ATE475666T1 - Verfahren zur herstellung von poly(alkoxylierten) oligonukleotiden - Google Patents
Verfahren zur herstellung von poly(alkoxylierten) oligonukleotidenInfo
- Publication number
- ATE475666T1 ATE475666T1 AT06808607T AT06808607T ATE475666T1 AT E475666 T1 ATE475666 T1 AT E475666T1 AT 06808607 T AT06808607 T AT 06808607T AT 06808607 T AT06808607 T AT 06808607T AT E475666 T1 ATE475666 T1 AT E475666T1
- Authority
- AT
- Austria
- Prior art keywords
- poly
- oligonucleotide
- alkoxylated
- oligonucleotides
- producing poly
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 6
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- -1 poly(alkoxide) Polymers 0.000 abstract 2
- 238000000108 ultra-filtration Methods 0.000 abstract 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical class NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 230000003196 chaotropic effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 abstract 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74289705P | 2005-12-07 | 2005-12-07 | |
| PCT/GB2006/004324 WO2007066069A2 (en) | 2005-12-07 | 2006-11-20 | Process for the preparation of poly(alkoxylated) oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE475666T1 true ATE475666T1 (de) | 2010-08-15 |
Family
ID=38123246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06808607T ATE475666T1 (de) | 2005-12-07 | 2006-11-20 | Verfahren zur herstellung von poly(alkoxylierten) oligonukleotiden |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8163891B2 (de) |
| EP (1) | EP1963351B1 (de) |
| AT (1) | ATE475666T1 (de) |
| CA (1) | CA2629753A1 (de) |
| DE (1) | DE602006015852D1 (de) |
| WO (1) | WO2007066069A2 (de) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1239390A (de) * | 1967-11-08 | 1971-07-14 | ||
| US3654682A (en) * | 1970-09-01 | 1972-04-11 | Edward H Newbould | Tool holder |
| US3891195A (en) * | 1974-05-14 | 1975-06-24 | Lif O Gen Inc | Cutting-welding torch |
| SE509931C2 (sv) * | 1996-09-27 | 1999-03-22 | Seco Tools Ab | Pinnfräs, pinnfräshuvud samt metod för montering av ett lösbart pinnfräshuvud på ett skaft till en pinnfräs |
-
2006
- 2006-11-20 AT AT06808607T patent/ATE475666T1/de not_active IP Right Cessation
- 2006-11-20 US US12/086,172 patent/US8163891B2/en not_active Expired - Fee Related
- 2006-11-20 DE DE602006015852T patent/DE602006015852D1/de active Active
- 2006-11-20 EP EP06808607A patent/EP1963351B1/de not_active Not-in-force
- 2006-11-20 CA CA002629753A patent/CA2629753A1/en not_active Abandoned
- 2006-11-20 WO PCT/GB2006/004324 patent/WO2007066069A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006015852D1 (de) | 2010-09-09 |
| CA2629753A1 (en) | 2007-06-14 |
| WO2007066069A3 (en) | 2007-09-20 |
| EP1963351A2 (de) | 2008-09-03 |
| US8163891B2 (en) | 2012-04-24 |
| US20100029924A1 (en) | 2010-02-04 |
| WO2007066069A2 (en) | 2007-06-14 |
| EP1963351B1 (de) | 2010-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |