MA23420A1 - Antagonistes bicycliques de fibrinogene. - Google Patents

Antagonistes bicycliques de fibrinogene.

Info

Publication number: MA23420A1
Authority: MA; Morocco
Prior art keywords: fibrinogen antagonists; bicyclic fibrinogen; bicyclic; antagonists; fibrinogen
Prior art date: 1994-01-07

Application number

MA23747A

Other languages

English (en)

Inventor

Francis Huffman William

Edward Bonsinell William

Mcculloch Keenan Richard

Wen-Fu Ku Thomas

Martin Samanen James

Nijole Uzinkas Irene

Francis Callahan James

Allen New Lander Kenneth

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-07

Filing date

1995-01-02

Publication date

1995-10-01

1995-01-02 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1995-10-01 Publication of MA23420A1 publication Critical patent/MA23420A1/fr

Links

FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 title 1
102000008946 Fibrinogen Human genes 0.000 title 1
108010049003 Fibrinogen Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
229940012952 fibrinogen Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)

MA23747A 1994-01-07 1995-01-02 Antagonistes bicycliques de fibrinogene. MA23420A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17901194A	1994-01-07	1994-01-07

Publications (1)

Publication Number	Publication Date
MA23420A1 true MA23420A1 (fr)	1995-10-01

Family

ID=22654859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA23747A MA23420A1 (fr)	1994-01-07	1995-01-02	Antagonistes bicycliques de fibrinogene.

Country Status (26)

Country	Link
US (1)	US6117866A (fr)
EP (1)	EP0738150B1 (fr)
JP (1)	JPH09508620A (fr)
KR (1)	KR100388772B1 (fr)
CN (1)	CN1117569C (fr)
AP (1)	AP542A (fr)
AT (1)	ATE238993T1 (fr)
AU (1)	AU699186B2 (fr)
BG (2)	BG62844B1 (fr)
BR (1)	BR9506499A (fr)
CZ (1)	CZ292323B6 (fr)
DE (1)	DE69530571T2 (fr)
DK (1)	DK0738150T3 (fr)
ES (1)	ES2197914T3 (fr)
HU (1)	HUT76282A (fr)
IL (1)	IL112243A (fr)
MA (1)	MA23420A1 (fr)
NO (1)	NO962859L (fr)
NZ (1)	NZ279394A (fr)
OA (1)	OA10368A (fr)
PT (1)	PT738150E (fr)
SG (1)	SG64884A1 (fr)
SK (1)	SK86996A3 (fr)
TW (1)	TW420682B (fr)
WO (1)	WO1995018619A1 (fr)
ZA (1)	ZA9545B (fr)

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US6569402B1 (en)	1998-12-18	2003-05-27	Bristol-Myers Squibb Pharma Company	Vitronectin receptor antagonist pharmaceuticals
EP1140864A2 (fr)	1998-12-18	2001-10-10	Du Pont Pharmaceuticals Company	Medicaments antagonistes du recepteur de la vitronectine
GB9908662D0 (en) *	1999-04-15	1999-06-09	Smithkline Beecham Plc	Novel process for preparing benzodiazepines
CO5180550A1 (es) *	1999-04-19	2002-07-30	Smithkline Beecham Corp	Inhibidores de fab i
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AR025976A1 (es)	1999-10-08	2002-12-26	Affinium Pharm Inc	Inhibidores de fab i.
US6730684B1 (en)	1999-10-08	2004-05-04	Affinium Pharmaceuticals, Inc.	Fab I inhibitors
US6762201B1 (en)	1999-10-08	2004-07-13	Affinium Pharmaceuticals, Inc.	Fab I inhibitors
SE9904377D0 (sv) *	1999-12-01	1999-12-01	Astra Pharma Prod	Pharmaceutical combinations
US6964974B2 (en)	2000-09-08	2005-11-15	Hoffmann-La Roche Inc.	2,3-oxidosqualene-lanosterol cyclase inhibitors
CA2444597A1 (fr)	2001-04-06	2002-10-06	Affinium Pharmaceuticals, Inc.	Inhibiteurs de fab i
US7645442B2 (en)	2001-05-24	2010-01-12	Alexza Pharmaceuticals, Inc.	Rapid-heating drug delivery article and method of use
US7090830B2 (en)	2001-05-24	2006-08-15	Alexza Pharmaceuticals, Inc.	Drug condensation aerosols and kits
US7585493B2 (en)	2001-05-24	2009-09-08	Alexza Pharmaceuticals, Inc.	Thin-film drug delivery article and method of use
US7458374B2 (en)	2002-05-13	2008-12-02	Alexza Pharmaceuticals, Inc.	Method and apparatus for vaporizing a compound
US7766013B2 (en)	2001-06-05	2010-08-03	Alexza Pharmaceuticals, Inc.	Aerosol generating method and device
US20070122353A1 (en)	2001-05-24	2007-05-31	Hale Ron L	Drug condensation aerosols and kits
WO2003059251A2 (fr)	2001-10-22	2003-07-24	The Scripps Research Institute	Composes de ciblage d'anticorps
AU2003301346A1 (en) *	2002-10-17	2004-05-04	The Trustees Of The University Of Pennsylvania	Method of treating neurological diseases and disorders
US20040105818A1 (en)	2002-11-26	2004-06-03	Alexza Molecular Delivery Corporation	Diuretic aerosols and methods of making and using them
US7913688B2 (en)	2002-11-27	2011-03-29	Alexza Pharmaceuticals, Inc.	Inhalation device for producing a drug aerosol
US20040234699A1 (en)	2003-05-21	2004-11-25	Alexza Molecular Delivery Corporation	Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
GB0321256D0 (en) *	2003-09-11	2003-10-08	Generics Uk Ltd	Novel crystalline compounds
US7759387B2 (en)	2003-10-08	2010-07-20	Piramal Life Sciences Limited	Fibrinogen receptor antagonists and their use
US7540286B2 (en)	2004-06-03	2009-06-02	Alexza Pharmaceuticals, Inc.	Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (fr)	2004-08-12	2012-11-21	Alexza Pharmaceuticals, Inc.	Dispositif d'administration de médicament en aérosol comprenant une unité de chauffage allumée par percussion
WO2007048127A2 (fr) *	2005-10-20	2007-04-26	The Scripps Research Institute	MARQUAGE DE PARTIES Fc POUR L'IMMUNOCOLORATION ET L'IMMUNOCIBLAGE
EP2687533B1 (fr)	2006-07-20	2017-07-19	Debiopharm International SA	Dérivés d'acrylamide en tant qu'inhibiteurs de FAB I
US8263613B2 (en)	2007-02-16	2012-09-11	Affinium Pharmaceuticals, Inc.	Salts, prodrugs and polymorphs of fab I inhibitors
EP2121088B1 (fr)	2007-03-09	2016-07-13	Alexza Pharmaceuticals, Inc.	Unité chauffante à utiliser dans un dispositif d'administration de médicament
WO2010093706A2 (fr)	2009-02-10	2010-08-19	The Scripps Research Institute	Vaccination programmée chimiquement
SMT201900411T1 (it)	2012-06-19	2019-09-09	Debiopharm Int Sa	Derivati di profaramci di (e)-n-metil-n-((3-metilbenzofuran-2-il)metil -3-(7-osso-5,6,7,8-tetraidro-1,8-naftiridin-3-il)acrilammide
BR122023021456A2 (pt)	2016-02-26	2024-02-20	Debiopharm International S.A.	Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica
US12214118B2 (en)	2018-02-02	2025-02-04	Alexza Pharmaceuticals, Inc.	Electrical condensation aerosol device
WO2019210308A1 (fr) *	2018-04-27	2019-10-31	Arrowhead Pharmaceuticals, Inc.	Ligands ciblant des intégrines et utilisations de ceux-ci
FI3923914T3 (fi)	2019-02-14	2023-04-27	Debiopharm Int Sa	Afabisiiniformulaatio, menetelmä sen valmistamiseksi
MA56184A (fr)	2019-06-14	2022-04-20	Debiopharm Int Sa	Afabicine pour utilisation dans le traitement d'infections bactériennes impliquant un biofilm

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EP0559793A1 (fr) *	1990-11-30	1993-09-15	Smithkline Beecham Corporation	Inhibiteurs de la protease du vih
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HUT71819A (en) *	1992-11-09	1996-02-28	Boots Co Plc	1,4-benzothiazepine derivatives and pharmaceutical compositions containing them
SG63579A1 (en) *	1992-12-21	1999-03-30	Smithkline Beecham Corp	Bicyclic fibrinogen antagonists
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ZA955391B (en) *	1994-06-29	1996-02-09	Smithkline Beecham Corp	Vitronectin receptor antagonists

1995
- 1995-01-02 MA MA23747A patent/MA23420A1/fr unknown
- 1995-01-04 IL IL11224395A patent/IL112243A/xx not_active IP Right Cessation
- 1995-01-05 ZA ZA9545A patent/ZA9545B/xx unknown
- 1995-01-06 AP APAP/P/1995/000710A patent/AP542A/en active
- 1995-01-09 WO PCT/US1995/000248 patent/WO1995018619A1/fr not_active Ceased
- 1995-01-09 DE DE69530571T patent/DE69530571T2/de not_active Expired - Fee Related
- 1995-01-09 DK DK95908006T patent/DK0738150T3/da active
- 1995-01-09 EP EP95908006A patent/EP0738150B1/fr not_active Expired - Lifetime
- 1995-01-09 SK SK869-96A patent/SK86996A3/sk unknown
- 1995-01-09 SG SG1996004249A patent/SG64884A1/en unknown
- 1995-01-09 NZ NZ279394A patent/NZ279394A/en not_active IP Right Cessation
- 1995-01-09 JP JP7518646A patent/JPH09508620A/ja not_active Ceased
- 1995-01-09 PT PT95908006T patent/PT738150E/pt unknown
- 1995-01-09 BR BR9506499A patent/BR9506499A/pt not_active Application Discontinuation
- 1995-01-09 AU AU16001/95A patent/AU699186B2/en not_active Ceased
- 1995-01-09 HU HU9601849A patent/HUT76282A/hu unknown
- 1995-01-09 AT AT95908006T patent/ATE238993T1/de not_active IP Right Cessation
- 1995-01-09 ES ES95908006T patent/ES2197914T3/es not_active Expired - Lifetime
- 1995-01-09 CN CN95191991A patent/CN1117569C/zh not_active Expired - Fee Related
- 1995-01-09 US US08/875,359 patent/US6117866A/en not_active Expired - Fee Related
- 1995-01-09 KR KR1019960703660A patent/KR100388772B1/ko not_active Expired - Fee Related
- 1995-01-09 CZ CZ19961981A patent/CZ292323B6/cs not_active IP Right Cessation
- 1995-02-16 TW TW084101430A patent/TW420682B/zh not_active IP Right Cessation
1996
- 1996-07-05 NO NO962859A patent/NO962859L/no unknown
- 1996-07-05 BG BG100698A patent/BG62844B1/bg unknown
- 1996-07-05 OA OA60858A patent/OA10368A/en unknown
1998
- 1998-10-22 BG BG102863A patent/BG102863A/xx unknown

