ATE480520T1 - Verfahren zur herstellung von 3-substituiertem 2- chlor-5-fluorpyridin bzw. einem salz davon - Google Patents
Verfahren zur herstellung von 3-substituiertem 2- chlor-5-fluorpyridin bzw. einem salz davonInfo
- Publication number
- ATE480520T1 ATE480520T1 AT04730645T AT04730645T ATE480520T1 AT E480520 T1 ATE480520 T1 AT E480520T1 AT 04730645 T AT04730645 T AT 04730645T AT 04730645 T AT04730645 T AT 04730645T AT E480520 T1 ATE480520 T1 AT E480520T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- salt
- producing
- following compound
- substituted
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- -1 3-substituted 2-chloro-5-fluoro-pyridine Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003132137 | 2003-05-09 | ||
| PCT/JP2004/006267 WO2004099149A1 (ja) | 2003-05-09 | 2004-04-30 | ２－クロロ－５－フルオロ－３－置換ピリジンまたはその塩の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE480520T1 true ATE480520T1 (de) | 2010-09-15 |
Family
ID=33432155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04730645T ATE480520T1 (de) | 2003-05-09 | 2004-04-30 | Verfahren zur herstellung von 3-substituiertem 2- chlor-5-fluorpyridin bzw. einem salz davon |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7414136B2 (de) |
| EP (1) | EP1626045B1 (de) |
| JP (1) | JP4765623B2 (de) |
| AT (1) | ATE480520T1 (de) |
| AU (1) | AU2004236085B2 (de) |
| CA (1) | CA2521695C (de) |
| DE (1) | DE602004029025D1 (de) |
| WO (1) | WO2004099149A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR067762A1 (es) * | 2007-07-31 | 2009-10-21 | Vertex Pharma | Proceso para preparar 5-fluoro-1h-pirazolo (3,4-b) piridin-3-amina y derivados de la misma |
| CN101768110B (zh) * | 2009-01-07 | 2012-09-12 | 上海开拓者化学研究管理有限公司 | 一种2-氯-5-氟吡啶-3-甲酸的制备方法 |
| CN101768111B (zh) * | 2009-01-07 | 2012-12-26 | 上海开拓者化学研究管理有限公司 | 一种2-氯-5-氟吡啶-3-甲酸的制备方法 |
| DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| DE102011003315A1 (de) | 2011-01-28 | 2012-08-02 | Bayer Schering Pharma Aktiengesellschaft | Annellierte Pyrimindine und Triazine und ihre Verwendung |
| PH12013500055A1 (en) | 2010-07-09 | 2017-08-23 | Bayer Ip Gmbh | Ring-fused pyrimidines and triazines and use thereof for the treatment and/or prophylaxis of cardiovascular diseases |
| DE102010031149A1 (de) | 2010-07-09 | 2012-01-12 | Bayer Schering Pharma Aktiengesellschaft | Annellierte Pyrimidine und Triazine und ihre Verwendung |
| DE102010031148A1 (de) | 2010-07-09 | 2012-01-12 | Bayer Schering Pharma Ag | Annellierte 4-Aminopyrimidine und ihre Verwendung |
| US8765769B2 (en) | 2010-07-09 | 2014-07-01 | Bayer Intellectual Property Gmbh | Ring-fused 4-aminopyrimidines and use thereof as stimulators of soluable guanylate cyclases |
| DE102011007891A1 (de) | 2011-04-21 | 2012-10-25 | Bayer Pharma Aktiengesellschaft | Annellierte 4-Aminopyrimidine und ihre Verwendung |
| DE102010031666A1 (de) | 2010-07-22 | 2012-01-26 | Bayer Schering Pharma Aktiengesellschaft | Carbamat-substituierte Diaminopyrimidine und ihre Verwendung |
| DE102010031667A1 (de) | 2010-07-22 | 2012-01-26 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Methyl-pyrimidin-5-ylcarbamate und ihre Verwendung |
| DE102010031665A1 (de) | 2010-07-22 | 2012-01-26 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Oxazolidinone und Oxazinanone und ihre Verwendung |
| DE102010040233A1 (de) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclische Aza-Heterocyclen und ihre Verwendung |
| ES2583086T3 (es) | 2011-04-21 | 2016-09-19 | Bayer Intellectual Property Gmbh | Pirazolopiridinas sustituidas con fluoroalquilo y su uso |
| DE102011007890A1 (de) | 2011-04-21 | 2012-10-25 | Bayer Pharma Aktiengesellschaft | Fluoralkyl-substituierte Pyrazolopyridine und ihre Verwendung |
| DE102012200357A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Fluoralkyl-substituierte Pyrazolopyridine und ihre Verwendung |
| DE102011078715A1 (de) | 2011-07-06 | 2013-01-10 | Bayer Pharma AG | Heteroaryl-substituierte Pyrazolopyridine und ihre Verwendung |
| US20140228366A1 (en) | 2011-07-06 | 2014-08-14 | Bayer Intellectual Property Gmbh | Heteroaryl-substituted pyrazolopyridines and use thereof as soluble guanylate cyclase stimulators |
| DE102012200354A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Heteroaryl-substituierte Pyrazolopyridine und ihre Verwendung |
| DE102011082041A1 (de) | 2011-09-02 | 2013-03-07 | Bayer Pharma AG | Substituierte annellierte Pyrimidine und ihre Verwendung |
| DE102012200351A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Pharma Aktiengesellschaft | Substituierte annellierte Pyrimidine und ihre Verwendung |
| MX348470B (es) | 2011-09-02 | 2017-06-13 | Bayer Ip Gmbh | Pirimidinas anilladas sustituidas y uso de las mismas. |
| DE102012200349A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
| DE102012200360A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
| DE102012200352A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung |
| JP6140738B2 (ja) | 2012-03-06 | 2017-05-31 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 置換アザ二環およびその使用 |
| JP2016510010A (ja) | 2013-03-01 | 2016-04-04 | バイエル・ファルマ・アクティエンゲゼルシャフト | トリフルオロメチル置換環縮合ピリミジンおよびその使用 |
| CA2917682A1 (en) | 2013-07-10 | 2015-01-15 | Bayer Pharma Aktiengesellschaft | Benzyl-1h-pyrazolo[3,4-b]pyridines and use thereof |
| WO2017121700A1 (de) | 2016-01-15 | 2017-07-20 | Bayer Pharma Aktiengesellschaft | 1,3-disubstituierte 1h-pyrazolo[3,4-b]pyridin- derivate und ihre verwendung als stimulatoren der löslichen guanylatcyclase |
| CN111574439A (zh) * | 2020-05-13 | 2020-08-25 | 山东汇盟生物科技有限公司 | 一种制备2-氨基-3氯-5-三氟甲基吡啶的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4778576A (en) * | 1986-07-31 | 1988-10-18 | The Dow Chemical Company | Nickel alloy anodes for electrochemical dechlorination |
| EP0333020A3 (de) * | 1988-03-18 | 1991-03-20 | Abbott Laboratories | Verfahren zur Herstellung von substituierten Pyridinen |
| US5250548A (en) * | 1990-09-10 | 1993-10-05 | Abbott Laboratories | Angiotensin II receptor antagonists |
| US5204478A (en) * | 1992-08-20 | 1993-04-20 | Warner-Lambert Company | Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride |
| GB9314412D0 (en) * | 1993-07-13 | 1993-08-25 | Rhone Poulenc Agriculture | New compositions of matter |
| WO1998050362A1 (en) * | 1997-05-09 | 1998-11-12 | Dow Agrosciences Llc | Preparation of 2,5-dichloro-(3-trifluoromethyl)pyridine |
| EP1229034B1 (de) * | 2001-01-31 | 2005-04-13 | Pfizer Products Inc. | Nikotinsäureamid-Derivate und ihre Mimetika als Inhibitoren von PDE4-Isozyms |
-
2004
- 2004-04-30 JP JP2005506008A patent/JP4765623B2/ja not_active Expired - Fee Related
- 2004-04-30 DE DE602004029025T patent/DE602004029025D1/de not_active Expired - Lifetime
- 2004-04-30 AU AU2004236085A patent/AU2004236085B2/en not_active Ceased
- 2004-04-30 WO PCT/JP2004/006267 patent/WO2004099149A1/ja not_active Ceased
- 2004-04-30 EP EP04730645A patent/EP1626045B1/de not_active Expired - Lifetime
- 2004-04-30 AT AT04730645T patent/ATE480520T1/de not_active IP Right Cessation
- 2004-04-30 CA CA2521695A patent/CA2521695C/en not_active Expired - Fee Related
-
2005
- 2005-11-03 US US11/265,179 patent/US7414136B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2004099149A1 (ja) | 2006-07-13 |
| AU2004236085B2 (en) | 2010-03-25 |
| WO2004099149A1 (ja) | 2004-11-18 |
| JP4765623B2 (ja) | 2011-09-07 |
| EP1626045A1 (de) | 2006-02-15 |
| EP1626045A4 (de) | 2008-08-27 |
| DE602004029025D1 (de) | 2010-10-21 |
| EP1626045B1 (de) | 2010-09-08 |
| US20060058529A1 (en) | 2006-03-16 |
| AU2004236085A1 (en) | 2004-11-18 |
| CA2521695A1 (en) | 2004-11-18 |
| US7414136B2 (en) | 2008-08-19 |
| CA2521695C (en) | 2011-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |