ATE478861T1 - Multizyklische verbindung und verwendungsverfahren - Google Patents
Multizyklische verbindung und verwendungsverfahrenInfo
- Publication number
- ATE478861T1 ATE478861T1 AT07751460T AT07751460T ATE478861T1 AT E478861 T1 ATE478861 T1 AT E478861T1 AT 07751460 T AT07751460 T AT 07751460T AT 07751460 T AT07751460 T AT 07751460T AT E478861 T1 ATE478861 T1 AT E478861T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- disease states
- modulating
- influencing
- kinases
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 102000001253 Protein Kinase Human genes 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 108060006633 protein kinase Proteins 0.000 abstract 2
- 102000003989 Aurora kinases Human genes 0.000 abstract 1
- 108090000433 Aurora kinases Proteins 0.000 abstract 1
- 101100481408 Danio rerio tie2 gene Proteins 0.000 abstract 1
- 101100481410 Mus musculus Tek gene Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000022131 cell cycle Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steam Or Hot-Water Central Heating Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77650706P | 2006-02-24 | 2006-02-24 | |
| US11/709,994 US7868177B2 (en) | 2006-02-24 | 2007-02-21 | Multi-cyclic compounds and method of use |
| PCT/US2007/004700 WO2007100646A1 (en) | 2006-02-24 | 2007-02-22 | Multi-cyclic compounds and method of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478861T1 true ATE478861T1 (de) | 2010-09-15 |
Family
ID=38242083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07751460T ATE478861T1 (de) | 2006-02-24 | 2007-02-22 | Multizyklische verbindung und verwendungsverfahren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7868177B2 (de) |
| EP (1) | EP1994030B1 (de) |
| AT (1) | ATE478861T1 (de) |
| AU (1) | AU2007221294B2 (de) |
| CA (1) | CA2643177C (de) |
| DE (1) | DE602007008694D1 (de) |
| ES (1) | ES2347489T3 (de) |
| WO (1) | WO2007100646A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1751136B1 (de) * | 2004-05-07 | 2014-07-02 | Amgen Inc. | Nitrogenierte heterozyklische derivate als proteinkinasemodulatoren und deren verwendung zur behandlung von angiogenese und krebs |
| US7560551B2 (en) * | 2006-01-23 | 2009-07-14 | Amgen Inc. | Aurora kinase modulators and method of use |
| WO2008057280A1 (en) * | 2006-10-27 | 2008-05-15 | Amgen Inc. | Multi-cyclic compounds and methods of use |
| GB0801416D0 (en) * | 2008-01-25 | 2008-03-05 | Piramed Ltd | Pharmaceutical compounds |
| TWI396689B (zh) | 2008-11-14 | 2013-05-21 | Amgen Inc | 作為磷酸二酯酶１０抑制劑之吡衍生物 |
| AR074343A1 (es) | 2008-11-14 | 2011-01-12 | Amgen Inc | Derivados de piridina y pirimidina como inhibidores de la fosfodiesterasa 10 |
| US8604217B2 (en) | 2009-11-12 | 2013-12-10 | Selvita S.A. | Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent |
| WO2011058139A1 (en) * | 2009-11-12 | 2011-05-19 | Selvita Sp. Z O. O. | A compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent |
| EP2550266B1 (de) | 2010-03-24 | 2018-05-09 | Amitech Therapeutics Solutions, Inc. | Heterozyklische verbindungen zur kinasehemmung |
| AU2012243226A1 (en) * | 2011-03-01 | 2013-09-26 | Npharmakon, Llc | Use of N-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine and related compounds |
| CN104302640A (zh) | 2012-03-16 | 2015-01-21 | 埃克希金医药品有限公司 | 3,5-二氨基吡唑激酶抑制剂 |
| CA3122383A1 (en) | 2013-05-07 | 2014-11-13 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis. |
| AU2014304562B8 (en) | 2013-08-08 | 2018-07-05 | Galapagos Nv | Thieno[2,3-c]pyrans as CFTR modulators |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| US9963444B2 (en) | 2014-05-19 | 2018-05-08 | Northeastern University | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof |
| MY191736A (en) | 2014-12-23 | 2022-07-13 | Axikin Pharmaceuticals Inc | 3,5-diaminopyrazole kinase inhibitors |
| WO2017047602A1 (ja) | 2015-09-18 | 2017-03-23 | 科研製薬株式会社 | ビアリール誘導体及びそれを含有する医薬 |
