BR0317430A - Compostos inibidores de quinase-2 de proteìna ativada por quinase de proteìna ativada por mitógeno - Google Patents

Compostos inibidores de quinase-2 de proteìna ativada por quinase de proteìna ativada por mitógeno

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Publication number
BR0317430A
BR0317430A BR0317430-1A BR0317430A BR0317430A BR 0317430 A BR0317430 A BR 0317430A BR 0317430 A BR0317430 A BR 0317430A BR 0317430 A BR0317430 A BR 0317430A
Authority
BR
Brazil
Prior art keywords
protein kinase
activated protein
mitogen
compounds
inhibitor compounds
Prior art date
Application number
BR0317430-1A
Other languages
English (en)
Inventor
David R Anderson
Matthew W Mahoney
Dennis P Phillion
Thomas E Rogers
Marvin J Meyers
Gennadiy Poda
Shridhar G Hedge
Megh Singh
David B Reitz
Kun K Wu
Ingrid P Buchler
Jin Xie
William F Vernier
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0317430A publication Critical patent/BR0317430A/pt

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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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Abstract

"COMPOSTOS INIBIDORES DE QUINASE-2 DE PROTEìNA ATIVADA POR QUINASE DE PROTEìNA ATIVADA POR MITóGENO". A presente invenção refere-se a descritos compostos que inibem a cinase-2 de proteína ativada por cinase de proteína ativada por mitógeno (MK-2). São descritos métodos para usar esses compostos para a inibição de MK-2 e para a prevenção ou tratamento de uma doença ou distúrbio que seja mediado pro TNF<244>, em que o método envolve administrar ao paciente um composto inibidor de MK-2 da presente invenção. Também são descritos composições terapêuticas, composições farmacêuticas e kits, que contêm os presentes compostos inibidores de MK-2.
BR0317430-1A 2002-12-20 2003-12-19 Compostos inibidores de quinase-2 de proteìna ativada por quinase de proteìna ativada por mitógeno BR0317430A (pt)

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PCT/US2003/040811 WO2004058762A1 (en) 2002-12-20 2003-12-19 Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds

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BR0317525-1A BR0317525A (pt) 2002-12-20 2003-12-19 Compostos pirazol acìclico, composição terapêutica e farmacêutica, kit, bem como respectivos usos

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