ATE480538T1 - 2-arylmethylazetidincarbapenemderivate und deren herstellung - Google Patents
2-arylmethylazetidincarbapenemderivate und deren herstellungInfo
- Publication number
- ATE480538T1 ATE480538T1 AT05721872T AT05721872T ATE480538T1 AT E480538 T1 ATE480538 T1 AT E480538T1 AT 05721872 T AT05721872 T AT 05721872T AT 05721872 T AT05721872 T AT 05721872T AT E480538 T1 ATE480538 T1 AT E480538T1
- Authority
- AT
- Austria
- Prior art keywords
- arylmethylazetidinecarbapenem
- derivatives
- production
- gram
- activities against
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 2
- 241000191967 Staphylococcus aureus Species 0.000 abstract 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020040068821A KR100599876B1 (ko) | 2004-08-31 | 2004-08-31 | 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법 |
| PCT/KR2005/000509 WO2006025634A1 (en) | 2004-08-31 | 2005-02-24 | 2-arylmethylazetidine carbapenem derivatives and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE480538T1 true ATE480538T1 (de) | 2010-09-15 |
Family
ID=36000255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05721872T ATE480538T1 (de) | 2004-08-31 | 2005-02-24 | 2-arylmethylazetidincarbapenemderivate und deren herstellung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7662810B2 (de) |
| EP (1) | EP1784407B1 (de) |
| JP (1) | JP4801049B2 (de) |
| KR (1) | KR100599876B1 (de) |
| CN (1) | CN100494200C (de) |
| AT (1) | ATE480538T1 (de) |
| DE (1) | DE602005023492D1 (de) |
| WO (1) | WO2006025634A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2004043961A1 (ja) * | 2002-11-13 | 2006-03-09 | 株式会社カネカ | 経口投与用カルバペネム化合物の製造方法 |
| CN103275081A (zh) * | 2007-09-12 | 2013-09-04 | 黄振华 | 培南类抗菌素 |
| KR101044559B1 (ko) * | 2007-09-20 | 2011-06-28 | 국제약품공업주식회사 | 티올 화합물의 산부가염 및 그의 제조방법 |
| KR101050976B1 (ko) * | 2007-09-20 | 2011-07-21 | 국제약품공업주식회사 | 카바페넴계 항생제의 합성 중간체의 산부가염 및 그의 제조방법 |
| EP2188287A4 (de) * | 2007-09-20 | 2011-03-02 | Kukje Pharm Ind Co Ltd | Säurezusatzsalze aus synthetischen zwischenprodukten für carbapenem-antibiotika und verfahren zu ihrer herstellung |
| CN101868460A (zh) * | 2007-11-23 | 2010-10-20 | 国际药品工业株式会社 | 2-芳基甲基吖丁啶-碳青霉烯-3-羧酸酯衍生物或其盐、其制备方法以及包含上述的药物组合物 |
| KR100950699B1 (ko) * | 2008-03-28 | 2010-03-31 | 국제약품공업주식회사 | 2-아릴메틸아제티딘-카바페넴-3-카복실산 에스테르유도체의 산부가염, 이의 제조방법 및 이를 포함하는 약학조성물 |
| KR100930586B1 (ko) * | 2007-11-23 | 2009-12-09 | 한국화학연구원 | 2-아릴메틸아제티딘-카바페넴-3-카복실산 에스테르 유도체,이의 제조방법 및 이를 포함하는 약학 조성물 |
| WO2010104336A2 (ko) * | 2009-03-13 | 2010-09-16 | 주식회사 대웅제약 | 아연 분말을 이용한 메로페넴의 개선된 제조방법 |
| IL312087A (en) * | 2021-10-20 | 2024-06-01 | Assembly Biosciences Inc | Process |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4552873A (en) * | 1981-08-19 | 1985-11-12 | Sankyo Company Limited | Carbapenem compounds, and compositions containing them |
| JPS5916892A (ja) * | 1982-07-19 | 1984-01-28 | Sankyo Co Ltd | カルバペネム−３−カルボン酸誘導体およびその製法 |
| US4698339A (en) * | 1983-09-28 | 1987-10-06 | Takeda Chemical Industries, Ltd. | Carbapenems, their production and use |
| JPS60233076A (ja) * | 1984-05-03 | 1985-11-19 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
| DE3617626A1 (de) * | 1986-05-26 | 1987-12-03 | Bayer Ag | Substituierte 6-hydroxymethyl-carbapenem-antibiotika, verfahren zu ihrer herstellung und ihre verwendung |
| JP3242677B2 (ja) * | 1990-08-10 | 2001-12-25 | 住友製薬株式会社 | 新規なβ−ラクタム化合物及びその製造法 |
| AU644008B2 (en) * | 1990-08-10 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production and use |
| AU682510B2 (en) * | 1993-07-01 | 1997-10-09 | Pfizer Japan Inc. | 2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives |
| US5707987A (en) * | 1994-02-25 | 1998-01-13 | Banyu Pharmaceutical Co., Ltd. | Carbapenem derivatives |
| US5496816A (en) * | 1994-03-14 | 1996-03-05 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| JP3209675B2 (ja) * | 1994-12-12 | 2001-09-17 | 日本ワイスレダリー株式会社 | チオール化合物 |
| JPH09202789A (ja) * | 1995-11-20 | 1997-08-05 | Suntory Ltd | ペネム誘導体およびこれを含有する抗菌剤 |
| TW420681B (en) * | 1995-12-08 | 2001-02-01 | Lederle Japan Ltd | Carbapenem-3-carboxylic acid ester derivatives |
| JPH1059970A (ja) * | 1996-08-16 | 1998-03-03 | Suntory Ltd | カルバペネム誘導体およびこれを含有する抗菌剤 |
| DE69810651T2 (de) * | 1997-10-07 | 2003-08-21 | Boehringer Ingelheim (Canada) Ltd., Laval | Azetidinonderivate zur behandlung von hcmv entzündungen |
| AU5450199A (en) * | 1998-09-10 | 2000-04-03 | Wyeth Lederle Japan, Ltd. | Carbapenem compounds |
| JP4260941B2 (ja) * | 1998-11-09 | 2009-04-30 | 株式会社片山製薬所 | アゼチジン−３−オール |
| JP2002212182A (ja) * | 2000-11-16 | 2002-07-31 | Sankyo Co Ltd | １−メチルカルバペネム誘導体 |
| IL155931A0 (en) * | 2000-11-16 | 2003-12-23 | Sankyo Co | 1-methylcarbapenem derivatives and pharmaceutical compositions containing the same |
| JP2003183282A (ja) * | 2001-12-21 | 2003-07-03 | Wyeth Lederle Japan Ltd | カルバペネム化合物 |
-
2004
- 2004-08-31 KR KR1020040068821A patent/KR100599876B1/ko not_active Expired - Fee Related
-
2005
- 2005-02-24 CN CNB2005800133642A patent/CN100494200C/zh not_active Expired - Fee Related
- 2005-02-24 JP JP2007509390A patent/JP4801049B2/ja not_active Expired - Fee Related
- 2005-02-24 US US11/578,007 patent/US7662810B2/en not_active Expired - Fee Related
- 2005-02-24 DE DE602005023492T patent/DE602005023492D1/de not_active Expired - Lifetime
- 2005-02-24 EP EP05721872A patent/EP1784407B1/de not_active Expired - Lifetime
- 2005-02-24 AT AT05721872T patent/ATE480538T1/de not_active IP Right Cessation
- 2005-02-24 WO PCT/KR2005/000509 patent/WO2006025634A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006025634A1 (en) | 2006-03-09 |
| WO2006025634A8 (en) | 2006-08-24 |
| US7662810B2 (en) | 2010-02-16 |
| CN100494200C (zh) | 2009-06-03 |
| DE602005023492D1 (de) | 2010-10-21 |
| KR100599876B1 (ko) | 2006-07-13 |
| EP1784407A4 (de) | 2009-02-11 |
| JP2007532693A (ja) | 2007-11-15 |
| US20070244089A1 (en) | 2007-10-18 |
| CN1946724A (zh) | 2007-04-11 |
| KR20060020081A (ko) | 2006-03-06 |
| JP4801049B2 (ja) | 2011-10-26 |
| EP1784407B1 (de) | 2010-09-08 |
| EP1784407A1 (de) | 2007-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2012134184A3 (ko) | 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물 | |
| WO2011073112A3 (en) | Mannose derivatives as antagonists of bacterial adhesion | |
| WO2008143343A1 (ja) | １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 | |
| PH12012502087A1 (en) | Novel hydroxamic acid derivative | |
| WO2010047737A3 (en) | Antimicrobial indoline compounds for treatment of bacterial infections | |
| NZ545472A (en) | 7-(4-substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl)quinolonecarboxylic acid derivative | |
| WO2005014585A8 (en) | Halogenated quinazolinyl nitrofurans as antibacterial agents | |
| WO2018208987A3 (en) | Antibacterial compounds | |
| WO2012031298A3 (en) | Ethynylbenzene derivatives | |
| WO2020061375A8 (en) | Antibacterial compounds | |
| NZ594675A (en) | Actagardine derivatives | |
| EA201070504A1 (ru) | КАРБАЦЕФЕМ β-ЛАКТАМОВЫЕ АНТИБИОТИКИ | |
| WO2007067559A3 (en) | Antibacterial agents | |
| ATE480538T1 (de) | 2-arylmethylazetidincarbapenemderivate und deren herstellung | |
| PA8678901A1 (es) | Derivados de quinolina como agentes antibacteriales | |
| WO2005070945A8 (ja) | メチシリン耐性黄色ブドウ球菌（ｍｒｓａ）に有効な新規アミノグリコシド系抗生物質 | |
| WO2007001335A3 (en) | Ramoplanin derivatives possessing antibacterial activity | |
| WO2009066917A3 (en) | 2-arylmethylazetidine-carbapenem-3-carboxylic acid ester derivative or its salt, process for the preparation thereof and pharmaceutical composition comprising the same | |
| WO2006055070A3 (en) | Novel lincomycin derivatives possessing antibacterial activity | |
| MX2024000036A (es) | Compuestos novedosos y su uso. | |
| WO2015024011A3 (en) | Antibacterial compounds | |
| WO2010036000A3 (en) | Novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone and pharmaceutical compositions thereof | |
| WO2010030811A3 (en) | CARBACEPHEM β-LACTAM ANTIBIOTICS | |
| MX2021003485A (es) | Derivados de indano para uso en el tratamiento de infeccion bacteriana. | |
| WO2009001192A3 (en) | Novel compounds and their use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |