ATE521587T1 - Verfahren zur herstellung von (z)-1-phenyl-1- diethylaminocarbonyl-2- aminomethylcyclopropanhydrochlorid - Google Patents

Verfahren zur herstellung von (z)-1-phenyl-1- diethylaminocarbonyl-2- aminomethylcyclopropanhydrochlorid

Info

Publication number: ATE521587T1
Authority: AT; Austria
Prior art keywords: diethylaminocarbonyl; phenyl; producing; aminomethylcyclopropane; hydrochloride
Prior art date: 2004-06-24

Application number

AT05755277T

Other languages

English (en)

Inventor

Yoshihide Niimoto

Hiroharu Kumazawa

Osamu Tokuda

Fumiaki Ibukuro

Original Assignee

Sumitomo Chemical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-24

Filing date

2005-06-23

Publication date

2011-09-15

2005-06-23 Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co

2011-09-15 Application granted granted Critical

2011-09-15 Publication of ATE521587T1 publication Critical patent/ATE521587T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
JOTWZGIFEGRKFM-UHFFFAOYSA-N 2-[(1,3-dioxoisoindol-2-yl)methyl]-n,n-diethyl-1-phenylcyclopropane-1-carboxamide Chemical compound C1C(CN2C(C3=CC=CC=C3C2=O)=O)C1(C(=O)N(CC)CC)C1=CC=CC=C1 JOTWZGIFEGRKFM-UHFFFAOYSA-N 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT05755277T 2004-06-24 2005-06-23 Verfahren zur herstellung von (z)-1-phenyl-1- diethylaminocarbonyl-2- aminomethylcyclopropanhydrochlorid ATE521587T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2004186982A JP4418717B2 (ja)	2004-06-24	2004-06-24	（ｚ）−１−フェニル−１−ジエチルアミノカルボニル−２−アミノメチルシクロプロパン塩酸塩の製造方法
PCT/JP2005/012011 WO2006001493A1 (ja)	2004-06-24	2005-06-23	（ｚ）－１－フェニルー１－ジエチルアミノカルボニル－２－アミノメチルシクロプロパン塩酸塩の製造方法

Publications (1)

Publication Number	Publication Date
ATE521587T1 true ATE521587T1 (de)	2011-09-15

Family

ID=35776203

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05755277T ATE521587T1 (de)	2004-06-24	2005-06-23	Verfahren zur herstellung von (z)-1-phenyl-1- diethylaminocarbonyl-2- aminomethylcyclopropanhydrochlorid

Country Status (13)

Country	Link
US (1)	US7592485B2 (de)
EP (1)	EP1770084B1 (de)
JP (1)	JP4418717B2 (de)
KR (1)	KR101126825B1 (de)
CN (1)	CN100590115C (de)
AT (1)	ATE521587T1 (de)
AU (1)	AU2005257478B2 (de)
CA (1)	CA2570833C (de)
ES (1)	ES2370830T3 (de)
IL (1)	IL179929A (de)
PT (1)	PT1770084E (de)
WO (1)	WO2006001493A1 (de)
ZA (1)	ZA200700447B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4828863B2 (ja) *	2005-01-28	2011-11-30	住友化学株式会社	（ｚ）−１−フェニル−１−（ｎ，ｎ−ジエチルアミノカルボニル）−２−フタルイミドメチルシクロプロパンの製造方法
US20100145099A1 (en) *	2007-02-28	2010-06-10	Ranbaxy Laboratories Limited	Novel polymorphic forms of milnacipran hydrochloride
FR2941454B1 (fr) *	2009-01-29	2011-04-01	Pf Medicament	Proced de synthese du (1s,2r)-milnacipran
US20100274050A1 (en) *	2009-04-23	2010-10-28	Glenmark Generics Limited	Solid milnacipran and process for the preparation of the same
WO2012145234A2 (en)	2011-04-21	2012-10-26	Emory University	Cyclopropyl derivatives and methods of use
WO2014009767A1 (en)	2012-07-07	2014-01-16	Micro Labs Limited	An improved process for the preparation of 1-aryl 2-aminomethyl cyclopropane carboxyamide (z) derivatives, their isomers and salts
CN103613513B (zh) *	2013-12-09	2016-01-20	上海现代制药股份有限公司	盐酸米那普仑中间体及其制备方法和应用
CN111362824B (zh) *	2018-12-25	2023-03-24	四川科瑞德制药股份有限公司	2-(氨甲基)-n,n-二乙基-1-苯基环丙烷甲酰胺及其盐的制备方法
CN112759542B (zh) *	2019-11-04	2022-04-01	上海现代制药股份有限公司	一种药物中间体及其制备和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2508035A1 (fr) *	1981-06-23	1982-12-24	Fabre Sa Pierre	Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
FR2581059B1 (fr) *	1985-04-25	1988-04-22	Pf Medicament	Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z)
CN104761637B (zh) *	2006-03-31	2021-10-15	中外制药株式会社	调控抗体血液动力学的方法

2004
- 2004-06-24 JP JP2004186982A patent/JP4418717B2/ja not_active Expired - Fee Related
2005
- 2005-06-23 US US11/630,253 patent/US7592485B2/en not_active Expired - Fee Related
- 2005-06-23 WO PCT/JP2005/012011 patent/WO2006001493A1/ja not_active Ceased
- 2005-06-23 ZA ZA200700447A patent/ZA200700447B/xx unknown
- 2005-06-23 ES ES05755277T patent/ES2370830T3/es not_active Expired - Lifetime
- 2005-06-23 AU AU2005257478A patent/AU2005257478B2/en not_active Ceased
- 2005-06-23 EP EP05755277A patent/EP1770084B1/de not_active Expired - Lifetime
- 2005-06-23 CN CN200580020578A patent/CN100590115C/zh not_active Expired - Fee Related
- 2005-06-23 AT AT05755277T patent/ATE521587T1/de active
- 2005-06-23 CA CA2570833A patent/CA2570833C/en not_active Expired - Fee Related
- 2005-06-23 KR KR1020077000604A patent/KR101126825B1/ko not_active Expired - Fee Related
- 2005-06-23 PT PT05755277T patent/PT1770084E/pt unknown
2006
- 2006-12-07 IL IL179929A patent/IL179929A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2006008569A (ja)	2006-01-12
CA2570833A1 (en)	2006-01-05
IL179929A (en)	2012-09-24
US7592485B2 (en)	2009-09-22
WO2006001493A1 (ja)	2006-01-05
IL179929A0 (en)	2007-05-15
AU2005257478B2 (en)	2011-03-24
PT1770084E (pt)	2011-10-07
KR20070039038A (ko)	2007-04-11
EP1770084B1 (de)	2011-08-24
US20080051604A1 (en)	2008-02-28
CN1972901A (zh)	2007-05-30
CA2570833C (en)	2012-12-18
AU2005257478A1 (en)	2006-01-05
ES2370830T3 (es)	2011-12-23
JP4418717B2 (ja)	2010-02-24
EP1770084A4 (de)	2008-10-29
KR101126825B1 (ko)	2012-03-23
ZA200700447B (en)	2008-06-25
EP1770084A1 (de)	2007-04-04
CN100590115C (zh)	2010-02-17

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2012-02-15

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