクレオチドに関する方法と材料
PL374463A1 (en) 2001-11-14 2005-10-17 Immunex Corporation Modulation of lir function to treat rheumatoid arthritis
EP1578367A4 (de) 2002-11-01 2012-05-02 Genentech Inc Zusammensetzungen und verfahren zur behandlung von immunerkrankungen
WO2005058953A2 (en) 2003-12-12 2005-06-30 Regeneron Pharmaceuticals, Inc. Ogh fusion polypeptides and therapeutic uses thereof
BRPI0507174A (pt) 2004-01-28 2008-04-01 Syntonix Pharmaceuticals Inc proteìnas de fusão hormÈnio-fc (fsh-fc) heterodiméricas estimuladoras de folìculo para o tratamento da infertilidade
GB0411773D0 (en) * 2004-05-26 2004-06-30 Avidex Ltd Method for the identification of polypeptides which bind to a given peptide mhc complex or cd 1-antigen complex
WO2006033811A2 (en) 2004-09-03 2006-03-30 The Trustees Of Columbia University In The City Of New York Ilt3 polypeptides and uses thereof
AU2006351162A1 (en) 2006-11-24 2008-05-29 Medigene Ag ILT-2 (LIRL ) variants with increased affinity for MHC class I molecules

Also Published As

Publication number Publication date
MX2007014585A (es) 2008-04-22
US8092807B2 (en) 2012-01-10
EA200702609A1 (ru) 2008-10-30
BRPI0611167A2 (pt) 2010-08-17
ES2348674T3 (es) 2010-12-10
EP1885752B1 (de) 2010-07-07
AU2006250976A1 (en) 2006-11-30
WO2006125963A3 (en) 2008-04-17
CN101268100A (zh) 2008-09-17
JP2008545404A (ja) 2008-12-18
EP1885752A2 (de) 2008-02-13
DE602006015306D1 (de) 2010-08-19
GB0510627D0 (en) 2005-06-29
US20090208447A1 (en) 2009-08-20
WO2006125963A2 (en) 2006-11-30
ZA200709924B (en) 2009-03-25
CA2609447A1 (en) 2006-11-30

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