ATE480771T1 - Ionenkanal-assayverfahren - Google Patents
Ionenkanal-assayverfahrenInfo
- Publication number
- ATE480771T1 ATE480771T1 AT06019986T AT06019986T ATE480771T1 AT E480771 T1 ATE480771 T1 AT E480771T1 AT 06019986 T AT06019986 T AT 06019986T AT 06019986 T AT06019986 T AT 06019986T AT E480771 T1 ATE480771 T1 AT E480771T1
- Authority
- AT
- Austria
- Prior art keywords
- ion channel
- assay method
- channel assay
- candidate compound
- cells
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21766600P | 2000-07-10 | 2000-07-10 | |
| US21721900P | 2000-07-10 | 2000-07-10 | |
| US21722100P | 2000-07-10 | 2000-07-10 | |
| US21767100P | 2000-07-10 | 2000-07-10 | |
| US09/804,480 US7312043B2 (en) | 2000-07-10 | 2001-03-12 | Ion channel assay methods |
| US09/804,457 US7399599B2 (en) | 2000-07-10 | 2001-03-12 | Ion channel assay methods |
| US09/804,580 US6686193B2 (en) | 2000-07-10 | 2001-03-12 | High throughput method and system for screening candidate compounds for activity against target ion channels |
| US09/804,458 US6969449B2 (en) | 2000-07-10 | 2001-03-12 | Multi-well plate and electrode assemblies for ion channel assays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE480771T1 true ATE480771T1 (de) | 2010-09-15 |
Family
ID=27575195
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01953433T ATE342504T1 (de) | 2000-07-10 | 2001-07-09 | Ionenkanal-testverfahren |
| AT06019986T ATE480771T1 (de) | 2000-07-10 | 2001-07-09 | Ionenkanal-assayverfahren |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01953433T ATE342504T1 (de) | 2000-07-10 | 2001-07-09 | Ionenkanal-testverfahren |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1757932B1 (de) |
| JP (1) | JP5209835B2 (de) |
| AT (2) | ATE342504T1 (de) |
| AU (4) | AU7588101A (de) |
| CA (1) | CA2413711C (de) |
| DE (2) | DE60143064D1 (de) |
| DK (1) | DK1303757T3 (de) |
| ES (1) | ES2273868T3 (de) |
| MX (1) | MXJL03000001A (de) |
| WO (1) | WO2002008748A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020144905A1 (en) | 1997-12-17 | 2002-10-10 | Christian Schmidt | Sample positioning and analysis system |
| US7244349B2 (en) | 1997-12-17 | 2007-07-17 | Molecular Devices Corporation | Multiaperture sample positioning and analysis system |
| US7615356B2 (en) * | 2000-07-10 | 2009-11-10 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| ATE342504T1 (de) * | 2000-07-10 | 2006-11-15 | Vertex Pharma San Diego Llc | Ionenkanal-testverfahren |
| US7067046B2 (en) | 2000-08-04 | 2006-06-27 | Essen Instruments, Inc. | System for rapid chemical activation in high-throughput electrophysiological measurements |
| EP1425065A4 (de) * | 2001-07-12 | 2004-12-15 | Merck & Co Inc | Elektrische feldstimulation mit eukaryontischen zellen |
| EP2332651A3 (de) * | 2001-10-25 | 2011-08-31 | Bar Ilan University | Interaktiver transparenter Biochip-Prozessor für einzeln adressierbare Zellen |
| US8003372B2 (en) | 2002-02-05 | 2011-08-23 | The University Court Of The University Of Glasgow | Device for performing cell assays |
| WO2004039489A2 (en) * | 2002-11-01 | 2004-05-13 | Cellectricon Ab | Computer programs,workstations, systems and methods for microfluidic substrates in cell |
| US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
| DE502004009820D1 (de) * | 2004-03-15 | 2009-09-10 | Lonza Cologne Ag | Behältnis und Vorrichtung zur Erzeugung von elektrischen Feldern in einzelnen Reaktionsräumen |
| US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
| US9975118B2 (en) | 2007-11-15 | 2018-05-22 | Seng Enterprises Ltd. | Device for the study of living cells |
| GB0723725D0 (en) * | 2007-12-05 | 2008-01-16 | Ge Healthcare Uk Ltd | Apparatus and method for detecting dna damage |
| AU2009257271A1 (en) * | 2008-06-13 | 2009-12-17 | Scott & White Healthcare | Characterization of biological samples |
| US8221411B2 (en) | 2008-07-28 | 2012-07-17 | Medtronic, Inc. | Systems and methods for cardiac tissue electroporation ablation |
| EP2278332A1 (de) | 2009-07-20 | 2011-01-26 | Fondazione Centro San Raffaele del Monte Tabor | Verfahren zur optischen Messung von Abweichungen der Zellmembranleitfähigkeit |
| JP5411096B2 (ja) * | 2010-08-31 | 2014-02-12 | 株式会社堀場製作所 | 粒子物性測定セル及び粒子物性測定装置 |
| EP2913390B1 (de) * | 2012-10-25 | 2020-12-09 | Hamamatsu Photonics K.K. | Elektrische stimulationsvorrichtung, zellbeobachtungsvorrichtung und zellbeobachtungsverfahren |
| US9772322B2 (en) | 2012-10-25 | 2017-09-26 | Hamamatsu Photonics K.K. | Cell observation device, and cell observation method |
| PE20160548A1 (es) | 2013-07-19 | 2016-05-21 | Vertex Pharma | Sulfonamidas como moduladores de canales de sodio |
| CA2931550C (en) | 2013-12-13 | 2023-09-26 | Vertex Pharmaceuticals Incorporated | Prodrugs of pyridone amides useful as modulators of sodium channels |
| MX388279B (es) | 2014-12-19 | 2025-03-18 | Univ Ottawa | Integracion de sensores de nanoporos dentro de agrupaciones de canales microfluidicos usando descargas disruptivas controladas. |
| EP3625214B1 (de) | 2017-05-16 | 2022-07-06 | Vertex Pharmaceuticals Incorporated | Deuterierte pyridonamide und deren prodrugs als modulatoren von natriumkanälen |
| CN116987589A (zh) * | 2017-10-19 | 2023-11-03 | 苏州壹达生物科技有限公司 | 一种流式电穿孔装置 |
| WO2019157505A1 (en) | 2018-02-12 | 2019-08-15 | Vertex Pharmaceuticals Incorporated | A method of treating pain |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| MX2022006865A (es) | 2019-12-06 | 2022-07-11 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio. |
| AU2022286511A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
| CN117794920A (zh) | 2021-06-04 | 2024-03-29 | 沃泰克斯药物股份有限公司 | N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂 |
| KR20240031299A (ko) | 2021-06-04 | 2024-03-07 | 버텍스 파마슈티칼스 인코포레이티드 | (2r,3s,4s,5r)-4-[[3-(3,4-디플루오로-2-메톡시-페닐)-4,5-디메틸-5-(트리플루오로메틸)테트라하이드로푸란-2-카르보닐]아미노]피리딘-2-카르복사미드를 포함하는 고체 투여 형태 및 투여 요법 |
| JP2024520646A (ja) | 2021-06-04 | 2024-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド類似体 |
| DE102021210044A1 (de) | 2021-09-10 | 2023-03-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Messsystem, Probenkörper, Elektrodenvorrichtung und Verfahren zum Messen einer Vielzahl von Analyten |
| JP2025513455A (ja) | 2022-04-22 | 2025-04-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の治療のためのヘテロアリール化合物 |
| WO2025090465A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2025090436A1 (en) * | 2023-10-25 | 2025-05-01 | St. Jude Medical, Cardiology Division, Inc. | Systems and methods for reducing microbubbles in electroporation applications |
| TW202606663A (zh) | 2024-06-28 | 2026-02-16 | 美商維泰克斯製藥公司 | 用於治療疼痛之雜芳基化合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4067951A (en) * | 1975-11-19 | 1978-01-10 | Bactomatic Inc. | Process for making impedance measuring module |
| US4970154A (en) * | 1987-10-09 | 1990-11-13 | Baylor College Of Medicine | Method for inserting foreign genes into cells using pulsed radiofrequency |
| US5187096A (en) * | 1991-08-08 | 1993-02-16 | Rensselaer Polytechnic Institute | Cell substrate electrical impedance sensor with multiple electrode array |
| JP3099049B2 (ja) * | 1992-07-29 | 2000-10-16 | 農林水産省果樹試験場長 | 電気的細胞融合及び電気的核酸導入のための大量処理用電極 |
| US5661035A (en) * | 1995-06-07 | 1997-08-26 | The Regents Of The University Of California | Voltage sensing by fluorescence resonance energy transfer |
| DE19529371C3 (de) * | 1995-08-10 | 2003-05-28 | Nmi Univ Tuebingen | Mikroelektroden-Anordnung |
| US6099960A (en) * | 1996-05-15 | 2000-08-08 | Hyperion Catalysis International | High surface area nanofibers, methods of making, methods of using and products containing same |
| US5972694A (en) * | 1997-02-11 | 1999-10-26 | Mathus; Gregory | Multi-well plate |
| US5981268A (en) * | 1997-05-30 | 1999-11-09 | Board Of Trustees, Leland Stanford, Jr. University | Hybrid biosensors |
| AU2150300A (en) * | 1998-12-07 | 2000-06-26 | Acacia Biosciences Inc. | Multi-channel electrode arrays |
| ATE342504T1 (de) * | 2000-07-10 | 2006-11-15 | Vertex Pharma San Diego Llc | Ionenkanal-testverfahren |
| US7312043B2 (en) * | 2000-07-10 | 2007-12-25 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
-
2001
- 2001-07-09 AT AT01953433T patent/ATE342504T1/de active
- 2001-07-09 JP JP2002514391A patent/JP5209835B2/ja not_active Expired - Lifetime
- 2001-07-09 MX MXJL03000001A patent/MXJL03000001A/es active IP Right Grant
- 2001-07-09 AU AU7588101A patent/AU7588101A/xx active Pending
- 2001-07-09 AU AU2001275881A patent/AU2001275881B2/en not_active Ceased
- 2001-07-09 EP EP06019986A patent/EP1757932B1/de not_active Expired - Lifetime
- 2001-07-09 ES ES01953433T patent/ES2273868T3/es not_active Expired - Lifetime
- 2001-07-09 DE DE60143064T patent/DE60143064D1/de not_active Expired - Lifetime
- 2001-07-09 DK DK01953433T patent/DK1303757T3/da active
- 2001-07-09 AT AT06019986T patent/ATE480771T1/de not_active IP Right Cessation
- 2001-07-09 CA CA2413711A patent/CA2413711C/en not_active Expired - Lifetime
- 2001-07-09 DE DE60123797T patent/DE60123797T2/de not_active Expired - Lifetime
- 2001-07-09 EP EP01953433A patent/EP1303757B1/de not_active Expired - Lifetime
- 2001-07-09 WO PCT/US2001/021652 patent/WO2002008748A2/en not_active Ceased
-
2006
- 2006-07-04 AU AU2006202851A patent/AU2006202851B2/en not_active Ceased
-
2009
- 2009-09-04 AU AU2009212941A patent/AU2009212941B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1303757B1 (de) | 2006-10-11 |
| DE60123797T2 (de) | 2007-10-18 |
| JP5209835B2 (ja) | 2013-06-12 |
| JP2004514115A (ja) | 2004-05-13 |
| EP1757932A2 (de) | 2007-02-28 |
| MXJL03000001A (es) | 2004-02-09 |
| AU2006202851B2 (en) | 2009-06-04 |
| EP1757932A3 (de) | 2007-07-18 |
| CA2413711C (en) | 2012-03-13 |
| AU7588101A (en) | 2002-02-05 |
| AU2009212941A1 (en) | 2009-10-01 |
| AU2001275881B2 (en) | 2006-04-06 |
| WO2002008748A2 (en) | 2002-01-31 |
| WO2002008748A3 (en) | 2002-05-02 |
| CA2413711A1 (en) | 2002-01-31 |
| AU2006202851A1 (en) | 2006-07-27 |
| ATE342504T1 (de) | 2006-11-15 |
| ES2273868T3 (es) | 2007-05-16 |
| DK1303757T3 (da) | 2007-02-05 |
| DE60143064D1 (de) | 2010-10-21 |
| EP1303757A2 (de) | 2003-04-23 |
| WO2002008748A9 (en) | 2003-06-12 |
| AU2009212941B2 (en) | 2012-06-28 |
| EP1757932B1 (de) | 2010-09-08 |
| DE60123797D1 (de) | 2006-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |