ATE475888T1 - Biomarker zur diagnose von alzheimer - Google Patents

Biomarker zur diagnose von alzheimer

Info

Publication number
ATE475888T1
ATE475888T1 AT08002793T AT08002793T ATE475888T1 AT E475888 T1 ATE475888 T1 AT E475888T1 AT 08002793 T AT08002793 T AT 08002793T AT 08002793 T AT08002793 T AT 08002793T AT E475888 T1 ATE475888 T1 AT E475888T1
Authority
AT
Austria
Prior art keywords
alzheimer
human
patients
disease
disclosed
Prior art date
Application number
AT08002793T
Other languages
English (en)
Inventor
Oezkan A Yalkinoglu
Gerhard Koenig
Denis Francois Hochstrasser
Jean-Charles Sanchez
Odile Carrette
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP02018283A external-priority patent/EP1394549A1/de
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Application granted granted Critical
Publication of ATE475888T1 publication Critical patent/ATE475888T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT08002793T 2002-08-23 2003-08-11 Biomarker zur diagnose von alzheimer ATE475888T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02018283A EP1394549A1 (de) 2002-08-23 2002-08-23 Biomarker zur Diagnose von Alzheimer Erkrankung
EP02026643 2002-11-29

Publications (1)

Publication Number Publication Date
ATE475888T1 true ATE475888T1 (de) 2010-08-15

Family

ID=31947886

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03792291T ATE403875T1 (de) 2002-08-23 2003-08-11 Polypeptid-biomarker zur diagnose von morbus alzheimer
AT08002793T ATE475888T1 (de) 2002-08-23 2003-08-11 Biomarker zur diagnose von alzheimer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03792291T ATE403875T1 (de) 2002-08-23 2003-08-11 Polypeptid-biomarker zur diagnose von morbus alzheimer

Country Status (10)

Country Link
EP (3) EP1953556B1 (de)
JP (1) JP4405919B2 (de)
AT (2) ATE403875T1 (de)
AU (3) AU2003251702B2 (de)
CA (6) CA2746000C (de)
DE (2) DE60333608D1 (de)
DK (3) DK1953556T3 (de)
ES (3) ES2347924T3 (de)
PT (1) PT1535076E (de)
WO (1) WO2004019043A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1469312A1 (de) * 2003-04-18 2004-10-20 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnose der Alzheimer Krankheit
WO2005001483A2 (en) * 2003-06-27 2005-01-06 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Methods for diagnisis and differential diagnosis of dementia disorders
EP2369348A1 (de) * 2003-11-07 2011-09-28 Ciphergen Biosystems, Inc. Biomarker für Morbus Alzheimer
US7749716B2 (en) * 2004-05-18 2010-07-06 Vermilllion, Inc. Methods of detecting a fragment of neurosecretory protein VGF for diagnosing alzheimer's disease
GB0502068D0 (en) 2005-02-01 2005-03-09 King S College London Screening method
US20100036094A1 (en) * 2005-04-06 2010-02-11 Mosaiques Diagnostics And Therapeutics Ag Polypeptide Markers for the Diagnosis of Alzheimer's Disease
ATE511643T1 (de) * 2005-06-16 2011-06-15 Vermillion Inc Fragment des neurosekretorischen proteins vgf als biomarker für morbus alzheimer
EP2322531A3 (de) 2006-02-28 2011-09-07 Phenomenome Discoveries Inc. Methoden für die diagnose von demenz und anderen neurologischen erkrankungen
EP1996949A4 (de) * 2006-03-11 2010-01-20 Univ Leland Stanford Junior Beta-2 mikroglobulin als biomarker für periphere arterienerkrankung
GB0616230D0 (en) * 2006-08-16 2006-09-27 Univ Cambridge Tech Biomarkers and uses thereof
EP2620147B1 (de) 2007-02-08 2020-06-03 Med-Life Discoveries LP Verbindungen zur Senkung des Cholesterins
WO2009114945A1 (en) 2008-03-21 2009-09-24 Neuman Manuela G Methods and kits for the differential diagnosis of alzheimer's disease versus frontotemporal dementia, and for the diagnosis of frontotemporal dementia, comprising fas-l and ckl 18 as biomarkers
US20110263450A1 (en) * 2008-09-26 2011-10-27 The University Of Melbourne Alzheimer's disease biomarkers
JP2010271078A (ja) 2009-05-19 2010-12-02 Mcbi:Kk 認知機能障害疾患を含む精神疾患のバイオマーカーおよび該バイオマーカーを用いた認知機能障害疾患を含む精神疾患の検出方法
US10487148B2 (en) 2010-01-28 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated impairments
US10626399B2 (en) 2010-01-28 2020-04-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating cognitive symptoms of an aging-associated impairment by modulating C-C chemokine receptor type 3 (CCR3)
US20160208011A1 (en) 2010-01-28 2016-07-21 The Board Of Trustees Of The Leland Stanford Junior University Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same
US9161968B2 (en) 2011-04-08 2015-10-20 The Board Of Trustees Of The Leland Stanford Junior University Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
JP6667438B2 (ja) 2013-12-09 2020-03-18 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 老化に関連する状態を処置する方法及び組成物
US10905779B2 (en) 2013-12-09 2021-02-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening human blood products comprising plasma using immunocompromised rodent models
GB201322094D0 (en) * 2013-12-13 2014-01-29 Electrophoretics Ltd Methods and compositions relating to alzheimers disease
ES2902467T3 (es) 2015-06-15 2022-03-28 Univ Leland Stanford Junior TIMP2 para su uso en el tratamiento de afecciones asociadas al envejecimiento
KR102572009B1 (ko) * 2020-10-21 2023-08-29 순천향대학교 산학협력단 시스타틴 c를 포함하는 퇴행성 신경 질환 진단용 바이오마커 조성물 및 이의 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
AU1153300A (en) * 1998-10-23 2000-05-15 Roger Nitsch Methods of diagnosing or prognosing alzheimer's disease
EP1259819A2 (de) * 2000-02-24 2002-11-27 Oxford GlycoSciences (UK) Limited Diagnose von bipolarer affektiver störung und unipolarer depression
AU2001240909A1 (en) * 2000-03-20 2001-10-03 Oxford Glycosciences (Uk) Limited Proteins, genes and their use for diagnosis and treatment of breast cancer
AU2001249835A1 (en) * 2000-04-03 2001-10-15 Oxford Glycosciences (Uk) Ltd. Diagnosis and treatment of alzheimer's disease
DE10291524D2 (de) * 2001-04-06 2004-07-01 Anker Thorsten Verfahren zum Nachweis chronisch-demenzieller Erkrankungen, zugehörige Peptide und Nachweisreagenzien
WO2003028543A2 (en) * 2001-10-03 2003-04-10 Pfizer Products Inc. Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of alzheimer's disease

Also Published As

Publication number Publication date
DK2221620T3 (da) 2014-01-06
EP1953556A2 (de) 2008-08-06
JP4405919B2 (ja) 2010-01-27
CA2745569C (en) 2015-07-14
EP1953556B1 (de) 2010-07-28
EP1535076B1 (de) 2008-08-06
EP1953556A3 (de) 2008-11-26
EP2221620B1 (de) 2013-10-02
EP2221620A3 (de) 2010-11-24
CA2746000A1 (en) 2004-03-04
AU2010212317B2 (en) 2013-01-10
AU2010212317A1 (en) 2010-09-09
CA2746000C (en) 2014-10-21
ES2347924T3 (es) 2010-11-25
AU2003251702B2 (en) 2010-06-03
EP1535076A2 (de) 2005-06-01
ES2311751T3 (es) 2009-02-16
ATE403875T1 (de) 2008-08-15
AU2010212316A1 (en) 2010-09-09
CA2745998C (en) 2013-11-26
DK1535076T3 (da) 2008-11-24
CA2496321E (en) 2004-03-04
CA2496321C (en) 2013-05-21
EP2221620A2 (de) 2010-08-25
AU2010212316B2 (en) 2012-05-24
DE60322719D1 (de) 2008-09-18
CA2745731A1 (en) 2004-03-04
WO2004019043A2 (en) 2004-03-04
ES2436318T3 (es) 2013-12-30
WO2004019043A3 (en) 2004-06-24
PT1535076E (pt) 2008-11-03
CA2745998A1 (en) 2004-03-04
JP2005536729A (ja) 2005-12-02
DK1953556T3 (da) 2010-10-25
CA2745569A1 (en) 2004-03-04
CA2745724A1 (en) 2004-03-04
DE60333608D1 (de) 2010-09-09
CA2745731C (en) 2015-05-12
CA2745724C (en) 2015-06-02
CA2496321A1 (en) 2004-03-04
AU2003251702A1 (en) 2004-03-11

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