ATE474319T1 - Verfahren zur reinigung von 225ac aus bestrahlten 226ra-targets - Google Patents
Verfahren zur reinigung von 225ac aus bestrahlten 226ra-targetsInfo
- Publication number
- ATE474319T1 ATE474319T1 AT07711580T AT07711580T ATE474319T1 AT E474319 T1 ATE474319 T1 AT E474319T1 AT 07711580 T AT07711580 T AT 07711580T AT 07711580 T AT07711580 T AT 07711580T AT E474319 T1 ATE474319 T1 AT E474319T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- formula
- solid support
- coated
- alkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 6
- 238000000605 extraction Methods 0.000 abstract 6
- 239000007787 solid Substances 0.000 abstract 6
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 5
- 238000004587 chromatography analysis Methods 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910017604 nitric acid Inorganic materials 0.000 abstract 3
- 238000010828 elution Methods 0.000 abstract 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- -1 n-octyl Chemical group 0.000 abstract 2
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052705 radium Inorganic materials 0.000 abstract 2
- HCWPIIXVSYCSAN-UHFFFAOYSA-N radium atom Chemical compound [Ra] HCWPIIXVSYCSAN-UHFFFAOYSA-N 0.000 abstract 2
- 230000000717 retained effect Effects 0.000 abstract 2
- 230000005526 G1 to G0 transition Effects 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B60/00—Obtaining metals of atomic number 87 or higher, i.e. radioactive metals
- C22B60/02—Obtaining thorium, uranium, or other actinides
- C22B60/0295—Obtaining thorium, uranium, or other actinides obtaining other actinides except plutonium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/206—Packing or coating
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B7/00—Working up raw materials other than ores, e.g. scrap, to produce non-ferrous metals and compounds thereof; Methods of a general interest or applied to the winning of more than two metals
- C22B7/005—Separation by a physical processing technique only, e.g. by mechanical breaking
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B7/00—Working up raw materials other than ores, e.g. scrap, to produce non-ferrous metals and compounds thereof; Methods of a general interest or applied to the winning of more than two metals
- C22B7/006—Wet processes
- C22B7/007—Wet processes by acid leaching
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B7/00—Working up raw materials other than ores, e.g. scrap, to produce non-ferrous metals and compounds thereof; Methods of a general interest or applied to the winning of more than two metals
- C22B7/009—General processes for recovering metals or metallic compounds from spent catalysts
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0089—Actinium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/20—Recycling
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Geology (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Manufacturing & Machinery (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Environmental & Geological Engineering (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Extraction Or Liquid Replacement (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006008023A DE102006008023B4 (de) | 2006-02-21 | 2006-02-21 | Verfahren zum Reinigen von 225Ac aus bestrahlten 226Ra-Targets |
| PCT/EP2007/001424 WO2007096119A2 (en) | 2006-02-21 | 2007-02-19 | Method for purification of 225ac from irradiated 226ra-targets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE474319T1 true ATE474319T1 (de) | 2010-07-15 |
Family
ID=38319730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07711580T ATE474319T1 (de) | 2006-02-21 | 2007-02-19 | Verfahren zur reinigung von 225ac aus bestrahlten 226ra-targets |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20090191122A1 (de) |
| EP (1) | EP1987522B1 (de) |
| JP (1) | JP5145545B2 (de) |
| CN (1) | CN101390171B (de) |
| AT (1) | ATE474319T1 (de) |
| CA (1) | CA2640768C (de) |
| DE (2) | DE102006008023B4 (de) |
| ES (1) | ES2350150T3 (de) |
| IN (1) | IN2015DN01010A (de) |
| RU (1) | RU2432632C2 (de) |
| WO (1) | WO2007096119A2 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004022200B4 (de) | 2004-05-05 | 2006-07-20 | Actinium Pharmaceuticals, Inc. | Radium-Target sowie Verfahren zu seiner Herstellung |
| DE102006008023B4 (de) | 2006-02-21 | 2008-05-29 | Actinium Pharmaceuticals, Inc. | Verfahren zum Reinigen von 225Ac aus bestrahlten 226Ra-Targets |
| CA2950532C (en) | 2006-09-08 | 2018-10-23 | Actinium Pharmaceuticals, Inc. | Method for the purification of radium from different sources |
| US9202602B2 (en) | 2010-02-10 | 2015-12-01 | Uchicago Argonne, Llc | Production of isotopes using high power proton beams |
| GB201007354D0 (en) * | 2010-04-30 | 2010-06-16 | Algeta Asa | Method |
| GB201314718D0 (en) * | 2013-08-16 | 2013-10-02 | Algeta As | Quantification method |
| AU2015229189B2 (en) | 2014-03-13 | 2020-04-09 | Bracco Diagnostics Inc. | Real time nuclear isotope detection |
| CZ305667B6 (cs) * | 2014-08-21 | 2016-01-27 | České Vysoké Učení Technické V Praze, Fakulta Jaderná A Fyzikálně Inženýrská, Katedra Jaderné Chemie | Způsob chromatografické separace směsi radionuklidů, chromatografický papír, způsob jeho přípravy a sada pro separaci směsi radionuklidů |
| JP6464475B2 (ja) * | 2015-03-02 | 2019-02-06 | 清水建設株式会社 | 放射性ストロンチウムの分析方法 |
| RU2741629C2 (ru) | 2016-09-20 | 2021-01-28 | Бракко Дайэгностикс Инк. | Системы и способы производства, инфузионного ввода и контроля доставки радиоактивного изотопа |
| US11798700B2 (en) | 2018-03-26 | 2023-10-24 | The University Of British Columbia | Systems, apparatus and methods for separating actinium, radium, and thorium |
| SG11202009326XA (en) | 2018-03-28 | 2020-10-29 | Bracco Diagnostics Inc | Early detection of radioisotope generator end life |
| US12170153B2 (en) | 2018-03-28 | 2024-12-17 | Bracco Diagnostics Inc. | Systems and techniques for calibrating radioisotope delivery systems with a gamma detector |
| EP3682959A1 (de) * | 2019-01-16 | 2020-07-22 | Sck Cen | Reinigung von actinium |
| CN113939885A (zh) * | 2019-04-08 | 2022-01-14 | 加利福尼亚大学董事会 | 用于制备锕-225的系统和方法 |
| KR102924918B1 (ko) * | 2019-06-19 | 2026-02-10 | 니혼 메디피직스 가부시키가이샤 | 226Ra 타깃의 제조 방법, 225Ac의 제조 방법 및 226Ra 타깃 제조용 전착액 |
| WO2020260210A1 (en) * | 2019-06-25 | 2020-12-30 | The European Union, Represented By The European Commission | Method for producing 225actinium from 226radium |
| JP7312621B2 (ja) | 2019-06-26 | 2023-07-21 | 株式会社日立製作所 | 放射性核種の製造方法および放射性核種の製造システム |
| RU2736600C1 (ru) * | 2019-07-02 | 2020-11-19 | Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" | Способ получения радионуклидного генератора актиния-228 |
| WO2021002275A1 (ja) | 2019-07-02 | 2021-01-07 | 日本メジフィジックス株式会社 | ２２６Ｒａ含有溶液の精製方法、２２６Ｒａターゲットの製造方法および２２５Ａｃの製造方法 |
| KR102211812B1 (ko) * | 2019-07-23 | 2021-02-04 | 한국원자력의학원 | 액화 라듐을 이용한 악티늄 생산 방법 |
| KR102233112B1 (ko) | 2019-07-25 | 2021-03-29 | 한국원자력의학원 | 액체 타겟을 이용한 핵종 생산 장치 |
| KR102264831B1 (ko) * | 2019-07-29 | 2021-06-15 | 한국원자력의학원 | 빔 조사 효율이 향상된 파우더형 타겟 및 이를 포함하는 핵종 생산 장치 및 생산방법 |
| EP3800648A1 (de) | 2019-10-04 | 2021-04-07 | Sck Cen | Verfahren und systeme zur herstellung von isotopen |
| EP3828899B1 (de) * | 2019-11-29 | 2022-01-05 | Ion Beam Applications | Verfahren zur herstellung von ac-225 aus ra-226 |
| CN115104159A (zh) | 2020-02-21 | 2022-09-23 | 布拉科诊断公司 | 放射性同位素发生器早期突破检测 |
| CN111724926B (zh) * | 2020-06-09 | 2022-08-09 | 西安迈斯拓扑科技有限公司 | 一种生产医用同位素225Ac的方法和装置 |
| AU2021309611A1 (en) | 2020-07-17 | 2023-02-16 | Nihon Medi-Physics Co., Ltd. | Method for producing 225Ac solution |
| US10867716B1 (en) * | 2020-09-11 | 2020-12-15 | King Abdulaziz University | Systems and methods for producing Actinium-225 |
| WO2022149578A1 (ja) * | 2021-01-08 | 2022-07-14 | 日本メジフィジックス株式会社 | Ａｃ－２２５溶液の製造方法およびＡｃ－２２５溶液を用いた医薬の製造方法 |
| EP4276207A4 (de) * | 2021-01-08 | 2025-06-11 | Nihon Medi-Physics Co., Ltd. | Verfahren zur rückgewinnung von ra-226, verfahren zur herstellung einer ra-226-lösung und verfahren zur herstellung einer ac-225-lösung |
| KR20230173150A (ko) | 2021-04-20 | 2023-12-26 | 테라파워, 엘엘씨 | Ac-225 생성용 티타니아 기반 발생기 |
| US11541134B1 (en) | 2021-08-02 | 2023-01-03 | Rayzebio, Inc. | Stabilized compositions of radionuclides and uses thereof |
| US12398445B2 (en) * | 2022-01-20 | 2025-08-26 | Purdue Research Foundation | Background Rn-rejected actinide in air spectroscopy |
| CN115869658B (zh) * | 2022-12-29 | 2025-01-28 | 中国核动力研究设计院 | 用于制备Ra-223的分离系统及其分离方法、应用和制备方法 |
| CN116741428A (zh) * | 2023-07-03 | 2023-09-12 | 西安迈斯拓扑科技有限公司 | 基于加速器辐照226Ra同时制备225Ac和212Pb的方法 |
| WO2026015045A1 (ru) * | 2024-07-12 | 2026-01-15 | Акционерное Общество "Государственный Научный Центр - Научно-Исследовательский Институт Атомных Реакторов" | Способ взаимного разделения радия, актиния и тория |
| WO2026063503A1 (ja) * | 2024-09-20 | 2026-03-26 | 日本メジフィジックス株式会社 | Ａｃ－２２５溶液の製造方法および該溶液を用いたＡｃ－２２５標識錯体の製造方法 |
| CN120183769B (zh) * | 2025-03-18 | 2026-03-24 | 西安迈斯拓扑科技有限公司 | 一种用于光核反应法制备铅-212和锕-225的分离纯化方法 |
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2006
- 2006-02-21 DE DE102006008023A patent/DE102006008023B4/de not_active Expired - Lifetime
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2007
- 2007-02-19 DE DE602007007733T patent/DE602007007733D1/de active Active
- 2007-02-19 RU RU2008129795/07A patent/RU2432632C2/ru active
- 2007-02-19 US US12/280,079 patent/US20090191122A1/en not_active Abandoned
- 2007-02-19 JP JP2008554697A patent/JP5145545B2/ja active Active
- 2007-02-19 CN CN2007800060725A patent/CN101390171B/zh active Active
- 2007-02-19 WO PCT/EP2007/001424 patent/WO2007096119A2/en not_active Ceased
- 2007-02-19 EP EP07711580A patent/EP1987522B1/de active Active
- 2007-02-19 CA CA2640768A patent/CA2640768C/en active Active
- 2007-02-19 ES ES07711580T patent/ES2350150T3/es active Active
- 2007-02-19 IN IN1010DEN2015 patent/IN2015DN01010A/en unknown
- 2007-02-19 AT AT07711580T patent/ATE474319T1/de not_active IP Right Cessation
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- 2014-03-31 US US14/231,354 patent/US9534277B1/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| US9534277B1 (en) | 2017-01-03 |
| WO2007096119A2 (en) | 2007-08-30 |
| DE602007007733D1 (de) | 2010-08-26 |
| US20090191122A1 (en) | 2009-07-30 |
| DE102006008023A1 (de) | 2007-08-30 |
| JP2009527731A (ja) | 2009-07-30 |
| JP5145545B2 (ja) | 2013-02-20 |
| US20170137916A1 (en) | 2017-05-18 |
| RU2432632C2 (ru) | 2011-10-27 |
| CA2640768C (en) | 2014-06-10 |
| CA2640768A1 (en) | 2007-08-30 |
| CN101390171B (zh) | 2013-02-13 |
| EP1987522B1 (de) | 2010-07-14 |
| DE102006008023B4 (de) | 2008-05-29 |
| CN101390171A (zh) | 2009-03-18 |
| ES2350150T3 (es) | 2011-01-19 |
| RU2008129795A (ru) | 2010-03-27 |
| US20170009320A1 (en) | 2017-01-12 |
| IN2015DN01010A (de) | 2015-07-10 |
| US9790573B2 (en) | 2017-10-17 |
| EP1987522A2 (de) | 2008-11-05 |
| US20130266475A1 (en) | 2013-10-10 |
| WO2007096119A3 (en) | 2007-10-25 |
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