Also Published As

Publication number	Publication date
IL112243A (en)	1999-12-31
AU1600195A (en)	1995-08-01
WO1995018619A9 (fr)	2004-10-21
CZ292323B6 (cs)	2003-09-17
DE69530571T2 (de)	2004-03-04
HU9601849D0 (en)	1996-09-30
ATE238993T1 (de)	2003-05-15
BR9506499A (pt)	1997-09-09
JPH09508620A (ja)	1997-09-02
BG100698A (bg)	1997-02-28
TW420682B (en)	2001-02-01
EP0738150A4 (fr)	1997-03-19
DK0738150T3 (da)	2003-08-25
AP9500710A0 (en)	1995-01-31
OA10368A (en)	2001-11-15
CZ198196A3 (en)	1997-06-11
AU699186B2 (en)	1998-11-26
BG62844B1 (bg)	2000-09-29
ZA9545B (en)	1996-01-23
SK86996A3 (en)	1997-02-05
HK1014668A1 (en)	1999-09-30
PT738150E (pt)	2003-08-29
WO1995018619A1 (fr)	1995-07-13
EP0738150B1 (fr)	2003-05-02
KR100388772B1 (ko)	2003-11-20
EP0738150A1 (fr)	1996-10-23
CN1143323A (zh)	1997-02-19
IL112243A0 (en)	1995-03-30
NO962859D0 (no)	1996-07-05
AP542A (en)	1996-10-01
NO962859L (no)	1996-09-05
DE69530571D1 (de)	2003-06-05
SG64884A1 (en)	1999-05-25
ES2197914T3 (es)	2004-01-16
HUT76282A (en)	1997-07-28
NZ279394A (en)	1998-05-27
CN1117569C (zh)	2003-08-13
BG102863A (en)	1999-05-31
US6117866A (en)	2000-09-12

Publication	Publication Date	Title
BR9506499A (pt)	1997-09-09	Antagonistas biciclicos de fibrinogênio
EP0986385A4 (fr)	2001-05-16	Antagonistes de gonadoliberine
ATE233260T1 (de)	2003-03-15	Muscarin-antagonisten
FI960156A7 (fi)	1996-01-12	Bentsyylioksikinuklidiinit aineet P antagonisteina
EP0702671A4 (fr)	1996-06-19	Antagonistes bicycliques du fibrinogene
FI946140L (fi)	1995-06-30	Diatsabisyklisiä neurokiniiniantagonisteja
BR9406946A (pt)	1996-08-06	Tetra-hidro-pirazolpiridinas bicíclicas
MA24261A1 (fr)	1998-04-01	Pyridines bicycliques condensees.
EP0866705A4 (fr)	1999-03-03	Antagonistes du recepteur de fibrinogene
FI954991A7 (fi)	1996-04-21	Bisyklisiä tetrahydropyrazolopyridiinejä
FI960516A7 (fi)	1996-08-07	Substituoituja bifenyylisulfonamidiendoteliiniantagonisteja
EP0799189A4 (fr)	1999-03-17	Antagonistes bicycliques du fibrinogene
FI953916A7 (fi)	1995-08-21	Fibrinogeenireseptoriantagonisteja
EP0796252A4 (fr)	1998-02-04	Antagonistes du fibrinogene a cycle double
ATE242215T1 (de)	2003-06-15	Fluoralkyl- und fluoralkoxysubstituierte hetero- cyclische bradykinin-antagonisten
DE69735811D1 (de)	2006-06-08	Piperazinoderivate als neurokinin-antagonisten
FI961985A0 (fi)	1996-05-09	Oscillatorkrets
FI961984A0 (fi)	1996-05-09	Oscillatorkrets
BR1100543A (pt)	2006-05-09	antagonistas bicìclicos de fibrinogênio
SI0738150T1 (en)	2003-10-31	Bicyclic fibrinogen antagonists
KR970702876A (ko)	1997-06-10	뉴로키닌 길항제(Neurokinine (tachykinine) antagonists)
FR2720962B1 (fr)	1996-08-23	Baguetteuse.
ZA944019B (en)	1995-01-18	Bicyclic fibrinogen antagonists
ES1023439Y (es)	1994-02-01	Nueva bayeta de limpieza.
ES1024827Y (es)	1994-06-01	Cepillo de dientes.