ATE480771T1 - Ionenkanal-assayverfahren - Google Patents
Ionenkanal-assayverfahrenInfo
- Publication number
- ATE480771T1 ATE480771T1 AT06019986T AT06019986T ATE480771T1 AT E480771 T1 ATE480771 T1 AT E480771T1 AT 06019986 T AT06019986 T AT 06019986T AT 06019986 T AT06019986 T AT 06019986T AT E480771 T1 ATE480771 T1 AT E480771T1
- Authority
- AT
- Austria
- Prior art keywords
- ion channel
- assay method
- channel assay
- candidate compound
- cells
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21766600P | 2000-07-10 | 2000-07-10 | |
| US21721900P | 2000-07-10 | 2000-07-10 | |
| US21722100P | 2000-07-10 | 2000-07-10 | |
| US21767100P | 2000-07-10 | 2000-07-10 | |
| US09/804,457 US7399599B2 (en) | 2000-07-10 | 2001-03-12 | Ion channel assay methods |
| US09/804,458 US6969449B2 (en) | 2000-07-10 | 2001-03-12 | Multi-well plate and electrode assemblies for ion channel assays |
| US09/804,580 US6686193B2 (en) | 2000-07-10 | 2001-03-12 | High throughput method and system for screening candidate compounds for activity against target ion channels |
| US09/804,480 US7312043B2 (en) | 2000-07-10 | 2001-03-12 | Ion channel assay methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE480771T1 true ATE480771T1 (de) | 2010-09-15 |
Family
ID=27575195
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01953433T ATE342504T1 (de) | 2000-07-10 | 2001-07-09 | Ionenkanal-testverfahren |
| AT06019986T ATE480771T1 (de) | 2000-07-10 | 2001-07-09 | Ionenkanal-assayverfahren |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01953433T ATE342504T1 (de) | 2000-07-10 | 2001-07-09 | Ionenkanal-testverfahren |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1303757B1 (de) |
| JP (1) | JP5209835B2 (de) |
| AT (2) | ATE342504T1 (de) |
| AU (4) | AU2001275881B2 (de) |
| CA (1) | CA2413711C (de) |
| DE (2) | DE60123797T2 (de) |
| DK (1) | DK1303757T3 (de) |
| ES (1) | ES2273868T3 (de) |
| MX (1) | MXJL03000001A (de) |
| WO (1) | WO2002008748A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020144905A1 (en) | 1997-12-17 | 2002-10-10 | Christian Schmidt | Sample positioning and analysis system |
| US7244349B2 (en) | 1997-12-17 | 2007-07-17 | Molecular Devices Corporation | Multiaperture sample positioning and analysis system |
| US7615356B2 (en) * | 2000-07-10 | 2009-11-10 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| EP1303757B1 (de) * | 2000-07-10 | 2006-10-11 | Vertex Pharmaceuticals (San Diego) LLC | Ionenkanal-testverfahren |
| US7067046B2 (en) | 2000-08-04 | 2006-06-27 | Essen Instruments, Inc. | System for rapid chemical activation in high-throughput electrophysiological measurements |
| WO2003006103A2 (en) * | 2001-07-12 | 2003-01-23 | Merck & Co., Inc. | Electrical field stimulation of eukaryotic cells |
| WO2003035824A1 (en) * | 2001-10-25 | 2003-05-01 | Bar-Ilan University | Interactive transparent individual cells biochip processor |
| US8003372B2 (en) | 2002-02-05 | 2011-08-23 | The University Court Of The University Of Glasgow | Device for performing cell assays |
| AU2003283663A1 (en) * | 2002-11-01 | 2004-05-25 | Cellectricon Ab | Computer programs,workstations, systems and methods for microfluidic substrates in cell |
| US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
| ES2294757T3 (es) * | 2004-03-15 | 2008-04-01 | Amaxa Ag | Recipiente y dispositivo para generar campos electricos en espacios de reaccion individuales. |
| US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
| US9975118B2 (en) | 2007-11-15 | 2018-05-22 | Seng Enterprises Ltd. | Device for the study of living cells |
| GB0723725D0 (en) * | 2007-12-05 | 2008-01-16 | Ge Healthcare Uk Ltd | Apparatus and method for detecting dna damage |
| CA2727818A1 (en) * | 2008-06-13 | 2009-12-13 | Scott And White Healthcare | Characterization of biological samples |
| US8221411B2 (en) * | 2008-07-28 | 2012-07-17 | Medtronic, Inc. | Systems and methods for cardiac tissue electroporation ablation |
| EP2278332A1 (de) | 2009-07-20 | 2011-01-26 | Fondazione Centro San Raffaele del Monte Tabor | Verfahren zur optischen Messung von Abweichungen der Zellmembranleitfähigkeit |
| JP5411096B2 (ja) * | 2010-08-31 | 2014-02-12 | 株式会社堀場製作所 | 粒子物性測定セル及び粒子物性測定装置 |
| WO2014065330A1 (ja) * | 2012-10-25 | 2014-05-01 | 浜松ホトニクス株式会社 | 細胞観察装置、電気刺激装置、及び細胞観察方法 |
| EP2913391B1 (de) * | 2012-10-25 | 2020-07-01 | Hamamatsu Photonics K.K. | Zellbeobachtungsvorrichtung und zellbeobachtungsverfahren |
| JP6337109B2 (ja) | 2013-07-19 | 2018-06-06 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ナトリウムチャネルの調節剤としてのスルホンアミド |
| JP6463580B2 (ja) | 2013-12-13 | 2019-02-06 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ナトリウムチャネルの調節剤として有用なピリドンアミドのプロドラッグ |
| JP6822960B2 (ja) | 2014-12-19 | 2021-01-27 | ジ ユニバーシティ オブ オタワ | 制御破壊を用いた複数のマイクロ流体チャネルアレイにおけるナノポアセンサの一体化 |
| BR112019024016A2 (pt) | 2017-05-16 | 2020-06-09 | Vertex Pharma | amidas de piridona deuteradas e profármacos das mesmas como moduladores de canais de sódio |
| CN116987589A (zh) * | 2017-10-19 | 2023-11-03 | 苏州壹达生物科技有限公司 | 一种流式电穿孔装置 |
| EP3752152A1 (de) | 2018-02-12 | 2020-12-23 | Vertex Pharmaceuticals Incorporated | Verfahren zur behandlung von schmerz |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| DK4069691T3 (da) | 2019-12-06 | 2024-10-28 | Vertex Pharma | Substituerede tetrahydrofuraner som modulatorer af natriumkanaler |
| EP4347033A1 (de) | 2021-06-04 | 2024-04-10 | Vertex Pharmaceuticals Incorporated | Hydroxy- und (halo)alkoxy-substituierte tetrahydrofurane als modulatoren von natriumkanälen |
| MA64853B1 (fr) | 2021-06-04 | 2025-11-28 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hétéro)aryl) tétrahydrofuran carboxamides utilisés en tant que modulateurs de canaux sodiques |
| CA3221939A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels |
| JP2024520649A (ja) | 2021-06-04 | 2024-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | （２ｒ，３ｓ，４ｓ，５ｒ）－４－［［３－（３，４－ジフルオロ－２－メトキシ－フェニル）－４，５－ジメチル－５－（トリフルオロメチル）テトラヒドロフラン－２－カルボニル］アミノ］ピリジン－２－カルボキサミドを含む固体剤形及び投与レジメン |
| DE102021210044A1 (de) | 2021-09-10 | 2023-03-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Messsystem, Probenkörper, Elektrodenvorrichtung und Verfahren zum Messen einer Vielzahl von Analyten |
| JP2025513455A (ja) | 2022-04-22 | 2025-04-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の治療のためのヘテロアリール化合物 |
| WO2025090465A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2025090436A1 (en) * | 2023-10-25 | 2025-05-01 | St. Jude Medical, Cardiology Division, Inc. | Systems and methods for reducing microbubbles in electroporation applications |
| US20260001877A1 (en) | 2024-06-28 | 2026-01-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4067951A (en) * | 1975-11-19 | 1978-01-10 | Bactomatic Inc. | Process for making impedance measuring module |
| US4970154A (en) * | 1987-10-09 | 1990-11-13 | Baylor College Of Medicine | Method for inserting foreign genes into cells using pulsed radiofrequency |
| US5187096A (en) * | 1991-08-08 | 1993-02-16 | Rensselaer Polytechnic Institute | Cell substrate electrical impedance sensor with multiple electrode array |
| JP3099049B2 (ja) * | 1992-07-29 | 2000-10-16 | 農林水産省果樹試験場長 | 電気的細胞融合及び電気的核酸導入のための大量処理用電極 |
| US5661035A (en) * | 1995-06-07 | 1997-08-26 | The Regents Of The University Of California | Voltage sensing by fluorescence resonance energy transfer |
| DE19529371C3 (de) * | 1995-08-10 | 2003-05-28 | Nmi Univ Tuebingen | Mikroelektroden-Anordnung |
| US6099960A (en) * | 1996-05-15 | 2000-08-08 | Hyperion Catalysis International | High surface area nanofibers, methods of making, methods of using and products containing same |
| US5972694A (en) * | 1997-02-11 | 1999-10-26 | Mathus; Gregory | Multi-well plate |
| US5981268A (en) * | 1997-05-30 | 1999-11-09 | Board Of Trustees, Leland Stanford, Jr. University | Hybrid biosensors |
| AU2150300A (en) * | 1998-12-07 | 2000-06-26 | Acacia Biosciences Inc. | Multi-channel electrode arrays |
| US7312043B2 (en) * | 2000-07-10 | 2007-12-25 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| EP1303757B1 (de) * | 2000-07-10 | 2006-10-11 | Vertex Pharmaceuticals (San Diego) LLC | Ionenkanal-testverfahren |
-
2001
- 2001-07-09 EP EP01953433A patent/EP1303757B1/de not_active Expired - Lifetime
- 2001-07-09 AT AT01953433T patent/ATE342504T1/de active
- 2001-07-09 AT AT06019986T patent/ATE480771T1/de not_active IP Right Cessation
- 2001-07-09 ES ES01953433T patent/ES2273868T3/es not_active Expired - Lifetime
- 2001-07-09 AU AU2001275881A patent/AU2001275881B2/en not_active Ceased
- 2001-07-09 DE DE60123797T patent/DE60123797T2/de not_active Expired - Lifetime
- 2001-07-09 DK DK01953433T patent/DK1303757T3/da active
- 2001-07-09 MX MXJL03000001A patent/MXJL03000001A/es active IP Right Grant
- 2001-07-09 AU AU7588101A patent/AU7588101A/xx active Pending
- 2001-07-09 CA CA2413711A patent/CA2413711C/en not_active Expired - Lifetime
- 2001-07-09 EP EP06019986A patent/EP1757932B1/de not_active Expired - Lifetime
- 2001-07-09 JP JP2002514391A patent/JP5209835B2/ja not_active Expired - Lifetime
- 2001-07-09 WO PCT/US2001/021652 patent/WO2002008748A2/en not_active Ceased
- 2001-07-09 DE DE60143064T patent/DE60143064D1/de not_active Expired - Lifetime
-
2006
- 2006-07-04 AU AU2006202851A patent/AU2006202851B2/en not_active Ceased
-
2009
- 2009-09-04 AU AU2009212941A patent/AU2009212941B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1757932A2 (de) | 2007-02-28 |
| EP1757932B1 (de) | 2010-09-08 |
| ES2273868T3 (es) | 2007-05-16 |
| AU2009212941B2 (en) | 2012-06-28 |
| DE60143064D1 (de) | 2010-10-21 |
| AU2009212941A1 (en) | 2009-10-01 |
| EP1303757B1 (de) | 2006-10-11 |
| AU7588101A (en) | 2002-02-05 |
| WO2002008748A9 (en) | 2003-06-12 |
| AU2006202851B2 (en) | 2009-06-04 |
| WO2002008748A3 (en) | 2002-05-02 |
| JP5209835B2 (ja) | 2013-06-12 |
| EP1303757A2 (de) | 2003-04-23 |
| AU2001275881B2 (en) | 2006-04-06 |
| DK1303757T3 (da) | 2007-02-05 |
| MXJL03000001A (es) | 2004-02-09 |
| DE60123797T2 (de) | 2007-10-18 |
| CA2413711C (en) | 2012-03-13 |
| CA2413711A1 (en) | 2002-01-31 |
| WO2002008748A2 (en) | 2002-01-31 |
| DE60123797D1 (de) | 2006-11-23 |
| EP1757932A3 (de) | 2007-07-18 |
| ATE342504T1 (de) | 2006-11-15 |
| AU2006202851A1 (en) | 2006-07-27 |
| JP2004514115A (ja) | 2004-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |