ATE479680T1 - Imidazolidinonylaminopyrimidinverbindungen zur behandlung von krebs - Google Patents

Imidazolidinonylaminopyrimidinverbindungen zur behandlung von krebs

Info

Publication number: ATE479680T1
Authority: AT; Austria
Prior art keywords: hydrogen; halo; imidazolidinonylaminopyrimidine; compounds; methyl
Prior art date: 2006-12-21

Application number

AT07855058T

Other languages

English (en)

Inventor

Hong-Yu Li

Harold Burns Brooks

Joyce Z Crich

James Robert Henry

Melissa Kate Slater

Yan Wang

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-21

Filing date

2007-12-11

Publication date

2010-09-15

2007-12-11 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2010-09-15 Application granted granted Critical

2010-09-15 Publication of ATE479680T1 publication Critical patent/ATE479680T1/de

Links

206010028980 Neoplasm Diseases 0.000 title abstract 2
201000011510 cancer Diseases 0.000 title abstract 2
IDNYTLARUCTDGK-UHFFFAOYSA-N 1-(pyrimidin-2-ylamino)imidazolidin-2-one Chemical class N1(C(NCC1)=O)NC1=NC=CC=N1 IDNYTLARUCTDGK-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000001475 halogen functional group Chemical group 0.000 abstract 5
150000002431 hydrogen Chemical class 0.000 abstract 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
VLUNZXPZDFIDHY-UHFFFAOYSA-N 1-(2-aminopyrimidin-4-yl)imidazolidin-2-one Chemical class NC1=NC=CC(N2C(NCC2)=O)=N1 VLUNZXPZDFIDHY-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
108010056274 polo-like kinase 1 Proteins 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT07855058T 2006-12-21 2007-12-11 Imidazolidinonylaminopyrimidinverbindungen zur behandlung von krebs ATE479680T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US87130206P	2006-12-21	2006-12-21
PCT/US2007/087044 WO2008076704A1 (en)	2006-12-21	2007-12-11	Imidazolidinonyl aminopyrimidine compounds for the treatment' of cancer

Publications (1)

Publication Number	Publication Date
ATE479680T1 true ATE479680T1 (de)	2010-09-15

Family

ID=39186811

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07855058T ATE479680T1 (de)	2006-12-21	2007-12-11	Imidazolidinonylaminopyrimidinverbindungen zur behandlung von krebs

Country Status (14)

Country	Link
US (1)	US8101628B2 (de)
EP (1)	EP2125793B1 (de)
JP (1)	JP5166441B2 (de)
KR (1)	KR101088291B1 (de)
CN (1)	CN101563342B (de)
AT (1)	ATE479680T1 (de)
AU (1)	AU2007334039B2 (de)
BR (1)	BRPI0721045A2 (de)
CA (1)	CA2671738A1 (de)
DE (1)	DE602007008952D1 (de)
EA (1)	EA016177B1 (de)
ES (1)	ES2349169T3 (de)
MX (1)	MX2009006634A (de)
WO (1)	WO2008076704A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI2125794T1 (sl)	2006-12-21	2011-02-28	Lilly Co Eli	Spojine imidazolidinonil aminopirimidina za zdravljenje raka
EA016781B1 (ru) *	2007-05-16	2012-07-30	Эли Лилли Энд Компани	Триазолиламинопиримидиновые соединения
WO2008144222A2 (en)	2007-05-16	2008-11-27	Eli Lilly And Company	Triazolyl aminopyrimidine compounds
CN108853111B (zh) *	2018-08-07	2020-06-05	浙江大学	一种组合物在制备治疗吉非替尼肝脏毒性药物中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4929726A (en)	1988-02-09	1990-05-29	Georgia State University Foundation, Inc.	Novel diazines and their method of preparation
US6939877B2 (en) *	2002-09-12	2005-09-06	Wyeth	Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
WO2004063192A1 (en) *	2003-01-10	2004-07-29	Pharmacopeia Drug Discovery, Inc.	Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators
GB0308466D0 (en)	2003-04-11	2003-05-21	Novartis Ag	Organic compounds
JP2007533602A (ja) *	2003-07-31	2007-11-22	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	置換ベンゾチオフェン化合物及びそれらの使用
AU2005316312B2 (en)	2004-12-17	2009-10-22	Amgen, Inc.	Aminopyrimidine compounds and methods of use
TW200800201A (en) *	2005-11-18	2008-01-01	Lilly Co Eli	Pyrimidinyl benzothiophene compounds
US8008481B2 (en) *	2006-03-31	2011-08-30	Ericsson Anna M	Indazole compounds
SI2125794T1 (sl)	2006-12-21	2011-02-28	Lilly Co Eli	Spojine imidazolidinonil aminopirimidina za zdravljenje raka
EA016781B1 (ru)	2007-05-16	2012-07-30	Эли Лилли Энд Компани	Триазолиламинопиримидиновые соединения
WO2008144222A2 (en)	2007-05-16	2008-11-27	Eli Lilly And Company	Triazolyl aminopyrimidine compounds

2007
- 2007-12-11 US US12/516,514 patent/US8101628B2/en not_active Expired - Fee Related
- 2007-12-11 EA EA200970615A patent/EA016177B1/ru not_active IP Right Cessation
- 2007-12-11 AU AU2007334039A patent/AU2007334039B2/en not_active Ceased
- 2007-12-11 WO PCT/US2007/087044 patent/WO2008076704A1/en not_active Ceased
- 2007-12-11 JP JP2009543061A patent/JP5166441B2/ja not_active Expired - Fee Related
- 2007-12-11 KR KR1020097012835A patent/KR101088291B1/ko not_active Expired - Fee Related
- 2007-12-11 AT AT07855058T patent/ATE479680T1/de not_active IP Right Cessation
- 2007-12-11 BR BRPI0721045-0A patent/BRPI0721045A2/pt not_active IP Right Cessation
- 2007-12-11 DE DE602007008952T patent/DE602007008952D1/de active Active
- 2007-12-11 CN CN2007800472640A patent/CN101563342B/zh not_active Expired - Fee Related
- 2007-12-11 CA CA002671738A patent/CA2671738A1/en not_active Abandoned
- 2007-12-11 MX MX2009006634A patent/MX2009006634A/es active IP Right Grant
- 2007-12-11 ES ES07855058T patent/ES2349169T3/es active Active
- 2007-12-11 EP EP07855058A patent/EP2125793B1/de not_active Not-in-force

Also Published As

Publication number	Publication date
MX2009006634A (es)	2009-06-30
EA016177B1 (ru)	2012-02-28
KR101088291B1 (ko)	2011-11-30
AU2007334039A1 (en)	2008-06-26
BRPI0721045A2 (pt)	2014-07-29
US20100076001A1 (en)	2010-03-25
WO2008076704A1 (en)	2008-06-26
ES2349169T3 (es)	2010-12-28
KR20090086114A (ko)	2009-08-10
EA200970615A1 (ru)	2009-10-30
CN101563342A (zh)	2009-10-21
US8101628B2 (en)	2012-01-24
JP2010513552A (ja)	2010-04-30
EP2125793B1 (de)	2010-09-01
CA2671738A1 (en)	2008-06-26
EP2125793A1 (de)	2009-12-02
CN101563342B (zh)	2012-09-05
AU2007334039B2 (en)	2012-02-16
JP5166441B2 (ja)	2013-03-21
DE602007008952D1 (de)	2010-10-14

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Legal Events

Date	Code	Title	Description
2011-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties