ATE474587T1 - Inhibitoren des hepatitis-c-virus - Google Patents
Inhibitoren des hepatitis-c-virusInfo
- Publication number
- ATE474587T1 ATE474587T1 AT05814026T AT05814026T ATE474587T1 AT E474587 T1 ATE474587 T1 AT E474587T1 AT 05814026 T AT05814026 T AT 05814026T AT 05814026 T AT05814026 T AT 05814026T AT E474587 T1 ATE474587 T1 AT E474587T1
- Authority
- AT
- Austria
- Prior art keywords
- hepatitis
- virus
- present
- methods
- virus inhibitors
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 101800001473 Spike glycoprotein E2 Proteins 0.000 abstract 1
- 108010067390 Viral Proteins Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000010710 hepatitis C virus infection Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61428004P | 2004-09-29 | 2004-09-29 | |
| PCT/US2005/034777 WO2006039326A2 (en) | 2004-09-29 | 2005-09-26 | Inhibitors of hepatitits c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE474587T1 true ATE474587T1 (de) | 2010-08-15 |
Family
ID=36143015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05814026T ATE474587T1 (de) | 2004-09-29 | 2005-09-26 | Inhibitoren des hepatitis-c-virus |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7381705B2 (de) |
| EP (1) | EP1797112B1 (de) |
| JP (1) | JP4980915B2 (de) |
| AT (1) | ATE474587T1 (de) |
| AU (1) | AU2005292135B2 (de) |
| CA (1) | CA2582095A1 (de) |
| DE (1) | DE602005022463D1 (de) |
| ES (1) | ES2349153T3 (de) |
| PL (1) | PL1797112T3 (de) |
| PT (1) | PT1797112E (de) |
| WO (1) | WO2006039326A2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070073039A1 (en) * | 2005-09-29 | 2007-03-29 | Chisari Francis V | Peptides that inhibit viral infections |
| AP2009005028A0 (en) | 2007-04-10 | 2009-12-31 | Univ Tulane | Soluble and membrane-anchored forms of lassa virussubunit proteins |
| WO2009021063A2 (en) * | 2007-08-06 | 2009-02-12 | The Regents Of The University Of California | Composition and method of use for hcv immunization |
| WO2009030872A1 (de) * | 2007-09-07 | 2009-03-12 | Mats Axel Atterdag Persson | Vorrichtung zum festlegen einer gliedmasse |
| JP2011505335A (ja) * | 2007-09-11 | 2011-02-24 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | 治療剤としてのＴＲＰ−６−トリプトレリンおよびＤ−Ｌｅｕ６−ロイプロリドの使用 |
| US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
| CA2658714A1 (en) * | 2009-03-17 | 2010-09-17 | Thomas Krey | Hcv-derived polypeptides and uses thereof |
| WO2013050048A2 (en) | 2011-10-07 | 2013-04-11 | Skau Aps | Identification and attenuation of the immunosuppressive domains in fusion proteins of enveloped rna viruses |
| CN104324361A (zh) * | 2014-05-16 | 2015-02-04 | 中国疾病预防控制中心病毒病预防控制所 | 丙型肝炎病毒(hcv)细胞进入抑制肽zte2序列及应用 |
| CN109232721B (zh) * | 2018-09-26 | 2021-06-29 | 广州市第八人民医院 | Hcv包膜蛋白高度保守区域的肽段418-429及其用途 |
| EP4003513A4 (de) * | 2019-07-26 | 2023-08-30 | The Scripps Research Institute | Gentechnisch veränderte hcv-e2-immunogene und entsprechende impfzusammensetzungen |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT54896A (en) * | 1989-03-17 | 1991-04-29 | Chiron Corp | Process for producing aquous diagnosticum and vaccine of nanbv |
| US5747239A (en) | 1990-02-16 | 1998-05-05 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines |
| ES2197170T3 (es) * | 1993-11-04 | 2004-01-01 | Innogenetics N.V. | Epitopos de celulas t humanas inmunologicamente dominantes del virus de la hepatitis c. |
| US6127116A (en) | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
| SE9503380D0 (sv) * | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| US6037348A (en) | 1996-02-09 | 2000-03-14 | Eli Lilly And Company | Inhibition of viral replication |
| JP2001514508A (ja) * | 1997-03-05 | 2001-09-11 | ユニバーシティー オブ ワシントン | Ｃ型肝炎ウイルスの複製を選択的に抑制する薬剤を同定するための新規なスクリーニング法 |
| US6153421A (en) | 1997-07-18 | 2000-11-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Cloned genomes of infectious hepatitis C viruses and uses thereof |
| US6127166A (en) * | 1997-11-03 | 2000-10-03 | Bayley; Hagan | Molluscan ligament polypeptides and genes encoding them |
| US7091324B2 (en) * | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
| EP1178116A1 (de) * | 2000-08-03 | 2002-02-06 | Hybrigenics S.A. | Sid nukleische Saüre und aus einem pathogenischen Stamm des Hepatitis C Viruses selektierte Polypeptide und deren Verwendungenthereof |
| CN100400101C (zh) * | 2000-08-17 | 2008-07-09 | 特里帕普股份公司 | 包含病毒唑的疫苗及其使用方法 |
| US20030232745A1 (en) | 2001-06-26 | 2003-12-18 | Olson William C. | Uses of DC-sign and DC-Signr for inhibiting hepatitis C virus infection |
| US7022323B2 (en) | 2001-06-26 | 2006-04-04 | Progenics Pharmaceuticals, Inc. | Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection |
| DK1558276T3 (da) | 2002-11-08 | 2012-10-22 | Univ Tulane | Flavivirus-fusionsinhibitorer |
| EP1638993A4 (de) * | 2003-06-10 | 2007-05-09 | Univ Melbourne | Immunmodulierende zusammensetzungen, anwendungen davon und verfahren zu deren herstellung |
-
2005
- 2005-09-26 DE DE602005022463T patent/DE602005022463D1/de active Active
- 2005-09-26 US US11/235,672 patent/US7381705B2/en not_active Expired - Fee Related
- 2005-09-26 ES ES05814026T patent/ES2349153T3/es active Active
- 2005-09-26 AU AU2005292135A patent/AU2005292135B2/en not_active Ceased
- 2005-09-26 AT AT05814026T patent/ATE474587T1/de not_active IP Right Cessation
- 2005-09-26 CA CA002582095A patent/CA2582095A1/en not_active Abandoned
- 2005-09-26 EP EP05814026A patent/EP1797112B1/de not_active Not-in-force
- 2005-09-26 PL PL05814026T patent/PL1797112T3/pl unknown
- 2005-09-26 WO PCT/US2005/034777 patent/WO2006039326A2/en not_active Ceased
- 2005-09-26 PT PT05814026T patent/PT1797112E/pt unknown
- 2005-09-26 JP JP2007534728A patent/JP4980915B2/ja not_active Expired - Fee Related
-
2008
- 2008-05-19 US US12/152,964 patent/US20080241156A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005292135B2 (en) | 2011-09-29 |
| PL1797112T3 (pl) | 2011-04-29 |
| PT1797112E (pt) | 2010-10-25 |
| AU2005292135A1 (en) | 2006-04-13 |
| ES2349153T3 (es) | 2010-12-28 |
| JP4980915B2 (ja) | 2012-07-18 |
| DE602005022463D1 (de) | 2010-09-02 |
| US20080241156A1 (en) | 2008-10-02 |
| US7381705B2 (en) | 2008-06-03 |
| JP2008514717A (ja) | 2008-05-08 |
| EP1797112A4 (de) | 2009-04-01 |
| WO2006039326A2 (en) | 2006-04-13 |
| EP1797112A2 (de) | 2007-06-20 |
| CA2582095A1 (en) | 2006-04-13 |
| EP1797112B1 (de) | 2010-07-21 |
| WO2006039326A3 (en) | 2007-05-10 |
| US20060069027A1 (en) | 2006-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |