ATE478070T1 - Heterozyklische aspartyl-proteasehemmer - Google Patents

Heterozyklische aspartyl-proteasehemmer

Info

Publication number
ATE478070T1
ATE478070T1 AT06817385T AT06817385T ATE478070T1 AT E478070 T1 ATE478070 T1 AT E478070T1 AT 06817385 T AT06817385 T AT 06817385T AT 06817385 T AT06817385 T AT 06817385T AT E478070 T1 ATE478070 T1 AT E478070T1
Authority
AT
Austria
Prior art keywords
protease inhibitors
aspartyl protease
heterocyclic aspartyl
heterocyclic
inhibitors
Prior art date
Application number
AT06817385T
Other languages
English (en)
Inventor
Zhaoning Zhu
Andrew Stamford
Brian Mckittrick
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE478070T1 publication Critical patent/ATE478070T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT06817385T 2005-10-27 2006-10-25 Heterozyklische aspartyl-proteasehemmer ATE478070T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73062205P 2005-10-27 2005-10-27
PCT/US2006/041716 WO2007050721A2 (en) 2005-10-27 2006-10-25 Heterocyclic aspartyl protease inhibitors

Publications (1)

Publication Number Publication Date
ATE478070T1 true ATE478070T1 (de) 2010-09-15

Family

ID=37873175

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06817385T ATE478070T1 (de) 2005-10-27 2006-10-25 Heterozyklische aspartyl-proteasehemmer

Country Status (12)

