ATE479435T1 - Substituierte imidazol-4-carboxamide als cholecystokinin-1-rezeptor-modulatoren - Google Patents
Substituierte imidazol-4-carboxamide als cholecystokinin-1-rezeptor-modulatorenInfo
- Publication number
- ATE479435T1 ATE479435T1 AT07755237T AT07755237T ATE479435T1 AT E479435 T1 ATE479435 T1 AT E479435T1 AT 07755237 T AT07755237 T AT 07755237T AT 07755237 T AT07755237 T AT 07755237T AT E479435 T1 ATE479435 T1 AT E479435T1
- Authority
- AT
- Austria
- Prior art keywords
- cholecystokinin
- substituted imidazole
- carboxamide
- receptor modulators
- receptor
- Prior art date
Links
- ZBNZAJFNDPPMDT-UHFFFAOYSA-N 1h-imidazole-5-carboxamide Chemical class NC(=O)C1=CNC=N1 ZBNZAJFNDPPMDT-UHFFFAOYSA-N 0.000 title abstract 3
- 108010089335 Cholecystokinin A Receptor Proteins 0.000 title abstract 3
- 102100034927 Cholecystokinin receptor type A Human genes 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 abstract 2
- 102000004859 Cholecystokinin Receptors Human genes 0.000 abstract 1
- 101000932701 Homo sapiens Cholecystokinin Proteins 0.000 abstract 1
- 101000946804 Homo sapiens Cholecystokinin receptor type A Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79196206P | 2006-04-14 | 2006-04-14 | |
| PCT/US2007/008901 WO2007120688A2 (en) | 2006-04-14 | 2007-04-10 | Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE479435T1 true ATE479435T1 (de) | 2010-09-15 |
Family
ID=38610143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07755237T ATE479435T1 (de) | 2006-04-14 | 2007-04-10 | Substituierte imidazol-4-carboxamide als cholecystokinin-1-rezeptor-modulatoren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7858629B2 (de) |
| EP (1) | EP2010178B1 (de) |
| JP (1) | JP2009533445A (de) |
| AT (1) | ATE479435T1 (de) |
| AU (1) | AU2007238804A1 (de) |
| CA (1) | CA2649927A1 (de) |
| DE (1) | DE602007008868D1 (de) |
| WO (1) | WO2007120688A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009533449A (ja) | 2006-04-14 | 2009-09-17 | メルク エンド カムパニー インコーポレーテッド | コレシストキニン−１受容体モジュレーターとしての置換イミダゾール４−カルボキサミド類 |
| MX2008013237A (es) | 2006-04-14 | 2009-03-06 | Merck & Co Inc | Imidazol 4-caroxamidas sustituidas como moduladores del receptor colecistoquinina-1. |
| EP2044055A4 (de) * | 2006-07-21 | 2011-03-23 | Takeda Pharmaceutical | Amidverbindungen |
| WO2010067233A1 (en) | 2008-12-08 | 2010-06-17 | Pfizer Inc. | 1,2,4 triazolo [4, 3 -a] [1,5] benzodiazepin-5 (6h) -ones as agonists of the cholecystokinin-1 receptor (cck-ir) |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2567959B1 (de) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamid-derivate als kinaseinhibitoren |
| BR112022006546A2 (pt) | 2019-10-07 | 2022-08-30 | Kallyope Inc | Agonistas de gpr119 |
| CA3173731A1 (en) | 2020-02-28 | 2021-09-02 | Kallyope, Inc. | Gpr40 agonists |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2133355A1 (en) | 1993-10-04 | 1995-04-05 | Itaru Nitta | Method for producing polypeptide |
| GB0011089D0 (en) | 2000-05-08 | 2000-06-28 | Black James Foundation | Gastrin and cholecystokinin receptor ligands (11) |
| WO2002055495A1 (en) | 2001-01-15 | 2002-07-18 | Glaxo Group Limited | Aryl piperidine derivatives as inducers of ldl-receptor expression |
| WO2003007887A2 (en) | 2001-07-20 | 2003-01-30 | Merck & Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
| US7109216B2 (en) * | 2001-09-21 | 2006-09-19 | Solvay Pharmaceuticals B.V. | 1H-imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity |
| GT200200188A (es) * | 2001-09-24 | 2003-06-25 | Preparacion y uso de derivados de imidazol para el tratamiento de la obesidad | |
| AU2003209388A1 (en) * | 2002-01-29 | 2003-09-02 | Merck And Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
| UA79804C2 (en) * | 2002-07-03 | 2007-07-25 | Janssen Pharmaceutica Nv | Cck-1 receptor modulators |
| PL378841A1 (pl) | 2003-04-21 | 2006-05-29 | Daiichi Pharmaceutical Co., Ltd. | Pochodna pięcioczłonowego układu heterocyklicznego |
| US20050026983A1 (en) | 2003-07-30 | 2005-02-03 | Pfizer Inc | Imidazole compounds and uses thereof |
| CA2534824A1 (en) | 2003-10-20 | 2005-05-06 | Solvay Pharmaceuticals B.V. | 1h-imidazole derivatives as cannabinoid receptor modulators |
| US20050124660A1 (en) * | 2003-10-27 | 2005-06-09 | Jochen Antel | Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds |
| US7250434B2 (en) * | 2003-12-22 | 2007-07-31 | Janssen Pharmaceutica N.V. | CCK-1 receptor modulators |
| KR20060133084A (ko) | 2004-04-03 | 2006-12-22 | 아스트라제네카 아베 | 치료제 |
| MX2008013237A (es) | 2006-04-14 | 2009-03-06 | Merck & Co Inc | Imidazol 4-caroxamidas sustituidas como moduladores del receptor colecistoquinina-1. |
| JP2009533449A (ja) | 2006-04-14 | 2009-09-17 | メルク エンド カムパニー インコーポレーテッド | コレシストキニン−１受容体モジュレーターとしての置換イミダゾール４−カルボキサミド類 |
-
2007
- 2007-04-10 DE DE602007008868T patent/DE602007008868D1/de active Active
- 2007-04-10 EP EP07755237A patent/EP2010178B1/de not_active Not-in-force
- 2007-04-10 JP JP2009505444A patent/JP2009533445A/ja not_active Withdrawn
- 2007-04-10 CA CA002649927A patent/CA2649927A1/en not_active Abandoned
- 2007-04-10 AT AT07755237T patent/ATE479435T1/de not_active IP Right Cessation
- 2007-04-10 WO PCT/US2007/008901 patent/WO2007120688A2/en not_active Ceased
- 2007-04-10 US US12/226,048 patent/US7858629B2/en not_active Expired - Fee Related
- 2007-04-10 AU AU2007238804A patent/AU2007238804A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2649927A1 (en) | 2007-10-25 |
| EP2010178A2 (de) | 2009-01-07 |
| JP2009533445A (ja) | 2009-09-17 |
| WO2007120688A3 (en) | 2008-07-17 |
| WO2007120688A2 (en) | 2007-10-25 |
| US7858629B2 (en) | 2010-12-28 |
| AU2007238804A1 (en) | 2007-10-25 |
| DE602007008868D1 (de) | 2010-10-14 |
| US20090239862A1 (en) | 2009-09-24 |
| EP2010178B1 (de) | 2010-09-01 |
| EP2010178A4 (de) | 2009-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |