ATE487725T1 - Neue kristalline polymorphe von clopidogrel - Google Patents

Neue kristalline polymorphe von clopidogrel

Info

Publication number: ATE487725T1
Authority: AT; Austria
Prior art keywords: forms; present; clopidogrel; relates; treating
Prior art date: 2003-09-11

Application number

AT04768414T

Other languages

English (en)

Inventor

Ramakrishnan Arul

Ajay Singh Rawat

Maheshkumar Gadakar

Rajesh Rao

Abhinay Pise

Jason Gray

Original Assignee

Generics Uk Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-11

Filing date

2004-09-09

Publication date

2010-11-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29226875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE487725(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-09-09 Application filed by Generics Uk Ltd filed Critical Generics Uk Ltd

2010-11-15 Application granted granted Critical

2010-11-15 Publication of ATE487725T1 publication Critical patent/ATE487725T1/de

Links

239000005552 B01AC04 - Clopidogrel Substances 0.000 title abstract 2
GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 title abstract 2
229960003009 clopidogrel Drugs 0.000 title abstract 2
230000007214 atherothrombosis Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
208000010125 myocardial infarction Diseases 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
FAGCFTXEUBQVEU-INIZCTEOSA-N (2s)-2-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5-yl)propanoic acid Chemical compound C1([C@](N2CC=3C=CSC=3CC2)(C(O)=O)C)=CC=CC=C1Cl FAGCFTXEUBQVEU-INIZCTEOSA-N 0.000 abstract 1
206010002388 Angina unstable Diseases 0.000 abstract 1
206010003178 Arterial thrombosis Diseases 0.000 abstract 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
101000783577 Dendroaspis angusticeps Thrombostatin Proteins 0.000 abstract 1
101000783578 Dendroaspis jamesoni kaimosae Dendroaspin Proteins 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
208000032382 Ischaemic stroke Diseases 0.000 abstract 1
208000005764 Peripheral Arterial Disease Diseases 0.000 abstract 1
208000030831 Peripheral arterial occlusive disease Diseases 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
208000007814 Unstable Angina Diseases 0.000 abstract 1
229940127218 antiplatelet drug Drugs 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
201000004332 intermediate coronary syndrome Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000106 platelet aggregation inhibitor Substances 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Liquid Crystal Substances (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT04768414T 2003-09-11 2004-09-09 Neue kristalline polymorphe von clopidogrel ATE487725T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0321256.0A GB0321256D0 (en)	2003-09-11	2003-09-11	Novel crystalline compounds
PCT/GB2004/003867 WO2005026174A1 (en)	2003-09-11	2004-09-09	Novel crystalline polymorphs of clopidogrel

Publications (1)

Publication Number	Publication Date
ATE487725T1 true ATE487725T1 (de)	2010-11-15

Family

ID=29226875

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04768414T ATE487725T1 (de)	2003-09-11	2004-09-09	Neue kristalline polymorphe von clopidogrel

Country Status (15)

Country	Link
US (1)	US7897613B2 (de)
EP (4)	EP1618113B1 (de)
AT (1)	ATE487725T1 (de)
AU (1)	AU2004272337B2 (de)
CA (3)	CA2809750A1 (de)
CY (1)	CY1115917T1 (de)
DE (1)	DE602004029999D1 (de)
DK (2)	DK1772456T3 (de)
ES (2)	ES2355729T3 (de)
GB (1)	GB0321256D0 (de)
HU (1)	HUE029256T2 (de)
PL (2)	PL1837337T3 (de)
PT (1)	PT1772456E (de)
SI (1)	SI1772456T1 (de)
WO (1)	WO2005026174A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1713812A1 (de) *	2004-01-13	2006-10-25	Zentiva, a.s.	Neue kristalline formen von clopidogrel-hydrobromid und verfahren zu deren herstellung
AU2005236046A1 (en)	2004-04-20	2005-11-03	Sanofi-Aventis	Clopidogrel salt and polymorphic forms thereof
MXPA06012205A (es) *	2004-04-20	2007-01-31	Sanofi Aventis	Formas polimorficas de hidrobromuro acetato de metil(+)-(s) - alfa- (2-clorofenil)-6,7-dihidrotieno[3,2-c]piridina-5 (4h), hidrobromuro de clopidogrel.
US20060235008A1 (en)	2004-08-19	2006-10-19	Hetero Drugs Limited	Novel polymorphs of efavirenz
EP1704152A2 (de)	2004-09-21	2006-09-27	Teva Pharmaceutical Industries Ltd	Kristallines clopidogrelhydrobromid und verfahren zu dessen herstellung
EP1674468A1 (de) *	2004-12-21	2006-06-28	Ratiopharm GmbH	Polymorphe von Clopidogrel Hydrobromid
US7932391B2 (en)	2005-09-08	2011-04-26	Zhejiang Hauhai Pharmaceutical Co., Ltd.	Method for the preparation of clopidogrel and its analogues of methyl-tetrahydrothieno[3,2-C]pyridine acetate
CN100417653C (zh) *	2005-09-08	2008-09-10	浙江华海药业股份有限公司	噻吩并四氢吡啶乙酸及其盐的制备方法
US8178550B2 (en) *	2006-04-05	2012-05-15	Opko Health, Inc.	Hydrochloride salts of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor
ITMI20062449A1 (it) *	2006-12-19	2008-06-20	Dipharma Spa	Forma cristallina di rabeprazolo sodico
WO2008081473A2 (en) *	2006-12-29	2008-07-10	Cadila Healthcare Limited	Process for preparing clopidogrel
EP1970054A3 (de)	2007-03-14	2009-06-03	Ranbaxy Laboratories Limited	Clopidogrel-Tabletten
EP2107061A1 (de)	2008-04-02	2009-10-07	Krka Tovarna Zdravil, D.D., Novo Mesto	Herstellungsverfahren für optisch angereichertes Clopidogrel
CN102573475B (zh) *	2009-08-14	2016-01-20	欧科生医股份有限公司	神经激肽-1拮抗剂的静脉内制剂
WO2012123958A1 (en)	2011-02-14	2012-09-20	Cadila Healthcare Limited	Highly pure salts of clopidogrel free of genotoxic impurities
US9233103B2 (en)	2011-03-25	2016-01-12	Takeda Pharmaceuticals U.S.A., Inc.	Methods for treating heartburn, gastric bleeding or hemorrhage in patients receiving clopidogrel therapy
TWI461215B (zh) *	2011-06-24	2014-11-21	Acenda Pharma Inc	用以改善酯類前驅藥吸收率的方法與改良之藥學組合物
CN103781478A (zh) *	2011-06-24	2014-05-07	艾森达制药有限公司	用以改善酯类前药吸收率的方法与改良的药学组合物
CA2911837C (en) *	2013-02-06	2022-05-31	Jingjun Huang	Stable pharmaceutical composition of clopidogrel free base for oral and parenteral delivery

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2530247B1 (fr)	1982-07-13	1986-05-16	Sanofi Sa	Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr)	1987-02-17	1992-01-24	Sanofi Sa	Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2652575B1 (fr)	1989-09-29	1992-01-24	Sanofi Sa	Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664596B1 (fr)	1990-07-10	1994-06-10	Sanofi Sa	Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
MA23420A1 (fr) *	1994-01-07	1995-10-01	Smithkline Beecham Corp	Antagonistes bicycliques de fibrinogene.
HU222283B1 (hu)	1997-05-13	2003-05-28	Sanofi-Synthelabo	Eljárás tieno[3,2-c]piridin-származékok előállítására
HU225503B1 (en)	1997-05-13	2007-01-29	Sanofi Aventis	Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them
HU225504B1 (en)	1997-05-13	2007-01-29	Sanofi Aventis	Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
FR2779726B1 (fr)	1998-06-15	2001-05-18	Sanofi Sa	Forme polymorphe de l'hydrogenosulfate de clopidogrel
US6248363B1 (en) *	1999-11-23	2001-06-19	Lipocine, Inc.	Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
HUP0200438A3 (en) *	2002-02-06	2003-10-28	Egis Gyogyszergyar Nyilvanosan	Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
EP1713812A1 (de)	2004-01-13	2006-10-25	Zentiva, a.s.	Neue kristalline formen von clopidogrel-hydrobromid und verfahren zu deren herstellung
MXPA06012205A (es)	2004-04-20	2007-01-31	Sanofi Aventis	Formas polimorficas de hidrobromuro acetato de metil(+)-(s) - alfa- (2-clorofenil)-6,7-dihidrotieno[3,2-c]piridina-5 (4h), hidrobromuro de clopidogrel.

