ATE473748T1 - Verfahren zur herstellung einer nucleinsäure enthaltenden kompositzusammenstellung - Google Patents

Verfahren zur herstellung einer nucleinsäure enthaltenden kompositzusammenstellung

Info

Publication number
ATE473748T1
ATE473748T1 AT99921242T AT99921242T ATE473748T1 AT E473748 T1 ATE473748 T1 AT E473748T1 AT 99921242 T AT99921242 T AT 99921242T AT 99921242 T AT99921242 T AT 99921242T AT E473748 T1 ATE473748 T1 AT E473748T1
Authority
AT
Austria
Prior art keywords
producing
nucleic acid
composition
containing nucleic
cationic carrier
Prior art date
Application number
AT99921242T
Other languages
English (en)
Inventor
Katsuhiro Sugihara
Junzo Seki
Kazuko Hirabayashi
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Application granted granted Critical
Publication of ATE473748T1 publication Critical patent/ATE473748T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT99921242T 1998-05-25 1999-05-24 Verfahren zur herstellung einer nucleinsäure enthaltenden kompositzusammenstellung ATE473748T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14276398 1998-05-25
PCT/JP1999/002713 WO1999061032A1 (en) 1998-05-25 1999-05-24 Process for producing composite preparation containing nucleic acid

Publications (1)

Publication Number Publication Date
ATE473748T1 true ATE473748T1 (de) 2010-07-15

Family

ID=15323024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99921242T ATE473748T1 (de) 1998-05-25 1999-05-24 Verfahren zur herstellung einer nucleinsäure enthaltenden kompositzusammenstellung

Country Status (10)

Country Link
US (2) US6545138B1 (de)
EP (1) EP1086699B1 (de)
JP (1) JP3785932B2 (de)
KR (1) KR100644172B1 (de)
CN (1) CN1166366C (de)
AT (1) ATE473748T1 (de)
CA (1) CA2333162C (de)
DE (1) DE69942581D1 (de)
RU (1) RU2222334C2 (de)
WO (1) WO1999061032A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2459373A1 (en) * 2001-09-04 2003-03-20 Nippon Shinyaku Co., Ltd. Method of evaluating efficacy of nucleic acid therapy
GB0127832D0 (en) * 2001-11-20 2002-01-09 Jagotec Ag Method for the preparation of pharmaceutical nanosuspensions
AU2003293196A1 (en) 2002-12-23 2004-07-29 Vical Incorporated Method for producing sterile polynucleotide based medicaments
WO2004106511A1 (ja) * 2003-05-30 2004-12-09 Nippon Shinyaku Co., Ltd. Ｂｃｌ−２の発現抑制をするオリゴ二本鎖ＲＮＡとそれを含有する医薬組成物
EP1637144A4 (de) * 2003-05-30 2010-01-13 Nippon Shinyaku Co Ltd Oligonucleinsäure enthaltender komposit und diesen enthaltende pharmazeutische zusammensetzung
EP1886688A4 (de) * 2005-05-30 2013-01-09 Nippon Shinyaku Co Ltd Verfahren zur herstellung einer zubereitung eines nukleinsäurehaltigen komplexes
US20080271995A1 (en) * 2007-05-03 2008-11-06 Sergey Savastiouk Agitation of electrolytic solution in electrodeposition
RU2397988C1 (ru) * 2009-02-24 2010-08-27 Общество с ограниченной ответственностью "ВИТАЛАНГ" Способ терминальной стерилизации высокополимерной дрожжевой рнк
WO2012129767A1 (zh) * 2011-03-28 2012-10-04 南京大学 阳离子修饰的琼脂糖水凝胶和核酸药物组合物及制法和应用
KR102589295B1 (ko) 2014-05-14 2023-10-13 타르그이뮨 테라퓨틱스 아게 개선된 폴리에틸렌이민 폴리에틸렌글리콜 벡터
CN109355334A (zh) * 2018-12-06 2019-02-19 江苏省农业科学院 一种制备聚肌胞的方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA805716B (en) * 1979-09-17 1982-04-28 Merck & Co Inc Pharmaceutical composition comprising modified polyriboinosi-interferonin primates
NZ194880A (en) 1979-09-17 1983-07-15 Merck & Co Inc Interferon-inducing composition containing modified polyriboinosinic-polyribocytidylic acid
JPS61103824A (ja) * 1984-10-27 1986-05-22 Nippon Kayaku Co Ltd ポリリボイノシン酸・ポリリボシチヂル酸・ポリ−レ−リジン複合体の注射用製剤の新規調製法
US5298614A (en) 1986-01-06 1994-03-29 Nippon Shinyaku Co. Ltd. Size limited double stranded poly I poly(cytidylate/4-thiouridylate)
JPS62252798A (ja) * 1986-01-06 1987-11-04 Nippon Shinyaku Co Ltd 核酸誘導体
JPH01104094A (ja) * 1987-07-03 1989-04-21 Nippon Shinyaku Co Ltd 核酸誘導体の製法及び製剤法
GB2207138B (en) 1987-07-03 1992-02-05 Nippon Shinyaku Co Ltd Preparation of nucleic acid derivatives.
GB8822857D0 (en) * 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
US5698721A (en) * 1992-12-17 1997-12-16 Megabios Corporation Catonic amphiphiles
KR100283601B1 (ko) * 1993-02-19 2001-03-02 아만 히데아키 글리세롤 유도체, 디바이스 및 의약 조성물
KR100372006B1 (ko) * 1993-10-06 2003-07-18 암겐 인코포레이티드 안정한단백질:인지질조성물및그의제조방법
AU686277B2 (en) * 1993-11-16 1998-02-05 Pacira Pharmaceuticals, Inc. Vesicles with controlled release of actives
US5908635A (en) * 1994-08-05 1999-06-01 The United States Of America As Represented By The Department Of Health And Human Services Method for the liposomal delivery of nucleic acids
WO1997045069A1 (en) * 1996-05-29 1997-12-04 Cell Genesys, Inc. Cationic polymer/lipid nucleic acid delivery vehicles
US6217900B1 (en) * 1997-04-30 2001-04-17 American Home Products Corporation Vesicular complexes and methods of making and using the same
TW524693B (en) * 1997-10-16 2003-03-21 Nippon Shinyaku Co Ltd Cancer cell nuclease activator
JP3804452B2 (ja) * 1998-03-24 2006-08-02 日本新薬株式会社 肝炎治療剤

Also Published As

Publication number Publication date
CA2333162A1 (en) 1999-12-02
EP1086699B1 (de) 2010-07-14
WO1999061032A1 (en) 1999-12-02
JP3785932B2 (ja) 2006-06-14
US6746690B2 (en) 2004-06-08
US6545138B1 (en) 2003-04-08
DE69942581D1 (de) 2010-08-26
CN1166366C (zh) 2004-09-15
CN1303293A (zh) 2001-07-11
KR20010043803A (ko) 2001-05-25
EP1086699A1 (de) 2001-03-28
KR100644172B1 (ko) 2006-11-10
RU2222334C2 (ru) 2004-01-27
EP1086699A4 (de) 2004-05-26
CA2333162C (en) 2011-07-26
US20030091622A1 (en) 2003-05-15

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