Country Link
US (3) US7763606B2 (de)
EP (1) EP1940828B1 (de)
JP (1) JP2009513656A (de)
CN (1) CN101296926A (de)
AR (1) AR057983A1 (de)
AT (1) ATE478070T1 (de)
CA (1) CA2626976A1 (de)
DE (1) DE602006016314D1 (de)
ES (1) ES2349433T3 (de)
PE (1) PE20070531A1 (de)
TW (1) TW200803847A (de)
WO (1) WO2007050721A2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763609B2 (en) * 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
WO2006041405A1 (en) * 2004-10-15 2006-04-20 Astrazeneca Ab Substituted amino-pyrimidones and uses thereof
EP1802587A4 (de) * 2004-10-15 2010-02-17 Astrazeneca Ab Substituierte aminoverbindungen und deren anwendungen
EP1831170A4 (de) * 2004-12-14 2009-10-14 Astrazeneca Ab Substituierte aminopyridine und deren verwendung
EP1896032B1 (de) 2005-06-14 2012-10-31 Merck Sharp & Dohme Corp. Herstellung und verwendung von verbindungen als proteasehemmer
SG162790A1 (en) 2005-06-14 2010-07-29 Schering Corp Aspartyl protease inhibitors
ATE482214T1 (de) * 2005-06-14 2010-10-15 Schering Corp Aspartylproteasehemmer
EP1951682A4 (de) * 2005-11-15 2011-06-15 Astrazeneca Ab Neue 2-aminopyrimidon- oder 2-aminopyridinonderivate und deren verwendung
CN101360720A (zh) * 2005-11-15 2009-02-04 阿斯利康(瑞典)有限公司 新颖的2-氨基嘧啶酮衍生物及其用途
TW200734311A (en) * 2005-11-21 2007-09-16 Astrazeneca Ab New compounds
CN101360716A (zh) * 2005-11-21 2009-02-04 阿斯利康(瑞典)有限公司 新颖的2-氨基-咪唑-4-酮化合物及其在制备用于治疗认知缺损、阿尔茨海默病、神经变性和痴呆的药物中的用途
AR058381A1 (es) * 2005-12-19 2008-01-30 Astrazeneca Ab Compuestos derivados de 2-aminopiridin-4-onas y una composicion farmaceutica
CN101460480A (zh) * 2006-04-05 2009-06-17 阿斯利康(瑞典)有限公司 2-氨基嘧啶-4-酮类化合物及其用于治疗或预防Aβ相关病理的用途
US8168641B2 (en) 2006-06-12 2012-05-01 Schering Corporation Aspartyl protease inhibitors
US20080051420A1 (en) * 2006-06-14 2008-02-28 Astrazeneca Ab New Compounds 317
TW200815447A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds IV
TW200815349A (en) * 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
TW200831484A (en) * 2006-12-20 2008-08-01 Astrazeneca Ab New compounds
TW200902499A (en) * 2007-05-15 2009-01-16 Astrazeneca Ab New compounds
TW200902503A (en) * 2007-05-15 2009-01-16 Astrazeneca Ab New compounds
CN101848897A (zh) 2007-09-06 2010-09-29 先灵公司 γ分泌酶调节剂
WO2009061699A1 (en) 2007-11-05 2009-05-14 Schering Corporation Gamma secretase modulators
CA2708300A1 (en) * 2007-12-11 2009-06-18 Schering Corporation Gamma secretase modulators
AU2009239536C1 (en) 2008-04-22 2012-12-13 Merck Sharp & Dohme Corp. Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use
AU2009314049B2 (en) 2008-11-13 2015-03-05 Merck Sharp & Dohme Corp. Gamma secretase modulators
US20100125081A1 (en) * 2008-11-14 2010-05-20 Astrazeneca Ab New compounds 574
WO2010056195A1 (en) * 2008-11-14 2010-05-20 Astrazeneca Ab New compounds 575
TW201020244A (en) * 2008-11-14 2010-06-01 Astrazeneca Ab New compounds
JP2012513399A (ja) 2008-12-22 2012-06-14 シェーリング コーポレイション γ−セクレターゼ調節剤
EP2379566A2 (de) 2008-12-22 2011-10-26 Schering Corporation Modulatoren von gamma-sekretase
WO2010147975A1 (en) 2009-06-16 2010-12-23 Schering Corporation Gamma secretase modulators
EP2443118A1 (de) 2009-06-16 2012-04-25 Schering Corporation Gammasekretasemodulatoren
WO2010147969A2 (en) 2009-06-16 2010-12-23 Schering Corporation Gamma secretase modulators
EP2281824A1 (de) 2009-08-07 2011-02-09 Noscira, S.A. Furan-Imidazolon-Derivate zur Behandlung von kognitiven, neurodegenerativen oder neuronalen Erkrankungen oder Funktionsstörungen
UA108363C2 (uk) 2009-10-08 2015-04-27 Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
EP2485591B1 (de) 2009-10-08 2016-03-23 Merck Sharp & Dohme Corp. Iminothiadiazindioxinverbindungen als bace-hemmer, zusammensetzungen und ihre verwendung
US8557826B2 (en) 2009-10-08 2013-10-15 Merck Sharp & Dohme Corp. Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions, and their use
EP2485920B1 (de) 2009-10-08 2016-04-27 Merck Sharp & Dohme Corp. Heterozyklische pentafluorsulfur-imin-verbindungen als bace-1-hemmer sowie zusammensetzungen damit und ihre verwendung
EP2643299B1 (de) 2010-11-22 2016-06-22 Noscira, S.A. Bipyridinsulfonamidderivate zur behandlung von neurodegenerativen erkrankungen oder zuständen
US9145426B2 (en) 2011-04-07 2015-09-29 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
EP2694489B1 (de) 2011-04-07 2017-09-06 Merck Sharp & Dohme Corp. C5-c6-oxacyclus-fusionierte thiadiazindioxidverbindungen als bace-hemmer sowie zusammensetzungen daraus und ihre verwendung
US9181236B2 (en) 2011-08-22 2015-11-10 Merck Sharp & Dohme Corp. 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use
CN104270945B (zh) 2012-03-19 2017-03-29 巴克老龄化研究所 App特异性bace抑制剂(asbi)及其用途
EP2908824B1 (de) 2012-10-17 2018-05-02 Merck Sharp & Dohme Corp. Tricyclische substituierte thiadiazindioxidverbindungen als bace-hemmer, zusammensetzungen und deren verwendung
WO2014062549A1 (en) 2012-10-17 2014-04-24 Merck Sharp & Dohme Corp. Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
US9489013B2 (en) 2012-12-20 2016-11-08 Merck Sharp & Dohme Corp. C6-azaspiro iminothiadiazine dioxides as bace inhibitors, compositions, and their use
WO2014099788A1 (en) 2012-12-21 2014-06-26 Merck Sharp & Dohme Corp. C5-spiro iminothiadiazine dioxides as bace inhibitors
CA2899938C (en) 2013-02-12 2021-10-19 Buck Institute For Research On Aging Hydantoins that modulate bace-mediated app processing

