ATE476521T1 - Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren - Google Patents
Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophorenInfo
- Publication number
- ATE476521T1 ATE476521T1 AT03761235T AT03761235T ATE476521T1 AT E476521 T1 ATE476521 T1 AT E476521T1 AT 03761235 T AT03761235 T AT 03761235T AT 03761235 T AT03761235 T AT 03761235T AT E476521 T1 ATE476521 T1 AT E476521T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- compositions
- multichromophores
- trapping
- target polynucleotide
- Prior art date
Links
- 102000040430 polynucleotide Human genes 0.000 title abstract 5
- 108091033319 polynucleotide Proteins 0.000 title abstract 5
- 239000002157 polynucleotide Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/107—Modifications characterised by incorporating a peptide nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/125—Specific component of sample, medium or buffer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/107—Alteration in the property of hybridised versus free label oligonucleotides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Manufacturing & Machinery (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39052402P | 2002-06-20 | 2002-06-20 | |
| US40626602P | 2002-08-26 | 2002-08-26 | |
| PCT/US2003/019678 WO2004001379A2 (en) | 2002-06-20 | 2003-06-20 | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE476521T1 true ATE476521T1 (de) | 2010-08-15 |
Family
ID=30003161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03761235T ATE476521T1 (de) | 2002-06-20 | 2003-06-20 | Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7214489B2 (de) |
| EP (2) | EP2278027A3 (de) |
| JP (1) | JP4528115B2 (de) |
| KR (1) | KR20050010956A (de) |
| CN (2) | CN1675377B (de) |
| AT (1) | ATE476521T1 (de) |
| AU (1) | AU2003243722A1 (de) |
| CA (1) | CA2489922C (de) |
| DE (1) | DE60333646D1 (de) |
| EA (1) | EA007652B1 (de) |
| IL (1) | IL165877A0 (de) |
| WO (1) | WO2004001379A2 (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| CA2473376A1 (en) | 2002-01-16 | 2003-07-31 | Invitrogen Dynal As | Method for isolating nucleic acids and protein from a single sample |
| US9371559B2 (en) | 2002-06-20 | 2016-06-21 | The Regents Of The University Of California | Compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| US7144950B2 (en) | 2003-09-17 | 2006-12-05 | The Regents Of The University Of California | Conformationally flexible cationic conjugated polymers |
| EA007652B1 (ru) * | 2002-06-20 | 2006-12-29 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Способ обнаружения и анализа полинуклеотидов с помощью светособирающих полихромофоров |
| US10001475B2 (en) | 2002-06-20 | 2018-06-19 | The Regents Of The University Of California | Light harvesting multichromophore compositions and methods of using the same |
| EP2316971A1 (de) | 2002-08-26 | 2011-05-04 | The Regents of the University of California | Verfahren und Zusammensetzungen zum Nachweis und zur Analyse von Polynuckleotiden unter Benutzung von lichtsammelnden Multichromophoren. |
| GB0229287D0 (en) * | 2002-12-16 | 2003-01-22 | Dna Res Innovations Ltd | Polyfunctional reagents |
| EP2161343B1 (de) * | 2003-02-13 | 2013-10-23 | The Regents Of the University of California | Verfahren und Zusammensetzungen zum Erkennen und Analysieren von polynucleotid-bindenden Protein-Wechselwirkungen mit lichtnutzenden Multichromophoren |
| US9017766B2 (en) | 2003-09-17 | 2015-04-28 | The Regents Of The University Of California | Methods and devices comprising soluble conjugated polymers |
| US8795781B2 (en) | 2004-09-03 | 2014-08-05 | The Regents Of The University Of California | Methods and devices utilizing soluble conjugated polymers |
| JP2008512523A (ja) | 2004-09-03 | 2008-04-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 可溶性共役ポリマー |
| CA2594458C (en) | 2005-01-10 | 2016-08-23 | The Regents Of The University Of California | Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays |
| WO2006074482A2 (en) * | 2005-01-10 | 2006-07-13 | The Regents Of The University Of California | Methods and kits for strand-specific polynucleotide detection with cationic multichromophores |
| US7666594B2 (en) * | 2005-01-31 | 2010-02-23 | The Regents Of The University Of California | Methods for assaying a sample for an aggregant |
| US8076842B2 (en) | 2005-03-01 | 2011-12-13 | The Regents Of The University Of California | Multilayer polymer light-emitting diodes for solid state lighting applications |
| EP1853722B1 (de) * | 2005-03-03 | 2010-02-24 | National Research Council of Canada | Verfahren und zusammensetzungen zum nachweis und zur analyse von nukleinsäuren mittels signalverstärkung |
| US8057989B2 (en) * | 2006-02-10 | 2011-11-15 | The University Of Hong Kong | Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes |
| US8309304B2 (en) | 2006-02-10 | 2012-11-13 | The University Of Hong Kong | Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes |
| JP5420414B2 (ja) | 2006-10-06 | 2014-02-19 | シリゲン グループ リミテッド | 指向性バイオマーカシグナル増幅用の蛍光方法および材料 |
| ITTO20060883A1 (it) * | 2006-12-14 | 2008-06-15 | Consiglio Naz Delle Ricerche Infm | Procedimento e microdispositivo a trasduzione ottica per l'identificazione e/o quantificazione di un analita in un campione biologico |
| KR20080060744A (ko) * | 2006-12-27 | 2008-07-02 | 한국조폐공사 | 피엔에이 함유 잉크 및 이의 확인방법 |
| US8765369B2 (en) * | 2007-07-13 | 2014-07-01 | National Research Council Of Canada | Ultrasensitive detection of target using target-ready particles |
| US20090137925A1 (en) * | 2007-11-23 | 2009-05-28 | Divya Cantor | Impedance Spectroscopy Cervix Scanning Apparatus and Method |
| US20090230362A1 (en) * | 2008-01-25 | 2009-09-17 | Bazan Guillermo C | Conjugated oligoelectrolyte electron transporting layers |
| US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
| US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
| US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
| SG177355A1 (en) | 2009-06-26 | 2012-02-28 | Sirigen Inc | Signal amplified biological detection with conjugated polymers |
| ES2977359T3 (es) | 2010-01-19 | 2024-08-22 | Sirigen Ii Ltd | Nuevos reactivos para la amplificación dirigida de la señal de un biomarcador |
| WO2015050869A1 (en) | 2013-10-02 | 2015-04-09 | Becton Dickinson And Company | Polymersome encapsulation of hydrophobic fluorescent polymers |
| KR20170106487A (ko) * | 2015-02-02 | 2017-09-20 | 투 포어 가이즈, 인코포레이티드 | 시료 배경으로부터의 표적 폴리뉴클레오티드의 나노포어 검출 |
| CN107428918B (zh) | 2015-03-12 | 2021-07-30 | 贝克顿·迪金森公司 | 紫外线吸收聚合物染料及其使用方法 |
| WO2016191004A1 (en) | 2015-05-26 | 2016-12-01 | Becton, Dickinson And Company | Methods and systems for high resolution fluorescence microscopy of polymeric dye-labeled samples using polarized light |
| ES2911298T3 (es) | 2015-12-16 | 2022-05-18 | Becton Dickinson Co | Colorantes poliméricos en tándem fluorescentes fotoestables que incluyen complejos de metales luminiscentes |
| WO2017172608A1 (en) | 2016-03-28 | 2017-10-05 | Aat Bioquest, Inc. | Polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection |
| ES3046711T3 (en) | 2016-04-15 | 2025-12-02 | Beckman Coulter Inc | Photoactive macromolecules and uses thereof |
| JP7173867B2 (ja) | 2016-04-22 | 2022-11-16 | ベクトン・ディキンソン・アンド・カンパニー | 多重高分子色素デバイス及びその使用方法 |
| WO2017222998A1 (en) | 2016-06-20 | 2017-12-28 | Beckman Coulter, Inc. | Dry-down processes for dye-conjugated reagents |
| CN118530607A (zh) | 2016-07-07 | 2024-08-23 | 贝克顿·迪金森公司 | 发荧光的水溶剂化共轭聚合物 |
| WO2018009861A1 (en) | 2016-07-08 | 2018-01-11 | Biolegend | Substituted polyfluorene compounds |
| CN109689796A (zh) | 2016-07-11 | 2019-04-26 | 贝克顿·迪金森公司 | 可激发蓝色的水溶剂化聚合物染料 |
| CN106770088B (zh) * | 2016-11-24 | 2019-06-11 | 北京科技大学 | 用于dna检测的荧光复合纳米粒子的制备及检测方法 |
| EP3551703A4 (de) | 2016-12-12 | 2021-01-20 | Becton, Dickinson and Company | Wasserlösliche polymerfarbstoffe |
| US11320437B2 (en) | 2017-02-08 | 2022-05-03 | Becton, Dickinson And Company | Dried dye reagent devices and methods for making and using the same |
| CN106857504B (zh) * | 2017-02-10 | 2020-03-10 | 中国科学院化学研究所 | 一种抑制和/或破坏生物膜的方法 |
| JP7270254B2 (ja) | 2017-06-16 | 2023-05-10 | デューク ユニバーシティ | 改善された標識検出、演算、検体感知、および調整可能な乱数生成のための共鳴体ネットワーク |
| WO2019023463A1 (en) | 2017-07-28 | 2019-01-31 | Biolegend | CONJUGATED POLYMERS AND METHODS OF USE |
| WO2019133399A1 (en) | 2017-12-26 | 2019-07-04 | Becton, Dickinson And Company | Deep ultraviolet-excitable water-solvated polymeric dyes |
| CN113396006A (zh) | 2018-11-13 | 2021-09-14 | 贝克顿·迪金森公司 | 干燥试剂滤网及其制造和使用方法 |
| CN111850103B (zh) * | 2020-08-20 | 2022-12-02 | 清华大学深圳国际研究生院 | 一种基于阳离子共轭聚合物和核酸酶辅助循环扩增的检测目的核酸的方法 |
| CA3198558A1 (en) | 2020-11-13 | 2022-05-19 | Rajesh VENKATESH | Additives for reducing non-specific interactions between fluorescent polymer conjugates and cells in a biological sample |
| CN117015711A (zh) | 2021-02-05 | 2023-11-07 | 贝克曼库尔特有限公司 | 用于阻止聚合物染料-抗体缀合物之间的非特异性相互作用的组合物和方法 |
| WO2022216450A1 (en) | 2021-04-07 | 2022-10-13 | Becton, Dickinson And Company | Water-soluble fluorescent polymeric dyes |
| US20240270971A1 (en) | 2021-05-04 | 2024-08-15 | Beckman Coulter, Inc. | Uv-absorbing polymers, compositions and uses thereof |
| MX2024005772A (es) | 2021-11-12 | 2024-07-22 | Beckman Coulter Inc | Novedosa formulación para la tinción de anticuerpos conjugados con polímeros. |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4950587A (en) | 1988-09-02 | 1990-08-21 | Eastman Kodak Company | J-aggregating dye polymers as spectral sensitizers for silver halide photographic compositions |
| US4948843A (en) | 1989-05-30 | 1990-08-14 | Eastman Kodak Company | Dye polymer/sol-gel composites |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5763162A (en) * | 1990-03-14 | 1998-06-09 | The Regents Of University Of California | Multichromophore fluorescent DNA intercalation complexes |
| ES2155822T3 (es) | 1990-12-06 | 2001-06-01 | Affymetrix Inc | Compuestos y su utilizacion en una estrategia de sintesis binaria. |
| US5408109A (en) | 1991-02-27 | 1995-04-18 | The Regents Of The University Of California | Visible light emitting diodes fabricated from soluble semiconducting polymers |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5677195A (en) | 1991-11-22 | 1997-10-14 | Affymax Technologies N.V. | Combinatorial strategies for polymer synthesis |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5536820A (en) | 1993-02-26 | 1996-07-16 | E. I. Du Pont De Nemours And Company | Avidin-binding azo reagents |
| US5681702A (en) | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
| US6117635A (en) * | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5881083A (en) | 1997-07-03 | 1999-03-09 | The Regents Of The University Of California | Conjugated polymers as materials for solid state laser |
| US6322901B1 (en) | 1997-11-13 | 2001-11-27 | Massachusetts Institute Of Technology | Highly luminescent color-selective nano-crystalline materials |
| US5990479A (en) * | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| WO1999035288A1 (en) | 1998-01-09 | 1999-07-15 | Minnesota Mining And Manufacturing Company | Enzyme-specific cleavable polynucleotide substrate and assay method |
| US5968762A (en) | 1998-03-19 | 1999-10-19 | The University Of Connecticut | Method for detecting bacteria in a sample |
| GB9819417D0 (en) | 1998-09-07 | 1998-10-28 | Secr Defence | Reaction method |
| EP2306195A3 (de) * | 1998-09-18 | 2012-04-25 | Massachusetts Institute of Technology | Biologische Anwendungen von Halbleiternanokristallen |
| AU782254B2 (en) | 1999-05-05 | 2005-07-14 | Regents Of The University Of California, The | Method for detecting biological agents |
| WO2003074738A1 (en) | 2000-01-18 | 2003-09-12 | Quantom Dot Corporation | Oligonucleotide-tagged semiconductor nanocrystals for microarray and fluorescence in situ hybridization |
| EP2365096A1 (de) | 2000-03-22 | 2011-09-14 | Life Technologies Corporation | Verfahren zur Verwendung von Halbleiternanokristallen in Nukleinsäureassays auf Kügelchenbasis |
| CA2409512A1 (en) | 2000-05-08 | 2001-11-15 | Qtl Biosystems Llc | Improvements to the fluorescent polymer-qtl approach to biosensing |
| US20020177136A1 (en) | 2000-08-23 | 2002-11-28 | Mcbranch Duncan W. | Peptide nucleic acid based molecular sensors for nucleic acids |
| AU2002255771B2 (en) | 2001-03-16 | 2007-10-18 | Qtl Biosystems, Llc | Fluorescent polymer superquenching-based bioassays |
| EP1373246B1 (de) | 2001-04-05 | 2012-09-12 | Geneohm Sciences Canada, Inc. | Erkennung von negativ-geladenen polymeren mit hilfe von wasserlöslichen kationischen polythiophenderivaten |
| CA2458405A1 (en) | 2001-08-23 | 2003-03-06 | Qtl Biosystems, Llc | Bio-sensing platforms for detection and quantitation of biological molecules |
| EA007652B1 (ru) | 2002-06-20 | 2006-12-29 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Способ обнаружения и анализа полинуклеотидов с помощью светособирающих полихромофоров |
| EP2316971A1 (de) * | 2002-08-26 | 2011-05-04 | The Regents of the University of California | Verfahren und Zusammensetzungen zum Nachweis und zur Analyse von Polynuckleotiden unter Benutzung von lichtsammelnden Multichromophoren. |
| WO2006074482A2 (en) * | 2005-01-10 | 2006-07-13 | The Regents Of The University Of California | Methods and kits for strand-specific polynucleotide detection with cationic multichromophores |
| JP2016031772A (ja) | 2014-07-30 | 2016-03-07 | 株式会社日立ハイテクファインシステムズ | 熱アシスト磁気ヘッド素子の検査方法及びその装置 |
-
2003
- 2003-06-20 EA EA200500041A patent/EA007652B1/ru unknown
- 2003-06-20 DE DE60333646T patent/DE60333646D1/de not_active Expired - Lifetime
- 2003-06-20 CA CA2489922A patent/CA2489922C/en not_active Expired - Lifetime
- 2003-06-20 AT AT03761235T patent/ATE476521T1/de not_active IP Right Cessation
- 2003-06-20 EP EP10008095A patent/EP2278027A3/de not_active Ceased
- 2003-06-20 KR KR10-2004-7020729A patent/KR20050010956A/ko not_active Withdrawn
- 2003-06-20 CN CN038198363A patent/CN1675377B/zh not_active Expired - Lifetime
- 2003-06-20 EP EP03761235A patent/EP1534857B1/de not_active Expired - Lifetime
- 2003-06-20 CN CN2012102827293A patent/CN102766695A/zh active Pending
- 2003-06-20 WO PCT/US2003/019678 patent/WO2004001379A2/en not_active Ceased
- 2003-06-20 JP JP2004516105A patent/JP4528115B2/ja not_active Expired - Lifetime
- 2003-06-20 US US10/600,286 patent/US7214489B2/en not_active Expired - Lifetime
- 2003-06-20 AU AU2003243722A patent/AU2003243722A1/en not_active Abandoned
-
2004
- 2004-12-20 IL IL16587704A patent/IL165877A0/xx unknown
-
2007
- 2007-05-08 US US11/746,055 patent/US8101416B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4528115B2 (ja) | 2010-08-18 |
| JP2005530182A (ja) | 2005-10-06 |
| IL165877A0 (en) | 2006-01-15 |
| EP2278027A2 (de) | 2011-01-26 |
| EP1534857A2 (de) | 2005-06-01 |
| CN102766695A (zh) | 2012-11-07 |
| CA2489922C (en) | 2016-08-16 |
| EA007652B1 (ru) | 2006-12-29 |
| KR20050010956A (ko) | 2005-01-28 |
| US20040219556A1 (en) | 2004-11-04 |
| EP2278027A3 (de) | 2011-02-16 |
| CN1675377A (zh) | 2005-09-28 |
| WO2004001379A3 (en) | 2004-06-03 |
| EA200500041A1 (ru) | 2005-08-25 |
| US20080280369A1 (en) | 2008-11-13 |
| EP1534857B1 (de) | 2010-08-04 |
| CA2489922A1 (en) | 2003-12-31 |
| WO2004001379A2 (en) | 2003-12-31 |
| DE60333646D1 (de) | 2010-09-16 |
| US7214489B2 (en) | 2007-05-08 |
| CN1675377B (zh) | 2012-10-03 |
| US8101416B2 (en) | 2012-01-24 |
| EP1534857A4 (de) | 2007-10-31 |
| AU2003243722A1 (en) | 2004-01-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60333646D1 (de) | Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren | |
| ATE448327T1 (de) | Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotidbindungsproteinwechselwirkungen unter verwendung licht sammelnder multichromophoren | |
| WO2004092324A3 (en) | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores | |
| DE60133111D1 (de) | Verfahren zur erkennung und zum assay von nukleinsäuresequenzen | |
| ATE398187T1 (de) | Verfahren zum nachweis von ziel-nukleinsäuren mittels pcr | |
| ATE452206T1 (de) | Verfahren für verbesserte lumineszenztests unter verwendung von mikropartikeln | |
| DE60216777D1 (de) | Multiplex-hpv-pcr-fluoreszenzassays unter verwendung mehrerer fluorophore | |
| RU2003100531A (ru) | Композиции, содержащие краситель на основе производного мочевины, для выявления аналита, и способы их использования | |
| ATE362995T1 (de) | Verfahren zum nachweis von cytosinmethylierungsmustern mit hoher sensitivität | |
| DE60331918D1 (de) | Verfahren und vorrichtung zur messung der anzahl weisser blutzellen | |
| DE602007000887D1 (de) | Reagens, Ausstattung und Verfahren zur Probenanalyse | |
| DE69024955D1 (de) | Ermittlung und quantifizierung mehrerer analyten unter verwendung von markierungstechniken | |
| RU2006105626A (ru) | Определение последовательности полинуклеотида | |
| DE50210825D1 (de) | Verfahren zur identifikation von fluoreszierenden, lumineszierenden und/oder absorbierenden substanzen auf und/oder in probenträgern | |
| WO2001068913A3 (en) | Nucleic acid detection method and system | |
| ATE494392T1 (de) | Zweifarbige echtzeit/endpunkt-quantifizierung von mikro-rnas (mirnas) | |
| WO2002084271A3 (en) | Methods and sensors for luminescent and optoelectronic detection and analysis of polynucleotides | |
| US20030190407A1 (en) | Method for forgery-proof marking;forgery-proof marking and kit | |
| DK1173748T3 (da) | Fremgangsmåde og indretning til detektering af variationer af optiske egenskaber af en prøve i en analyseproces | |
| FI20010041A0 (fi) | Menetelmä ja testikitti polynukleotidimäärien vaihteluiden kvantitatiiviseen ja/tai vertailevaan arviointiin solu- tai kudosnäytteistä | |
| ATE493516T1 (de) | Verfahren und vorrichtung zur authentifizierung von mit einer markierung versehenen gegenständen | |
| ATE553221T1 (de) | Verfahren zum nachweis von amplifikation oder deletion in einem genomischen dna-fragment | |
| EP1400588A4 (de) | Polynucleotidsonde und primer mit ursprung im hepatitis-e-virus von japanern, chips damit, kits damit und verfahren zur erkennung des hepatitis-e-virus damit | |
| DE60017750D1 (de) | Amplifizierungsverfahen zum nachweis von zielnukleinsäuren unter verwendung von fluoreszenzenergieübertragung | |
| DE60031042D1 (de) | Verfahren und Vorrichtung zur schnellen Messung von Zellschichten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |