ATE476966T1 - Feste dispersion mit schwer wasserlöslichem wirkstoff - Google Patents
Feste dispersion mit schwer wasserlöslichem wirkstoffInfo
- Publication number
- ATE476966T1 ATE476966T1 AT07825366T AT07825366T ATE476966T1 AT E476966 T1 ATE476966 T1 AT E476966T1 AT 07825366 T AT07825366 T AT 07825366T AT 07825366 T AT07825366 T AT 07825366T AT E476966 T1 ATE476966 T1 AT E476966T1
- Authority
- AT
- Austria
- Prior art keywords
- active ingredients
- water soluble
- solid dispersion
- poorly water
- soluble active
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82972006P | 2006-10-17 | 2006-10-17 | |
| PCT/IB2007/003062 WO2008047201A2 (en) | 2006-10-17 | 2007-10-08 | Solid dispersion comprising a poorly water soluble drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE476966T1 true ATE476966T1 (de) | 2010-08-15 |
Family
ID=39048880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07825366T ATE476966T1 (de) | 2006-10-17 | 2007-10-08 | Feste dispersion mit schwer wasserlöslichem wirkstoff |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8372836B2 (de) |
| EP (1) | EP2101741B1 (de) |
| JP (1) | JP2008100997A (de) |
| AR (1) | AR063317A1 (de) |
| AT (1) | ATE476966T1 (de) |
| DE (1) | DE602007008470D1 (de) |
| TW (1) | TW200819148A (de) |
| WO (1) | WO2008047201A2 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8535716B2 (en) | 2004-04-01 | 2013-09-17 | Tsrl, Inc. | Methods and composition of extended delivery of water insoluble drugs |
| MX2007013780A (es) * | 2005-05-04 | 2008-02-05 | Pfizer Ltd | Derivados 2 amido-6-amino-8-oxo purina como moduladores del receptor como tipo peaje (toll) para el tratamiento del cancer y las infecciones virales tal como la hepatitis c. |
| US20100048524A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| WO2010091306A1 (en) | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| US20120076838A1 (en) * | 2009-05-27 | 2012-03-29 | Samyang Biopharmaceuticals Corporation | Poorly soluble drug containing microsphere with improved bioavailabilty and method of preparing the same |
| EP2585048B1 (de) * | 2010-06-23 | 2018-04-11 | CymaBay Therapeutics, Inc. | Zusammensetzungen von 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidin |
| EP2836559B1 (de) | 2012-04-11 | 2016-05-25 | Dow Global Technologies LLC | Zusammensetzung mit einem organischen verdünnungsmittel und celluloseether |
| JP6626712B2 (ja) | 2012-05-02 | 2019-12-25 | キャプシュゲル・ベルジウム・エヌ・ヴィ | 放出制御ポリマーの水性分散液並びにそのシェル及びカプセル |
| KR102160903B1 (ko) | 2012-07-17 | 2020-10-05 | 다우 글로벌 테크놀로지스 엘엘씨 | 고도로 치환된 하이드록시알킬 메틸셀룰로즈를 포함하는 고체 분산물 |
| EP2875072B1 (de) | 2012-07-17 | 2017-03-15 | Dow Global Technologies LLC | Zubereitung enthaltend ein organisches flüssiges lösungsmittel und einen niedrig viskosen celluloseether |
| EP2956121B1 (de) * | 2013-02-12 | 2018-05-30 | Bend Research, Inc. | Feste dispersionen mit geringer wasserlöslichkeit |
| US9737538B2 (en) | 2013-02-12 | 2017-08-22 | Bend Research, Inc. | Solid dispersions of low-water solubility actives |
| EP2968370A4 (de) | 2013-03-14 | 2016-09-21 | Univ Maryland | Mittel zur androgenrezeptor-abwärtsregelung und verwendungen davon |