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH527828A (de) 1967-04-13 1972-09-15 Ciba Geigy Ag Verfahren zur Herstellung von 2,4-Benzdiazepinen
DE3477388D1 (en) 1983-03-04 1989-04-27 Arco Chem Co Production of polyurethane-forming components having free-isocyanate or hydroxy groups
US4550169A (en) * 1983-11-21 1985-10-29 American Cyanamid Company Platinum chelates of 2-hydrazino-azoles
CA2104060A1 (en) 1992-11-10 1994-05-11 Robert Ed Johnson Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents
AU2002306734A1 (en) 2001-03-15 2002-10-03 The Johns Hopkins University Inhibitors of plasmepsins
JP4283681B2 (ja) * 2002-03-04 2009-06-24 アンブリリア バイオファーマ インコーポレーテッド Ｈｉｖアスパルチルプロテアーゼ阻害剤としての尿素誘導体
AU2004294933B2 (en) 2003-11-21 2011-11-17 Johns Hopkins University Biomolecule partition motifs and uses thereof
SG163508A1 (en) * 2003-12-15 2010-08-30 Schering Corp Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
SG162790A1 (en) 2005-06-14 2010-07-29 Schering Corp Aspartyl protease inhibitors
AU2006259574A1 (en) 2005-06-14 2006-12-28 Schering Corporation The preparation and use of compounds as aspartyl protease inhibitors
US7759353B2 (en) 2005-06-14 2010-07-20 Schering Corporation Substituted spiro iminopyrimidinones as aspartyl protease inhibitors, compositions, and methods of treatment

Also Published As

Publication number Publication date
US20100247519A1 (en) 2010-09-30
CA2626976A1 (en) 2007-05-03
US7763606B2 (en) 2010-07-27
WO2007050721A3 (en) 2007-06-14
HK1119680A1 (en) 2009-03-13
EP1940828A2 (de) 2008-07-09
TW200803847A (en) 2008-01-16
PE20070531A1 (es) 2007-07-13
US20070099898A1 (en) 2007-05-03
US8012960B2 (en) 2011-09-06
AR057983A1 (es) 2008-01-09
EP1940828B1 (de) 2010-08-18
WO2007050721A2 (en) 2007-05-03
CN101296926A (zh) 2008-10-29
US8202854B2 (en) 2012-06-19
ES2349433T3 (es) 2011-01-03
US20110280867A1 (en) 2011-11-17
DE602006016314D1 (de) 2010-09-30
JP2009513656A (ja) 2009-04-02

Similar Documents

Publication Publication Date Title
ATE478070T1 (de) Heterozyklische aspartyl-proteasehemmer
ATE439835T1 (de) Heterozyklische aspartyl-proteasehemmer
ATE482214T1 (de) Aspartylproteasehemmer
DK1699455T3 (da) Heterocykliske aspartylproteasehæmmere
ATE530554T1 (de) Serinprotease-hemmer
IL195592A0 (en) Heterocyclic aspartyl protease inhibitors
ZA200710386B (en) Aspartyl protease inhibitors
IL187814A0 (en) Aspartyl protease inhibitors
LTPA2017010I1 (lt) Proteazomos inhibitoriai
ZA200905837B (en) Heterocyclic aspartyl protease inhibitors
EP1981519A4 (de) Proteasehemmung
NO20076678L (no) Glutamataggrekanaseinhibitorer
DK1940839T3 (da) Pyridopyrimidione Inhibitors of P13Ka
DE602005019971D1 (de) Inhibitoren von cysteinprotease
DK1848718T3 (da) E1 aktiveringsenzymhæmmere
ATE538092T1 (de) Asparaginsäureproteaseinhibitoren
DK2032535T3 (da) Spiro-cycliske nitriler som protease-inhibitorer
DK1817276T3 (da) Cathepsin cysteine protease inhibitors
ATE429417T1 (de) Hiv-protease-inhibitoren
ATE418545T1 (de) Nnrt-inhibitoren
EP1715920A4 (de) Cathepsincysteinproteasehemmer
TH0801000834A (th) ตัวยับยั้งเฮเทอโรไซคลิก แอสพาร์ทิลโปรตีเอส
TH101958B (th) สารยับยั้งแอสพาร์ติค โปรติเอส
HK1124854A (en) Heterocyclic aspartyl protease inhibitors
DE602004014762D1 (de) Proteasehemmer

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties