DK3063275T3 - Terapeutiske nuklease-albumin-fusioner og fremgangsmåder - Google Patents

Terapeutiske nuklease-albumin-fusioner og fremgangsmåder Download PDF

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Publication number
DK3063275T3
DK3063275T3 DK14802986T DK14802986T DK3063275T3 DK 3063275 T3 DK3063275 T3 DK 3063275T3 DK 14802986 T DK14802986 T DK 14802986T DK 14802986 T DK14802986 T DK 14802986T DK 3063275 T3 DK3063275 T3 DK 3063275T3
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Denmark
Prior art keywords
mergers
albumin
procedures
therapeutic nuclease
nuclease
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DK14802986T
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English (en)
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James Arthur Posada
Chris Gabel
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Resolve Therapeutics Llc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21001—Deoxyribonuclease I (3.1.21.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DK14802986T 2013-10-31 2014-10-31 Terapeutiske nuklease-albumin-fusioner og fremgangsmåder DK3063275T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361898384P 2013-10-31 2013-10-31
US201361898370P 2013-10-31 2013-10-31
US201361898393P 2013-10-31 2013-10-31
PCT/US2014/063572 WO2015066550A1 (en) 2013-10-31 2014-10-31 Therapeutic nuclease-albumin fusions and methods

Publications (1)

Publication Number Publication Date
DK3063275T3 true DK3063275T3 (da) 2019-11-25

Family

ID=51982759

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14802986T DK3063275T3 (da) 2013-10-31 2014-10-31 Terapeutiske nuklease-albumin-fusioner og fremgangsmåder

Country Status (8)

Country Link
US (3) US10988745B2 (da)
EP (1) EP3063275B1 (da)
DK (1) DK3063275T3 (da)
ES (1) ES2759252T3 (da)
HR (1) HRP20192080T1 (da)
PL (1) PL3063275T3 (da)
SI (1) SI3063275T1 (da)
WO (2) WO2015066557A1 (da)

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SI3063275T1 (sl) 2013-10-31 2020-02-28 Resolve Therapeutics, Llc Terapevtske fuzije nukleaza-albumin in postopki
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AU2017290389B2 (en) * 2016-07-01 2024-09-26 Resolve Therapeutics, Llc Optimized binuclease fusions and methods
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CN115066494A (zh) * 2020-01-11 2022-09-16 耶鲁大学 用于治疗、改善、和/或预防由DNAse1和/或DNAse1L3缺陷引起或与之相关的疾病或障碍的组合物和方法
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CN112480247B (zh) * 2020-11-10 2023-09-22 华通福源生物技术(北京)股份有限公司 抗人血清白蛋白单克隆抗体

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US20160251638A1 (en) 2016-09-01
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EP3063275A1 (en) 2016-09-07
US12163165B2 (en) 2024-12-10
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US20210355462A1 (en) 2021-11-18
US10988745B2 (en) 2021-04-27

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