ATE484506T1 - Substituierte diazepin-sulfonamide als bombesin- rezeptor-subtyp-3-modulatoren - Google Patents

Substituierte diazepin-sulfonamide als bombesin- rezeptor-subtyp-3-modulatoren

Info

Publication number: ATE484506T1
Authority: AT; Austria
Prior art keywords: sulfonamides; bombesine; modulators; receptor subtype; substituted diazepine
Prior art date: 2006-12-11

Application number

AT07862652T

Other languages

English (en)

Inventor

Robert K Baker

Linda L Chang

Marc Chioda

Harry R Chobanian

Ying-Duo Gao

Yan Guo

Linus S Lin

Ping Liu

Ravi P Nargund

Kathleen M Rupprecht

Shouwu Miao

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-11

Filing date

2007-12-07

Publication date

2010-10-15

2007-12-07 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2010-10-15 Application granted granted Critical

2010-10-15 Publication of ATE484506T1 publication Critical patent/ATE484506T1/de

Links

-1 DIAZEPINE SULFONAMIDES Chemical class 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
102100028628 Bombesin receptor subtype-3 Human genes 0.000 abstract 2
108010063504 bombesin receptor subtype 3 Proteins 0.000 abstract 2
239000003446 ligand Substances 0.000 abstract 2
108010073466 Bombesin Receptors Proteins 0.000 abstract 1
101000695054 Homo sapiens Bombesin receptor subtype-3 Proteins 0.000 abstract 1
KUFVCQHJVFZQNY-UHFFFAOYSA-N N1N=C(C=CC=C1)S(=O)(=O)N Chemical class N1N=C(C=CC=C1)S(=O)(=O)N KUFVCQHJVFZQNY-UHFFFAOYSA-N 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
230000006806 disease prevention Effects 0.000 abstract 1
208000037765 diseases and disorders Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Addiction (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)

AT07862652T 2006-12-11 2007-12-07 Substituierte diazepin-sulfonamide als bombesin- rezeptor-subtyp-3-modulatoren ATE484506T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US87437606P	2006-12-11	2006-12-11
PCT/US2007/025104 WO2008073311A2 (en)	2006-12-11	2007-12-07	Substituted diazepine sulfonamides as bombesin receptor subtype-3 modulators

Publications (1)

Publication Number	Publication Date
ATE484506T1 true ATE484506T1 (de)	2010-10-15

Family

ID=39512271

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07862652T ATE484506T1 (de)	2006-12-11	2007-12-07	Substituierte diazepin-sulfonamide als bombesin- rezeptor-subtyp-3-modulatoren

Country Status (9)

Country	Link
US (1)	US8153626B2 (de)
EP (1)	EP2102201B1 (de)
JP (1)	JP5313161B2 (de)
CN (1)	CN101605788A (de)
AT (1)	ATE484506T1 (de)
AU (1)	AU2007332867B2 (de)
CA (1)	CA2671482C (de)
DE (1)	DE602007009873D1 (de)
WO (1)	WO2008073311A2 (de)

Families Citing this family (9)

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EP2637667A4 (de) *	2010-11-08	2014-06-25	Albireo Ab	Ibat-hemmer zur behandlung von stoffwechselerkrankungen und verwandten leiden
EP2729017A1 (de) *	2011-07-04	2014-05-14	Unilever N.V.	Verfahren zur reduzierung der energieaufnahme durch genuss eines mit luft durchsetzten produkts mindestens dreimal pro tag
EP2567959B1 (de)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamid-derivate als kinaseinhibitoren
MX389242B (es)	2015-06-15	2025-03-20	Nmd Pharma As	Compuestos para su uso en el tratamiento de trastornos neuromusculares
US11730714B2 (en)	2017-12-14	2023-08-22	Nmd Pharma A/S	Compounds for the treatment of neuromuscular disorders
US11147788B2 (en)	2017-12-14	2021-10-19	Nmd Pharma A/S	Compounds for the treatment of neuromuscular disorders
US11591284B2 (en)	2017-12-14	2023-02-28	Nmd Pharma A/S	Compounds for the treatment of neuromuscular disorders
US12440477B2 (en)	2017-12-14	2025-10-14	Nmd Pharma A/S	Compounds for the treatment of neuromuscular disorders
CN116987040B (zh) *	2023-06-21	2025-09-23	中国中医科学院中药研究所	二苯并二氮杂卓衍生物及其制备方法和应用

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JPH07243068A (ja)	1994-03-08	1995-09-19	Murata:Kk	金属表面の電解処理方法
HUP9901652A3 (en) *	1995-12-15	2000-04-28	Novo Nordisk As	Use of piperidine-carboxylic acid derivatives for producing pharmaceutical compositions suitable for reducing blood glucose
CN1246847A (zh)	1996-12-23	2000-03-08	杜邦药品公司	作为Xa因子抑制剂的含氮杂芳族化合物
CA2314401A1 (en)	1997-12-22	1999-07-01	Du Pont Pharmaceuticals Company	Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors
DE10224844A1 (de)	2002-06-05	2004-01-08	Solvay Pharmaceuticals Gmbh	Nicht-peptidische BRS-3-Agonisten
WO2004007464A1 (ja)	2002-07-10	2004-01-22	Sumitomo Pharmaceuticals Co., Ltd.	イミダゾール誘導体
WO2004046091A2 (en)	2002-11-19	2004-06-03	Galderma Research & Development, S.N.C.	Biaromatic compounds which activate ppar-gama type receptors, and use thereof in cosmetic or pharmaceutical compositions
PL376736A1 (pl)	2002-11-25	2006-01-09	Galderma Research & Development, S.N.C.	Nowe związki diaromatyczne, które aktywują receptor typu PPAR<$Egamma> i ich zastosowanie w kompozycjach kosmetycznych lub farmaceutycznych
AU2003297431A1 (en)	2002-12-20	2004-07-22	Pharmacia Corporation	Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds
JP2006518738A (ja)	2003-02-12	2006-08-17	トランス　テック　ファーマ，インコーポレイテッド	治療薬としての置換アゾール誘導体
US7141596B2 (en) *	2003-10-08	2006-11-28	Incyte Corporation	Inhibitors of proteins that bind phosphorylated molecules
GB0328796D0 (en) *	2003-12-12	2004-01-14	Biofocus Plc	Compounds which interact with the G-protein coupled receptor family
US20050187277A1 (en) *	2004-02-12	2005-08-25	Mjalli Adnan M.	Substituted azole derivatives, compositions, and methods of use
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EA010888B1 (ru) *	2004-05-25	2008-12-30	Пфайзер Продактс, Инк.	Тетраазабензо[е]азуленовые производные и их аналоги
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2007
- 2007-12-07 US US12/517,836 patent/US8153626B2/en active Active
- 2007-12-07 AU AU2007332867A patent/AU2007332867B2/en not_active Ceased
- 2007-12-07 JP JP2009541314A patent/JP5313161B2/ja not_active Expired - Fee Related
- 2007-12-07 AT AT07862652T patent/ATE484506T1/de not_active IP Right Cessation
- 2007-12-07 DE DE602007009873T patent/DE602007009873D1/de active Active
- 2007-12-07 CN CNA2007800511664A patent/CN101605788A/zh active Pending
- 2007-12-07 EP EP07862652A patent/EP2102201B1/de not_active Not-in-force
- 2007-12-07 CA CA2671482A patent/CA2671482C/en not_active Expired - Fee Related
- 2007-12-07 WO PCT/US2007/025104 patent/WO2008073311A2/en not_active Ceased

Also Published As

Publication number	Publication date
CN101605788A (zh)	2009-12-16
US8153626B2 (en)	2012-04-10
EP2102201A2 (de)	2009-09-23
CA2671482C (en)	2012-01-24
AU2007332867A1 (en)	2008-06-19
AU2007332867B2 (en)	2012-02-16
US20100317645A1 (en)	2010-12-16
JP2010512387A (ja)	2010-04-22
WO2008073311A3 (en)	2008-10-30
JP5313161B2 (ja)	2013-10-09
WO2008073311A2 (en)	2008-06-19
DE602007009873D1 (de)	2010-11-25
EP2102201B1 (de)	2010-10-13
CA2671482A1 (en)	2008-06-19

Legal Events

Date	Code	Title	Description
2011-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
NO20084792L (no)	2009-01-13	Substituerte imidazol-4-karboksamider som kolecystokinin-1-reseptormodulatorer
DE602007007594D1 (de)	2010-08-19	Substituierte imidazol-4-carboxamide als cholecystokinin-1-rezeptor-modulatoren
DE602007009873D1 (de)	2010-11-25	Substituierte diazepin-sulfonamide als bombesin-rezeptor-subtyp-3-modulatoren
DE602007008868D1 (de)	2010-10-14	Substituierte imidazol-4-carboxamide als cholecystokinin-1-rezeptor-modulatoren
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