ATE476521T1 - Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren - Google Patents
Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophorenInfo
- Publication number
- ATE476521T1 ATE476521T1 AT03761235T AT03761235T ATE476521T1 AT E476521 T1 ATE476521 T1 AT E476521T1 AT 03761235 T AT03761235 T AT 03761235T AT 03761235 T AT03761235 T AT 03761235T AT E476521 T1 ATE476521 T1 AT E476521T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- compositions
- multichromophores
- trapping
- target polynucleotide
- Prior art date
Links
- 102000040430 polynucleotide Human genes 0.000 title abstract 5
- 108091033319 polynucleotide Proteins 0.000 title abstract 5
- 239000002157 polynucleotide Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/107—Modifications characterised by incorporating a peptide nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/125—Specific component of sample, medium or buffer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/107—Alteration in the property of hybridised versus free label oligonucleotides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Medical Informatics (AREA)
- Manufacturing & Machinery (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39052402P | 2002-06-20 | 2002-06-20 | |
| US40626602P | 2002-08-26 | 2002-08-26 | |
| PCT/US2003/019678 WO2004001379A2 (en) | 2002-06-20 | 2003-06-20 | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE476521T1 true ATE476521T1 (de) | 2010-08-15 |
Family
ID=30003161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03761235T ATE476521T1 (de) | 2002-06-20 | 2003-06-20 | Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7214489B2 (de) |
| EP (2) | EP1534857B1 (de) |
| JP (1) | JP4528115B2 (de) |
| KR (1) | KR20050010956A (de) |
| CN (2) | CN102766695A (de) |
| AT (1) | ATE476521T1 (de) |
| AU (1) | AU2003243722A1 (de) |
| CA (1) | CA2489922C (de) |
| DE (1) | DE60333646D1 (de) |
| EA (1) | EA007652B1 (de) |
| IL (1) | IL165877A0 (de) |
| WO (1) | WO2004001379A2 (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| AU2003202026A1 (en) | 2002-01-16 | 2003-09-02 | Dynal Biotech Asa | Method for isolating nucleic acids and protein from a single sample |
| US10001475B2 (en) | 2002-06-20 | 2018-06-19 | The Regents Of The University Of California | Light harvesting multichromophore compositions and methods of using the same |
| US9371559B2 (en) | 2002-06-20 | 2016-06-21 | The Regents Of The University Of California | Compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| AU2003243722A1 (en) * | 2002-06-20 | 2004-01-06 | The Regents Of The University Of California | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| US7144950B2 (en) | 2003-09-17 | 2006-12-05 | The Regents Of The University Of California | Conformationally flexible cationic conjugated polymers |
| WO2004092324A2 (en) | 2002-08-26 | 2004-10-28 | The Regents Of The University Of California | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| GB0229287D0 (en) * | 2002-12-16 | 2003-01-22 | Dna Res Innovations Ltd | Polyfunctional reagents |
| CN1771335A (zh) * | 2003-02-13 | 2006-05-10 | 加州大学评议会 | 使用集光多生色团检测和分析多核苷酸－结合蛋白相互作用的方法和组合物 |
| WO2005056628A2 (en) | 2003-09-17 | 2005-06-23 | The Regents Of The University Of California | Methods and devices comprising soluble conjugated polymers |
| JP5909314B2 (ja) | 2004-09-03 | 2016-04-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 可溶性共役ポリマーを使用する方法及びデバイス |
| US8309672B2 (en) | 2004-09-03 | 2012-11-13 | The Regents Of The University Of California | Soluble conjugated polymers |
| WO2006074471A2 (en) * | 2005-01-10 | 2006-07-13 | The Regents Of The University Of California | Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays |
| WO2006074482A2 (en) | 2005-01-10 | 2006-07-13 | The Regents Of The University Of California | Methods and kits for strand-specific polynucleotide detection with cationic multichromophores |
| WO2006083932A2 (en) | 2005-01-31 | 2006-08-10 | The Regents Of The University | Methods and compositions for aggregant detection |
| JP5529382B2 (ja) | 2005-03-01 | 2014-06-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 固体照明に用いられる多層ポリマー発光ダイオード |
| ATE458835T1 (de) * | 2005-03-03 | 2010-03-15 | Ca Nat Research Council | Verfahren und zusammensetzungen zum nachweis und zur analyse von nukleinsäuren mittels signalverstärkung |
| US8057989B2 (en) * | 2006-02-10 | 2011-11-15 | The University Of Hong Kong | Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes |
| US8309304B2 (en) | 2006-02-10 | 2012-11-13 | The University Of Hong Kong | Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes |
| JP5420414B2 (ja) | 2006-10-06 | 2014-02-19 | シリゲン グループ リミテッド | 指向性バイオマーカシグナル増幅用の蛍光方法および材料 |
| ITTO20060883A1 (it) * | 2006-12-14 | 2008-06-15 | Consiglio Naz Delle Ricerche Infm | Procedimento e microdispositivo a trasduzione ottica per l'identificazione e/o quantificazione di un analita in un campione biologico |
| KR20080060744A (ko) * | 2006-12-27 | 2008-07-02 | 한국조폐공사 | 피엔에이 함유 잉크 및 이의 확인방법 |
| WO2009009889A1 (en) * | 2007-07-13 | 2009-01-22 | National Research Council Of Canada | Ultrasensitive detection of target using target-ready particles |
| US20090137925A1 (en) * | 2007-11-23 | 2009-05-28 | Divya Cantor | Impedance Spectroscopy Cervix Scanning Apparatus and Method |
| US20090230362A1 (en) * | 2008-01-25 | 2009-09-17 | Bazan Guillermo C | Conjugated oligoelectrolyte electron transporting layers |
| US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
| US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
| US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
| WO2010151807A1 (en) | 2009-06-26 | 2010-12-29 | Sirigen, Inc. | Signal amplified biological detection with conjugated polymers |
| EP4322238A3 (de) | 2010-01-19 | 2024-05-15 | Sirigen II Limited | Neuartige reagenzien für ausgerichtete biomarkersignalverstärkung |
| US9557337B2 (en) | 2013-10-02 | 2017-01-31 | Becton, Dickinson And Company | Polymersome encapsulation of hydrophobic fluorescent polymers |
| US11098348B2 (en) | 2015-02-02 | 2021-08-24 | Ontera Inc. | Nanopore detection of target polynucleotides from sample background |
| EP4328270A2 (de) | 2015-03-12 | 2024-02-28 | Becton, Dickinson and Company | Uv-absorbierende polymerfarbstoffe und verfahren zur verwendung davon |
| WO2016191004A1 (en) | 2015-05-26 | 2016-12-01 | Becton, Dickinson And Company | Methods and systems for high resolution fluorescence microscopy of polymeric dye-labeled samples using polarized light |
| ES2911298T3 (es) | 2015-12-16 | 2022-05-18 | Becton Dickinson Co | Colorantes poliméricos en tándem fluorescentes fotoestables que incluyen complejos de metales luminiscentes |
| CN108473505B (zh) | 2016-03-28 | 2019-11-05 | 阿特生物探索公司 | 聚芴并[4,5-cde]氧杂环庚三烯偶联物及其在分析物检测方法中的用途 |
| ES3046711T3 (en) | 2016-04-15 | 2025-12-02 | Beckman Coulter Inc | Photoactive macromolecules and uses thereof |
| CN120820389A (zh) | 2016-04-22 | 2025-10-21 | 贝克顿·迪金森公司 | 多重聚合染料装置及其使用方法 |
| US11249075B2 (en) | 2016-06-20 | 2022-02-15 | Beckman Coulter, Inc. | Dry-down processes for dye-conjugated reagents |
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| CN119306927A (zh) | 2016-07-11 | 2025-01-14 | 贝克顿·迪金森公司 | 可激发蓝色的水溶剂化聚合物染料 |
| CN106770088B (zh) * | 2016-11-24 | 2019-06-11 | 北京科技大学 | 用于dna检测的荧光复合纳米粒子的制备及检测方法 |
| JP7097885B2 (ja) | 2016-12-12 | 2022-07-08 | ベクトン・ディキンソン・アンド・カンパニー | 水溶性ポリマー色素 |
| CA3052595A1 (en) | 2017-02-08 | 2018-08-16 | Becton, Dickinson And Company | Dried dye reagent devices and methods for making and using the same |
| CN106857504B (zh) * | 2017-02-10 | 2020-03-10 | 中国科学院化学研究所 | 一种抑制和/或破坏生物膜的方法 |
| CN116519642A (zh) | 2017-06-16 | 2023-08-01 | 杜克大学 | 用于改善标记检测、计算、分析物感应和可调随机数生成的谐振器网络和方法 |
| EP3974496B1 (de) | 2017-07-28 | 2022-12-14 | BioLegend, Inc. | Konjugierte polymere und verfahren zur verwendung |
| CN111094462A (zh) | 2017-12-26 | 2020-05-01 | 贝克顿·迪金森公司 | 深紫外线可激发的水溶剂化聚合物染料 |
| US11992844B2 (en) | 2018-11-13 | 2024-05-28 | Becton, Dickinson And Company | Dried reagent strainers and methods for making and using the same |
| CN111850103B (zh) * | 2020-08-20 | 2022-12-02 | 清华大学深圳国际研究生院 | 一种基于阳离子共轭聚合物和核酸酶辅助循环扩增的检测目的核酸的方法 |
| AU2021380843A1 (en) | 2020-11-13 | 2023-06-15 | Beckman Coulter, Inc. | Additives for reducing non-specific interactions between fluorescent polymer conjugates and cells in a biological sample |
| JP2024509725A (ja) | 2021-02-05 | 2024-03-05 | ベックマン コールター， インコーポレイテッド | ポリマー色素－抗体コンジュゲート間の非特異的相互作用を阻止する組成物および方法 |
| EP4267971A4 (de) | 2021-04-07 | 2024-08-07 | Becton, Dickinson and Company | Wasserlösliche fluoreszierende polymerfarbstoffe |
| US20240270971A1 (en) | 2021-05-04 | 2024-08-15 | Beckman Coulter, Inc. | Uv-absorbing polymers, compositions and uses thereof |
| WO2023086103A1 (en) | 2021-11-12 | 2023-05-19 | Beckman Coulter, Inc. | Novel formulation for drying of polymer dye conjugated antibodies |
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| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
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| AU2003243722A1 (en) | 2002-06-20 | 2004-01-06 | The Regents Of The University Of California | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| WO2004092324A2 (en) * | 2002-08-26 | 2004-10-28 | The Regents Of The University Of California | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| WO2006074482A2 (en) * | 2005-01-10 | 2006-07-13 | The Regents Of The University Of California | Methods and kits for strand-specific polynucleotide detection with cationic multichromophores |
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-
2003
- 2003-06-20 AU AU2003243722A patent/AU2003243722A1/en not_active Abandoned
- 2003-06-20 CA CA2489922A patent/CA2489922C/en not_active Expired - Lifetime
- 2003-06-20 WO PCT/US2003/019678 patent/WO2004001379A2/en not_active Ceased
- 2003-06-20 KR KR10-2004-7020729A patent/KR20050010956A/ko not_active Withdrawn
- 2003-06-20 EA EA200500041A patent/EA007652B1/ru unknown
- 2003-06-20 CN CN2012102827293A patent/CN102766695A/zh active Pending
- 2003-06-20 EP EP03761235A patent/EP1534857B1/de not_active Expired - Lifetime
- 2003-06-20 DE DE60333646T patent/DE60333646D1/de not_active Expired - Lifetime
- 2003-06-20 AT AT03761235T patent/ATE476521T1/de not_active IP Right Cessation
- 2003-06-20 EP EP10008095A patent/EP2278027A3/de not_active Ceased
- 2003-06-20 JP JP2004516105A patent/JP4528115B2/ja not_active Expired - Lifetime
- 2003-06-20 US US10/600,286 patent/US7214489B2/en not_active Expired - Lifetime
- 2003-06-20 CN CN038198363A patent/CN1675377B/zh not_active Expired - Lifetime
-
2004
- 2004-12-20 IL IL16587704A patent/IL165877A0/xx unknown
-
2007
- 2007-05-08 US US11/746,055 patent/US8101416B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20080280369A1 (en) | 2008-11-13 |
| JP4528115B2 (ja) | 2010-08-18 |
| CN102766695A (zh) | 2012-11-07 |
| DE60333646D1 (de) | 2010-09-16 |
| WO2004001379A3 (en) | 2004-06-03 |
| US7214489B2 (en) | 2007-05-08 |
| EP1534857A4 (de) | 2007-10-31 |
| EP2278027A2 (de) | 2011-01-26 |
| EP1534857A2 (de) | 2005-06-01 |
| CN1675377A (zh) | 2005-09-28 |
| EP2278027A3 (de) | 2011-02-16 |
| CA2489922A1 (en) | 2003-12-31 |
| EP1534857B1 (de) | 2010-08-04 |
| KR20050010956A (ko) | 2005-01-28 |
| IL165877A0 (en) | 2006-01-15 |
| US8101416B2 (en) | 2012-01-24 |
| CN1675377B (zh) | 2012-10-03 |
| EA200500041A1 (ru) | 2005-08-25 |
| AU2003243722A1 (en) | 2004-01-06 |
| EA007652B1 (ru) | 2006-12-29 |
| CA2489922C (en) | 2016-08-16 |
| WO2004001379A2 (en) | 2003-12-31 |
| JP2005530182A (ja) | 2005-10-06 |
| US20040219556A1 (en) | 2004-11-04 |
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