ATE500249T1 - Synthese von himbacinanaloga - Google Patents

Synthese von himbacinanaloga

Info

Publication number
ATE500249T1
ATE500249T1 AT06718299T AT06718299T ATE500249T1 AT E500249 T1 ATE500249 T1 AT E500249T1 AT 06718299 T AT06718299 T AT 06718299T AT 06718299 T AT06718299 T AT 06718299T AT E500249 T1 ATE500249 T1 AT E500249T1
Authority
AT
Austria
Prior art keywords
synthesis
himbacin
analogs
himbacin analogs
Prior art date
Application number
AT06718299T
Other languages
English (en)
Inventor
Tiruvettipuram Thiruvengadam
Tao Wang
Jing Liao
John Chiu
David Tsai
Hong-Chang Lee
Wenxue Wu
Xiaoyong Fu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE500249T1 publication Critical patent/ATE500249T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C07D307/885—3,3-Diphenylphthalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT06718299T 2005-01-14 2006-01-12 Synthese von himbacinanaloga ATE500249T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64393205P 2005-01-14 2005-01-14
PCT/US2006/001208 WO2006076564A1 (en) 2005-01-14 2006-01-12 Synthesis of himbacine analogs

Publications (1)

Publication Number Publication Date
ATE500249T1 true ATE500249T1 (de) 2011-03-15

Family

ID=36228637

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06718299T ATE500249T1 (de) 2005-01-14 2006-01-12 Synthese von himbacinanaloga

Country Status (13)

Country Link
EP (1) EP1853592B1 (de)
JP (2) JP4681617B2 (de)
CN (1) CN101137647A (de)
AR (1) AR052870A1 (de)
AT (1) ATE500249T1 (de)
CA (1) CA2594741A1 (de)
DE (1) DE602006020414D1 (de)
ES (1) ES2360721T3 (de)
MX (1) MX2007008631A (de)
PT (1) PT1853592E (de)
SG (1) SG158885A1 (de)
WO (1) WO2006076564A1 (de)
ZA (1) ZA200705792B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS51315B (sr) * 2005-01-14 2010-12-31 Schering Corporation EGZO-i DIASTEREO-SELEKTIVNA SINTEZA ANALOGA HIMBACINA
PL2558465T3 (pl) 2010-04-16 2015-05-29 Sanofi Sa Trycykliczne pirydylo-winylo-pirole jako inhibitory receptora aktywowanego proteazą 1 (PAR1)
ES2527535T3 (es) 2010-04-16 2015-01-26 Sanofi Piridil-vinil-pirazolo-quinolinas como inhibidores de PAR1
US9604971B2 (en) * 2013-07-22 2017-03-28 Aralez Pharmaceuticals Trading Dac Co-crystal of the PAR-1 receptor antagonists vorapaxar and aspirin
CN105330689B (zh) * 2014-08-08 2018-08-17 博瑞生物医药（苏州）股份有限公司 制备Himbacine类似物中间体的制备方法
CN105985303B (zh) * 2015-02-13 2020-08-14 上海彩迩文生化科技有限公司 抗凝血剂的制备方法、中间体及其制备方法
CN106478608A (zh) * 2015-09-01 2017-03-08 博瑞生物医药（苏州）股份有限公司 沃拉帕沙的硫酸盐的结晶多晶型物
CN105348241B (zh) * 2015-12-11 2017-09-05 南京华威医药科技开发有限公司 一种硫酸沃拉帕沙中间体的合成方法
ITUB20160876A1 (it) 2016-02-19 2017-08-19 Dambrosio Enzo Maria Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo
CN107129477A (zh) * 2016-02-26 2017-09-05 上海星泰医药科技有限公司 ((1R,3aR,4aR,6R,8aR,9S,9aR)-9-甲酰基-1-甲基-3-氧杂十二氢萘[2,3-c]-6-呋喃基)羧酸乙酯的制备方法
CN106749138B (zh) * 2016-12-07 2019-08-16 扬子江药业集团四川海蓉药业有限公司 一种硫酸沃拉帕沙中间体醛的制备方法
CN107955014B (zh) * 2017-11-10 2019-06-28 南阳师范学院 萘并呋喃酮类化合物及制备与在制备抗肿瘤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ504218A (en) * 1997-11-25 2002-04-26 Schering Corp Thrombin receptor antagonists
US6063847A (en) * 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
US7235567B2 (en) * 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
WO2003033501A1 (en) * 2001-10-18 2003-04-24 Schering Corporation Himbacine analogues as thrombin receptor antagonists
DE60335679D1 (de) * 2002-04-16 2011-02-17 Schering Corp Tricyclischer Thrombinrezeptorantagonist
RS51315B (sr) * 2005-01-14 2010-12-31 Schering Corporation EGZO-i DIASTEREO-SELEKTIVNA SINTEZA ANALOGA HIMBACINA

Also Published As

Publication number Publication date
EP1853592A1 (de) 2007-11-14
JP2011046751A (ja) 2011-03-10
CN101137647A (zh) 2008-03-05
PT1853592E (pt) 2011-05-10
ZA200705792B (en) 2008-08-27
AR052870A1 (es) 2007-04-11
SG158885A1 (en) 2010-02-26
WO2006076564A1 (en) 2006-07-20
JP4681617B2 (ja) 2011-05-11
EP1853592B1 (de) 2011-03-02
MX2007008631A (es) 2007-09-12
JP2008526981A (ja) 2008-07-24
CA2594741A1 (en) 2006-07-20
DE602006020414D1 (en) 2011-04-14
ES2360721T3 (es) 2011-06-08

Similar Documents

Publication Publication Date Title
ATE458726T1 (de) Exo- und diastereoselektive synthese von himbacin-analoga
ATE486853T1 (de) Synthese von acylaminoalkenylenamiden als substanz-p-antagonisten
DK1778618T3 (da) Syntese af triethylentetraminer
EP1845849A4 (de) Exoskelett für die beine
EP1874239A4 (de) Halb angetriebenes exoskelett der unteren extremität
DK2377869T3 (da) Syntese af Bortezomib
DK1868967T3 (da) Kulbrintesyntese
EP1943338A4 (de) Zellfreie synthese membrangebundener polypeptide
EP1848778A4 (de) Neusynthese von bakteriochlorinen
CY2013046I1 (el) Καινοτομος χρηση των αντισωματων αντι il-1bhta
DK1916890T3 (da) Forbedrede egenskaber for græsendofytter
ZA200705792B (en) Synthesis of himbacine analogs
ZA201206140B (en) An exo-selective synthesis of himbacine analogs
EP1957474A4 (de) Synthese von ftsz-hemmern
EP1863800A4 (de) Synthese von avrainvillamid, stephacidin b und analoga davon
NO20055643D0 (no) Preparation of lodixanol
EP2217247A4 (de) Neue synthese von beta-nucleosiden
ATE390411T1 (de) Stereoselektive synthese von vitamin-d-analoga
ATE402145T1 (de) Synthese von pyrrol-2-carbonsäurenitrilen
ATE479663T1 (de) Stereoselektive synthese von (s)-1-methyl-3- phenylpiperazin
ATE484500T1 (de) Synthese von ccr5 rezeptor antagonisten
DE602006006853D1 (de) Synthese von neuem Dihydrobenzoxazin
ITBO20050402A1 (it) Sintesi di composti organici
ATE374742T1 (de) Synthese von 2-chlormethyl-6- methylbenzoesäureestern
DE602005010833D1 (de) Synthese von kohlenstoffmarkierten perfluoralkylverbindungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1853592

Country of ref document: EP