ATE476521T1 - Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren - Google Patents
Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophorenInfo
- Publication number
- ATE476521T1 ATE476521T1 AT03761235T AT03761235T ATE476521T1 AT E476521 T1 ATE476521 T1 AT E476521T1 AT 03761235 T AT03761235 T AT 03761235T AT 03761235 T AT03761235 T AT 03761235T AT E476521 T1 ATE476521 T1 AT E476521T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- compositions
- multichromophores
- trapping
- target polynucleotide
- Prior art date
Links
- 102000040430 polynucleotide Human genes 0.000 title abstract 5
- 108091033319 polynucleotide Proteins 0.000 title abstract 5
- 239000002157 polynucleotide Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/107—Modifications characterised by incorporating a peptide nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/125—Specific component of sample, medium or buffer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/107—Alteration in the property of hybridised versus free label oligonucleotides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39052402P | 2002-06-20 | 2002-06-20 | |
| US40626602P | 2002-08-26 | 2002-08-26 | |
| PCT/US2003/019678 WO2004001379A2 (en) | 2002-06-20 | 2003-06-20 | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE476521T1 true ATE476521T1 (de) | 2010-08-15 |
Family
ID=30003161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03761235T ATE476521T1 (de) | 2002-06-20 | 2003-06-20 | Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7214489B2 (de) |
| EP (2) | EP1534857B1 (de) |
| JP (1) | JP4528115B2 (de) |
| KR (1) | KR20050010956A (de) |
| CN (2) | CN102766695A (de) |
| AT (1) | ATE476521T1 (de) |
| AU (1) | AU2003243722A1 (de) |
| CA (1) | CA2489922C (de) |
| DE (1) | DE60333646D1 (de) |
| EA (1) | EA007652B1 (de) |
| IL (1) | IL165877A0 (de) |
| WO (1) | WO2004001379A2 (de) |
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|---|---|---|---|---|
| GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| CN1617938A (zh) | 2002-01-16 | 2005-05-18 | 戴诺生物技术有限公司 | 从单个样品中分离核酸和蛋白质的方法 |
| US10001475B2 (en) | 2002-06-20 | 2018-06-19 | The Regents Of The University Of California | Light harvesting multichromophore compositions and methods of using the same |
| DE60333646D1 (de) * | 2002-06-20 | 2010-09-16 | Univ California | Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren |
| US9371559B2 (en) | 2002-06-20 | 2016-06-21 | The Regents Of The University Of California | Compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| US7144950B2 (en) | 2003-09-17 | 2006-12-05 | The Regents Of The University Of California | Conformationally flexible cationic conjugated polymers |
| CA2497152C (en) * | 2002-08-26 | 2016-06-07 | The Regents Of The University Of California | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| GB0229287D0 (en) * | 2002-12-16 | 2003-01-22 | Dna Res Innovations Ltd | Polyfunctional reagents |
| CN1771335A (zh) * | 2003-02-13 | 2006-05-10 | 加州大学评议会 | 使用集光多生色团检测和分析多核苷酸－结合蛋白相互作用的方法和组合物 |
| JP5219371B2 (ja) | 2003-09-17 | 2013-06-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 可溶性共役ポリマーを含む方法及びデバイス |
| JP2008512523A (ja) | 2004-09-03 | 2008-04-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 可溶性共役ポリマー |
| JP5909314B2 (ja) | 2004-09-03 | 2016-04-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 可溶性共役ポリマーを使用する方法及びデバイス |
| WO2006074482A2 (en) * | 2005-01-10 | 2006-07-13 | The Regents Of The University Of California | Methods and kits for strand-specific polynucleotide detection with cationic multichromophores |
| WO2006074471A2 (en) | 2005-01-10 | 2006-07-13 | The Regents Of The University Of California | Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays |
| US7666594B2 (en) * | 2005-01-31 | 2010-02-23 | The Regents Of The University Of California | Methods for assaying a sample for an aggregant |
| DE112006000495B4 (de) | 2005-03-01 | 2017-11-09 | The Regents Of The University Of California | Mehrschichtige Licht emittierende Polymer-Diode für Festkörper Beleuchtungs-Anwendungen |
| AU2006220201B8 (en) * | 2005-03-03 | 2011-11-17 | National Research Council Of Canada | Methods and compositions for the detection and analysis of nucleic acids by signal amplification |
| US8057989B2 (en) | 2006-02-10 | 2011-11-15 | The University Of Hong Kong | Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes |
| US8309304B2 (en) | 2006-02-10 | 2012-11-13 | The University Of Hong Kong | Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes |
| JP5420414B2 (ja) | 2006-10-06 | 2014-02-19 | シリゲン グループ リミテッド | 指向性バイオマーカシグナル増幅用の蛍光方法および材料 |
| ITTO20060883A1 (it) * | 2006-12-14 | 2008-06-15 | Consiglio Naz Delle Ricerche Infm | Procedimento e microdispositivo a trasduzione ottica per l'identificazione e/o quantificazione di un analita in un campione biologico |
| KR20080060744A (ko) * | 2006-12-27 | 2008-07-02 | 한국조폐공사 | 피엔에이 함유 잉크 및 이의 확인방법 |
| US8765369B2 (en) * | 2007-07-13 | 2014-07-01 | National Research Council Of Canada | Ultrasensitive detection of target using target-ready particles |
| US20090137925A1 (en) * | 2007-11-23 | 2009-05-28 | Divya Cantor | Impedance Spectroscopy Cervix Scanning Apparatus and Method |
| US20090230362A1 (en) * | 2008-01-25 | 2009-09-17 | Bazan Guillermo C | Conjugated oligoelectrolyte electron transporting layers |
| US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
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| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
| SG177355A1 (en) | 2009-06-26 | 2012-02-28 | Sirigen Inc | Signal amplified biological detection with conjugated polymers |
| ES2977359T3 (es) | 2010-01-19 | 2024-08-22 | Sirigen Ii Ltd | Nuevos reactivos para la amplificación dirigida de la señal de un biomarcador |
| US9557337B2 (en) | 2013-10-02 | 2017-01-31 | Becton, Dickinson And Company | Polymersome encapsulation of hydrophobic fluorescent polymers |
| KR20190127983A (ko) | 2015-02-02 | 2019-11-13 | 투 포어 가이즈, 인코포레이티드 | 시료 배경으로부터의 표적 폴리뉴클레오티드의 나노포어 검출 |
| EP3268434A4 (de) | 2015-03-12 | 2019-03-27 | Becton, Dickinson and Company | Uv-absorbierende polymerfarbstoffe und verfahren zur verwendung davon |
| WO2016191004A1 (en) | 2015-05-26 | 2016-12-01 | Becton, Dickinson And Company | Methods and systems for high resolution fluorescence microscopy of polymeric dye-labeled samples using polarized light |
| WO2017105928A1 (en) | 2015-12-16 | 2017-06-22 | Becton, Dickinson And Company | Photostable fluorescent polymeric tandem dyes including luminescent metal complexes |
| CN108473505B (zh) | 2016-03-28 | 2019-11-05 | 阿特生物探索公司 | 聚芴并[4,5-cde]氧杂环庚三烯偶联物及其在分析物检测方法中的用途 |
| WO2017180998A2 (en) | 2016-04-15 | 2017-10-19 | Beckman Coulter, Inc. | Photoactive macromolecules and uses thereof |
| CN120820389A (zh) | 2016-04-22 | 2025-10-21 | 贝克顿·迪金森公司 | 多重聚合染料装置及其使用方法 |
| WO2017222998A1 (en) | 2016-06-20 | 2017-12-28 | Beckman Coulter, Inc. | Dry-down processes for dye-conjugated reagents |
| EP3481901A4 (de) | 2016-07-07 | 2020-07-15 | Becton, Dickinson and Company | Fluoreszierende wassersolvatierte konjugierte polymere |
| WO2018009861A1 (en) | 2016-07-08 | 2018-01-11 | Biolegend | Substituted polyfluorene compounds |
| WO2018013389A1 (en) | 2016-07-11 | 2018-01-18 | Becton, Dickinson And Company | Blue-excitable water-solvated polymeric dyes |
| CN106770088B (zh) * | 2016-11-24 | 2019-06-11 | 北京科技大学 | 用于dna检测的荧光复合纳米粒子的制备及检测方法 |
| CN109923179A (zh) * | 2016-12-12 | 2019-06-21 | 贝克顿·迪金森公司 | 水溶性聚合物染料 |
| JP7058662B2 (ja) | 2017-02-08 | 2022-04-22 | ベクトン・ディキンソン・アンド・カンパニー | 乾燥色素試薬装置、ならびにその製造及び使用方法 |
| CN106857504B (zh) * | 2017-02-10 | 2020-03-10 | 中国科学院化学研究所 | 一种抑制和/或破坏生物膜的方法 |
| KR102795781B1 (ko) | 2017-06-16 | 2025-04-15 | 듀크 유니버시티 | 개선된 라벨 검출, 계산, 분석물 감지, 및 조정 가능한 난수 생성을 위한 공진기 네트워크 |
| CN111032823B (zh) | 2017-07-28 | 2024-12-20 | 百进生物科技公司 | 共轭聚合物及其使用方法 |
| WO2019133399A1 (en) | 2017-12-26 | 2019-07-04 | Becton, Dickinson And Company | Deep ultraviolet-excitable water-solvated polymeric dyes |
| US11992844B2 (en) | 2018-11-13 | 2024-05-28 | Becton, Dickinson And Company | Dried reagent strainers and methods for making and using the same |
| CN111850103B (zh) * | 2020-08-20 | 2022-12-02 | 清华大学深圳国际研究生院 | 一种基于阳离子共轭聚合物和核酸酶辅助循环扩增的检测目的核酸的方法 |
| EP4244625A1 (de) | 2020-11-13 | 2023-09-20 | Beckman Coulter, Inc. | Additive zur reduzierung nichtspezifischer wechselwirkungen zwischen fluoreszierenden polymerkonjugaten und zellen in einer biologischen probe |
| CN117015711A (zh) | 2021-02-05 | 2023-11-07 | 贝克曼库尔特有限公司 | 用于阻止聚合物染料-抗体缀合物之间的非特异性相互作用的组合物和方法 |
| CN116917738A (zh) | 2021-04-07 | 2023-10-20 | 贝克顿·迪金森公司 | 水溶性荧光聚合物染料 |
| JP7898458B2 (ja) | 2021-05-04 | 2026-07-31 | ベックマン コールター， インコーポレイテッド | Ｕｖ吸収性ポリマー、組成物およびその使用 |
| CA3237877A1 (en) | 2021-11-12 | 2023-05-19 | Aditya JARARE | Novel formulation for drying of polymer dye conjugated antibodies |
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| DK0562025T3 (da) | 1990-12-06 | 2001-06-18 | Affymetrix Inc | Forbindelser og deres anvendelse i en binær syntesestrategi |
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| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
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| DE60333646D1 (de) | 2002-06-20 | 2010-09-16 | Univ California | Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren |
| CA2497152C (en) * | 2002-08-26 | 2016-06-07 | The Regents Of The University Of California | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
| WO2006074482A2 (en) * | 2005-01-10 | 2006-07-13 | The Regents Of The University Of California | Methods and kits for strand-specific polynucleotide detection with cationic multichromophores |
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-
2003
- 2003-06-20 DE DE60333646T patent/DE60333646D1/de not_active Expired - Lifetime
- 2003-06-20 CN CN2012102827293A patent/CN102766695A/zh active Pending
- 2003-06-20 EP EP03761235A patent/EP1534857B1/de not_active Expired - Lifetime
- 2003-06-20 AU AU2003243722A patent/AU2003243722A1/en not_active Abandoned
- 2003-06-20 WO PCT/US2003/019678 patent/WO2004001379A2/en not_active Ceased
- 2003-06-20 EP EP10008095A patent/EP2278027A3/de not_active Ceased
- 2003-06-20 JP JP2004516105A patent/JP4528115B2/ja not_active Expired - Lifetime
- 2003-06-20 EA EA200500041A patent/EA007652B1/ru unknown
- 2003-06-20 CN CN038198363A patent/CN1675377B/zh not_active Expired - Lifetime
- 2003-06-20 KR KR10-2004-7020729A patent/KR20050010956A/ko not_active Withdrawn
- 2003-06-20 CA CA2489922A patent/CA2489922C/en not_active Expired - Lifetime
- 2003-06-20 US US10/600,286 patent/US7214489B2/en not_active Expired - Lifetime
- 2003-06-20 AT AT03761235T patent/ATE476521T1/de not_active IP Right Cessation
-
2004
- 2004-12-20 IL IL16587704A patent/IL165877A0/xx unknown
-
2007
- 2007-05-08 US US11/746,055 patent/US8101416B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN102766695A (zh) | 2012-11-07 |
| JP4528115B2 (ja) | 2010-08-18 |
| EP2278027A3 (de) | 2011-02-16 |
| WO2004001379A3 (en) | 2004-06-03 |
| US20040219556A1 (en) | 2004-11-04 |
| US20080280369A1 (en) | 2008-11-13 |
| EA007652B1 (ru) | 2006-12-29 |
| EP2278027A2 (de) | 2011-01-26 |
| IL165877A0 (en) | 2006-01-15 |
| DE60333646D1 (de) | 2010-09-16 |
| WO2004001379A2 (en) | 2003-12-31 |
| CN1675377B (zh) | 2012-10-03 |
| CN1675377A (zh) | 2005-09-28 |
| AU2003243722A1 (en) | 2004-01-06 |
| EA200500041A1 (ru) | 2005-08-25 |
| EP1534857A2 (de) | 2005-06-01 |
| CA2489922C (en) | 2016-08-16 |
| JP2005530182A (ja) | 2005-10-06 |
| CA2489922A1 (en) | 2003-12-31 |
| US8101416B2 (en) | 2012-01-24 |
| US7214489B2 (en) | 2007-05-08 |
| KR20050010956A (ko) | 2005-01-28 |
| EP1534857B1 (de) | 2010-08-04 |
| EP1534857A4 (de) | 2007-10-31 |
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