ATE476521T1 - Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren - Google Patents
Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophorenInfo
- Publication number
- ATE476521T1 ATE476521T1 AT03761235T AT03761235T ATE476521T1 AT E476521 T1 ATE476521 T1 AT E476521T1 AT 03761235 T AT03761235 T AT 03761235T AT 03761235 T AT03761235 T AT 03761235T AT E476521 T1 ATE476521 T1 AT E476521T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- compositions
- multichromophores
- trapping
- target polynucleotide
- Prior art date
Links
- 102000040430 polynucleotide Human genes 0.000 title abstract 5
- 108091033319 polynucleotide Proteins 0.000 title abstract 5
- 239000002157 polynucleotide Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/107—Modifications characterised by incorporating a peptide nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/125—Specific component of sample, medium or buffer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/107—Alteration in the property of hybridised versus free label oligonucleotides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Medical Informatics (AREA)
- Manufacturing & Machinery (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39052402P | 2002-06-20 | 2002-06-20 | |
| US40626602P | 2002-08-26 | 2002-08-26 | |
| PCT/US2003/019678 WO2004001379A2 (en) | 2002-06-20 | 2003-06-20 | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE476521T1 true ATE476521T1 (de) | 2010-08-15 |
Family
ID=30003161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03761235T ATE476521T1 (de) | 2002-06-20 | 2003-06-20 | Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7214489B2 (de) |
| EP (2) | EP1534857B1 (de) |
| JP (1) | JP4528115B2 (de) |
| KR (1) | KR20050010956A (de) |
| CN (2) | CN1675377B (de) |
| AT (1) | ATE476521T1 (de) |
| AU (1) | AU2003243722A1 (de) |
| CA (1) | CA2489922C (de) |
| DE (1) | DE60333646D1 (de) |
| EA (1) | EA007652B1 (de) |
| IL (1) | IL165877A0 (de) |
| WO (1) | WO2004001379A2 (de) |
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| GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| CN1617938A (zh) | 2002-01-16 | 2005-05-18 | 戴诺生物技术有限公司 | 从单个样品中分离核酸和蛋白质的方法 |
| CN1675377B (zh) * | 2002-06-20 | 2012-10-03 | 加州大学评议会 | 利用获取光的多发色团检测和分析多核苷酸的方法和组合物 |
| US7144950B2 (en) | 2003-09-17 | 2006-12-05 | The Regents Of The University Of California | Conformationally flexible cationic conjugated polymers |
| US9371559B2 (en) | 2002-06-20 | 2016-06-21 | The Regents Of The University Of California | Compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| US10001475B2 (en) | 2002-06-20 | 2018-06-19 | The Regents Of The University Of California | Light harvesting multichromophore compositions and methods of using the same |
| KR20050055717A (ko) * | 2002-08-26 | 2005-06-13 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 집광 다발색단을 사용하여 폴리뉴클레오티드를 검출 및 분석하기 위한 방법 및 조성물 |
| GB0229287D0 (en) * | 2002-12-16 | 2003-01-22 | Dna Res Innovations Ltd | Polyfunctional reagents |
| ES2440920T3 (es) | 2003-02-13 | 2014-01-31 | The Regents Of The University Of California | Métodos y composiciones para la detección y análisis de interacciones de proteínas que se unen a polinucleótidos utilizando multicromóforos captadores de luz |
| JP5219371B2 (ja) | 2003-09-17 | 2013-06-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 可溶性共役ポリマーを含む方法及びデバイス |
| DE112005002132T5 (de) | 2004-09-03 | 2008-03-06 | The Regents Of The University Of California, Oakland | Lösliche konjugierte Polymere |
| JP5909314B2 (ja) | 2004-09-03 | 2016-04-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 可溶性共役ポリマーを使用する方法及びデバイス |
| WO2006074482A2 (en) * | 2005-01-10 | 2006-07-13 | The Regents Of The University Of California | Methods and kits for strand-specific polynucleotide detection with cationic multichromophores |
| US7897684B2 (en) | 2005-01-10 | 2011-03-01 | The Regents Of The University Of California | Conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays |
| US7666594B2 (en) | 2005-01-31 | 2010-02-23 | The Regents Of The University Of California | Methods for assaying a sample for an aggregant |
| JP5529382B2 (ja) | 2005-03-01 | 2014-06-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 固体照明に用いられる多層ポリマー発光ダイオード |
| WO2006092063A1 (en) * | 2005-03-03 | 2006-09-08 | National Research Council Canada | Methods and compositions for the detection and analysis of nucleic acids by signal amplification |
| US8309304B2 (en) | 2006-02-10 | 2012-11-13 | The University Of Hong Kong | Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes |
| US8057989B2 (en) * | 2006-02-10 | 2011-11-15 | The University Of Hong Kong | Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes |
| US8158444B2 (en) | 2006-10-06 | 2012-04-17 | Sirigen, Inc. | Fluorescent methods and materials for directed biomarker signal amplification |
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| KR20080060744A (ko) * | 2006-12-27 | 2008-07-02 | 한국조폐공사 | 피엔에이 함유 잉크 및 이의 확인방법 |
| WO2009009889A1 (en) * | 2007-07-13 | 2009-01-22 | National Research Council Of Canada | Ultrasensitive detection of target using target-ready particles |
| US20090137925A1 (en) * | 2007-11-23 | 2009-05-28 | Divya Cantor | Impedance Spectroscopy Cervix Scanning Apparatus and Method |
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| US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| WO2022104147A1 (en) | 2020-11-13 | 2022-05-19 | Beckman Coulter, Inc. | Additives for reducing non-specific interactions between fluorescent polymer conjugates and cells in a biological sample |
| SG177355A1 (en) | 2009-06-26 | 2012-02-28 | Sirigen Inc | Signal amplified biological detection with conjugated polymers |
| CA2786713C (en) | 2010-01-19 | 2018-03-06 | Sirigen Group Limited | Novel reagents for directed biomarker signal amplification |
| US9557337B2 (en) | 2013-10-02 | 2017-01-31 | Becton, Dickinson And Company | Polymersome encapsulation of hydrophobic fluorescent polymers |
| HK1245348A1 (zh) * | 2015-02-02 | 2018-08-24 | 奥特拉公司 | 来自样品背景的靶多核苷酸的纳米孔隙检测 |
| CN107428918B (zh) * | 2015-03-12 | 2021-07-30 | 贝克顿·迪金森公司 | 紫外线吸收聚合物染料及其使用方法 |
| US10408759B2 (en) | 2015-05-26 | 2019-09-10 | Becton, Dickinson And Company | Methods and systems for high resolution fluorescence microscopy of polymeric dye-labeled samples using polarized light |
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| JP7097885B2 (ja) | 2016-12-12 | 2022-07-08 | ベクトン・ディキンソン・アンド・カンパニー | 水溶性ポリマー色素 |
| CN110337331B (zh) | 2017-02-08 | 2022-04-26 | 贝克顿·迪金森公司 | 干染料试剂装置以及制造和使用所述干染料试剂装置的方法 |
| CN106857504B (zh) * | 2017-02-10 | 2020-03-10 | 中国科学院化学研究所 | 一种抑制和/或破坏生物膜的方法 |
| IL271386B2 (en) | 2017-06-16 | 2025-02-01 | Univ Duke | Enhanced resonator networks for label detection, computation, analyte sensing, and tunable random number generation |
| EP3658648B1 (de) | 2017-07-28 | 2021-10-27 | BioLegend, Inc. | Konjugierte polymere und verfahren zur verwendung |
| CN119286279A (zh) | 2017-12-26 | 2025-01-10 | 贝克顿·迪金森公司 | 深紫外线可激发的水溶剂化聚合物染料 |
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| CN111850103B (zh) * | 2020-08-20 | 2022-12-02 | 清华大学深圳国际研究生院 | 一种基于阳离子共轭聚合物和核酸酶辅助循环扩增的检测目的核酸的方法 |
| AU2022216619A1 (en) | 2021-02-05 | 2023-09-07 | Beckman Coulter, Inc. | Compositions and methods for preventing non-specific interactions between polymer dyes-antibody conjugates |
| WO2022216450A1 (en) | 2021-04-07 | 2022-10-13 | Becton, Dickinson And Company | Water-soluble fluorescent polymeric dyes |
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| CN1675377B (zh) | 2002-06-20 | 2012-10-03 | 加州大学评议会 | 利用获取光的多发色团检测和分析多核苷酸的方法和组合物 |
| KR20050055717A (ko) * | 2002-08-26 | 2005-06-13 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 집광 다발색단을 사용하여 폴리뉴클레오티드를 검출 및 분석하기 위한 방법 및 조성물 |
| WO2006074482A2 (en) * | 2005-01-10 | 2006-07-13 | The Regents Of The University Of California | Methods and kits for strand-specific polynucleotide detection with cationic multichromophores |
| JP2016031772A (ja) | 2014-07-30 | 2016-03-07 | 株式会社日立ハイテクファインシステムズ | 熱アシスト磁気ヘッド素子の検査方法及びその装置 |
-
2003
- 2003-06-20 CN CN038198363A patent/CN1675377B/zh not_active Expired - Lifetime
- 2003-06-20 US US10/600,286 patent/US7214489B2/en not_active Expired - Lifetime
- 2003-06-20 EP EP03761235A patent/EP1534857B1/de not_active Expired - Lifetime
- 2003-06-20 DE DE60333646T patent/DE60333646D1/de not_active Expired - Lifetime
- 2003-06-20 WO PCT/US2003/019678 patent/WO2004001379A2/en not_active Ceased
- 2003-06-20 EP EP10008095A patent/EP2278027A3/de not_active Ceased
- 2003-06-20 JP JP2004516105A patent/JP4528115B2/ja not_active Expired - Lifetime
- 2003-06-20 AT AT03761235T patent/ATE476521T1/de not_active IP Right Cessation
- 2003-06-20 AU AU2003243722A patent/AU2003243722A1/en not_active Abandoned
- 2003-06-20 KR KR10-2004-7020729A patent/KR20050010956A/ko not_active Withdrawn
- 2003-06-20 CA CA2489922A patent/CA2489922C/en not_active Expired - Lifetime
- 2003-06-20 EA EA200500041A patent/EA007652B1/ru unknown
- 2003-06-20 CN CN2012102827293A patent/CN102766695A/zh active Pending
-
2004
- 2004-12-20 IL IL16587704A patent/IL165877A0/xx unknown
-
2007
- 2007-05-08 US US11/746,055 patent/US8101416B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20080280369A1 (en) | 2008-11-13 |
| CN1675377B (zh) | 2012-10-03 |
| CN102766695A (zh) | 2012-11-07 |
| KR20050010956A (ko) | 2005-01-28 |
| AU2003243722A1 (en) | 2004-01-06 |
| CA2489922C (en) | 2016-08-16 |
| IL165877A0 (en) | 2006-01-15 |
| CN1675377A (zh) | 2005-09-28 |
| EP1534857A2 (de) | 2005-06-01 |
| JP4528115B2 (ja) | 2010-08-18 |
| WO2004001379A2 (en) | 2003-12-31 |
| US8101416B2 (en) | 2012-01-24 |
| CA2489922A1 (en) | 2003-12-31 |
| EP2278027A2 (de) | 2011-01-26 |
| EA007652B1 (ru) | 2006-12-29 |
| WO2004001379A3 (en) | 2004-06-03 |
| DE60333646D1 (de) | 2010-09-16 |
| EA200500041A1 (ru) | 2005-08-25 |
| EP2278027A3 (de) | 2011-02-16 |
| US7214489B2 (en) | 2007-05-08 |
| EP1534857A4 (de) | 2007-10-31 |
| US20040219556A1 (en) | 2004-11-04 |
| JP2005530182A (ja) | 2005-10-06 |
| EP1534857B1 (de) | 2010-08-04 |
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