ATE485379T1 - Zytotoxische ribonukleasevarianten - Google Patents

Zytotoxische ribonukleasevarianten

Info

Publication number
ATE485379T1
ATE485379T1 AT06784926T AT06784926T ATE485379T1 AT E485379 T1 ATE485379 T1 AT E485379T1 AT 06784926 T AT06784926 T AT 06784926T AT 06784926 T AT06784926 T AT 06784926T AT E485379 T1 ATE485379 T1 AT E485379T1
Authority
AT
Austria
Prior art keywords
rnase
variants
result
cytotoxicity
cytotoxic
Prior art date
Application number
AT06784926T
Other languages
English (en)
Inventor
Ronald Raines
Julie Mitchell
Thomas Rutkoski
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of ATE485379T1 publication Critical patent/ATE485379T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT06784926T 2005-06-16 2006-06-16 Zytotoxische ribonukleasevarianten ATE485379T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69097005P 2005-06-16 2005-06-16
PCT/US2006/023298 WO2006138458A1 (en) 2005-06-16 2006-06-16 Cytotoxic ribonuclease variants

Publications (1)

Publication Number Publication Date
ATE485379T1 true ATE485379T1 (de) 2010-11-15

Family

ID=37116805

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06784926T ATE485379T1 (de) 2005-06-16 2006-06-16 Zytotoxische ribonukleasevarianten

Country Status (7)

Country Link
US (6) US7416875B2 (de)
EP (1) EP1910541B1 (de)
JP (1) JP5114392B2 (de)
AT (1) ATE485379T1 (de)
DE (1) DE602006017705D1 (de)
ES (1) ES2354280T3 (de)
WO (1) WO2006138458A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505853A (ja) 2004-04-13 2008-02-28 クインテセンス バイオサイエンシーズ インコーポレーティッド 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体
EP1910541B1 (de) 2005-06-16 2010-10-20 Wisconsin Alumni Research Foundation Zytotoxische ribonukleasevarianten
EP1896579A2 (de) 2005-06-16 2008-03-12 Wisconsin Alumni Research Foundation Zytotoxische ribonuklease-varianten
US8840882B2 (en) 2006-06-23 2014-09-23 Quintessence Biosciences, Inc. Modified ribonucleases
WO2008010991A2 (en) 2006-07-17 2008-01-24 Quintessence Biosciences, Inc. Methods and compositions for the treatment of cancer
US20090054339A1 (en) * 2007-08-22 2009-02-26 Marshall Vivienne S Novel cellular factor-containing solution compositions
WO2009048909A1 (en) 2007-10-08 2009-04-16 Quintessence Biosciences, Inc. Compositions and methods for ribonuclease-based therapies
BRPI0920743A2 (pt) 2008-10-01 2016-09-20 Quintessence Biosciences Inc ribonucleases terapeuticas
MX341084B (es) 2009-11-02 2016-08-05 Univ Washington Composiciones de nucleasas terapéuticas y métodos.
ES2666303T3 (es) 2011-04-29 2018-05-03 University Of Washington Composiciones terapéuticas de nucleasa y métodos
HRP20192080T1 (hr) 2013-10-31 2020-02-07 Resolve Therapeutics, Llc Terapeutske fuzije nukleaza-albumine i postupci
CA3029627A1 (en) 2016-07-01 2018-01-04 Resolve Therapeutics, Llc Optimized binuclease fusions and methods
CA3073537A1 (en) 2017-08-22 2019-02-28 Sanabio, Llc Soluble interferon receptors and uses thereof
US11286469B2 (en) 2017-11-09 2022-03-29 Wisconsin Alumni Research Foundation Combination chemotherapy for the treatment of cancer

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389537A (en) 1994-01-21 1995-02-14 Wisconsin Alumni Research Foundation Nuclease having altered specificity
AU2002301972B2 (en) 1997-10-15 2005-12-01 Wisconsin Alumni Research Foundation Human Ribonuclease A with Reduced Ribonuclease Inhibitor Affinity
US6280991B1 (en) 1997-10-15 2001-08-28 Wisconsin Alumni Research Foundation Engineered cytotoxic ribonclease
US5840296A (en) 1997-10-15 1998-11-24 Raines; Ronald T. Engineered cytotoxic ribonuclease A
US6239257B1 (en) 1998-12-30 2001-05-29 Alfacell Corporation Family of proteins belonging to the pancreatic ribonuclease a superfamily
CA2489446A1 (en) 2002-06-14 2003-12-24 Wisconsin Alumni Research Foundation Ribonuclease zymogen design
JP2008505853A (ja) 2004-04-13 2008-02-28 クインテセンス バイオサイエンシーズ インコーポレーティッド 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体
US20060084771A1 (en) 2004-10-15 2006-04-20 Wong Shing Jane B Method of preparing modified diallyl-N,N-disubstituted ammonium halide polymers
EP1910541B1 (de) 2005-06-16 2010-10-20 Wisconsin Alumni Research Foundation Zytotoxische ribonukleasevarianten
EP1896579A2 (de) 2005-06-16 2008-03-12 Wisconsin Alumni Research Foundation Zytotoxische ribonuklease-varianten
JP2008017144A (ja) 2006-07-05 2008-01-24 Toshiba Corp 無線受信装置および方法
BRPI0920743A2 (pt) 2008-10-01 2016-09-20 Quintessence Biosciences Inc ribonucleases terapeuticas

Also Published As

Publication number Publication date
US8524480B2 (en) 2013-09-03
US9255260B2 (en) 2016-02-09
US8247190B2 (en) 2012-08-21
US7977079B2 (en) 2011-07-12
WO2006138458A1 (en) 2006-12-28
EP1910541A1 (de) 2008-04-16
DE602006017705D1 (de) 2010-12-02
JP5114392B2 (ja) 2013-01-09
US20140335593A1 (en) 2014-11-13
US7416875B2 (en) 2008-08-26
US20120322137A1 (en) 2012-12-20
JP2008543312A (ja) 2008-12-04
US20110287514A1 (en) 2011-11-24
US20070003537A1 (en) 2007-01-04
US20140004594A1 (en) 2014-01-02
US8802413B2 (en) 2014-08-12
US20100233809A1 (en) 2010-09-16
EP1910541B1 (de) 2010-10-20
ES2354280T3 (es) 2011-03-11

Similar Documents

Publication Publication Date Title
ATE485379T1 (de) Zytotoxische ribonukleasevarianten
BR132020020122E2 (pt) arranjo de filtro para fixação de forma rosqueável a uma cabeça de filtro
CL2007003849A1 (es) Compuestos derivados de nafto[c]pirrol sustituidos con aminoacidos, utiles para tratar el cancer.
EA201171325A1 (ru) Нуклеиновые кислоты, связывающиеся с гепсидином
NZ594968A (en) Humanized c-kit antibody
IL185683A (en) Dual specificity oligonucleotide and processes using the same
EA201100084A1 (ru) Сшиваемая полимерная композиция
GT200500226A (es) Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa
CR7970S (es) Botella
ES2530670T3 (es) Anticuerpo anti-FGF23 y composición farmacéutica que comprende el mismo
WO2007101698A3 (en) Modified molecules which promote hematopoiesis
CL2008000666A1 (es) Compuestos derivados de triciclos sustituidos, inhibidores del transportador de metales divalentes-1; y uso para tratar una enfermedad asociada con un trastorno del hierro.
ATE532814T1 (de) Neue ammonium-polyurethan- und/oder polycarbonat- verbindungen
BRPI0913179A2 (pt) processo para produzir gás de hidrocarboneto purificado, e, gás natural liquefeito .
DK1987357T3 (da) Polypeptider, som genkendes af anti-Trichinella-antistoffer, og anvendelser deraf
ATE524076T1 (de) Niedrig-glykämische mischungen
WO2008009634A3 (en) Factor viia analogues with increased activity for treating thrombocytopenia
DE50305442D1 (de) Mitnehmer für kettenkratzförderer, insbesondere des untertagebetriebes
DK1664102T3 (da) Isoleret photoprotein mtclytin, samt dets anvendelse
EA200702543A1 (ru) Циклопентадиенильно-флуоренильные лиганды с углеродными мостиками
SE0701694L (sv) Nya bronkdilaterande a,b-omättade amider
UA92793C2 (ru) Пептидное соединение с биологической активностью, способ его получения и его применения
ATE473233T1 (de) Neue morphinderivate
ATE553291T1 (de) Abschirmteil
TW200716177A (en) Isolated photoprotein aqdecay, and its use

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties