ATE478157T1 - Nukleinsäure-ligand-inhibitoren gegen dna polymerasen - Google Patents
Nukleinsäure-ligand-inhibitoren gegen dna polymerasenInfo
- Publication number
- ATE478157T1 ATE478157T1 AT00914690T AT00914690T ATE478157T1 AT E478157 T1 ATE478157 T1 AT E478157T1 AT 00914690 T AT00914690 T AT 00914690T AT 00914690 T AT00914690 T AT 00914690T AT E478157 T1 ATE478157 T1 AT E478157T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- dna polymerases
- acid ligand
- inhibitors against
- against dna
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 5
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 title 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 108010006785 Taq Polymerase Proteins 0.000 abstract 1
- 108010020713 Tth polymerase Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/258,797 US6183967B1 (en) | 1995-06-07 | 1999-03-01 | Nucleic acid ligand inhibitors to DNA polymerases |
| PCT/US2000/004702 WO2000052207A1 (en) | 1999-03-01 | 2000-02-24 | Nucleic acid ligand inhibitors to dna polymerases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478157T1 true ATE478157T1 (de) | 2010-09-15 |
Family
ID=22982164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00914690T ATE478157T1 (de) | 1999-03-01 | 2000-02-24 | Nukleinsäure-ligand-inhibitoren gegen dna polymerasen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6183967B1 (de) |
| EP (2) | EP1171632B1 (de) |
| JP (2) | JP4738599B2 (de) |
| AT (1) | ATE478157T1 (de) |
| AU (1) | AU781567B2 (de) |
| CA (1) | CA2362526A1 (de) |
| DE (1) | DE60044845D1 (de) |
| DK (1) | DK1171632T3 (de) |
| ES (1) | ES2349213T3 (de) |
| HK (1) | HK1044803B (de) |
| PT (1) | PT1171632E (de) |
| WO (1) | WO2000052207A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6830902B1 (en) * | 1999-07-02 | 2004-12-14 | Invitrogen Corporation | Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis |
| US7312325B2 (en) * | 2000-09-26 | 2007-12-25 | Duke University | RNA aptamers and methods for identifying the same |
| DK2070939T3 (da) * | 2001-05-25 | 2014-06-23 | Univ Duke | Modulatorer af farmakologiske midler |
| US6667165B2 (en) | 2001-11-13 | 2003-12-23 | Eppendorf Ag | Method and compositions for reversible inhibition of thermostable polymerases |
| EP1594982A4 (de) * | 2003-01-29 | 2006-04-12 | Quanta Biosciences Inc | Verfahren und zusammensetzungen zum nachweis und zur quantifizierung von rna |
| AU2004227353B2 (en) | 2003-04-01 | 2010-02-25 | Luminex Corporation | Polymerase inhibitor and method of using same |
| US7727969B2 (en) * | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
| EP2460811A1 (de) * | 2004-04-22 | 2012-06-06 | Regado Biosciences, Inc. | Verbesserte Modulatoren von Gerinnungsfaktoren |
| WO2005123913A2 (en) * | 2004-06-09 | 2005-12-29 | Nustar Laboratory | Reversibly modified thermostable enzyme compositions and methods of making and using the same |
| US20060019288A1 (en) * | 2004-06-30 | 2006-01-26 | Applera Corporation | Methods, reaction mixtures, and kits for ligating polynucleotides |
| ATE541055T1 (de) * | 2004-10-18 | 2012-01-15 | Univ Brandeis | Reagenzien und verfahren zur verbesserung der reproduzierbarkeit und zur reduzierung des mispriming bei der pcr-amplifikation |
| US20060228726A1 (en) * | 2005-01-06 | 2006-10-12 | Martin Patrick K | Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification |
| US20070059713A1 (en) * | 2005-09-09 | 2007-03-15 | Lee Jun E | SSB-DNA polymerase fusion proteins |
| US20070212704A1 (en) | 2005-10-03 | 2007-09-13 | Applera Corporation | Compositions, methods, and kits for amplifying nucleic acids |
| WO2007092538A2 (en) * | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
| CN106566855B (zh) * | 2006-07-31 | 2021-11-09 | 苏州新海生物科技股份有限公司 | 使用可逆修饰寡核苷酸扩增核酸 |
| US9045522B2 (en) | 2006-07-31 | 2015-06-02 | Wanli Bi | Nucleic acid amplification using a reversibly modified oligonucleotide |
| CN101802225B (zh) | 2007-07-17 | 2013-10-30 | 私募蛋白质体公司 | 检测样品的多元分析 |
| GB0806562D0 (en) | 2008-04-10 | 2008-05-14 | Fermentas Uab | Production of nucleic acid |
| EP2113574A1 (de) | 2008-04-28 | 2009-11-04 | Biotype AG | Stoffe und Verfahren für Profilierungstest auf DNA-Basis |
| US8841429B2 (en) * | 2009-11-03 | 2014-09-23 | Vivonics, Inc. | Nucleic acid ligands against infectious prions |
| US8236570B2 (en) * | 2009-11-03 | 2012-08-07 | Infoscitex | Methods for identifying nucleic acid ligands |
| KR20130138700A (ko) * | 2012-06-11 | 2013-12-19 | 삼성테크윈 주식회사 | 절단가능한 올리고뉴클레오티드 저해제에 의한 ｄｎａ 폴리머라제의 제어된 저해 및 재활성화 |
| US11473140B2 (en) * | 2013-11-26 | 2022-10-18 | Lc Sciences Lc | Highly selective omega primer amplification of nucleic acid sequences |
| CN103966184A (zh) * | 2014-05-06 | 2014-08-06 | 江西省科学院微生物研究所 | 一种实时热启动Taq酶及其制备方法 |
| JP7106461B2 (ja) | 2016-06-07 | 2022-07-26 | セファイド | 熱安定性ポリメラーゼ阻害剤組成物及び方法 |
| CN107619430B (zh) * | 2017-10-17 | 2021-01-15 | 江西省科学院微生物研究所 | 一种热稳定的Taq酶温控亲和性配体及其制备方法、应用 |
| EP3818170A4 (de) * | 2018-07-02 | 2022-03-09 | Swift Biosciences, Inc. | Temperaturgesteuerte dna-polymeraseinhibitoren |
| CN112770776B (zh) | 2018-07-30 | 2025-08-19 | 瑞德库尔有限责任公司 | 用于样品处理或分析的方法和系统 |
| EP4097251A1 (de) | 2020-01-29 | 2022-12-07 | 10X Genomics, Inc. | Zusammensetzungen und verfahren zur analytdetektion |
| JP2023531027A (ja) * | 2020-06-22 | 2023-07-20 | ▲蘇▼州新海生物科技股▲ふん▼有限公司 | 核酸リガンド、およびその使用 |
| CA3189769A1 (en) * | 2020-07-29 | 2022-02-03 | Mgi Tech Co., Ltd. | Method for loading nucleic acid molecule on solid support |
| KR102661292B1 (ko) * | 2021-09-09 | 2024-04-30 | 포항공과대학교 산학협력단 | 금속 이온 반응성 dna 중합 효소 스위치 및 이에 의해 제어되는 등온 증폭 방법 |
| CN114214298A (zh) * | 2021-12-30 | 2022-03-22 | 苏州译酶生物科技有限公司 | 一种热启动Taq DNA聚合酶的制备方法 |
| CN115044588B (zh) * | 2022-06-16 | 2023-04-25 | 湖北省疾病预防控制中心（湖北省预防医学科学院） | 一种核酸适配体及热启动dna聚合酶 |
| CN115851889B (zh) * | 2022-11-30 | 2025-12-05 | 北京全式金生物技术股份有限公司 | 松三糖和可逆结合因子Oligo在提升荧光定量PCR全预混体系的保存稳定性中的应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE229046T1 (de) | 1985-03-30 | 1987-12-17 | Marc Genf/Geneve Ballivet | Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren. |
| WO1989006694A1 (en) | 1988-01-15 | 1989-07-27 | Trustees Of The University Of Pennsylvania | Process for selection of proteinaceous substances which mimic growth-inducing molecules |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| US5693502A (en) * | 1990-06-11 | 1997-12-02 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand inhibitors to DNA polymerases |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5874557A (en) * | 1990-06-11 | 1999-02-23 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand inhibitors to DNA polymerases |
| US5472841A (en) | 1990-06-11 | 1995-12-05 | Nexstar Pharmaceuticals, Inc. | Methods for identifying nucleic acid ligands of human neutrophil elastase |
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US5763173A (en) * | 1990-06-11 | 1998-06-09 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand inhibitors to DNA polymerases |
| US5503978A (en) | 1990-06-11 | 1996-04-02 | University Research Corporation | Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase |
| US5459015A (en) | 1990-06-11 | 1995-10-17 | Nexstar Pharmaceuticals, Inc. | High-affinity RNA ligands of basic fibroblast growth factor |
| US5527894A (en) | 1990-06-11 | 1996-06-18 | Nexstar Pharmacueticals, Inc. | Ligands of HIV-1 tat protein |
| ES2259800T3 (es) | 1990-06-11 | 2006-10-16 | Gilead Sciences, Inc. | Procedimientos de uso de ligandos de acido nucleico. |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US5543293A (en) | 1990-06-11 | 1996-08-06 | Nexstar Pharmaceuticals, Inc. | DNA ligands of thrombin |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| US5476766A (en) | 1990-06-11 | 1995-12-19 | Nexstar Pharmaceuticals, Inc. | Ligands of thrombin |
| US5580737A (en) | 1990-06-11 | 1996-12-03 | Nexstar Pharmaceuticals, Inc. | High-affinity nucleic acid ligands that discriminate between theophylline and caffeine |
| US5587468A (en) | 1990-06-11 | 1996-12-24 | University Research Corporation | High affinity nucleic acid ligands to HIV integrase |
| JPH06508022A (ja) | 1991-02-21 | 1994-09-14 | ギリアド サイエンシズ，インコーポレイテッド | 生体分子に特異的なアプタマーおよび生産方法 |
| US5338671A (en) | 1992-10-07 | 1994-08-16 | Eastman Kodak Company | DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody |
| US5567604A (en) | 1993-04-23 | 1996-10-22 | Aronex Pharmaceuticals, Inc. | Anti-viral guanosine-rich oligonucleotides |
| US6020130A (en) * | 1995-06-07 | 2000-02-01 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands that bind to and inhibit DNA polymerases |
| US20170110787A1 (en) | 2015-10-14 | 2017-04-20 | Apple Inc. | Electronic Devices With Millimeter Wave Antennas And Metal Housings |
| US12393593B2 (en) | 2023-09-12 | 2025-08-19 | Optum, Inc. | Priority-driven federated query-based data caching |
-
1999
- 1999-03-01 US US09/258,797 patent/US6183967B1/en not_active Expired - Fee Related
-
2000
- 2000-02-24 HK HK02105273.5A patent/HK1044803B/en unknown
- 2000-02-24 DK DK00914690.3T patent/DK1171632T3/da active
- 2000-02-24 AU AU36047/00A patent/AU781567B2/en not_active Expired
- 2000-02-24 ES ES00914690T patent/ES2349213T3/es not_active Expired - Lifetime
- 2000-02-24 AT AT00914690T patent/ATE478157T1/de active
- 2000-02-24 WO PCT/US2000/004702 patent/WO2000052207A1/en not_active Ceased
- 2000-02-24 EP EP00914690A patent/EP1171632B1/de not_active Expired - Lifetime
- 2000-02-24 PT PT00914690T patent/PT1171632E/pt unknown
- 2000-02-24 JP JP2000602817A patent/JP4738599B2/ja not_active Expired - Lifetime
- 2000-02-24 CA CA002362526A patent/CA2362526A1/en not_active Abandoned
- 2000-02-24 EP EP10007279A patent/EP2241635A1/de not_active Withdrawn
- 2000-02-24 DE DE60044845T patent/DE60044845D1/de not_active Expired - Lifetime
-
2011
- 2011-01-13 JP JP2011004936A patent/JP2011103890A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011103890A (ja) | 2011-06-02 |
| AU3604700A (en) | 2000-09-21 |
| EP2241635A1 (de) | 2010-10-20 |
| JP4738599B2 (ja) | 2011-08-03 |
| WO2000052207A9 (en) | 2001-10-25 |
| HK1044803B (en) | 2011-04-29 |
| EP1171632B1 (de) | 2010-08-18 |
| AU781567B2 (en) | 2005-06-02 |
| ES2349213T3 (es) | 2010-12-29 |
| US6183967B1 (en) | 2001-02-06 |
| JP2002537825A (ja) | 2002-11-12 |
| CA2362526A1 (en) | 2000-09-08 |
| WO2000052207A1 (en) | 2000-09-08 |
| EP1171632A1 (de) | 2002-01-16 |
| HK1044803A1 (en) | 2002-11-01 |
| DE60044845D1 (de) | 2010-09-30 |
| DK1171632T3 (da) | 2010-11-08 |
| EP1171632A4 (de) | 2005-03-30 |
| PT1171632E (pt) | 2010-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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