ATE486058T1 - Prolinamidderivate als nk3-antagonisten - Google Patents

Prolinamidderivate als nk3-antagonisten

Info

Publication number
ATE486058T1
ATE486058T1 AT08760181T AT08760181T ATE486058T1 AT E486058 T1 ATE486058 T1 AT E486058T1 AT 08760181 T AT08760181 T AT 08760181T AT 08760181 T AT08760181 T AT 08760181T AT E486058 T1 ATE486058 T1 AT E486058T1
Authority
AT
Austria
Prior art keywords
antagonists
prolinamide derivatives
prolinamide
derivatives
adhd
Prior art date
Application number
AT08760181T
Other languages
English (en)
Inventor
Bo Han
Henner Knust
Matthias Nettekoven
Hasane Ratni
Xihan Wu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE486058T1 publication Critical patent/ATE486058T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
AT08760181T 2007-06-07 2008-05-29 Prolinamidderivate als nk3-antagonisten ATE486058T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07109781 2007-06-07
PCT/EP2008/056589 WO2008148689A1 (en) 2007-06-07 2008-05-29 Prolinamide derivatives as nk3 antagonists

Publications (1)

Publication Number Publication Date
ATE486058T1 true ATE486058T1 (de) 2010-11-15

Family

ID=39639487

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08760181T ATE486058T1 (de) 2007-06-07 2008-05-29 Prolinamidderivate als nk3-antagonisten

Country Status (14)

Country Link
US (1) US7528136B2 (de)
EP (1) EP2155672B1 (de)
JP (1) JP2010529069A (de)
KR (1) KR101163292B1 (de)
CN (1) CN101679241B (de)
AT (1) ATE486058T1 (de)
AU (1) AU2008258665B2 (de)
BR (1) BRPI0812447A2 (de)
CA (1) CA2689560A1 (de)
DE (1) DE602008003221D1 (de)
ES (1) ES2351378T3 (de)
IL (1) IL202236A0 (de)
MX (1) MX2009013115A (de)
WO (1) WO2008148689A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2525353T3 (es) 2009-04-28 2014-12-22 Chugai Seiyaku Kabushiki Kaisha Derivado de espiroimidazolona
US8314250B2 (en) 2009-11-24 2012-11-20 Hoffmann-La Roche Inc. Sultam derivatives
US8618303B2 (en) * 2011-01-07 2013-12-31 Hoffmann-La Roche Inc. Pyrrolidine derivatives
US9073881B2 (en) 2011-09-23 2015-07-07 Hoffmann-La Roche Inc. Benzoic acid derivatives
JP6092261B2 (ja) 2012-02-24 2017-03-08 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 抗ウイルス化合物
CA2892621C (en) 2012-12-10 2021-02-16 Chugai Seiyaku Kabushiki Kaisha Hydantoin derivative
EP3153166B1 (de) * 2014-06-09 2022-08-03 Chugai Seiyaku Kabushiki Kaisha Hydantoinderivathaltige pharmazeutische zusammensetzung
CN105153005A (zh) * 2015-08-05 2015-12-16 上海瑞博化学有限公司 一种4-羰基-脯氨酸衍生物的制备方法
US11491136B2 (en) 2017-02-14 2022-11-08 Research Triangle Institute Proline-based neuropeptide FF receptor modulators
KR102453438B1 (ko) 2020-06-15 2022-10-12 주식회사 한중엔시에스 리저버 일체형 진공 펌프

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1169731A (zh) * 1994-12-13 1998-01-07 诺瓦蒂斯有限公司 速激肽拮抗剂
JO2696B1 (en) * 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
CA2565953A1 (en) * 2004-05-12 2005-11-24 Pfizer Products Inc. Piperidine derivatives as nk1 and nk3 antagonists

Also Published As

Publication number Publication date
JP2010529069A (ja) 2010-08-26
KR20100028629A (ko) 2010-03-12
AU2008258665B2 (en) 2012-07-05
MX2009013115A (es) 2010-01-15
US7528136B2 (en) 2009-05-05
CN101679241A (zh) 2010-03-24
KR101163292B1 (ko) 2012-07-05
EP2155672B1 (de) 2010-10-27
ES2351378T3 (es) 2011-02-03
EP2155672A1 (de) 2010-02-24
CN101679241B (zh) 2012-06-27
DE602008003221D1 (de) 2010-12-09
BRPI0812447A2 (pt) 2014-12-02
US20080306086A1 (en) 2008-12-11
WO2008148689A1 (en) 2008-12-11
AU2008258665A1 (en) 2008-12-11
CA2689560A1 (en) 2008-12-11
IL202236A0 (en) 2010-06-16

Similar Documents

Publication Publication Date Title
ATE486058T1 (de) Prolinamidderivate als nk3-antagonisten
MX2013001614A (es) Compuestos heterociclico.
PE20071152A1 (es) Compuestos derivados de azabiciclo[3.1.0]hex como moduladores de receptores de dopamina d3
TNSN08372A1 (en) Heterocyclic amides for use as pharmaceuticals
PE20121640A1 (es) Derivados de pirazina como inhibidores de bace
MA32898B1 (fr) Modulateurs allosteriques positifs du recepteur m1 d'arylmethylbenzoquinazolinone
JO2910B1 (en) Organic compounds
ATE438632T1 (de) Aryl-4-ethinylisoxazolderivate
TW200800958A (en) N-substituted-azacyclylamines as histamine-3 antagonists
MX2010002899A (es) Derivados de azaciclilisoquinolinona e isoindolinona como antagonistas de la histamina-3.
IL186777A0 (en) (3,4-dihydro-quinazolin-2-yl) - (2-aryloxy-ethyl) - amines having an activity on the 5 - ht receptor
MX2011008850A (es) Derivados de piperidina como antagonistas del receptor de neuroquinina 3 (nk3).
ATE466854T1 (de) 1h-indol-6-ylpiperazin-1-ylmethanonderivate zur verwendung als h3-rezeptormodulatoren
PE20141168A1 (es) Derivados de pirazolidin-3-ona
ATE512142T1 (de) Pyrimidin- und chinazolinderivate als modulatoren der somatostatin-rezeptor aktivität
EA201070495A1 (ru) МОДУЛЯТОРЫ АКТИВНОСТИ γ-СЕКРЕТАЗЫ ИЗ ГРУППЫ ПИПЕРИДИНИЛА И ПИПЕРАЗИНИЛА
MX2012001799A (es) Derivados de pirrolidina como antagonistas del receptor de neuroquinona 3 (nk3).
MX2012006293A (es) Derivados de pirrolidina como antagonista del receptor nk-3.
ATE546455T1 (de) Spiropiperidinderivate als nk3-antagonisten
ATE461172T1 (de) Azetidinderivate als antagonisten des muskarinrezeptors
ATE549316T1 (de) Piperidinderivate als nk3-rezeptorantagonisten
MX2011008178A (es) Derivados de pirrolidina como antagonistas del receptor de neuroquinina 3 (nk3).
MX2013007411A (es) Derivados de pirrolidina como antagonistas del receptor de neuroquinina 3 (nk3).
ATE498622T1 (de) Prolinamidtetrazolderivate als nk3- rezeptorantagonisten
MX2011007506A (es) Derivados de piperidina como antagonistas del receptor de neuroquinina 3 (nk3).

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 2155672

Country of ref document: EP