2003
- 2003-09-11 GB GBGB0321256.0A patent/GB0321256D0/en not_active Ceased
2004
- 2004-09-09 EP EP04768414A patent/EP1618113B1/de not_active Expired - Lifetime
- 2004-09-09 DK DK06124851.4T patent/DK1772456T3/en active
- 2004-09-09 DE DE602004029999T patent/DE602004029999D1/de not_active Expired - Lifetime
- 2004-09-09 HU HUE06124847A patent/HUE029256T2/en unknown
- 2004-09-09 CA CA2809750A patent/CA2809750A1/en not_active Abandoned
- 2004-09-09 AT AT04768414T patent/ATE487725T1/de active
- 2004-09-09 AU AU2004272337A patent/AU2004272337B2/en not_active Ceased
- 2004-09-09 CA CA2536052A patent/CA2536052C/en not_active Expired - Fee Related
- 2004-09-09 EP EP06124851.4A patent/EP1772456B1/de not_active Expired - Lifetime
- 2004-09-09 PT PT61248514T patent/PT1772456E/pt unknown
- 2004-09-09 EP EP09159491A patent/EP2149578A1/de not_active Withdrawn
- 2004-09-09 ES ES04768414T patent/ES2355729T3/es not_active Expired - Lifetime
- 2004-09-09 PL PL06124847T patent/PL1837337T3/pl unknown
- 2004-09-09 CA CA2810312A patent/CA2810312A1/en not_active Abandoned
- 2004-09-09 PL PL06124851T patent/PL1772456T3/pl unknown
- 2004-09-09 WO PCT/GB2004/003867 patent/WO2005026174A1/en not_active Ceased
- 2004-09-09 DK DK04768414.7T patent/DK1618113T3/da active
- 2004-09-09 US US10/571,419 patent/US7897613B2/en not_active Expired - Fee Related
- 2004-09-09 ES ES06124851.4T patent/ES2528198T3/es not_active Expired - Lifetime
- 2004-09-09 SI SI200432211T patent/SI1772456T1/sl unknown
- 2004-09-09 EP EP06124847.2A patent/EP1837337B1/de not_active Expired - Lifetime
2015
- 2015-01-12 CY CY20151100024T patent/CY1115917T1/el unknown

Also Published As

Publication number	Publication date
GB0321256D0 (en)	2003-10-08
EP1837337A1 (de)	2007-09-26
CA2536052A1 (en)	2005-03-24
US7897613B2 (en)	2011-03-01
EP1772456A1 (de)	2007-04-11
PT1772456E (pt)	2015-02-06
PL1772456T3 (pl)	2015-03-31
US20070281964A1 (en)	2007-12-06
WO2005026174A1 (en)	2005-03-24
EP1837337B1 (de)	2016-04-06
EP1772456B1 (de)	2014-10-29
ES2355729T3 (es)	2011-03-30
CA2810312A1 (en)	2005-03-24
AU2004272337A1 (en)	2005-03-24
DK1772456T3 (en)	2015-01-19
AU2004272337B2 (en)	2008-02-14
EP2149578A1 (de)	2010-02-03
EP1618113A1 (de)	2006-01-25
PL1837337T3 (pl)	2017-02-28
SI1772456T1 (sl)	2015-03-31
DE602004029999D1 (de)	2010-12-23
CY1115917T1 (el)	2017-01-25
ES2528198T3 (es)	2015-02-05
CA2536052C (en)	2013-06-25
DK1618113T3 (da)	2011-02-07
HUE029256T2 (en)	2017-02-28
EP1618113B1 (de)	2010-11-10
CA2809750A1 (en)	2005-03-24

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