ATE486059T1 - Synthese und verfahren zu deren verwendung von tetrahydroindolon analogen und derivaten - Google Patents

Synthese und verfahren zu deren verwendung von tetrahydroindolon analogen und derivaten

Info

Publication number
ATE486059T1
ATE486059T1 AT02725584T AT02725584T ATE486059T1 AT E486059 T1 ATE486059 T1 AT E486059T1 AT 02725584 T AT02725584 T AT 02725584T AT 02725584 T AT02725584 T AT 02725584T AT E486059 T1 ATE486059 T1 AT E486059T1
Authority
AT
Austria
Prior art keywords
derivatives
synthesis
analogues
tetrahydroindolone
tetrahydroindolone analogues
Prior art date
Application number
AT02725584T
Other languages
English (en)
Inventor
David Fick
Mark Foreman
Alvin Glasky
Original Assignee
Spectrum Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrum Pharmaceuticals Inc filed Critical Spectrum Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE486059T1 publication Critical patent/ATE486059T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
AT02725584T 2001-04-20 2002-04-08 Synthese und verfahren zu deren verwendung von tetrahydroindolon analogen und derivaten ATE486059T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/839,289 US6759427B2 (en) 2001-04-20 2001-04-20 Synthesis and methods of use of tetrahydroindolone analogues and derivatives
PCT/US2002/011142 WO2002085856A1 (en) 2001-04-20 2002-04-08 Synthesis and methods of use of tetrahydroindolone analogues and derivatives

Publications (1)

Publication Number Publication Date
ATE486059T1 true ATE486059T1 (de) 2010-11-15

Family

ID=25279337

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02725584T ATE486059T1 (de) 2001-04-20 2002-04-08 Synthese und verfahren zu deren verwendung von tetrahydroindolon analogen und derivaten

Country Status (7)

Country Link
US (6) US6759427B2 (de)
EP (1) EP1383742B1 (de)
AT (1) ATE486059T1 (de)
DE (1) DE60238113D1 (de)
DK (1) DK1383742T3 (de)
ES (1) ES2385932T3 (de)
WO (1) WO2002085856A1 (de)

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US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
EP1715921B1 (de) * 2003-09-25 2013-04-24 Abraxis BioScience, Inc. Tetrahydroindolon-derivate zur Behandlung von neurologischen Erkrankungen
US20050107439A1 (en) * 2003-11-10 2005-05-19 Helton David R. Composition and method for treating emesis
WO2006133634A1 (en) * 2005-06-14 2006-12-21 Beijing Gylongly Biodemtech Co., Ltd Tetrahydroindole derivatives and tetrahydroindazole derivatives, and use thereof
CA2642931A1 (en) * 2006-02-27 2007-09-07 Serenex, Inc. Cyclohexylamino, benzene, pyridine, and pyridazine derivatives
DK2089417T3 (en) 2006-10-12 2015-03-23 Bhi Ltd Partnership Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid
EP2219648A4 (de) * 2007-11-09 2010-11-03 Cenomed Biosciences Llc Behandlung von postraumatischem stress mit tetrahydroindolon-arylpiperazin-verbindungen
US20090264443A1 (en) * 2008-04-18 2009-10-22 David Helton Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds
CN102448495A (zh) * 2009-05-29 2012-05-09 安斯泰来制药株式会社 用于预防和/或治疗注意缺陷/多动障碍的新型医药组合物
RU2503452C2 (ru) * 2011-11-24 2014-01-10 Общество С Ограниченной Ответственностью "Консорциум-Пик" Фармацевтическая композиция на основе растительной докозагексаеновой кислоты для профилактики синдрома гиперактивности у детей
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
JP7173867B2 (ja) 2016-04-22 2022-11-16 ベクトン・ディキンソン・アンド・カンパニー 多重高分子色素デバイス及びその使用方法
CN110337331B (zh) 2017-02-08 2022-04-26 贝克顿·迪金森公司 干染料试剂装置以及制造和使用所述干染料试剂装置的方法
US11992844B2 (en) 2018-11-13 2024-05-28 Becton, Dickinson And Company Dried reagent strainers and methods for making and using the same
CN115210229A (zh) 2020-01-03 2022-10-18 博格有限责任公司 多环酰胺作为治疗癌症的ube2k调节剂

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Also Published As

Publication number Publication date
US20090192319A1 (en) 2009-07-30
US6759427B2 (en) 2004-07-06
US8063233B2 (en) 2011-11-22
US20030022892A1 (en) 2003-01-30
EP1383742B1 (de) 2010-10-27
ES2385932T3 (es) 2012-08-03
US8734818B2 (en) 2014-05-27
US7531670B2 (en) 2009-05-12
DE60238113D1 (de) 2010-12-09
US20020198218A1 (en) 2002-12-26
US6982269B2 (en) 2006-01-03
DK1383742T3 (da) 2011-02-14
EP1383742A1 (de) 2004-01-28
US20050096317A1 (en) 2005-05-05
US20130225648A1 (en) 2013-08-29
US8377456B2 (en) 2013-02-19
US20120070385A1 (en) 2012-03-22
WO2002085856A1 (en) 2002-10-31

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