| WO2017102091A1 (en) | 2015-12-18 | 2017-06-22 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| TW201838981A (zh) * | 2017-03-17 | 2018-11-01 | 美商建南德克公司 | 嘧啶基-吡啶氧基-萘基化合物以及治療ire1相關之疾病及病症的方法 |
| US10689357B2 (en) | 2018-05-08 | 2020-06-23 | Northeastern University | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof |
| WO2020047518A1 (en) * | 2018-08-30 | 2020-03-05 | The Regents Of The University Of California | Ire1 kinase inhibitors and uses thereof |
| TWI831829B (zh) | 2018-09-12 | 2024-02-11 | 美商建南德克公司 | 苯氧基-吡啶基-嘧啶化合物及使用方法 |
| CN112689528B (zh) | 2018-09-12 | 2024-05-14 | 基因泰克公司 | 嘧啶基-杂芳氧基-萘基化合物和使用方法 |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2020142612A1 (en) | 2019-01-03 | 2020-07-09 | Genentech, Inc. | Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases. |
| CA3128084A1 (en) * | 2019-02-14 | 2020-08-20 | Bridgene Biosciences, Inc. | Fgfr inhibitors for the treatment of cancer |
| TWI756636B (zh) | 2019-02-18 | 2022-03-01 | 美商建南德克公司 | 嘧啶并嘧啶化合物及使用方法 |
| EP3983400B1 (de) | 2019-06-11 | 2025-05-28 | Genentech, Inc. | Chinazolinylinverbindungen und verfahren zur verwendung |
| US20260234112A1 (en) * | 2023-02-06 | 2026-08-13 | Type6 Therapeutics, Inc. | Compounds, compositions, and methods of use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69622183D1 (de) * | 1995-11-07 | 2002-08-08 | Kirin Brewery | Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen |
| EE05345B1 (et) | 1999-02-10 | 2010-10-15 | Astrazeneca Ab | Kinasoliini derivaadid angiogeneesi inhibiitoritena |
| BR0111754A (pt) * | 2000-06-28 | 2003-04-29 | Astrazeneca Ab | Uso de um composto, método para inibir aurora 2 quinase em um animal de sangue quente, composto, e, composição farmacêutica |
| KR100600550B1 (ko) | 2000-10-20 | 2006-07-13 | 에자이 가부시키가이샤 | 질소 함유 방향환 유도체 |
| CA2454538A1 (en) | 2001-06-22 | 2003-01-03 | Kirin Beer Kabushiki Kaisha | Quinoline derivatives and quinazoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same |
| ATE446093T1 (de) | 2001-12-24 | 2009-11-15 | Astrazeneca Ab | Substituierte chinazolin-derivate als aurora- kinase inhibitoren |
| EP1517904A4 (de) | 2002-05-23 | 2007-02-21 | Merck & Co Inc | Inhibitoren von mitotischem kinesin |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| GB0219054D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
| US7262200B2 (en) | 2002-10-25 | 2007-08-28 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
| US7189729B2 (en) | 2003-09-30 | 2007-03-13 | Irm Llc | Methods and compositions as protein kinase inhibitors |
| DE10349587A1 (de) | 2003-10-24 | 2005-05-25 | Merck Patent Gmbh | Benzimidazolylderivate |
| EP1751136B1 (de) | 2004-05-07 | 2014-07-02 | Amgen Inc. | Nitrogenierte heterozyklische derivate als proteinkinasemodulatoren und deren verwendung zur behandlung von angiogenese und krebs |
| US7989461B2 (en) * | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
-
2007
- 2007-02-21 US US11/709,994 patent/US7868177B2/en not_active Expired - Fee Related
- 2007-02-22 WO PCT/US2007/004700 patent/WO2007100646A1/en not_active Ceased
- 2007-02-22 CA CA2643177A patent/CA2643177C/en not_active Expired - Fee Related
- 2007-02-22 DE DE602007008694T patent/DE602007008694D1/de active Active
- 2007-02-22 EP EP07751460A patent/EP1994030B1/de active Active
- 2007-02-22 AT AT07751460T patent/ATE478861T1/de not_active IP Right Cessation
- 2007-02-22 ES ES07751460T patent/ES2347489T3/es active Active
- 2007-02-22 AU AU2007221294A patent/AU2007221294B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2347489T3 (es) | 2010-10-29 |
| CA2643177A1 (en) | 2007-09-07 |
| DE602007008694D1 (de) | 2010-10-07 |
| WO2007100646A1 (en) | 2007-09-07 |
| EP1994030A1 (de) | 2008-11-26 |
| CA2643177C (en) | 2011-06-14 |
| AU2007221294A1 (en) | 2007-09-07 |
| US20070213325A1 (en) | 2007-09-13 |
| EP1994030B1 (de) | 2010-08-25 |
| AU2007221294B2 (en) | 2011-08-25 |
| US7868177B2 (en) | 2011-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |