ATE476654T1 - Plattform für protein-profiling - Google Patents

Plattform für protein-profiling

Info

Publication number
ATE476654T1
ATE476654T1 AT02723286T AT02723286T ATE476654T1 AT E476654 T1 ATE476654 T1 AT E476654T1 AT 02723286 T AT02723286 T AT 02723286T AT 02723286 T AT02723286 T AT 02723286T AT E476654 T1 ATE476654 T1 AT E476654T1
Authority
AT
Austria
Prior art keywords
active
activity
methods
proteins
probes
Prior art date
Application number
AT02723286T
Other languages
English (en)
Inventor
Matthew Patricelli
Original Assignee
Activx Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Activx Biosciences Inc filed Critical Activx Biosciences Inc
Application granted granted Critical
Publication of ATE476654T1 publication Critical patent/ATE476654T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors
    • G01N30/82—Automatic means therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT02723286T 2001-03-02 2002-03-01 Plattform für protein-profiling ATE476654T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27300701P 2001-03-02 2001-03-02
PCT/US2002/006234 WO2002071066A1 (en) 2001-03-02 2002-03-01 Protein profiling platform

Publications (1)

Publication Number Publication Date
ATE476654T1 true ATE476654T1 (de) 2010-08-15

Family

ID=23042159

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02723286T ATE476654T1 (de) 2001-03-02 2002-03-01 Plattform für protein-profiling

Country Status (5)

Country Link
US (1) US7179655B2 (de)
EP (1) EP1370867B1 (de)
AT (1) ATE476654T1 (de)
DE (1) DE60237194D1 (de)
WO (1) WO2002071066A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60230927D1 (de) * 2001-07-16 2009-03-05 Caprotec Bioanalytics Gmbh Fangverbindungen, ihre entnahme und verfahren zur analysierung des proteoms und von komplexen zusammensetzungen
WO2003079014A1 (en) * 2002-03-03 2003-09-25 Activx Biosciences, Inc. Tethered activity-based probes and uses thereof
AU2003286553A1 (en) * 2002-10-18 2004-05-04 Promega Corporation Methods for separating molecules
DE602004030212D1 (de) * 2003-01-16 2011-01-05 Caprotec Bioanalytics Gmbh Verfahren zur identifizierung von auf arzneimittel nicht-zielgerichteten proteinen
GB0317123D0 (en) * 2003-07-22 2003-08-27 Xzillion Gmbh & Co Kg Characterising polypeptides
EP1705482B1 (de) * 2003-12-11 2017-09-27 Kazuhiro Imai Nachweis-, trenn- und identifizierungsverfahren für spuren von exprimiertem protein/peptid
WO2005108597A2 (en) * 2004-04-30 2005-11-17 Mark Hayward Process for high throughput liquid or gas chromatography/mass spectrometry-based biomolecular screening for drug discovery
WO2006096704A2 (en) 2005-03-07 2006-09-14 Invitrogen Corporation Isotopically-labeled proteome standards
US7964843B2 (en) 2008-07-18 2011-06-21 The George Washington University Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
US8901487B2 (en) 2007-07-20 2014-12-02 George Washington University Subcellular analysis by laser ablation electrospray ionization mass spectrometry
US8067730B2 (en) 2007-07-20 2011-11-29 The George Washington University Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry
EP2403964B1 (de) 2009-03-02 2021-09-08 Massachusetts Institute of Technology Verfahren und produkte zur in-vivo-profilerstellung von enzymen
KR101881714B1 (ko) 2009-10-26 2018-07-24 네스텍 소시에테아노님 항-ｔｎｆ 약물 및 자가항체의 검출을 위한 검정법
GB2495036B (en) 2010-07-07 2019-03-27 Thermo Fisher Scient Gmbh Kits for analyte mass spectrometry quantitation using a universal reporter
ES2881535T3 (es) 2011-03-15 2021-11-29 Massachusetts Inst Technology Detección multiplexada con indicadores codificados con isótopos
EP3130921B1 (de) 2011-07-06 2018-09-12 Nestec S.A. Tests für den nachweis neutralisierender autoantikörper gegen biologische therapie mit tnf-alpha
CA2841752A1 (en) 2011-07-14 2013-06-13 The George Washington University Plume collimation for laser ablation electrospray ionization mass spectrometry
WO2014197840A1 (en) 2013-06-07 2014-12-11 Massachusetts Institute Of Technology Affinity-based detection of ligand-encoded synthetic biomarkers
US9252003B2 (en) 2013-06-07 2016-02-02 Pierce Biotechnology, Inc. Absolute quantitation of proteins and protein modifications by mass spectrometry with multiplexed internal standards
GB201404756D0 (en) * 2014-03-17 2014-04-30 Analytica Llc Q Profiling apparatus and method
EP3536705A1 (de) 2014-12-05 2019-09-11 Société des Produits Nestlé S.A. Isoliertes lösliches alpha-4 integrin, beta-7 intergrin und alpha-4/beta-7 heterodimer integrin
WO2017031378A1 (en) 2015-08-18 2017-02-23 Krusemark Casey J Systems and methods for proteomic activity analysis using dna-encoded probes
EP3440013A4 (de) 2016-04-08 2021-03-17 Massachusetts Institute of Technology Verfahren zur spezifischen profilierung der protease-aktivität an lymphknoten
CA3022928A1 (en) 2016-05-05 2017-11-09 Massachusetts Institute Of Technology Methods and uses for remotely triggered protease activity measurements
US20180128832A1 (en) * 2016-11-09 2018-05-10 Richard-Allan Scientific Company Proteogenomic analysis system and methods
AU2018248327B2 (en) 2017-04-07 2024-10-10 Massachusetts Institute Of Technology Methods to spatially profile protease activity in tissue and sections
US11054428B2 (en) 2018-03-05 2021-07-06 Massachusetts Institute Of Technology Inhalable nanosensors with volatile reporters and uses thereof
WO2019183334A1 (en) 2018-03-21 2019-09-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbents, devices and methods
US11732009B2 (en) 2018-06-08 2023-08-22 Glympse Bio, Inc. Activity sensor with tunable analyte
US11028425B2 (en) 2018-06-08 2021-06-08 Glympse Bio, Inc. Diagnosis and monitoring of liver disease
WO2020068920A2 (en) 2018-09-25 2020-04-02 Massachusetts Institute Of Technology Lung protease nanosensors and uses thereof
WO2020150560A1 (en) 2019-01-17 2020-07-23 Massachusetts Institute Of Technology Sensors for detecting and imaging of cancer metastasis
US12338483B2 (en) 2019-02-28 2025-06-24 Georgia Tech Research Corporation Compositions and methods for logic-gated profiling of biologic activity
CN116438456A (zh) 2020-09-11 2023-07-14 格里姆普斯生物股份有限公司 用于疾病检测/诊断、分期、监测和治疗的离体蛋白酶活性检测
CN116559459A (zh) * 2022-01-28 2023-08-08 中国科学院大连化学物理研究所 一种鉴定配体分子结合靶蛋白和结合位点的方法
GB2632290B (en) * 2023-07-31 2026-04-08 Thermo Fisher Scient Bremen Gmbh A method, device and computer software for preparing a liquid protein sample for proteome analysis

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4433051A (en) 1981-10-14 1984-02-21 Yeda Research And Development Co., Ltd. Derivatives of α-difluoromethylornithine useful in analysis
US4481094A (en) 1982-05-17 1984-11-06 Techamerica Group, Inc. Stabilized polyacrylamide gels and system for SDS electrophoresis
US4415655A (en) 1982-05-17 1983-11-15 Techamerica Group, Inc. Electrophoretic separation of isoenzymes utilizing a stable polyacrylamide system
US4865707A (en) 1986-10-21 1989-09-12 Northeastern University Capillary gel electrophoresis columns
US4946794A (en) 1986-12-18 1990-08-07 Protein Databases, Inc. Visualization of proteins on electrophoresis gels using planar dyes
US5041538A (en) 1987-08-28 1991-08-20 The Salk Institute For Biological Studies Mammalian follistatin
AU7779191A (en) 1990-04-11 1991-10-30 Indu Parikh Method for the purification of epidermal growth factor
US5290920A (en) 1992-04-16 1994-03-01 Allelix Biopharmaceuticals Inc. Method of purifying human epidermal growth factor
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
WO1994028418A1 (en) 1993-05-28 1994-12-08 Baylor College Of Medicine Method and apparatus for desorption and ionization of analytes
US5856082A (en) * 1994-08-31 1999-01-05 University Of British Columbia Devices and methods for characterizing proteins and peptides
US6127134A (en) 1995-04-20 2000-10-03 Carnegie Mellon University Difference gel electrophoresis using matched multiple dyes
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
GB9717926D0 (en) 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
AU2463299A (en) 1998-01-23 1999-08-09 Analytica Of Branford, Inc. Mass spectrometry from surfaces
EP1329513B1 (de) * 1998-08-25 2011-12-07 University of Washington Schnelle quantitative Analyse von Proteinen oder Proteinfunktionen in komplexen Gemischen
US6379970B1 (en) 1999-04-30 2002-04-30 The Arizona Board Of Regents On Behalf Of The University Of Arizona Analysis of differential protein expression
AU2001224349A1 (en) * 2000-04-10 2001-10-23 The Scripps Research Institute Proteomic analysis
AU2002232681A1 (en) * 2000-11-10 2002-05-21 The Regents Of The Univeristy Of California Activity-dependent cysteine protease profiling reagent

Also Published As

Publication number Publication date
DE60237194D1 (de) 2010-09-16
EP1370867B1 (de) 2010-08-04
US20020182651A1 (en) 2002-12-05
WO2002071066A1 (en) 2002-09-12
EP1370867A4 (de) 2005-01-26
EP1370867A1 (de) 2003-12-17
US7179655B2 (en) 2007-02-20

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