DK1844150T3 - Rekombinant ekspression af proteiner i en to-kædet form med disulfidbroer - Google Patents

Rekombinant ekspression af proteiner i en to-kædet form med disulfidbroer

Info

Publication number: DK1844150T3
Authority: DK; Denmark
Prior art keywords: dichain; ile; phe; leu; val
Prior art date: 2005-01-21

Application number

DK06705826.3T

Other languages

English (en)

Inventor

Volker Specht

Original Assignee

Merz Pharma Gmbh & Co Kgaa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-21

Filing date

2006-01-20

Publication date

2012-05-29

2006-01-20 Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa

2012-05-29 Application granted granted Critical

2012-05-29 Publication of DK1844150T3 publication Critical patent/DK1844150T3/da

Links

108090000623 proteins and genes Proteins 0.000 title abstract 4
102000004169 proteins and genes Human genes 0.000 title abstract 4
238000003259 recombinant expression Methods 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
241000588724 Escherichia coli Species 0.000 abstract 2
210000004027 cell Anatomy 0.000 abstract 2
229920001184 polypeptide Polymers 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 1
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK06705826.3T 2005-01-21 2006-01-20 Rekombinant ekspression af proteiner i en to-kædet form med disulfidbroer DK1844150T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102005002978A DE102005002978B4 (de)	2005-01-21	2005-01-21	Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form
PCT/DE2006/000088 WO2006076902A2 (de)	2005-01-21	2006-01-20	Rekombinante expression von proteinen in einer disulfidverbrückten, zweikettigen form

Publications (1)

Publication Number	Publication Date
DK1844150T3 true DK1844150T3 (da)	2012-05-29

Family

ID=36603464

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06705826.3T DK1844150T3 (da)	2005-01-21	2006-01-20	Rekombinant ekspression af proteiner i en to-kædet form med disulfidbroer

Country Status (15)

Country	Link
US (1)	US20080103098A1 (da)
EP (1)	EP1844150B1 (da)
JP (2)	JP5107055B2 (da)
KR (1)	KR20070104605A (da)
CN (2)	CN103320459A (da)
AT (1)	ATE546533T1 (da)
AU (1)	AU2006207726B2 (da)
BR (1)	BRPI0606612A2 (da)
CA (1)	CA2593520C (da)
DE (2)	DE102005002978B4 (da)
DK (1)	DK1844150T3 (da)
ES (1)	ES2380677T3 (da)
IL (1)	IL184112A0 (da)
RU (1)	RU2412253C2 (da)
WO (1)	WO2006076902A2 (da)

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JP5795539B2 (ja)	2009-02-19	2015-10-14	メルツファルマゲーエムベーハーウントコンパニーカーゲーアーアー	高純度の神経毒素を製造するための手段および方法
TW201120210A (en)	2009-11-05	2011-06-16	Hoffmann La Roche	Glycosylated repeat-motif-molecule conjugates
SI2526200T1 (sl)	2010-01-22	2016-07-29	Merz Pharma Gmbh & Co. Kgaa	In vitro preizkus za kvanitificiranje aktivnosti klostridijskega nevrotoksina
SI2684890T1 (sl) *	2010-01-25	2016-10-28	Allergan, Inc.	Metode znotrajcelične pretvorbe enoverižnih beljakovin v njihovo dvoverižno obliko
EP2553102B1 (en) *	2010-03-30	2015-12-09	Pfenex Inc.	High level expression of recombinant toxin proteins
TWI510246B (zh) *	2010-04-30	2015-12-01	Molecular Partners Ag	抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
CA2807488A1 (en) *	2010-08-11	2012-02-16	Merz Pharma Gmbh & Co. Kgaa	Selective manufacture of recombinant neurotoxin polypeptides
WO2013091895A1 (en)	2011-12-23	2013-06-27	Merz Pharma Gmbh & Co. Kgaa	Novel method for the manufacturing of di-chain proteins for use in humans
CN103509807B (zh) *	2012-09-14	2015-04-15	山东大学	糖基化的麦芽糖结合蛋白及其制备方法与应用
GB201219602D0 (en)	2012-10-31	2012-12-12	Syntaxin Ltd	Recombinant clostridium botulinum neurotoxins
WO2014079495A1 (en) *	2012-11-21	2014-05-30	Syntaxin Limited	Methods for the manufacture of proteolytically processed polypeptides
ES2704237T3 (es)	2014-03-05	2019-03-15	Merz Pharma Gmbh & Co Kgaa	Nuevas neurotoxinas clostridiales recombinantes con un aumento de la duración del efecto
AU2015367329B2 (en)	2014-12-19	2021-02-18	Merz Pharma Gmbh & Co. Kgaa	Means and methods for the determination of the biological activity of BoNT/E in cells
CN107108703B (zh) *	2015-01-09	2022-09-23	益普生生物创新有限公司	阳离子神经毒素
TW201718627A (zh)	2015-06-11	2017-06-01	梅茲製藥有限兩合公司	重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞
TWI799366B (zh)	2015-09-15	2023-04-21	美商建南德克公司	胱胺酸結骨架平臺
US11078472B2 (en)	2016-01-20	2021-08-03	Merz Pharma Gmbh & Co., Kgaa	Recombinant clostridial neurotoxins with increased duration of effect
MX395130B (es)	2016-03-02	2025-03-24	Merz Pharma Gmbh & Co Kgaa	Composicion que comprende toxina botulinica
EP3263710A1 (en)	2016-07-01	2018-01-03	Ipsen Biopharm Limited	Production of activated clostridial neurotoxins
EP3290437A1 (en)	2016-08-31	2018-03-07	Merz Pharma GmbH & Co. KGaA	Novel recombinant clostridial neurotoxins with decreased duration of effect
EP3312193A1 (en)	2016-10-19	2018-04-25	Merz Pharma GmbH & Co. KGaA	Novel recombinant botulinum neurotoxins with accelerated onset of effect
EP3333179A1 (en)	2016-12-07	2018-06-13	Merz Pharma GmbH & Co. KGaA	Novel recombinant botulinum toxin with accelarated onset of effect
EP3335719A1 (en)	2016-12-14	2018-06-20	Merz Pharma GmbH & Co. KGaA	Novel recombinant botulinum neurotoxins with a stabilized light chain
WO2018233813A1 (en)	2017-06-20	2018-12-27	Merz Pharma Gmbh & Co. Kgaa	Novel recombinant botulinum toxin with increased duration of effect
ES2930237T3 (es)	2017-07-06	2022-12-09	Merz Pharma Gmbh & Co Kgaa	Neurotoxinas botulínicas recombinantes nuevas con mayor duración de efectos
US20210008156A1 (en)	2017-10-26	2021-01-14	Merz Pharma Gmbh & Co. Kgaa	Novel recombinant botulinum neurotoxins with increased duration of effect
WO2019101308A1 (en)	2017-11-22	2019-05-31	Merz Pharma Gmbh & Co. Kgaa	Novel recombinant botulinum toxin with increased duration of effect
EP3752128B1 (de) *	2018-02-16	2025-01-15	preclinics discovery GmbH	Nukleinsäure-basiertes botulinum neurotoxin zur therapeutischen anwendung
US12493044B2 (en) *	2018-05-30	2025-12-09	The Governing Council Of The University Of Toronto	Methods and kits for identifying a protein associated with receptor-ligand interactions
CN111655734A (zh) *	2019-04-28	2020-09-11	广州市雷德生物科技有限公司	一种促进蛋白二聚体形成的拉链扣结构及其应用
KR102610179B1 (ko)	2019-12-18	2023-12-05	엠브릭스 주식회사	보툴리눔 신경 독소의 안전한 제조 방법
CN114957482B (zh) *	2021-02-26	2024-09-24	重庆誉颜制药有限公司	一种经修饰的神经毒素的单链多肽及其用途
CN113480667B (zh) *	2021-08-17	2023-03-28	长春萤火虫生物科技有限公司	一种人粒细胞集落刺激因子突变体重组融合蛋白及其制备方法和应用
EP4436985A4 (en) *	2022-05-24	2025-10-15	Jhm Biopharmaceutical Hangzhou Co Ltd	RECOMBINANT BOTULINUM NEUROTOXIN TYPE A AND PROCESS FOR ITS PREPARATION
CN115894641B (zh) *	2022-09-13	2023-09-29	君合盟生物制药(杭州)有限公司	A型肉毒素突变体及其基因工程菌的构建
CN115819526A (zh) *	2022-12-02	2023-03-21	海雅美生物技术(珠海)有限公司	一种重组肉毒杆菌神经毒素及其制备方法和应用
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2005
- 2005-01-21 DE DE102005002978A patent/DE102005002978B4/de not_active Expired - Fee Related
2006
- 2006-01-20 CN CN2013102392934A patent/CN103320459A/zh active Pending
- 2006-01-20 DK DK06705826.3T patent/DK1844150T3/da active
- 2006-01-20 BR BRPI0606612-7A patent/BRPI0606612A2/pt not_active IP Right Cessation
- 2006-01-20 JP JP2007551542A patent/JP5107055B2/ja not_active Expired - Fee Related
- 2006-01-20 CN CN2006800029573A patent/CN101107361B/zh not_active Expired - Fee Related
- 2006-01-20 ES ES06705826T patent/ES2380677T3/es not_active Expired - Lifetime
- 2006-01-20 WO PCT/DE2006/000088 patent/WO2006076902A2/de not_active Ceased
- 2006-01-20 EP EP06705826A patent/EP1844150B1/de not_active Expired - Lifetime
- 2006-01-20 US US11/814,511 patent/US20080103098A1/en not_active Abandoned
- 2006-01-20 AU AU2006207726A patent/AU2006207726B2/en not_active Ceased
- 2006-01-20 DE DE112006000677T patent/DE112006000677A5/de not_active Withdrawn
- 2006-01-20 RU RU2007127624/10A patent/RU2412253C2/ru not_active IP Right Cessation
- 2006-01-20 KR KR1020077018752A patent/KR20070104605A/ko not_active Abandoned
- 2006-01-20 AT AT06705826T patent/ATE546533T1/de active
- 2006-01-20 CA CA2593520A patent/CA2593520C/en not_active Expired - Fee Related
2007
- 2007-06-21 IL IL184112A patent/IL184112A0/en unknown
2012
- 2012-08-16 JP JP2012180318A patent/JP2012254088A/ja active Pending

Also Published As

Publication number	Publication date
CN101107361B (zh)	2013-07-17
AU2006207726A1 (en)	2006-07-27
KR20070104605A (ko)	2007-10-26
CN103320459A (zh)	2013-09-25
DE112006000677A5 (de)	2007-12-27
US20080103098A1 (en)	2008-05-01
WO2006076902A2 (de)	2006-07-27
JP2008527983A (ja)	2008-07-31
ATE546533T1 (de)	2012-03-15
ES2380677T3 (es)	2012-05-17
DE102005002978B4 (de)	2013-04-25
CN101107361A (zh)	2008-01-16
RU2007127624A (ru)	2009-02-27
RU2412253C2 (ru)	2011-02-20
JP2012254088A (ja)	2012-12-27
DE102005002978A1 (de)	2006-08-03
EP1844150A2 (de)	2007-10-17
IL184112A0 (en)	2007-10-31
BRPI0606612A2 (pt)	2009-07-07
AU2006207726B2 (en)	2011-04-14
CA2593520C (en)	2013-11-19
EP1844150B1 (de)	2012-02-22
CA2593520A1 (en)	2006-07-27
JP5107055B2 (ja)	2012-12-26
WO2006076902A3 (de)	2006-11-02

Publication	Publication Date	Title
DK1844150T3 (da)	2012-05-29	Rekombinant ekspression af proteiner i en to-kædet form med disulfidbroer
WO2005017149A8 (en)	2006-01-19	Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
NZ593837A (en)	2013-01-25	Recombinantly modified plasmin
ATE417595T1 (de)	2009-01-15	Keratin-bindende polypeptide
RU2011106744A (ru)	2012-09-10	Инсулин, стабилизированный галогеном
NZ596787A (en)	2014-03-28	Growth hormone polypeptides and methods of making and using same
ATE517119T1 (de)	2011-08-15	Einzelketteninsulin
DE60332645D1 (de)	2010-07-01	Ii-key/antigene epitop-hybrid-peptid-vakzine
ATE168719T1 (de)	1998-08-15	Osteogene peptide
CA2443365A1 (en)	2004-05-19	Methods for the recombinant production of antifusogenic peptides
ATE540981T1 (de)	2012-01-15	Lösliche fusionsproteine enthaltend heterologe polypeptide
KR960704934A (ko)	1996-10-09	항혈전활성을 갖는 펩티드 및 이의 제조방법(Peptide having antithrombotic activity and process for producing the same)
DK0479912T3 (da)	1994-10-10	Fremgangsmåde til hæmning af N-endereglens forløb i levende celler
WO2001005810A3 (de)	2001-05-17	CYCLISCHE PEPTIDDERIVATE ALS INHIBITOREN DES INTEGRINS αvβ¿6?
DK1904529T3 (da)	2010-11-15	Anvendelse af Stefin A som et scaffoldprotein
WO2004014937A3 (en)	2005-02-17	Thrombin peptide derivatives
DE60114363D1 (de)	2005-12-01	Oligomere von konformationsbeschränkten, nicht-peptidischen di- oder tripeptid-mimetika, und ihre verwendung zur synthese von künstlichen polypeptiden und proteinen
BRPI0715331B8 (pt)	2021-05-25	polipeptídeo que compreende uma porção n-terminal e uma porção c-terminal, e uso do mesmo
ATE317443T1 (de)	2006-02-15	N-terminal verlängerte proteine exprimiert in hefe
Suzuki et al.	1990	Primary structure of a constituent polypeptide chain (AIII) of the giant haemoglobin from the deep-sea tube worm Lamellibrachia. A possible H2S-binding site
ATE362939T1 (de)	2007-06-15	Dimere von thrombinpeptidderivaten
Jurgilas et al.	2003	PO41, a snake venom metalloproteinase inhibitor isolated from Philander opossum serum
WO2003038061A3 (en)	2004-09-10	Ehrlichia disulfide bond formation proteins and uses thereof
WO2006097432A3 (de)	2007-04-19	Keratin-biktdende desmoplakinpolypeptidsequenzen
SG170092A1 (en)	2011-04-29	Peptides of regulatory or accessory proteins of hiv, compositions and the utilization thereof