ATE479676T1 - Als antikoagulanzien verwendbare phenylglycinamid-derivate - Google Patents
Als antikoagulanzien verwendbare phenylglycinamid-derivateInfo
- Publication number
- ATE479676T1 ATE479676T1 AT06717735T AT06717735T ATE479676T1 AT E479676 T1 ATE479676 T1 AT E479676T1 AT 06717735 T AT06717735 T AT 06717735T AT 06717735 T AT06717735 T AT 06717735T AT E479676 T1 ATE479676 T1 AT E479676T1
- Authority
- AT
- Austria
- Prior art keywords
- anticoagulants
- derivatives usable
- phenylglycinamide
- phenylglycinamide derivatives
- usable
- Prior art date
Links
- KIYRSYYOVDHSPG-UHFFFAOYSA-N 2-amino-2-phenylacetamide Chemical class NC(=O)C(N)C1=CC=CC=C1 KIYRSYYOVDHSPG-UHFFFAOYSA-N 0.000 title 1
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 229940127219 anticoagulant drug Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64275105P | 2005-01-10 | 2005-01-10 | |
| PCT/US2006/000571 WO2006076246A2 (en) | 2005-01-10 | 2006-01-09 | Phenylglycinamide derivatives useful as anticoagulants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE479676T1 true ATE479676T1 (de) | 2010-09-15 |
Family
ID=36587246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06717735T ATE479676T1 (de) | 2005-01-10 | 2006-01-09 | Als antikoagulanzien verwendbare phenylglycinamid-derivate |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7622585B2 (de) |
| EP (1) | EP1856096B1 (de) |
| AR (1) | AR054321A1 (de) |
| AT (1) | ATE479676T1 (de) |
| DE (1) | DE602006016566D1 (de) |
| ES (1) | ES2349428T3 (de) |
| PE (1) | PE20061117A1 (de) |
| TW (1) | TW200637843A (de) |
| WO (1) | WO2006076246A2 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7576098B2 (en) * | 2004-12-08 | 2009-08-18 | Bristol-Myers Squibb Company | Heterocyclic compounds as inhibitors of factor VIIa |
| DE602006011752D1 (de) * | 2005-06-24 | 2010-03-04 | Bristol Myers Squibb Co | Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate |
| TW200745062A (en) * | 2005-12-23 | 2007-12-16 | Bristol Myers Squibb Co | Macrocyclic factor VIIA inhibitors useful as anticoagulants |
| WO2007082131A1 (en) * | 2006-01-09 | 2007-07-19 | Bristol-Myers Squibb Company | Process for the preparation of hydroxy substituted heterocycles |
| EP2061756B1 (de) | 2006-06-08 | 2013-09-25 | Bristol-Myers Squibb Company | 2-aminocarbonylphenylamino-2-phenylacetamide als faktor-viia-hemmer zur verwendung als antikoagulantien |
| JP2010513562A (ja) * | 2006-12-20 | 2010-04-30 | ブリストル−マイヤーズ スクイブ カンパニー | 抗凝血剤として有用な二環状ラクタム第ｖｉｉａ因子阻害剤 |
| PE20081775A1 (es) * | 2006-12-20 | 2008-12-18 | Bristol Myers Squibb Co | Compuestos macrociclicos como inhibidores del factor viia |
| US20110160232A1 (en) * | 2007-10-04 | 2011-06-30 | Pingda Ren | Certain chemical entities and therapeutic uses thereof |
| WO2009114870A2 (en) | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Kinase inhibitors and methods of use |
| US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
| MX2011000216A (es) | 2008-07-08 | 2011-03-29 | Intellikine Inc | Inhibidores de cinasa y metodos para su uso. |
| EP2149565A1 (de) | 2008-07-24 | 2010-02-03 | Bayer Schering Pharma AG | Sulfonsubstituierte Chinazolinderivate als Immunmodulatoren zur Behandlung von enzündlichen und allergischen Erkrankungen |
| JP5417860B2 (ja) * | 2008-08-26 | 2014-02-19 | 住友化学株式会社 | α−ヒドロキシエステル類の製造方法 |
| US8476431B2 (en) * | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
| KR101594002B1 (ko) | 2010-10-06 | 2016-02-15 | 글락소스미스클라인 엘엘씨 | Ｐｉ３ 키나제 억제제로서의 벤즈이미다졸 유도체 |
| TWI592411B (zh) | 2011-02-23 | 2017-07-21 | 英特爾立秦有限責任公司 | 激酶抑制劑之組合及其用途 |
| EP3104702B1 (de) | 2014-02-11 | 2022-08-10 | Merck Sharp & Dohme LLC | Faktor-xia-hemmer |
| EP3104703B1 (de) | 2014-02-11 | 2020-11-18 | Merck Sharp & Dohme Corp. | Faktor-xia-hemmer |
| WO2015164308A1 (en) | 2014-04-22 | 2015-10-29 | Merck Sharp & Dohme Corp. | FACTOR XIa INHIBITORS |
| US9868727B2 (en) | 2014-07-28 | 2018-01-16 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| BR112018008506B8 (pt) | 2015-10-29 | 2023-12-05 | Merck Sharp & Dohme | Compostos inibidores do fator xia, composição farmacêutica e usos dos mesmos |
| WO2017074833A1 (en) | 2015-10-29 | 2017-05-04 | Merck Sharp & Dohme Corp. | Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use |
| WO2017158147A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| US10143681B2 (en) | 2016-08-22 | 2018-12-04 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| CN112225647A (zh) * | 2020-10-14 | 2021-01-15 | 河南中医药大学 | 一种合成5-溴-2-甲氧基苯酚的方法 |
| CN117466714A (zh) * | 2023-10-30 | 2024-01-30 | 中国科学技术大学 | 一种2,4-二氯-5-卤代苯酚的制备方法 |
| CN118344240A (zh) * | 2024-04-16 | 2024-07-16 | 中国科学技术大学 | 一种2,4-二氯-5-溴苯酚的制备方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023236A (en) | 1988-04-07 | 1991-06-11 | Corvas, Inc. | Factor VII/VIIA active site inhibitors |
| FR2667864B2 (fr) | 1990-03-07 | 1994-08-05 | Rhone Poulenc Sante | Derives de n-phenyl glycinamides, leur preparation et les medicaments les contenant. |
| US5843442A (en) | 1990-10-22 | 1998-12-01 | Corvas International, Inc. | Blood coagulation protein antagonists and uses therefor |
| US5563127A (en) | 1993-03-24 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Boronic acid and ester inhibitors of thrombin |
| US5602101A (en) * | 1994-03-04 | 1997-02-11 | Eli Lilly And Company | Antithrombotic agents |
| US5866542A (en) | 1994-10-18 | 1999-02-02 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
| AU6944696A (en) | 1995-09-14 | 1997-04-01 | Shionogi & Co., Ltd. | Novel phenylacetic acid derivatives and medicinal composition containing the same |
| IL123986A (en) | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| SI0921116T1 (en) * | 1997-12-04 | 2003-10-31 | F. Hoffmann - La Roche Ag | N-(4-carbamimido-phenyl)-glycine amide derivatives |
| AU2300699A (en) | 1998-02-17 | 1999-08-30 | Ono Pharmaceutical Co. Ltd. | Amidino derivatives and drugs containing the same as the active ingredient |
| US6335324B1 (en) | 1998-06-25 | 2002-01-01 | Bristol-Myers Squibb Co. | Beta lactam compounds and their use as inhibitors of tryptase |
| CN1245381C (zh) | 1998-12-14 | 2006-03-15 | 弗·哈夫曼-拉罗切有限公司 | 苯基甘氨酸衍生物 |
| IL144032A0 (en) | 1999-01-13 | 2002-04-21 | Genentech Inc | Serine protease inhibitors |
| WO2001044172A1 (en) | 1999-12-15 | 2001-06-21 | Axys Pharmaceuticals, Inc. | Salicylamides as serine protease and factor xa inhibitors |
| EP1254901A4 (de) | 2000-01-26 | 2003-03-05 | Ono Pharmaceutical Co | Stickstoffhältige, 5-gliedrige, zyklische verbindungen und diese als wirkstoffe enthaltende medikamente |
| US6548694B2 (en) | 2000-05-23 | 2003-04-15 | Hoffman-La Roche Inc. | N-(4-carbamimidoyl-phenyl)-glycine derivatives |
| DE10027025A1 (de) * | 2000-05-31 | 2001-12-06 | Merck Patent Gmbh | Clycinamide |
| AU2001281059A1 (en) | 2000-08-02 | 2002-02-13 | Smith Kline Beecham Corporation | Fatty acid synthase inhibitors |
| CA2426430C (en) | 2000-10-20 | 2014-10-07 | Biocryst Pharmaceuticals, Inc. | Biaryl compounds as serine protease inhibitors |
| EP1332131A2 (de) | 2000-11-07 | 2003-08-06 | Bristol-Myers Squibb Company | Säurederivate und ihre verwendung als inhibitoren von serinproteasen |
| DE60139510D1 (de) | 2001-04-06 | 2009-09-17 | Biocryst Pharm Inc | Biarylverbindungen als serinproteaseinhibitoren |
| DE10139060A1 (de) | 2001-08-08 | 2003-02-20 | Merck Patent Gmbh | Phenylderivate |
| US6642386B2 (en) | 2002-02-06 | 2003-11-04 | Hoffmann-La Roche Inc. | N-(4-carbamimidoyl-phenyl)-glycine derivatives |
| DE10214832A1 (de) | 2002-04-04 | 2003-10-16 | Merck Patent Gmbh | Phenylderivate 4 |
| US7144895B2 (en) | 2003-02-11 | 2006-12-05 | Bristol-Myers Squibb Co. | Benzene acetamide compounds useful as serine protease inhibitors |
| US7122559B2 (en) | 2003-02-11 | 2006-10-17 | Bristol-Myers Squibb Company | Phenylglycine derivatives useful as serine protease inhibitors |
| US20050107409A1 (en) | 2003-03-10 | 2005-05-19 | Boehringer Ingelheim International Gmbh | Aromatic bicyclic compounds, preparation thereof and their use as pharmaceutical compositions |
| DE10310278A1 (de) * | 2003-03-10 | 2004-09-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue aromatische Bicyclen, deren Herstellung und deren Verwendung als Arzneimittel |
| US7309708B2 (en) | 2003-11-20 | 2007-12-18 | Birstol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7576098B2 (en) | 2004-12-08 | 2009-08-18 | Bristol-Myers Squibb Company | Heterocyclic compounds as inhibitors of factor VIIa |
| DE602006011752D1 (de) | 2005-06-24 | 2010-03-04 | Bristol Myers Squibb Co | Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate |
-
2006
- 2006-01-09 AR ARP060100077A patent/AR054321A1/es unknown
- 2006-01-09 WO PCT/US2006/000571 patent/WO2006076246A2/en not_active Ceased
- 2006-01-09 DE DE602006016566T patent/DE602006016566D1/de not_active Expired - Lifetime
- 2006-01-09 ES ES06717735T patent/ES2349428T3/es not_active Expired - Lifetime
- 2006-01-09 TW TW095100708A patent/TW200637843A/zh unknown
- 2006-01-09 PE PE2006000049A patent/PE20061117A1/es not_active Application Discontinuation
- 2006-01-09 EP EP06717735A patent/EP1856096B1/de not_active Expired - Lifetime
- 2006-01-09 US US11/328,479 patent/US7622585B2/en active Active
- 2006-01-09 AT AT06717735T patent/ATE479676T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200637843A (en) | 2006-11-01 |
| EP1856096B1 (de) | 2010-09-01 |
| WO2006076246A2 (en) | 2006-07-20 |
| US7622585B2 (en) | 2009-11-24 |
| PE20061117A1 (es) | 2006-10-13 |
| AR054321A1 (es) | 2007-06-20 |
| US20060166997A1 (en) | 2006-07-27 |
| DE602006016566D1 (de) | 2010-10-14 |
| EP1856096A2 (de) | 2007-11-21 |
| WO2006076246A3 (en) | 2006-09-28 |
| ES2349428T3 (es) | 2011-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |