BRPI0407031A - Composições e métodos para tratamento de câncer empregando igsf9 e liv-1 - Google Patents

Composições e métodos para tratamento de câncer empregando igsf9 e liv-1

Info

Publication number
BRPI0407031A
BRPI0407031A BR0407031-3A BRPI0407031A BRPI0407031A BR PI0407031 A BRPI0407031 A BR PI0407031A BR PI0407031 A BRPI0407031 A BR PI0407031A BR PI0407031 A BRPI0407031 A BR PI0407031A
Authority
BR
Brazil
Prior art keywords
polypeptides
igsf9
liv
methods
compositions
Prior art date
Application number
BR0407031-3A
Other languages
English (en)
Inventor
Karen Mclachlan
Scott Glaser
Robert J Peach
Tony Rowe
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of BRPI0407031A publication Critical patent/BRPI0407031A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

"COMPOSIçõES E MéTODOS PARA TRATAMENTO DE CâNCER EMPREGANDO IGSF9 E LIV-1". A presente invenção refere-se a polipeptídeos de IGSF9 e LIV-1 humanos e DNA (RNA) codificando tais polipeptídeos. Os polipeptídeos e/ou polinucleotídeo descritos são particularmente úteis na geração de anticorpos, ambos modificados e nativos, que ligam-se à IGSF9 ou LIV-1. São também descritas composições farmacêuticas e vacinas compreendendo os anticorpos, polipeptídeos e polinucleotídeos da invenção. São também descritos métodos para utilizar tais polipeptídeos para identificar ligandos, antagonistas e agonistas para os referidos polipeptídeos. Finalmente, métodos compreendendo as composições acima mencionadas são descritos para o tratamento, diagnose e/ou prognose de distúrbios neoplásicos.
BR0407031-3A 2003-01-27 2004-01-27 Composições e métodos para tratamento de câncer empregando igsf9 e liv-1 BRPI0407031A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44253503P 2003-01-27 2003-01-27
PCT/US2004/002044 WO2004066933A2 (en) 2003-01-27 2004-01-27 Compositions and methods for treating cancer using igsf9 and liv-1

Publications (1)

Publication Number Publication Date
BRPI0407031A true BRPI0407031A (pt) 2006-01-17

Family

ID=32825236

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0407031-3A BRPI0407031A (pt) 2003-01-27 2004-01-27 Composições e métodos para tratamento de câncer empregando igsf9 e liv-1

Country Status (16)

Country Link
US (2) US20040258616A1 (pt)
EP (1) EP1596806A4 (pt)
JP (1) JP2006520194A (pt)
KR (1) KR20050102627A (pt)
CN (1) CN1849337A (pt)
AU (1) AU2004207538A1 (pt)
BR (1) BRPI0407031A (pt)
CA (1) CA2514062A1 (pt)
EA (1) EA200501197A1 (pt)
IS (1) IS7960A (pt)
MX (1) MXPA05007940A (pt)
NO (1) NO20053986L (pt)
PL (1) PL379264A1 (pt)
RS (1) RS20050577A (pt)
WO (1) WO2004066933A2 (pt)
ZA (1) ZA200506671B (pt)

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US20040141983A1 (en) * 1999-03-15 2004-07-22 Protein Design Labs, Inc. Compositions against cancer antigen LIV-1 and uses thereof
WO2004067564A2 (en) 2003-01-29 2004-08-12 Protein Design Labs, Inc. Compositions against cancer antigen liv-1 and uses thereof
US20080070836A1 (en) * 2003-12-26 2008-03-20 Toshio Hirano Emt-Inducing Agents
US20090214517A1 (en) * 2004-07-27 2009-08-27 Justin Wong Compositions and methods of use for modulators of nectin 4, semaphorin 4b, igsf9, and kiaa0152 in treating disease
TW200813231A (en) * 2006-04-13 2008-03-16 Novartis Vaccines & Diagnostic Methods of treating, diagnosing or detecting cancer
KR20110091423A (ko) * 2010-02-05 2011-08-11 국립암센터 항―ｔｍａｐ／ｃｋａｐ２ 항체를 포함하는 암의 예후 진단용 조성물
EP3786185A1 (en) * 2010-12-06 2021-03-03 Seagen Inc. Humanized antibodies to liv-1 and use of same to treat cancer
AU2017235545A1 (en) 2016-03-15 2018-10-25 Seagen Inc. Combination therapy using a LIV1-ADC and a chemotherapeutic
US11512114B2 (en) 2017-05-09 2022-11-29 Cyano Biotech Gmbh Modified microcystins and nodularins
CN110563845A (zh) * 2019-09-12 2019-12-13 滨州医学院 抗igsf9抗体、药物组合物及其应用
WO2021201571A1 (ko) * 2020-03-31 2021-10-07 웰마커바이오 주식회사 Igsf1 에 대한 항체를 유효성분으로 포함하는 암 예방 또는 치료용 약학 조성물 및 이를 이용한 암 치료 방법
CN116082503B (zh) * 2022-08-19 2023-08-04 滨州医学院 一种靶向人igsf9的单克隆抗体及其应用
TW202421668A (zh) * 2022-11-25 2024-06-01 大陸商江蘇恆瑞醫藥股份有限公司 抗liv-1抗體、其藥物偶聯物及其醫藥用途
CN117379561B (zh) * 2023-10-13 2025-07-22 滨州医学院 一种靶向人igsf9的抗体偶联药物及其制备方法与应用

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Also Published As

Publication number Publication date
WO2004066933A3 (en) 2006-03-02
CA2514062A1 (en) 2004-08-12
JP2006520194A (ja) 2006-09-07
US20040258616A1 (en) 2004-12-23
WO2004066933A2 (en) 2004-08-12
NO20053986L (no) 2005-10-27
CN1849337A (zh) 2006-10-18
ZA200506671B (en) 2006-09-27
EA200501197A1 (ru) 2006-04-28
MXPA05007940A (es) 2007-06-14
NO20053986D0 (no) 2005-08-26
RS20050577A (sr) 2007-09-21
AU2004207538A1 (en) 2004-08-12
IS7960A (is) 2005-07-27
KR20050102627A (ko) 2005-10-26
EP1596806A2 (en) 2005-11-23
PL379264A1 (pl) 2006-08-07
EP1596806A4 (en) 2007-08-29
US20070071674A1 (en) 2007-03-29

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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