ATE479663T1 - Stereoselektive synthese von (s)-1-methyl-3- phenylpiperazin - Google Patents

Stereoselektive synthese von (s)-1-methyl-3- phenylpiperazin

Info

Publication number
ATE479663T1
ATE479663T1 AT07730171T AT07730171T ATE479663T1 AT E479663 T1 ATE479663 T1 AT E479663T1 AT 07730171 T AT07730171 T AT 07730171T AT 07730171 T AT07730171 T AT 07730171T AT E479663 T1 ATE479663 T1 AT E479663T1
Authority
AT
Austria
Prior art keywords
phenylpiperazine
methyl
stereoselective synthesis
stereoselective
synthesis
Prior art date
Application number
AT07730171T
Other languages
English (en)
Inventor
Vliet Michiel Van
Gerardus Johannes Kemperman
Goedheijt Marcel Schreuder
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of ATE479663T1 publication Critical patent/ATE479663T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
AT07730171T 2006-06-16 2007-06-14 Stereoselektive synthese von (s)-1-methyl-3- phenylpiperazin ATE479663T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06115607 2006-06-16
PCT/EP2007/055914 WO2007144409A1 (en) 2006-06-16 2007-06-14 Stereoselective synthesis of (s)-1-methyl-3-phenylpiperazine

Publications (1)

Publication Number Publication Date
ATE479663T1 true ATE479663T1 (de) 2010-09-15

Family

ID=36781960

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07730171T ATE479663T1 (de) 2006-06-16 2007-06-14 Stereoselektive synthese von (s)-1-methyl-3- phenylpiperazin

Country Status (13)

Country Link
US (1) US20100036126A1 (de)
EP (1) EP2038260B1 (de)
JP (1) JP5216762B2 (de)
CN (1) CN101472901B (de)
AR (1) AR061378A1 (de)
AT (1) ATE479663T1 (de)
DE (1) DE602007008898D1 (de)
ES (1) ES2349484T3 (de)
MX (1) MX2008016121A (de)
PL (1) PL2038260T3 (de)
SI (1) SI2038260T1 (de)
TW (1) TW200815370A (de)
WO (1) WO2007144409A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102126982A (zh) * 2005-09-26 2011-07-20 住友化学株式会社 光学活性的哌嗪化合物的制造方法
CN101679431B (zh) 2007-04-11 2013-08-14 Msd欧斯股份有限公司 制备四环苯并氮杂卓的对映异构体的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
WO2001060800A1 (en) * 2000-02-21 2001-08-23 Kuraray Co., Ltd. Processes for preparing quinoline derivatives and intermediates thereof
ATE392410T1 (de) * 2001-09-14 2008-05-15 Medichem Sa Zwischenprodukte für die herstellung von mirtazapin und verfahren zu deren herstellung
US7041826B2 (en) * 2003-06-02 2006-05-09 Aurobindo Pharma Ltd. Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate
UA83666C2 (ru) * 2003-07-10 2008-08-11 Н.В. Органон Способ получения энантиомерно чистого миртазапина

Also Published As

Publication number Publication date
US20100036126A1 (en) 2010-02-11
ES2349484T3 (es) 2011-01-04
JP5216762B2 (ja) 2013-06-19
AR061378A1 (es) 2008-08-20
WO2007144409A1 (en) 2007-12-21
CN101472901A (zh) 2009-07-01
EP2038260A1 (de) 2009-03-25
SI2038260T1 (sl) 2011-01-31
JP2009539939A (ja) 2009-11-19
MX2008016121A (es) 2009-01-15
TW200815370A (en) 2008-04-01
EP2038260B1 (de) 2010-09-01
CN101472901B (zh) 2011-08-03
PL2038260T3 (pl) 2011-02-28
DE602007008898D1 (de) 2010-10-14

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