| EP3033088A4 (de) | 2013-08-12 | 2017-03-08 | Tokai Pharmaceuticals, Inc. | Biomarker zur behandlung neoplastischer störungen mit androgen-anzielenden therapien |
| CN105530918A (zh) | 2013-09-25 | 2016-04-27 | 陶氏环球技术有限责任公司 | 包含有机液体稀释剂和特定羟烷基甲基纤维素的组合物 |
| EP3092231B1 (de) | 2013-12-11 | 2018-06-27 | Ironwood Pharmaceuticals, Inc. | Sgc-stimulatoren |
| EP3082803A4 (de) * | 2013-12-20 | 2017-05-31 | Phosphorex Inc. | Feste indirubindispersionszusammensetzung |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| EP3120843A4 (de) * | 2014-05-15 | 2017-11-15 | Theravalues Corporation | Zusammensetzung zur oralen einnahme |
| KR102377103B1 (ko) | 2014-05-20 | 2022-03-23 | 뉴트리션 ＆ 바이오사이언시즈 유에스에이 1, 엘엘씨 | 에스테르화된 셀룰로오스 에테르를 포함하는 캡슐 쉘 |
| DE102014012020A1 (de) * | 2014-08-13 | 2016-02-18 | Clariant International Ltd. | VOC-arme Amine als oberflächenaktiver Bestandteil in Dispersionen |
| US20170298055A1 (en) | 2014-09-17 | 2017-10-19 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| CA2964068A1 (en) | 2014-09-19 | 2016-03-24 | Board Of Regents, The University Of Texas System | Methods of preparing extrudates |
| EP3226861A2 (de) * | 2014-12-05 | 2017-10-11 | Centre National de la Recherche Scientifique (CNRS) | Verbindungen zur behandlung von zystischer fibrose |
| US10835496B2 (en) | 2015-04-21 | 2020-11-17 | Eiger Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising lonafarnib and ritonavir |
| US20180250232A1 (en) * | 2015-09-03 | 2018-09-06 | Merck Sharp & Dohme Corp. | Process for preparing spray dried solid dispersions of (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide for pharmaceutical preparations |
| JP6971043B2 (ja) | 2016-03-04 | 2021-11-24 | 株式会社リコー | 微粒子の製造方法 |
| KR20180129943A (ko) | 2016-04-15 | 2018-12-05 | 노비라 테라퓨틱스, 인코포레이티드 | 캡시드 조립 억제제를 포함하는 배합물 및 방법 |
| JP2020524718A (ja) * | 2017-06-22 | 2020-08-20 | キュラデブ・ファーマ・リミテッドＣｕｒａｄｅｖ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ | ヒトｓｔｉｎｇの複素環式小分子調節因子 |
| JP2021515769A (ja) | 2018-03-14 | 2021-06-24 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | カプシド集合調節剤の投薬レジメン |
| JP7244536B2 (ja) | 2018-04-06 | 2023-03-22 | キャプシュゲル・ベルジウム・エヌ・ヴィ | メタクリル酸メチル－メタクリル酸コポリマーからなる低アスペクト比の粒子のための噴霧乾燥方法 |
| TW202019416A (zh) | 2018-07-30 | 2020-06-01 | 日商中外製藥股份有限公司 | 乙內醯脲衍生物的固體分散體 |
| JP7590409B2 (ja) * | 2019-08-15 | 2024-11-26 | キャプシュゲル・ベルジウム・エヌ・ヴィ | 噴霧された固体分散体の処理助剤としてのアンモニア |
| JPWO2024143501A1 (de) | 2022-12-28 | 2024-07-04 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1027886B1 (de) * | 1999-02-10 | 2008-07-09 | Pfizer Products Inc. | Pharmazeutische feste Dispersionen |
| WO2003000292A1 (en) * | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Pharmaceutical compositions comprising low-solubility and/or acid-sensitive drugs and neutralized acidic polymers |
| MXPA03011784A (es) * | 2001-06-22 | 2004-04-02 | Pfizer Prod Inc | Composiciones farmaceuticas de dispersiones de farmacos y polimeros neutros. |
| EP1961419B1 (de) * | 2002-12-20 | 2010-03-24 | Pfizer Products Inc. | Dosierungsform enthaltend einen CETP-Hemmer und einen HMG-CoA Reduktase Hemmer |
| EP2548894A1 (de) * | 2005-02-03 | 2013-01-23 | Bend Research, Inc. | Pharmazeutische Zusammensetzungen mit erhöhter Leistung |
| MX2007013780A (es) * | 2005-05-04 | 2008-02-05 | Pfizer Ltd | Derivados 2 amido-6-amino-8-oxo purina como moduladores del receptor como tipo peaje (toll) para el tratamiento del cancer y las infecciones virales tal como la hepatitis c. |
| US8828438B2 (en) * | 2005-05-31 | 2014-09-09 | Bend Research, Inc. | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors and HMG-CoA reductase |
| JP2009528989A (ja) * | 2006-02-17 | 2009-08-13 | ファイザー・リミテッド | Ｔｌｒ７変調剤としての３−デアザプリン誘導体 |
-
2007
- 2007-10-08 AT AT07825366T patent/ATE476966T1/de not_active IP Right Cessation
- 2007-10-08 DE DE602007008470T patent/DE602007008470D1/de active Active
- 2007-10-08 EP EP07825366A patent/EP2101741B1/de not_active Ceased
- 2007-10-08 US US12/311,543 patent/US8372836B2/en not_active Expired - Fee Related
- 2007-10-08 WO PCT/IB2007/003062 patent/WO2008047201A2/en not_active Ceased
- 2007-10-12 JP JP2007266713A patent/JP2008100997A/ja active Pending
- 2007-10-16 AR ARP070104580A patent/AR063317A1/es not_active Application Discontinuation
- 2007-10-16 TW TW096138648A patent/TW200819148A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20100029667A1 (en) | 2010-02-04 |
| TW200819148A (en) | 2008-05-01 |
| AR063317A1 (es) | 2009-01-21 |
| JP2008100997A (ja) | 2008-05-01 |
| EP2101741B1 (de) | 2010-08-11 |
| WO2008047201A3 (en) | 2008-06-26 |
| WO2008047201A2 (en) | 2008-04-24 |
| DE602007008470D1 (en) | 2010-09-23 |
| US8372836B2 (en) | 2013-02-12 |
| EP2101741A2 (de) | 2009-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0818874A2 (pt) | Liberação de agentes ativos | |
| EP2037789A4 (de) | Mischvorrichtung | |
| BRPI0912615A2 (pt) | agonistas de receptor y2 e/ou y4 de longa ação | |
| BRPI0806918A2 (pt) | Agentes de alvejamento para substratos celulósicos | |
| BRPI0812753A2 (pt) | Combinações de substância ativas acaricidas | |
| ATE482618T1 (de) | Wirkstoffkombinationen | |
| DE602007000878D1 (de) | Biodiesel-Kaltfiltrierverfahren | |
| EP2183821A4 (de) | Verbinder mit isolationsschneidkontakt | |
| BRPI0820819A2 (pt) | Formulação de anticorpos | |
| EP2001443A4 (de) | Granulatformulierung | |
| DE602007011880D1 (de) | Partikelmischgerät | |
| FR2896094B1 (fr) | Structure de connecteur | |
| ATE484194T1 (de) | Wirkstoffkombinationen | |
| EP2061866A4 (de) | Schnelles thermocycler-gerät | |
| DE602007009238D1 (de) | Biplanare elektrode mit sperr-gates | |
| DK2349829T3 (da) | Flydende tørdok | |
| DE502007001779D1 (de) | Anhängekupplung | |
| BRPI0812228A2 (pt) | Combinações de substâncias ativas fungicidas | |
| BRPI0817974A2 (pt) | Combinações de substâncias ativas com propriedades inseticidas e acaricidas. | |
| DE602007010950D1 (de) | Dosierpumpe | |
| AT503451B8 (de) | Festkörperlaser | |
| BRPI0716049A2 (pt) | dispersÕes de nanourÉias, contendo substÂncias ativas | |
| EE200800057A (et) | Antimikroobne ravimvorm | |
| BRPI0820538A2 (pt) | Isoformas de neuregulina solúveis ativas modificadas pós-traducionalmente | |
| BRPI0907524A2 (pt) | Formulação de microcápsula de malation estabilizadas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |